LOCUS       NM_001172223            1745 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MOB kinase activator 2 (MOB2), transcript variant 1,
            mRNA.
ACCESSION   NM_001172223
VERSION     NM_001172223.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1745)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1745)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1745)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 1745)
  AUTHORS   Jiang,K., Yao,G., Hu,L., Yan,Y., Liu,J., Shi,J., Chang,Y.,
            Zhang,Y., Liang,D., Shen,D., Zhang,G., Meng,S. and Piao,H.
  TITLE     MOB2 suppresses GBM cell migration and invasion via regulation of
            FAK/Akt and cAMP/PKA signaling
  JOURNAL   Cell Death Dis 11 (4), 230 (2020)
   PUBMED   32286266
  REMARK    GeneRIF: MOB2 suppresses GBM cell migration and invasion via
            regulation of FAK/Akt and cAMP/PKA signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1745)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1745)
  AUTHORS   Gomez,V., Gundogdu,R., Gomez,M., Hoa,L., Panchal,N., O'Driscoll,M.
            and Hergovich,A.
  TITLE     Regulation of DNA damage responses and cell cycle progression by
            hMOB2
  JOURNAL   Cell Signal 27 (2), 326-339 (2015)
   PUBMED   25460043
  REMARK    GeneRIF: hMOB2 interacts with RAD50, facilitating the recruitment
            of the MRE11-RAD50-NBS1 (MRN) DNA damage sensor complex and
            activated ATM to DNA damaged chromatin.
REFERENCE   7  (bases 1 to 1745)
  AUTHORS   Hauri,S., Wepf,A., van Drogen,A., Varjosalo,M., Tapon,N.,
            Aebersold,R. and Gstaiger,M.
  TITLE     Interaction proteome of human Hippo signaling: modular control of
            the co-activator YAP1
  JOURNAL   Mol Syst Biol 9, 713 (2013)
   PUBMED   24366813
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1745)
  AUTHORS   Leng,J.J., Tan,H.M., Chen,K., Shen,W.G. and Tan,J.W.
  TITLE     Growth-inhibitory effects of MOB2 on human hepatic carcinoma cell
            line SMMC-7721
  JOURNAL   World J Gastroenterol 18 (48), 7285-7289 (2012)
   PUBMED   23326134
  REMARK    GeneRIF: MOB2 overexpression induces apoptosis and inhibits the
            growth of human hepatic cancer cells
REFERENCE   9  (bases 1 to 1745)
  AUTHORS   Kohler,R.S., Schmitz,D., Cornils,H., Hemmings,B.A. and Hergovich,A.
  TITLE     Differential NDR/LATS interactions with the human MOB family reveal
            a negative role for human MOB2 in the regulation of human NDR
            kinases
  JOURNAL   Mol Cell Biol 30 (18), 4507-4520 (2010)
   PUBMED   20624913
  REMARK    GeneRIF: Data indicate that human MOB2 is a negative regulator of
            human NDR kinases in biochemical and biological settings.
REFERENCE   10 (bases 1 to 1745)
  AUTHORS   Devroe,E., Erdjument-Bromage,H., Tempst,P. and Silver,P.A.
  TITLE     Human Mob proteins regulate the NDR1 and NDR2 serine-threonine
            kinases
  JOURNAL   J Biol Chem 279 (23), 24444-24451 (2004)
   PUBMED   15067004
  REMARK    GeneRIF: Binds to and stimulates the kinase activity of the related
            human serine-threonine kinases NDR1 and NDR2.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091196.6, DC413532.1, AK296658.1, BC047291.1 and AW874617.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001172223.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.852508.1, ERR279857.515.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329957.7/ ENSP00000328694.6
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC091196.6         95457-95517         c
            62-541              DC413532.1         1-480
            542-1240            AK296658.1         509-1207
            1241-1739           BC047291.1         965-1463
            1740-1745           AW874617.1         24-29               c
FEATURES             Location/Qualifiers
     source          1..1745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1745
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /note="MOB kinase activator 2"
                     /db_xref="GeneID:81532"
                     /db_xref="HGNC:HGNC:24904"
                     /db_xref="MIM:611969"
     exon            1..333
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1030
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /note="isoform 1 is encoded by transcript variant 1; Mps
                     one binder kinase activator-like 2; MOB2 Mps One Binder
                     homolog"
                     /codon_start=1
                     /product="MOB kinase activator 2 isoform 1"
                     /protein_id="NP_001165694.1"
                     /db_xref="CCDS:CCDS53591.1"
                     /db_xref="GeneID:81532"
                     /db_xref="HGNC:HGNC:24904"
                     /db_xref="MIM:611969"
                     /translation="MLGDHCSLPEDQARPGQSLQSGLCCKMVLQAVSKVLRKSKAKPN
                     GKKPAAEERKAYLEPEHTKARITDFQFKELVVLPREIDLNEWLASNTTTFFHHINLQY
                     STISEFCTGETCQTMAVCNTQYYWYDERGKKVKCTAPQYVDFVMSSVQKLVTDEDVFP
                     TKYGREFPSSFESLVRKICRHLFHVLAHIYWAHFKETLALELHGHLNTLYVHFILFAR
                     EFNLLDPKETAIMDDLTEVLCSGAGGVHSGGSGDGAGSGGPGAQNHVKER"
     exon            334..494
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            495..588
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            589..713
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            714..1745
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1722..1727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /note="hexamer: AATAAA"
     polyA_site      1745
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /note="major polyA site"
ORIGIN      
        1 ctcttctggc agccatgcca cttggaaaag gccaattcag acgctccctc gtttcaccag
       61 ccttggccag cccttgcctc tggaaagggg gcagctgttt gtctctgcca ggcgtcccat
      121 tggccaggga gtgaggctgg agggcccggc agcaggcatt tgcgagtgct ggccagccgg
      181 caccccgccc cgcttctcct ccccaccttc ccgtcgccca ctcatgctgg gagaccactg
      241 cagtctccct gaagaccaag cccggcccgg ccagtccctg caaagtggac tctgctgcaa
      301 aatggtgctt caggctgtca gcaaagtgct caggaagtcc aaagccaagc ctaatggcaa
      361 gaagcccgct gcggaggaga ggaaggccta cctggagcct gagcacacca aggccaggat
      421 caccgacttc cagttcaagg agctggtggt gctgccccgc gagattgacc ttaacgagtg
      481 gctggccagc aacaccacga cgtttttcca ccacatcaac ctgcagtata gcaccatctc
      541 cgagttctgc acaggagaga cgtgtcagac gatggccgtg tgcaacacac agtactactg
      601 gtatgacgag cgggggaaga aggtcaagtg cacggcccca cagtacgttg acttcgtcat
      661 gagctccgtg cagaagctgg tgacggatga ggacgtgttc cccacaaaat acggcagaga
      721 attccccagc tcctttgagt ccctggtgag gaagatctgc agacacctgt tccacgtgct
      781 ggcacacatc tactgggccc acttcaagga gacgctggcc ctggagctgc acggacactt
      841 gaacacgctc tacgtccact tcatcctctt tgctcgggag ttcaacctgc tggaccccaa
      901 agagaccgcc atcatggacg acctcaccga ggtgctatgc agcggggccg gcggggtcca
      961 cagtgggggc agtggggatg gggccggcag cgggggcccg ggagcacaga accacgtgaa
     1021 ggagagatga gccccccggg ccggacaggg gcacacgtgt gcaaagagac ggtggtgtgt
     1081 gttctctcct gcatctgcgt gtgcacacat gtgctgggca cgcgtgtggt gaggtctgag
     1141 agggccccgg gctgcactgg tgtgggctgc acaggcacag acgcagacgg ccccggccgt
     1201 gtcctgtggc cccctgtcgg atggatgcgt gccgtttgta gagaagagcc tttgggccca
     1261 ttcactcgtt cagcagacac gcatgggact gatgctttga gttttcttct gtggggtttt
     1321 cctttctctg gtctccgtgc agcccctgcc ctccctcggg tgctgctggc ctcaaaggag
     1381 gaactcgtgg ggggagggtg tgatttgcag acctgggtct ctgctctgct ctgggggtgg
     1441 ggcttgcttt cacagagacc ctccttccct ctcacccctc ctctcccggc ctcgccagga
     1501 gtcttggctg ttggcagctc agaggtgggg gaggcctgtg gtgtgaggtg ccctgcacct
     1561 gctcctgctc ctgtcacccc ttcctgctgc ctcctccatg cccaaggaac acccatggtg
     1621 cagtcctcag gcaaggccag gacggggctg aggccctgcg tggagatgct gcaccagcgg
     1681 aaggctgaga cccgcttacc ttagttcatc tgttcactcg taataaaaag aattctctca
     1741 ggtca
//
