LOCUS       NM_173468               6930 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MOB kinase activator 1B (MOB1B), transcript variant 2,
            mRNA.
ACCESSION   NM_173468
VERSION     NM_173468.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6930)
  AUTHORS   Pang,H., Wang,J., Wei,Q., Liu,J., Chu,X., Yuan,C., Yang,B., Li,M.,
            Ma,D., Tang,Y., Wang,C. and Zhang,J.
  TITLE     miR-548ag functions as an oncogene by suppressing MOB1B in the
            development of obesity-related endometrial cancer
  JOURNAL   Cancer Sci 114 (4), 1507-1518 (2023)
   PUBMED   36445107
  REMARK    GeneRIF: miR-548ag functions as an oncogene by suppressing MOB1B in
            the development of obesity-related endometrial cancer.
REFERENCE   2  (bases 1 to 6930)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6930)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 6930)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6930)
  AUTHORS   Bae,J.S., Jeon,Y., Kim,S.M., Jang,J.Y., Park,M.K., Kim,I.H.,
            Hwang,D.S., Lim,D.S. and Lee,H.
  TITLE     Depletion of MOB1A/B causes intestinal epithelial degeneration by
            suppressing Wnt activity and activating BMP/TGF-beta signaling
  JOURNAL   Cell Death Dis 9 (11), 1083 (2018)
   PUBMED   30349003
  REMARK    GeneRIF: MOB1A/B has an essential function for intestinal
            epithelial homeostasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6930)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   7  (bases 1 to 6930)
  AUTHORS   Chow,A., Hao,Y. and Yang,X.
  TITLE     Molecular characterization of human homologs of yeast MOB1
  JOURNAL   Int J Cancer 126 (9), 2079-2089 (2010)
   PUBMED   19739119
REFERENCE   8  (bases 1 to 6930)
  AUTHORS   Praskova,M., Xia,F. and Avruch,J.
  TITLE     MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell
            proliferation
  JOURNAL   Curr Biol 18 (5), 311-321 (2008)
   PUBMED   18328708
REFERENCE   9  (bases 1 to 6930)
  AUTHORS   Bichsel,S.J., Tamaskovic,R., Stegert,M.R. and Hemmings,B.A.
  TITLE     Mechanism of activation of NDR (nuclear Dbf2-related) protein
            kinase by the hMOB1 protein
  JOURNAL   J Biol Chem 279 (34), 35228-35235 (2004)
   PUBMED   15197186
REFERENCE   10 (bases 1 to 6930)
  AUTHORS   Devroe,E., Erdjument-Bromage,H., Tempst,P. and Silver,P.A.
  TITLE     Human Mob proteins regulate the NDR1 and NDR2 serine-threonine
            kinases
  JOURNAL   J Biol Chem 279 (23), 24444-24451 (2004)
   PUBMED   15067004
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021989.8, BC038112.1 and
            AC093851.5.
            
            On Jun 2, 2019 this sequence version replaced NM_173468.3.
            
            Summary: The protein encoded by this gene is similar to the yeast
            Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential
            for spindle pole body duplication and mitotic checkpoint
            regulation. Three transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant differs in the 5' UTR and coding
            sequence compared to variant 1. The resulting isoform (2) has a
            shorter and distinct N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038112.1, SRR1660809.176545.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309395.7/ ENSP00000310189.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC021989.8         107613-107635
            24-2741             BC038112.1         6-2723
            2742-6930           AC093851.5         2001-6189
FEATURES             Location/Qualifiers
     source          1..6930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..6930
                     /gene="MOB1B"
                     /gene_synonym="MATS2; MOB4A; MOBKL1A"
                     /note="MOB kinase activator 1B"
                     /db_xref="GeneID:92597"
                     /db_xref="HGNC:HGNC:29801"
                     /db_xref="MIM:609282"
     exon            1..182
                     /gene="MOB1B"
                     /gene_synonym="MATS2; MOB4A; MOBKL1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..819
                     /gene="MOB1B"
                     /gene_synonym="MATS2; MOB4A; MOBKL1A"
                     /note="isoform 2 is encoded by transcript variant 2; mps
                     one binder kinase activator-like 1A; mob1A; mob1 homolog
                     1A; MOB1, Mps One Binder kinase activator-like 1A; MOB1
                     Mps One Binder homolog B"
                     /codon_start=1
                     /product="MOB kinase activator 1B isoform 2"
                     /protein_id="NP_775739.1"
                     /db_xref="CCDS:CCDS34002.1"
                     /db_xref="GeneID:92597"
                     /db_xref="HGNC:HGNC:29801"
                     /db_xref="MIM:609282"
                     /translation="MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMA
                     VMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTN
                     IKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYA
                     HIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR"
     exon            183..349
                     /gene="MOB1B"
                     /gene_synonym="MATS2; MOB4A; MOBKL1A"
                     /inference="alignment:Splign:2.1.0"
     exon            350..443
                     /gene="MOB1B"
                     /gene_synonym="MATS2; MOB4A; MOBKL1A"
                     /inference="alignment:Splign:2.1.0"
     exon            444..577
                     /gene="MOB1B"
                     /gene_synonym="MATS2; MOB4A; MOBKL1A"
                     /inference="alignment:Splign:2.1.0"
     exon            578..741
                     /gene="MOB1B"
                     /gene_synonym="MATS2; MOB4A; MOBKL1A"
                     /inference="alignment:Splign:2.1.0"
     exon            742..6930
                     /gene="MOB1B"
                     /gene_synonym="MATS2; MOB4A; MOBKL1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6905..6910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOB1B"
                     /gene_synonym="MATS2; MOB4A; MOBKL1A"
                     /note="hexamer: AATAAA"
     polyA_site      6930
                     /gene="MOB1B"
                     /gene_synonym="MATS2; MOB4A; MOBKL1A"
                     /note="major polyA site"
ORIGIN      
        1 attggaacta gctgagccga actagttgcg gccaccgagc agccggctct cggcacctcc
       61 tcctccgcct ccctgtctcc tgttccattc gcctttcctc ttctttcctg gcccacgccg
      121 ctccgaggcc tcgcgaccgc cgagcctgca gcctgccccg cggccaacat gagcttcttg
      181 tttggtagtc gctcttctaa aacttttaaa ccaaagaaga acattccaga gggttctcac
      241 cagtatgagc tcttaaaaca cgcagaagcc acacttggca gtggcaacct tcggatggct
      301 gtcatgcttc ctgaagggga agatctcaat gaatgggttg cagttaacac tgtggatttc
      361 ttcaatcaga tcaacatgct ttatggaact atcacagact tctgtacaga agagagttgt
      421 ccagtgatgt cagctggccc aaaatatgag tatcattggg cagatggaac gaacataaag
      481 aaacctatta agtgctctgc accaaagtat attgattact tgatgacttg ggttcaggac
      541 cagttggatg atgagacgtt atttccatca aaaattggtg tcccgttccc aaagaatttc
      601 atgtctgtgg caaaaactat actcaaacgc ctctttaggg tttatgctca catttatcat
      661 cagcattttg accctgtgat ccagcttcag gaggaagcac atctaaatac atctttcaag
      721 cactttattt tttttgtcca ggaattcaac cttattgata gaagagaact tgcaccactc
      781 caagaactga ttgaaaaact cacctcaaaa gacagataaa aggatgcaga gctgtgcaaa
      841 ttgttcctca aatgaagcag tgtggagtgt attggggatt ttgttatatt ttgtttttat
      901 ctggattgtt tttgtcctag gtttgggggc gggggcttgt ttgggttcct ttttctttat
      961 tctgattatg tgaaaccata ttctattgct aggggaagcc aagaaccatt ctctatacac
     1021 ttgataaggg taaatttatc ttagtgtttt taaacttggt tttggttact tgaggagttt
     1081 tttaataata ttgtgtgctg caagaaagtg cttgttgatt gaactgccga tggattggtt
     1141 tctgtgtggt ataaattgtg gcccatttat gaagtcccca aaagagttat gtttttaagt
     1201 gccttggcag gctcacttct gaggtgcaaa acatagatat agaactgaac agggcttgaa
     1261 acaatattag gattactacc cagggcactt actggtgcat gttgtaacat atctatgata
     1321 aaagccatag tttacctaaa atggtgattt ccagccttta ctgctttgaa gaaacagaat
     1381 ttgtaaaggt atgcatgtag aacataaaaa atatttctta attatttttt atattgatgg
     1441 taatatatta cgttcaacaa tgcttaaagc tctacaagca ggtcttttcc cacctcttga
     1501 tatctgtgat actgaaactt gaggatgttg aaatgtatta cattttggct tctttctaca
     1561 tgttaactgc actgtagatg taaaaattca ggttatatat aggattgcca tcttcagagg
     1621 tgatgctgaa ctgtgaggtt tcctagtaat tgccaaatga gccgtaagtc tgcagaattc
     1681 ccttctactt tgaagagaag gggataggaa tgtatatttg gctgggggca tggagatgtt
     1741 cgtatgtatg aggagttagg gatggggagt caagttctag aaagttttgt ctgaaaacct
     1801 ttgaatagaa tggcatgaag attttaatca attacttata aacaaagtct tagagacttc
     1861 cttttaggaa tcaacttcca tgagaagtta aaaataaatt attaatttta ggtacagaca
     1921 ttaaacatgg aatttaagga ctgttggggg aaattgatca cttcttagca tttccattca
     1981 gtgaatggag ctgatgtttg cctgtcattt taagatgata ccataccttc tttggttatt
     2041 ataggtccag tttgaagcat tctgacttct ggtttttcca ccctgaaagg aaatgttttt
     2101 ctttgcagca gtattagata atgaaaaatg ctaattcagt agttattaac ttctaaattt
     2161 tattcgccat gactttctag tgaattatta ccataaataa caatttcaga aacttagttt
     2221 ttagaataaa tattaatttt tccacttcag ttttattcta gaaaataccc tttttagaaa
     2281 tccagtttta gttttgtcat tttcgataaa tctttcttca gttagaaata tatatccttc
     2341 cttcagttga aacatatacc tttttcacat ctaggaagaa atgcttgctc tgaaatagta
     2401 tagattaaaa acactcagta gaaaagaatc taaaattaaa tgaatttgtt ttgccattaa
     2461 agtagagcag tgatacaatt taatgccatt acaattatgt tgactagaaa ctgccttttt
     2521 ctccacttca tttctagcaa ttatttacca agtaccaaca gtagaagtaa caggaaagcc
     2581 tggcagagtt aaatatcttg gacatttatt ggtaaagctt atttataaac tgcagtcaga
     2641 gctagttaat ttccttaaat ctttttgtat tcagatagat aatatgaatc attatgggtt
     2701 gattcagaaa taaaatttgt gaggtgattt tgaatcttgt ccatatagga aaatgaagca
     2761 cagaattact cagtcttcca tattgtattt gacttcatat caatctagta aaaaaggagt
     2821 tgcaatagcc aagtatagag agaatagtga aaaattaatc ttgccctttc aagccttata
     2881 cagtagtaca ctgtacttgt ttttagtagt aagacctact ttcccactat atgtagatag
     2941 tttgttttca ctgtgccaga atctcaggtg cctgcttaga gtatttcttt aatcacagtc
     3001 actgggaagt aaggagatgt atatatgtgt atatatggta acaaagcata gcagttctct
     3061 aggggagagg cctggcattg cacatggtgt tacatggcta caagtaagga aaaaatcaga
     3121 aagtgaaaga actgatgtaa taaaaggttg atttggttgg ttcccatgaa agttagtaag
     3181 atgccctttt aaatataagg atcagtgctt tgttctgcag cagagtttgc tgataaatgt
     3241 ctgttggatt ctttttggat ttctttaatt aatttgtaag taaccaagat aattattttc
     3301 ccccttgctc tctatattaa tacgtagcta taaagcaaca gttggttttc ttatcctttg
     3361 ataaaagcat cccataaaat ataaagtagt aagttaacat agtattattg tcacacacaa
     3421 tgcttttttt ggttaaatgt tgatacgaag caatgttttg gaattacttt aattgatgga
     3481 gtagtggtgg tagagagaaa ttaataacaa aaagagtgaa aatattttaa ttagcagtag
     3541 atggtgctac tggctttcat ttgctgactt gattattccc tttctcttaa aaaccatggc
     3601 attagactgc actaaattaa caagcatgtt agttgctggt agaggttttg gaggttaatt
     3661 taccttaaat tggaagactt ttaattgcag tctctttcta ccttccctct gttagtcatt
     3721 tgtaaattct aaatggtcac cataaaatgt attaggtagg agaagatacg ttttatgtat
     3781 aatatatctc agactgagtt actgcctgtc ttatcaggat ggataaaaca ctacagtctc
     3841 ttatcaggaa atagagatga tgtggatatt tatatattac atatataacc accagactcc
     3901 attttatata ttagcatttt ccttgcttat gggaaaatag caaaacaaca tttcatttat
     3961 acttttgttt acccctctct gagacaggtt ttgataacca ctgaaatggt agaatatgtg
     4021 agatacaaat attgagttgt agaactttct ttttaaggtg aataagtcat gccttaacat
     4081 ccaaataaga gttcatcttc agagtggttc ttttgggagc actgtttatt ccagctatac
     4141 tgcaaaagta taatgttttt ggaactgttc tagagcatac catgaaaagc agtttgttat
     4201 tatgcaggaa aatcagtttc atcattttag ttacactaaa cacttttggc agcttaatat
     4261 gaccttttta aatttttttt atttttttta tttttatttc tttaagatgg agtcttgctc
     4321 tgttgcccgg gctggagtac aatggcatga tctcagctca ctgcaacctc cacctcctgg
     4381 gttcaagcat ttctcctgcc tcagcctccc aagtagctgg gattacaggc agcaccacac
     4441 ctggctaatt ttcatatttt tagtagagat ggggtttcaa catattggcc aggctggtct
     4501 caaactcctg acctcaagtg atccgccctc cccagcctcc caaagtgctg ggattacagg
     4561 tgtgagccac cacagccagc cagtatgacc tatcttaatc atcagctcaa ctgtaattta
     4621 aatttggctg ttctctggag ctaaaccatt agggaagttc aaaggaatgt gccatgattt
     4681 ccgaatttgc acaagagaat gttttaagca ttggtagcat aattgaataa aagaatagtt
     4741 tcctgatgtc actattttga agtggaaatt atcacttgga tgtggaggtt ttacttttta
     4801 aaaacattca gcttaattac cttaccttaa ttaccttagt tagatatact aatggaaaaa
     4861 aaccaagtcc tttctctaga acttgttttc tatttttgtt ccttttcatg aaaacttctc
     4921 aatttaattt taactactgt aggatagtat tgattgaatg gatactatgg aaaagtggat
     4981 ccaatattta agatagaagt agtttaagga gacaacagcc tttactgcca ttttttttta
     5041 aatgttttca ctcagatgaa caatttgact ttaataaaag actggagatt tttgtacaaa
     5101 gaaataggaa taagtttcat atactaatta tgctgagttt taagcctaca tatcacaaaa
     5161 tatttagaat tgtataacct tttcatatat ttataacttt taatgtcttt ttaaaagatg
     5221 tgggaccaaa aatatattta taatttggaa atgtgactgc ataccaataa gaaaacttac
     5281 cttattttga aatttatctg ggatattaaa gaatctacca attcttaaaa acacagattt
     5341 atactttaag cttattttaa aattaaagaa tatataccaa ttcttagaaa cactttaagg
     5401 actactctta aataacttaa atatcagagt tttgttgtaa tattaaaatt taccgtggaa
     5461 atcactgttg ttcagctatc accttaattg tgtatgatat gataaatgtt tagcagtaaa
     5521 gctatcttaa gatttaatgg aaaagtttaa tttgaagatg taacaaaaat tctgaccaca
     5581 gttgattctg aatttttaag gctttcctaa taggctgatc acagagaata atccattttg
     5641 aaggtataaa actgcactgt atgtctgtca cttgtagctg aactgattca cattttgaca
     5701 aaagagagaa aatacaaaaa tgagttttgc aaatgtaata actttttctg catatagaac
     5761 taaataattg aaaaatatgg gctatagttc tcaaaggtag atagtaaaat cactggcttt
     5821 ttccagctgt atgtttttcc actgtgcgtg tacacacaca ctggaaaata attaggctga
     5881 ttttgcaggt cttcattgtt agagattctg aagtatttac tgtcaattca taggtttcag
     5941 tttatttagg aaattagtgt ttgacagctt tttttaaatt atttcactga agctgagatt
     6001 attagtgata caaagttaaa atttcaatat ttaatttctc tatatattat taatattaaa
     6061 ttgtttttta cttataaatt catgttctca tctgatttaa tattaaattt gtataggtgg
     6121 gcgtttctta ccattttgca caagtttttg tttttctgaa atacttaatt gtgcaggttg
     6181 taaaaaagat tagtgcattt tcattttaag gatgctttgc tccttaaatt gttcgacaga
     6241 aatgactttt tagggaaagt agtttttttg gagctactaa cttgtattta ttattgtaca
     6301 tgcataacca gggtggtgag ggcactaatc ttgtaggaaa cacttacttg atgttttatt
     6361 tgaacttttc ctataggttt aacttttact gcatagaatt aacactagga acagtgtcat
     6421 gaaatctggg ttgaaggaga atacagtata tatgagaaca cttaaagttc aaatagaaat
     6481 catttctgaa gacaaaagca gaggaatatt gtcagtgcca agtaatggaa gaataagggc
     6541 ggcatttaca ctgtgcaagt attgagaaga gtgcataaag acagggaact actctcatgg
     6601 agacagtttc tctcttataa tcaagtaact agaaggggaa aaatcatcta agttatgaaa
     6661 tccaacatag gcgctatatt acaaactgtg ccggattatg caaattgtag ttgttactga
     6721 tcaaagttta attgcttcat ttttgtttaa aaagggatac tgatgtcaga aaatctgtaa
     6781 tatgttttat tcaaaagatg taaataatgt atacagactt gtatgtgatg ggatgggaaa
     6841 tatttaaatt ctaggtgttt tttttttttt aaagaagaaa ctcaatgttt ataagaaaaa
     6901 aatgaataaa tagttacgtt tggccatgaa
//
