LOCUS       NM_018221               4896 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MOB kinase activator 1A (MOB1A), transcript variant 1,
            mRNA.
ACCESSION   NM_018221
VERSION     NM_018221.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4896)
  AUTHORS   Yang,P., Zhang,D., Wang,T., Ji,J., Jin,C., Peng,C., Tan,Y.,
            Zhou,J., Wang,L., Feng,Y. and Sun,Y.
  TITLE     CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer
            progression via promoting degradation of MOB1A to inhibit the Hippo
            pathway
  JOURNAL   Cell Death Dis 13 (9), 796 (2022)
   PUBMED   36123327
  REMARK    GeneRIF: CAF-derived exosomal WEE2-AS1 facilitates colorectal
            cancer progression via promoting degradation of MOB1A to inhibit
            the Hippo pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4896)
  AUTHORS   Jin,J., Zhang,L., Li,X., Xu,W., Yang,S., Song,J., Zhang,W.,
            Zhan,J., Luo,J. and Zhang,H.
  TITLE     Oxidative stress-CBP axis modulates MOB1 acetylation and activates
            the Hippo signaling pathway
  JOURNAL   Nucleic Acids Res 50 (7), 3817-3834 (2022)
   PUBMED   35349706
  REMARK    GeneRIF: Oxidative stress-CBP axis modulates MOB1 acetylation and
            activates the Hippo signaling pathway.
REFERENCE   3  (bases 1 to 4896)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4896)
  AUTHORS   Meng,L., Chang,S., Sang,Y., Ding,P., Wang,L., Nan,X., Xu,R.,
            Liu,F., Gu,L., Zheng,Y., Li,Z. and Sang,M.
  TITLE     Circular RNA circCCDC85A inhibits breast cancer progression via
            acting as a miR-550a-5p sponge to enhance MOB1A expression
  JOURNAL   Breast Cancer Res 24 (1), 1 (2022)
   PUBMED   34983617
  REMARK    GeneRIF: Circular RNA circCCDC85A inhibits breast cancer
            progression via acting as a miR-550a-5p sponge to enhance MOB1A
            expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4896)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4896)
  AUTHORS   Lai,Z.C., Wei,X., Shimizu,T., Ramos,E., Rohrbaugh,M.,
            Nikolaidis,N., Ho,L.L. and Li,Y.
  TITLE     Control of cell proliferation and apoptosis by mob as tumor
            suppressor, mats
  JOURNAL   Cell 120 (5), 675-685 (2005)
   PUBMED   15766530
  REMARK    GeneRIF: Mats1 can rescue the lethality associated with loss of
            Mats function in Drosophila; As Mats1 is mutated in human tumors,
            Mats-mediated growth inhibition and tumor suppression is likely
            conserved in humans
REFERENCE   7  (bases 1 to 4896)
  AUTHORS   Bichsel,S.J., Tamaskovic,R., Stegert,M.R. and Hemmings,B.A.
  TITLE     Mechanism of activation of NDR (nuclear Dbf2-related) protein
            kinase by the hMOB1 protein
  JOURNAL   J Biol Chem 279 (34), 35228-35235 (2004)
   PUBMED   15197186
REFERENCE   8  (bases 1 to 4896)
  AUTHORS   Stavridi,E.S., Harris,K.G., Huyen,Y., Bothos,J., Verwoerd,P.M.,
            Stayrook,S.E., Pavletich,N.P., Jeffrey,P.D. and Luca,F.C.
  TITLE     Crystal structure of a human Mob1 protein: toward understanding
            Mob-regulated cell cycle pathways
  JOURNAL   Structure 11 (9), 1163-1170 (2003)
   PUBMED   12962634
REFERENCE   9  (bases 1 to 4896)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   10 (bases 1 to 4896)
  AUTHORS   Moreno,C.S., Lane,W.S. and Pallas,D.C.
  TITLE     A mammalian homolog of yeast MOB1 is both a member and a putative
            substrate of striatin family-protein phosphatase 2A complexes
  JOURNAL   J Biol Chem 276 (26), 24253-24260 (2001)
   PUBMED   11319234
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY030276.1, BC003398.1,
            AK001650.1, AC073263.5 and AL122062.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018221.4.
            
            Summary: The protein encoded by this gene is a component of the
            Hippo signaling pathway, which controls organ size and tumor growth
            by enhancing apoptosis. Loss of the encoded protein results in cell
            proliferation and cancer formation. The encoded protein is also
            involved in the control of microtubule stability during
            cytokinesis. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Nov
            2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.626460.1,
                                           SRR1660803.34615.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396049.5/ ENSP00000379364.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                HY030276.1         92-102
            12-1340             BC003398.1         1-1329
            1341-1932           AK001650.1         1319-1910
            1933-1933           AC073263.5         83974-83974         c
            1934-2386           AK001650.1         1912-2364
            2387-3557           AL122062.1         190-1360
            3558-3558           AC073263.5         82349-82349         c
            3559-4826           AL122062.1         1362-2629
            4827-4896           AC073263.5         81011-81080         c
FEATURES             Location/Qualifiers
     source          1..4896
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..4896
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
                     /note="MOB kinase activator 1A"
                     /db_xref="GeneID:55233"
                     /db_xref="HGNC:HGNC:16015"
                     /db_xref="MIM:609281"
     exon            1..219
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..856
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
                     /note="isoform 1 is encoded by transcript variant 1; mps
                     one binder kinase activator-like 1B; mob1 alpha; MOB1, Mps
                     One Binder kinase activator-like 1B; MOB1 Mps One Binder
                     homolog A; mob1 homolog 1B"
                     /codon_start=1
                     /product="MOB kinase activator 1A isoform 1"
                     /protein_id="NP_060691.2"
                     /db_xref="CCDS:CCDS46340.1"
                     /db_xref="GeneID:55233"
                     /db_xref="HGNC:HGNC:16015"
                     /db_xref="MIM:609281"
                     /translation="MSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQA
                     VMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTN
                     IKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYA
                     HIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR"
     exon            220..386
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            387..480
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            481..614
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            615..778
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            779..4896
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3865..3870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
                     /note="hexamer: AATAAA"
     polyA_site      3885
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
     regulatory      4806..4811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
                     /note="hexamer: AATAAA"
     regulatory      4811..4816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
                     /note="hexamer: AATATA"
     polyA_site      4826
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
                     /note="major polyA site"
     polyA_site      4830
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
     regulatory      4872..4877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
                     /note="hexamer: AATATA"
     polyA_site      4896
                     /gene="MOB1A"
                     /gene_synonym="C2orf6; MABKL1B; MATS1; MOB1; Mob4B;
                     MOBK1B; MOBKL1B"
ORIGIN      
        1 atttcgggtc tgcgaggtgg ggtaggcggg caaggcgggc gccgaggttt gcaaaggctc
       61 gcagcggcca gaaacccggc tccgagcggc ggcggcccgg cttccgctgc ccgtgagcta
      121 aggacggtcc gctccctcta gccagctccg aatcctgatc caggcggggg ccaggggccc
      181 ctcgcctccc ctctgaggac cgaagatgag cttcctcttc agcagccgct cttctaaaac
      241 attcaaacca aagaagaata tccctgaagg atctcatcag tatgaactct taaaacatgc
      301 agaagcaact ctaggaagtg ggaatctgag acaagctgtt atgttgcctg agggagagga
      361 tctcaatgaa tggattgctg tgaacactgt ggatttcttt aaccagatca acatgttata
      421 tggaactatt acagaattct gcactgaagc aagctgtcca gtcatgtctg caggtccgag
      481 atatgaatat cactgggcag atggtactaa tattaaaaag ccaatcaaat gttctgcacc
      541 aaaatacatt gactatttga tgacttgggt tcaagatcag cttgatgatg aaactctttt
      601 tccttctaag attggtgtcc catttcccaa aaactttatg tctgtggcaa agactattct
      661 aaagcgtctg ttcagggttt atgcccatat ttatcaccag cactttgatt ctgtgatgca
      721 gctgcaagag gaggcccacc tcaacacctc ctttaagcac tttattttct ttgttcagga
      781 gtttaatctg attgataggc gtgagctggc acctcttcaa gaattaatag agaaacttgg
      841 atcaaaagac agataaatgt ttcttctaga acacagttac ccccttgctt catctattgc
      901 tagaactatc tcattgctat ctgttataga ctagtgatac aaactttaag aaaacaggat
      961 aaaaagatac ccattgcctg tgtctactga taaaattatc ccaaaggtag gttggtgtga
     1021 tagtttccga gtaagacctt aaggacacag ccaaatctta agtactgtgt gaccactctt
     1081 gttgttatca catagtcata cttggttgta atatgtgatg gttaacctgt agcttataaa
     1141 tttacttatt attcttttac tcatttactc agtcatttct ttacaagaaa atgattgaat
     1201 ctgttttagg tgacagcaca atggacatta agaatttcca tcaataattt atgaataagt
     1261 ttccagaaca aatttcctaa taacacaatc agattggttt tattctttta ttttacgaat
     1321 aaaaaatgta tttttcagta tccttgagat ttagaacatc tgtgtcactt cagataacat
     1381 tttagtttca agtttgtatg gtagtgtttt tatagataag atacgtctat tttttcaaaa
     1441 ttcatgattg cagtttaaat catcatatga cgtgtgggtg ggagcaacca aagttatttt
     1501 tacagggact ttattttttg atctttattt gagattgttt tcatatctat ctaaattatt
     1561 aggagtgtgt gtatcagaag taatttttta atgtcttcta aggatggtct tccaggcttt
     1621 taaactgaaa agcttaattc agatagtagc ttttggctga gaaaaggaat ccaaaatatt
     1681 aataaattta gatctcaaaa ccactatttt tattatttca ttatttttca gaggccttaa
     1741 aattctggat aagagaatgg aggaaaatac tcagagtact tgattatttt atttcctttt
     1801 attaaaaaat tacttctatg tttttattgt ctcttgagcc ttagttaaga gtagtgtaga
     1861 aatgcatgaa cttcatccta ataaggataa aacttaagga aaaccacaat aaaccatgaa
     1921 ggtgtacaca tcttataaca cagataaagt tttggtgtgc tacctattct tgagagagtg
     1981 agtgagtgta tgtgtttaaa ggaaacaaaa tgggagaaat aagttttaaa aaaatcctca
     2041 ttttgttaat attcaaaaga tggactgagc ttccacttgg gttttatctt gttttaattg
     2101 tttttgtatc aaaacttgaa attcctctat ttctattggg atataaaagc cttccccttc
     2161 agtgaagaaa acatttattt tttatttgat tcctaggatt tagtaaactc tagctgtcta
     2221 tttaaaatgt actgaggcac aacaagtatt atactggaag acttgccaaa ctggcaaagc
     2281 tttaagttca tcagcattct atgtggttca gagctgtgat ttttgcaaag tattttacca
     2341 acctcctcga tggctttgat aaaggttaga tttgatgttt ttttttagat ttatttttct
     2401 tactccacta aactataaag aaaataatta cttagaaact ccattttaaa taatcatttc
     2461 ctagaaattc ttaaatatat acagaatttt aaagaaaaca tttcatctga tttagttagc
     2521 atccacatat cattgaggaa ttaaagtgtg ggacagtcat tattaaaaaa aagagagaaa
     2581 agccctctat tagacattcc acaatccatg ttttaagctt atccaaaggt ccaaatgtca
     2641 gccattctgt atgttcatgt tgatcatttg cgaacaagaa agcaggtttc taggtatcac
     2701 ttaggatgtg aactgcctct caactttaaa ccctgttagc tttacttttt taagtccaca
     2761 agtgatgaaa ctagtttctc agctaggctt gtactttcct cattatttct agtatttcaa
     2821 atattctcaa acaaaagagt taccactttt ctccatttat tttcagttat ggaaatgttc
     2881 cctctcttca ccactaagct ccaaagcaaa tgaaagacga tcacatgtca ggacagtagt
     2941 aaaggcagct tataaatggg acataaatca gagatgtgtt ggtattttga gactcaagac
     3001 tgtccttttt taaaataaaa ataaaaacat taccaggttc ccaagccaat ctggcttaac
     3061 caacagtgca ctgaaatatt agtgtttacc tccaaggcta gggagccaag gggaggagga
     3121 gaattggagg aaggggagat aatgggaaga ggatggcgcc ttcctgagtt ggctagaggg
     3181 ccaacctttg ataacagttt gacgaaatca atcttttttt tttttttttt tgagacagag
     3241 tctcactctg tcacccaggc tggagtacag tggtgggatc tcggctcact gcaagctctg
     3301 cctcccaggt tcatgccatt ctcctgcccc agcctctcct gagtagctgg aactacaggt
     3361 gcccgccacc acgcccagct aattttttct atttttagtc atgcctggct aattttttgt
     3421 atttttagta gagatggggt ttcaccgtgt tagccaggat ggtctccatc tccttacctc
     3481 gcaatccgcc cgcctcagcc tcccaaagtg ttgggattac aggcatgagc caccgtgccc
     3541 ggcctataga aatcaatctt tttgactctt ctcactttta tctccccatg cccaaggttt
     3601 gcctgttcca taacactcac tcccttcccc cttgctaatc agaagccatc tcctctcagt
     3661 gtctgatctc tgctcttcat acatgattac agtcatgggg tagagagtgc ttgctaaatt
     3721 atgcagttaa tcctatggtg ctttaatttt caggccttca aaaaacactt gtacagtgat
     3781 gtgcagattt ttaaacagtt gaacttcctt gtactacagt ttttgtattg acagccaaat
     3841 ttgtctttca ttcttcagat tgtgaataaa gtgattttta cagggcttcc agcaaagttt
     3901 ttcctttcat ctaaggcttg tagaacccta gcttatatag ctgcttacat gagaaatgca
     3961 aaatctgtat tcaccatgac tttagtaaca aaggtaaagt tttttagtag tgccaaggca
     4021 agaggaacaa tcttggtggt agtactaagt tttgtcaata ttgtggtttc ctgattgtat
     4081 tgttggcttt ctctctgagc attgaggtat actagaagta gagcttctca aacataatat
     4141 cattacctca taagcattaa caaatcaggc ccaaagagcg taagtcctag aaatttgttt
     4201 taaagcagcc ctagtcatgg tgctggtgct accgccttgt tttaggagcc tgcctcctgt
     4261 cagtatgaaa ccctcacctg aaaaatgcca gcctggacac caaacactga gccccttcaa
     4321 caggcacatt atttccccct gagatccata agggaattta gtttctacta ttgtagagtt
     4381 ctgaaaagag gtaaaatagt agtcctttgg tcatcctatt tttgctttca attttgatat
     4441 ttcagactgt aaaaggcctt gggggatgat agtacatgtg gtagcagtaa tttttttgaa
     4501 gcaactgcac tgacattcat ttgagttttc tctcattatc agattctgtt ccaaacaagt
     4561 attctgtaga tccaaatgga ttaccagtgt gctacagact tcttattata gaacagcatt
     4621 ctattctaca tcaaaaatag tttgtgtaag ttagttttgg ttaccatcta aaatattttt
     4681 aaatgttctt tacataaaaa tttatgttgt gttttaaaat ccttaggggc tttatctatt
     4741 tttctaagtc agttaactgt acttctaaaa aaagtatttt gtatctactt ttgtaacttc
     4801 gtcagaataa aatatattga aagcaagaaa tgactgatta aagtatgtat atcaacacac
     4861 atttctattt aaatatagaa acttgagagt tttgca
//
