LOCUS       NM_022151               2407 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens modulator of apoptosis 1 (MOAP1), mRNA.
ACCESSION   NM_022151
VERSION     NM_022151.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2407)
  AUTHORS   Xu,X., Yang,M., Liu,X., Gong,A., Guo,Q., Xu,W. and Qian,H.
  TITLE     Tripartite motif-containing 68-stabilized modulator of apoptosis-1
            retards the proliferation and metastasis of lung cancer
  JOURNAL   Biochem Biophys Res Commun 648, 11-20 (2023)
   PUBMED   36724555
  REMARK    GeneRIF: Tripartite motif-containing 68-stabilized modulator of
            apoptosis-1 retards the proliferation and metastasis of lung
            cancer.
REFERENCE   2  (bases 1 to 2407)
  AUTHORS   Zurowska,K., Alam,A., Ganser-Pornillos,B.K. and Pornillos,O.
  TITLE     Structural evidence that MOAP1 and PEG10 are derived from
            retrovirus/retrotransposon Gag proteins
  JOURNAL   Proteins 90 (1), 309-313 (2022)
   PUBMED   34357660
  REMARK    GeneRIF: Structural evidence that MOAP1 and PEG10 are derived from
            retrovirus/retrotransposon Gag proteins.
REFERENCE   3  (bases 1 to 2407)
  AUTHORS   Pandeya,A., Khalko,R.K., Mishra,A., Singh,N., Singh,S., Saha,S.,
            Yadav,S., Saxena,S. and Gosipatala,S.B.
  TITLE     Human Cytomegalovirus miR-UL70-3p Downregulates the H2O2-Induced
            Apoptosis by Targeting the Modulator of Apoptosis-1 (MOAP1)
  JOURNAL   Int J Mol Sci 23 (1), 18 (2021)
   PUBMED   35008453
  REMARK    GeneRIF: Human Cytomegalovirus miR-UL70-3p Downregulates the
            H2O2-Induced Apoptosis by Targeting the Modulator of Apoptosis-1
            (MOAP1).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2407)
  AUTHORS   Chang,H.C., Tao,R.N., Tan,C.T., Wu,Y.J., Bay,B.H. and Yu,V.C.
  TITLE     The BAX-binding protein MOAP1 associates with LC3 and promotes
            closure of the phagophore
  JOURNAL   Autophagy 17 (11), 3725-3739 (2021)
   PUBMED   33783314
  REMARK    GeneRIF: The BAX-binding protein MOAP1 associates with LC3 and
            promotes closure of the phagophore.
REFERENCE   5  (bases 1 to 2407)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2407)
  AUTHORS   Vos,M.D., Dallol,A., Eckfeld,K., Allen,N.P., Donninger,H.,
            Hesson,L.B., Calvisi,D., Latif,F. and Clark,G.J.
  TITLE     The RASSF1A tumor suppressor activates Bax via MOAP-1
  JOURNAL   J Biol Chem 281 (8), 4557-4563 (2006)
   PUBMED   16344548
  REMARK    GeneRIF: RASSF1A is a tumor suppressor that activates Bax via
            MOAP-1
REFERENCE   7  (bases 1 to 2407)
  AUTHORS   Tan,K.O., Fu,N.Y., Sukumaran,S.K., Chan,S.L., Kang,J.H., Poon,K.L.,
            Chen,B.S. and Yu,V.C.
  TITLE     MAP-1 is a mitochondrial effector of Bax
  JOURNAL   Proc Natl Acad Sci U S A 102 (41), 14623-14628 (2005)
   PUBMED   16199525
REFERENCE   8  (bases 1 to 2407)
  AUTHORS   Baksh,S., Tommasi,S., Fenton,S., Yu,V.C., Martins,L.M.,
            Pfeifer,G.P., Latif,F., Downward,J. and Neel,B.G.
  TITLE     The tumor suppressor RASSF1A and MAP-1 link death receptor
            signaling to Bax conformational change and cell death
  JOURNAL   Mol Cell 18 (6), 637-650 (2005)
   PUBMED   15949439
  REMARK    GeneRIF: RASSF1A and MAP-1 are important components between death
            receptors and the apoptotic machenery.
REFERENCE   9  (bases 1 to 2407)
  AUTHORS   Tan,K.O., Tan,K.M., Chan,S.L., Yee,K.S., Bevort,M., Ang,K.C. and
            Yu,V.C.
  TITLE     MAP-1, a novel proapoptotic protein containing a BH3-like motif
            that associates with Bax through its Bcl-2 homology domains
  JOURNAL   J Biol Chem 276 (4), 2802-2807 (2001)
   PUBMED   11060313
REFERENCE   10 (bases 1 to 2407)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG699993.1 and BC015044.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022151.4.
            
            Summary: The protein encoded by this gene was identified by its
            interaction with apoptosis regulator BAX protein. This protein
            contains a Bcl-2 homology 3 (BH3)-like motif, which is required for
            the association with BAX. When overexpressed, this gene has been
            shown to mediate caspase-dependent apoptosis. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.963213.1,
                                           SRR3476690.306588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151358, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298894.5/ ENSP00000298894.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BG699993.1         17-75
            60-2407             BC015044.1         1-2348
FEATURES             Location/Qualifiers
     source          1..2407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..2407
                     /gene="MOAP1"
                     /gene_synonym="MAP-1; PNMA4"
                     /note="modulator of apoptosis 1"
                     /db_xref="GeneID:64112"
                     /db_xref="HGNC:HGNC:16658"
                     /db_xref="MIM:609485"
     exon            1..88
                     /gene="MOAP1"
                     /gene_synonym="MAP-1; PNMA4"
                     /inference="alignment:Splign:2.1.0"
     exon            89..243
                     /gene="MOAP1"
                     /gene_synonym="MAP-1; PNMA4"
                     /inference="alignment:Splign:2.1.0"
     exon            244..2407
                     /gene="MOAP1"
                     /gene_synonym="MAP-1; PNMA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..1419
                     /gene="MOAP1"
                     /gene_synonym="MAP-1; PNMA4"
                     /note="paraneoplastic antigen like 4; MAP1; paraneoplastic
                     antigen Ma4; paraneoplastic Ma antigen family member 4"
                     /codon_start=1
                     /product="modulator of apoptosis 1"
                     /protein_id="NP_071434.2"
                     /db_xref="CCDS:CCDS9908.1"
                     /db_xref="GeneID:64112"
                     /db_xref="HGNC:HGNC:16658"
                     /db_xref="MIM:609485"
                     /translation="MTLRLLEDWCRGMDMNPRKALLIAGISQSCSVAEIEEALQAGLA
                     PLGEYRLLGRMFRRDENRKVALVGLTAETSHALVPKEIPGKGGIWRVIFKPPDPDNTF
                     LSRLNEFLAGEGMTVGELSRALGHENGSLDPEQGMIPEMWAPMLAQALEALQPALQCL
                     KYKKLRVFSGRESPEPGEEEFGRWMFHTTQMIKAWQVPDVEKRRRLLESLRGPALDVI
                     RVLKINNPLITVDECLQALEEVFGVTDNPRELQVKYLTTYQKDEEKLSAYVLRLEPLL
                     QKLVQRGAIERDAVNQARLDQVIAGAVHKTIRRELNLPEDGPAPGFLQLLVLIKDYEA
                     AEEEEALLQAILEGNFT"
     regulatory      2387..2392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MOAP1"
                     /gene_synonym="MAP-1; PNMA4"
                     /note="hexamer: AATAAA"
     polyA_site      2407
                     /gene="MOAP1"
                     /gene_synonym="MAP-1; PNMA4"
                     /note="major polyA site"
ORIGIN      
        1 gcgcagcttc cccgagcgag accaaaacag gtggaatccg ggctggagcc ggagctccgg
       61 cggcgcgggt ggcggcacgt ccctccagac agtaccacag gcacctggag taccggcatc
      121 ggtcgctgtg gcccccgagt gtccgtcaga gcctagggga gcctgccctc ccgcgcctcg
      181 tcggggcccg gccaggcacc ttggccgccg gcgcacggac gcgggcacga gcactagatc
      241 acggctgctg gacctcggca cgttgacaag atttctctgg ggtaccgcgg aggattactt
      301 tgaatttcgg tggtcgcctg tggtctggca tatttagaac ttaagtctat tatttcgggc
      361 accatgactt tgaggctttt agaagactgg tgcaggggga tggacatgaa ccctcggaaa
      421 gcgctattga ttgccggcat ctcccagagc tgcagtgtgg cagaaatcga ggaggctctg
      481 caggctggtt tagctccctt gggggagtac agactgcttg gaaggatgtt caggagggat
      541 gagaacagga aagtagcctt agtagggctt actgcggaga ctagtcacgc cctggtccct
      601 aaggagatac cgggaaaagg gggtatctgg agagtgatct ttaagccccc tgacccagat
      661 aatacatttt taagcagatt aaatgaattt ttagcgggag agggcatgac agtgggtgag
      721 ttgagcagag ctcttggaca tgaaaatggc tccttagacc cagagcaggg catgatcccg
      781 gaaatgtggg cccctatgtt ggcacaggca ttagaggctc ttcagcctgc cctgcaatgc
      841 ttgaagtata aaaagctgag agtgttctcg ggcagggagt ctccagaacc aggagaagaa
      901 gaatttggac gctggatgtt tcatactact cagatgataa aggcgtggca ggtgccagat
      961 gtagagaaga gaaggcgatt gctagagagc cttcgaggcc cagcacttga tgttattcgt
     1021 gtcctcaaga taaacaatcc tttaattact gtcgatgaat gtctgcaggc tcttgaggag
     1081 gtatttgggg ttacagataa tcctagggag ttgcaggtca aatatctaac cacttaccag
     1141 aaggatgagg aaaagttgtc ggcttatgta ctaaggctgg agcctttgtt acagaagctg
     1201 gtacagagag gagcaattga gagagatgct gtgaatcagg cccgcctaga ccaagtcatt
     1261 gctggggcag tccacaaaac aattcgcaga gagcttaatc tgccagagga tggcccagcc
     1321 cctggtttct tgcagttatt ggtactaata aaggattatg aggcagctga ggaggaggag
     1381 gcccttctcc aggcaatatt ggaaggtaat ttcacctgag tctcagggaa ccacgaaggg
     1441 atatggcaat gagtagagca tgaaggtaga acagtctata tactcttgtg acacatacaa
     1501 tccctacctt gtgctgccaa gtaactcatt tttgtgcaat tctcagtata agccctttgt
     1561 cgtttctgtg cctatttaaa gtctcctaaa ggtgtaattg actaggaagg atgtagttct
     1621 acactgccat ttacctattt aaattcatcc ttgtgaatat ctttgttgtt gttgttgaga
     1681 cagagtctcg ctctgtcacc caggctggag tgcagtggcg tgatcttggc tcactgcatc
     1741 ctccgccttc caggtttaag ctattctcct gcctcagttg cccgagtagc tgggactaca
     1801 ggcatgtgcc accacgccca gctaagtttt gcattatcag tagagacggg gtttcaccat
     1861 gttggccagg ctagtttcga actcctgacc tcaagtgatc cacctgcttc ggcctctgaa
     1921 agtgctggga ttacaggcgt gagacactgc gcccagcctc atccctgtga atttcttatt
     1981 gtacacaagt tctttcacta tctgtgtgca gtgctctgag gggacagaca aggcttgggt
     2041 gtatatgcca accagatctc attgaagtat cagcttgttt ggtactaggt gcaagtgtag
     2101 catgtcacat gtgaccatgt tggatcattg acaattttta ggtatgtact gacctacatt
     2161 tatgatgaag atcctgagcg gaggttaaga tattaagtta ttttccatat gaatcagaat
     2221 tatattgatt ctgtgcaatc aaaacaaaag gcagaataga atgctgagat tggttaagtt
     2281 tgcaatgacc atcttgaacc acagatttct gctatgtgtc atcaaaacat ctagttctga
     2341 gtaacatttt cacgattgtt ataaaattat aggtgtgaac ttctaaaata aaggaatgct
     2401 aataaaa
//
