LOCUS       NM_020310               4925 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens MAX network transcriptional repressor (MNT), mRNA.
ACCESSION   NM_020310
VERSION     NM_020310.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4925)
  AUTHORS   Zhao,G., Liang,J., Zhang,Y., Shan,G., Bian,Y., Gu,J., Zhan,C. and
            Ge,D.
  TITLE     MNT inhibits lung adenocarcinoma ferroptosis and chemosensitivity
            by suppressing SAT1
  JOURNAL   Commun Biol 7 (1), 680 (2024)
   PUBMED   38831092
  REMARK    GeneRIF: MNT inhibits lung adenocarcinoma ferroptosis and
            chemosensitivity by suppressing SAT1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4925)
  AUTHORS   Lavin,D.P., Abassi,L., Inayatullah,M. and Tiwari,V.K.
  TITLE     Mnt Represses Epithelial Identity To Promote
            Epithelial-to-Mesenchymal Transition
  JOURNAL   Mol Cell Biol 41 (11), e0018321 (2021)
   PUBMED   34460331
  REMARK    GeneRIF: Mnt Represses Epithelial Identity To Promote
            Epithelial-to-Mesenchymal Transition.
REFERENCE   3  (bases 1 to 4925)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4925)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4925)
  AUTHORS   Lafita-Navarro,M.C., Liano-Pons,J., Quintanilla,A., Varela,I.,
            Blanco,R., Ourique,F., Bretones,G., Aresti,J., Molina,E.,
            Carroll,P., Hurlin,P., Romero,O.A., Sanchez-Cespedes,M.,
            Eisenman,R.N., Delgado,M.D. and Leon,J.
  TITLE     The MNT transcription factor autoregulates its expression and
            supports proliferation in MYC-associated factor X (MAX)-deficient
            cells
  JOURNAL   J Biol Chem 295 (7), 2001-2017 (2020)
   PUBMED   31919096
  REMARK    GeneRIF: The MNT transcription factor autoregulates its expression
            and supports proliferation in MYC-associated factor X
            (MAX)-deficient cells.
REFERENCE   6  (bases 1 to 4925)
  AUTHORS   Cairo,S., Merla,G., Urbinati,F., Ballabio,A. and Reymond,A.
  TITLE     WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted
            region, is a new member of the Mlx transcription factor network
  JOURNAL   Hum Mol Genet 10 (6), 617-627 (2001)
   PUBMED   11230181
REFERENCE   7  (bases 1 to 4925)
  AUTHORS   Meroni,G., Cairo,S., Merla,G., Messali,S., Brent,R., Ballabio,A.
            and Reymond,A.
  TITLE     Mlx, a new Max-like bHLHZip family member: the center stage of a
            novel transcription factors regulatory pathway?
  JOURNAL   Oncogene 19 (29), 3266-3277 (2000)
   PUBMED   10918583
REFERENCE   8  (bases 1 to 4925)
  AUTHORS   Lo Nigro,C., Venesio,T., Reymond,A., Meroni,G., Alberici,P.,
            Cainarca,S., Enrico,F., Stack,M., Ledbetter,D.H., Liscia,D.S.,
            Ballabio,A. and Carrozzo,R.
  TITLE     The human ROX gene: genomic structure and mutation analysis in
            human breast tumors
  JOURNAL   Genomics 49 (2), 275-282 (1998)
   PUBMED   9598315
REFERENCE   9  (bases 1 to 4925)
  AUTHORS   Hirotsune,S., Pack,S.D., Chong,S.S., Robbins,C.M., Pavan,W.J.,
            Ledbetter,D.H. and Wynshaw-Boris,A.
  TITLE     Genomic organization of the murine Miller-Dieker/lissencephaly
            region: conservation of linkage with the human region
  JOURNAL   Genome Res 7 (6), 625-634 (1997)
   PUBMED   9199935
REFERENCE   10 (bases 1 to 4925)
  AUTHORS   Meroni,G., Reymond,A., Alcalay,M., Borsani,G., Tanigami,A.,
            Tonlorenzi,R., Lo Nigro,C., Messali,S., Zollo,M., Ledbetter,D.H.,
            Brent,R., Ballabio,A. and Carrozzo,R.
  TITLE     Rox, a novel bHLHZip protein expressed in quiescent cells that
            heterodimerizes with Max, binds a non-canonical E box and acts as a
            transcriptional repressor
  JOURNAL   EMBO J 16 (10), 2892-2906 (1997)
   PUBMED   9184233
  REMARK    Erratum:[EMBO J 1997 Oct 1;16(19):6055]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006435.7, CN428913.1,
            CN428911.1, X96401.1, BM469815.1, BQ675978.1, BM820333.1,
            BM876428.1, CA950091.1 and BM876168.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020310.2.
            
            Summary: The Myc/Max/Mad network comprises a group of transcription
            factors that co-interact to regulate gene-specific transcriptional
            activation or repression. This gene encodes a protein member of the
            Myc/Max/Mad network. This protein has a
            basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds
            the canonical DNA sequence CANNTG, known as the E box, following
            heterodimerization with Max proteins. This protein is likely a
            transcriptional repressor and an antagonist of Myc-dependent
            transcriptional activation and cell growth. This protein represses
            transcription by binding to DNA binding proteins at its N-terminal
            Sin3-interaction domain. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC117563.1, X96401.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000174618.5/ ENSP00000174618.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC006435.7         74085-74180         c
            97-108              CN428913.1         13-24
            109-136             CN428911.1         1-28
            137-1682            X96401.1           1-1546
            1683-1683           BM469815.1         183-183
            1684-2430           X96401.1           1548-2294
            2431-2482           AC006435.7         59636-59687         c
            2483-2948           X96401.1           2351-2816
            2949-3592           BQ675978.1         82-725
            3593-4120           BM820333.1         75-602
            4121-4400           BM876428.1         59-338
            4401-4698           CA950091.1         268-565
            4699-4924           BM876168.1         16-241              c
            4925-4925           X96401.1           4775-4775
FEATURES             Location/Qualifiers
     source          1..4925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..4925
                     /gene="MNT"
                     /gene_synonym="bHLHd3; lncRNA-HAL; MAD6; MXD6; ROX"
                     /note="MAX network transcriptional repressor"
                     /db_xref="GeneID:4335"
                     /db_xref="HGNC:HGNC:7188"
                     /db_xref="MIM:603039"
     exon            1..421
                     /gene="MNT"
                     /gene_synonym="bHLHd3; lncRNA-HAL; MAD6; MXD6; ROX"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..2097
                     /gene="MNT"
                     /gene_synonym="bHLHd3; lncRNA-HAL; MAD6; MXD6; ROX"
                     /note="Max-interacting protein; myc antagonist MNT; class
                     D basic helix-loop-helix protein 3; MAX binding protein;
                     MNT, MAX dimerization protein"
                     /codon_start=1
                     /product="max-binding protein MNT"
                     /protein_id="NP_064706.1"
                     /db_xref="CCDS:CCDS11018.1"
                     /db_xref="GeneID:4335"
                     /db_xref="HGNC:HGNC:7188"
                     /db_xref="MIM:603039"
                     /translation="MSIETLLEAARFLEWQAQQQQRAREEQERLRLEQEREQEQKKAN
                     SLARLAHTLPVEEPRMEAPPLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQPLP
                     PPPPLPAAAQPLPLAPRQPALVGAPGLSIKEPAPLPSRPQVPTPAPLLPDSKATIPPN
                     GSPKPLQPLPTPVLTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEVKSSEQKKRPGG
                     IGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEK
                     EYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASE
                     GEDNIDEDMEEDRAGLGPPKLSHRPQPELLKSTLPPPSTTPAPLPPHPHPHPHSVALP
                     PAHLPVQQQQPQQKTPLPAPPPPPAAPAQTLVPAPAHLVATAGGGSTVIAHTATTHAS
                     VIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQL
                     PLYPQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPV
                     TMVTMPSFPVSTLKLA"
     exon            422..1001
                     /gene="MNT"
                     /gene_synonym="bHLHd3; lncRNA-HAL; MAD6; MXD6; ROX"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1043
                     /gene="MNT"
                     /gene_synonym="bHLHd3; lncRNA-HAL; MAD6; MXD6; ROX"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1155
                     /gene="MNT"
                     /gene_synonym="bHLHd3; lncRNA-HAL; MAD6; MXD6; ROX"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1348
                     /gene="MNT"
                     /gene_synonym="bHLHd3; lncRNA-HAL; MAD6; MXD6; ROX"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..4925
                     /gene="MNT"
                     /gene_synonym="bHLHd3; lncRNA-HAL; MAD6; MXD6; ROX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4903..4908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MNT"
                     /gene_synonym="bHLHd3; lncRNA-HAL; MAD6; MXD6; ROX"
                     /note="hexamer: AATAAA"
     polyA_site      4925
                     /gene="MNT"
                     /gene_synonym="bHLHd3; lncRNA-HAL; MAD6; MXD6; ROX"
                     /note="major polyA site"
ORIGIN      
        1 atcttgttgc aaagcccttt cttgtcggcg ggactcccgg gggccgcggg gcgggaggca
       61 tcggaaggga ggtagagagg gaggggaaga agggaggcag tgccgccttt tttttttttt
      121 tgcatcccat ttttttaaat ttgcaatttt atattttgca aatattttga gagacattga
      181 tttttctccc cgtgctcccc cgttcttccc tgcggagtgc gctgcgccgc ccagccctgt
      241 cgccccccgg aggtgatccc tccctcctgc ctgcccgcca gcctgacctg tgcccggctc
      301 gcgggccgca gcctcggccc cggcgcgccc ccggcagctc tcggcgcgat gagcatagag
      361 acgctactgg aggcggcccg cttcctggaa tggcaagcgc agcaacaaca gagagcacgt
      421 gaggagcagg agcggcttcg cttggagcag gagcgagagc aggaacagaa gaaggccaat
      481 agcctggcca ggctggcaca tacccttcct gtggaggaac cccgcatgga ggcgccaccc
      541 ctgcctctgt ctccaccggc tcccccgccg gcacccccac caccacttgc cacccctgcc
      601 ccactgactg tcatccctat ccctgtggtg accaactccc ctcagcctct acccccaccc
      661 ccacccttgc ccgcggcagc ccagcctctg cccctggcgc ctcgtcagcc ggccctggtt
      721 ggcgcccccg gactcagcat taaggagcct gcccccctgc ccagcaggcc gcaggtgccc
      781 acccctgctc ccctactgcc ggactcgaag gccaccattc cacccaatgg cagccccaag
      841 cctttgcagc ccctccccac gcctgtcctg accatagcgc cacaccctgg agtccagcct
      901 cagctggccc cccagcagcc gcccccaccc acgctgggga ccctgaagtt ggcaccagct
      961 gaagaagtca aatccagtga acagaagaag aggcccgggg ggatcggaac cagagaagtc
     1021 cacaacaaat tggagaagaa caggagggcc catctgaaag agtgctttga gaccctgaag
     1081 cggaacatcc ccaacgtgga tgacaagaag acgtccaatc tgagcgtgct gcggacggcg
     1141 ctgcggtaca tccagtccct gaagaggaag gagaaggaat atgagcatga aatggagcgg
     1201 ctggcacgtg agaagattgc cacgcagcag cggctggcag agctcaagca cgagctgagc
     1261 cagtggatgg acgtactgga gattgaccgc gtgctgcggc agacgggcca gcccgaggat
     1321 gaccaggcct ccacctccac cgcctctgag ggtgaggaca acatagacga ggatatggag
     1381 gaggaccggg cgggcctggg cccacctaag ctgagccatc gtccccagcc ggagctgctg
     1441 aagtccaccc tgccaccccc cagcaccacc cctgcgcctc tgcctccaca cccacaccct
     1501 cacccccact ccgtggccct acctcctgcc cacctccccg tgcagcagca gcagccacag
     1561 cagaagaccc ctctgccagc ccctcctccc ccaccggctg cccctgccca gacactggtg
     1621 ccagctccag cccatctggt ggcgacggct gggggtggct ccacggtcat cgcccacaca
     1681 gccaccactc acgcttcagt catccagact gtgaaccacg ttctgcaggg gccaggcggc
     1741 aagcacatcg cccacatcgc cccctcggcc cccagccctg cggtgcaact ggcgcctgcc
     1801 acacccccca ttgggcacat cactgtgcac cctgccaccc tcaaccatgt ggcccacctg
     1861 ggctcccagc tgcccttgta cccgcagccc gtggcagtga gccacatcgc ccacaccctc
     1921 tcgcaccagc aagtcaacgg cacggccggc ctggggcccc cggctactgt catggcaaag
     1981 ccggccgtgg gggctcaggt ggtgcaccac ccccagctgg tgggccagac cgtgctcaac
     2041 cctgtgacca tggtcaccat gccctccttc ccagtcagca cactcaagct ggcttgagga
     2101 cgaggccact cagaggcccc cagtggggac agggaggggg acctgtcccc cactctctca
     2161 cccaccagct ccacacattc cagccaggcc caggccagcc cccccaccca cccccaggcc
     2221 tcctagggga agggggtgca aagactctga gccaagggag ggaagggcca ccctgctgca
     2281 ctaggacttg gtaagatgac tctgagaaaa tgcgagactc tgatggaatg tgccacctgt
     2341 ccggcccagt gccagctcca gtgccgctcc tgcttcccct ccctaccctc ggaaatcagt
     2401 gcgatgtgga cgtcacgctc cctgacttct cccccgccct gccccgcctt cgtgtgctgc
     2461 tgctgctatt gctgtctggt gaggtggccc aggcccccgg ctttcctccg gagcctcatg
     2521 ttctcttccc aggcctttgg aggggaaatg gggaaagcag aactgaagcc acttggccca
     2581 gaaagctgcg gattggggtg ataaggggcc ttgctctgag cacaggtgac agatcatagg
     2641 aagtggctgg tctggagtcc cacccggaca ggtggggcct cagcctgggg ctctctgacc
     2701 cggttgcagt cactgtgatt cgttaccgta gatactactt aaaatgattc tctaccaaca
     2761 ataaaccaaa cccagccact gccaagcttc ctgtgccctc accccaatcc ctgccactgg
     2821 gctctggacc tcaggagggc aggctgaggt ggggaaggag ggacttggct gtccttcccc
     2881 ttccccgtcc cctgcagcct gggtctggat gggaggagag ccactgggcc cctgtcccca
     2941 gtccccagtc cccagccctg ggcttggctc ttggcttcca gaaggcagca aagaggggcg
     3001 ctgtcctgcg ttcagcccct gatctctgac ctctgctgag tgctgggcac tgctccaagg
     3061 gacaggtggg cctggcggcc tgtgggtttg ggtgcctcct gcagtttggg agacatggac
     3121 cagcatctgg tcttgtttcc aggagcatag aagccacatc gttgagacat caggaaggta
     3181 aaaacccagc ggcttagcca agccctaagc ctgtccccag accaaccctg ggacctatac
     3241 agaacagagg gccagagcta gggctgctgc ttctgctcca gcccctttgc ctctgtcctc
     3301 ccatcccctc aacaccctgc ttctcccggg gacgcttttg agtgggccct gcccggggag
     3361 ctgcagagca gcagcacctt tctctgagaa gaggtccttg gttgggtcaa ggacagggct
     3421 gagcgtggaa gggggaggag tcaggggctc tgtgttagga tgcggctttc tctgcctctg
     3481 ggcagcctgc tttggccttt ccttgtatgt gggtgtttat tacaagtggc tttgtgtcag
     3541 acacgctcgg ctccccacct ggacacacac tcaccagtgg cctttcagtg tagcgggagg
     3601 aagccggtgt ccctggatgt gaagctcaca ctgatgggct ggggcagggg cctgggccgg
     3661 cgagggggcc ggggggaggg gacagagctg aggatttcct ggagtgccct gcaggcacag
     3721 aggaggtcag caaaggtctt gaatagattt tctctggaaa taaagaatcc ttagatgcct
     3781 aaaaattccc ttcctgttcc ctcctggtcc tggacacctc ccaggggact gttccttatt
     3841 tctctctcct ggtgtgggta aagggacagt tacaaaccag gtcaccatcc tcagaggctg
     3901 agccctgtac ccaccccagc acagccacct ccgccagacc ccgtggctct gggagagcca
     3961 gctttgctat tcccattgtg acagcgatgg caggcctgac ccacggggca gttagagcag
     4021 cctcgtggag ctcgcccctc ccctcagcct gcccacctct ccctgcatcc tgaggccagt
     4081 ggcccccggg cctgcacaga tacctcatca tccacccgct gcccctcccc gtccctgtcc
     4141 cccagcatcg ggggcctgca aatctagtgc cgaatgacta tgtccagatt ggtgacgatg
     4201 ggtgttgctg tttttcttgt cgtttgtgaa cgctgtgatg ctgtgtgccc aagtgggcag
     4261 tcaccaccca gcccttcctt gggcgtctcc cccagagtgc tgtcgggacc acatctgtcc
     4321 tcaccctgtg ggaccgcctg gccctccctc cctagccctt ccagcctggg acacacacac
     4381 acacacacac acacacacac gcacgcacac gcacacatct tacctctcat gcgtgtttta
     4441 ccttttgatg ttcagagtgg ctcactggct gggagtcctt acctcgggga gagggggagg
     4501 ttggttcctt ggggggccaa agaaggcagg gaatgcctgg agggtaactg gggggccacc
     4561 atgacccctt ctctctccag aaacagctgc ttctcccccc atcccagggt cccaccccca
     4621 acccccagag gtggcccttg tttacagtga ggactcggcc actgtgtctc tgtttcctga
     4681 aatataaact gtagcgaccc cagactgtag agatttttat gtgtttggat acatctgctg
     4741 tgtggaaaaa aaaaaaaact acaaaaaccc taattttgta catactgtat ttttactatt
     4801 gaactgtatt ctagtggctg ttcatgctcc aagactttag ttaccgagac atgaatacta
     4861 tccatgtaat aagcacttgc ctggaataaa atataaaact gaaataaacc tgcactgaaa
     4921 cctga
//
