LOCUS       NM_002432               1716 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens myeloid cell nuclear differentiation antigen (MNDA),
            mRNA.
ACCESSION   NM_002432
VERSION     NM_002432.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1716)
  AUTHORS   Meng,Y., Zhang,M., Li,X., Wang,X., Dong,Q., Zhang,H., Zhai,Y.,
            Song,Q., He,F., Tian,C. and Sun,A.
  TITLE     Myeloid cell-expressed MNDA enhances M2 polarization to facilitate
            the metastasis of hepatocellular carcinoma
  JOURNAL   Int J Biol Sci 20 (8), 2814-2832 (2024)
   PUBMED   38904028
  REMARK    GeneRIF: Myeloid cell-expressed MNDA enhances M2 polarization to
            facilitate the metastasis of hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1716)
  AUTHORS   Bottardi,S., Layne,T., Ramon,A.C., Quansah,N., Wurtele,H.,
            Affar,E.B. and Milot,E.
  TITLE     MNDA, a PYHIN factor involved in transcriptional regulation and
            apoptosis control in leukocytes
  JOURNAL   Front Immunol 15, 1395035 (2024)
   PUBMED   38680493
  REMARK    GeneRIF: MNDA, a PYHIN factor involved in transcriptional
            regulation and apoptosis control in leukocytes.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1716)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1716)
  AUTHORS   Bottardi,S., Guieze,R., Bourgoin,V., Fotouhi-Ardakani,N., Douge,A.,
            Darracq,A., Lakehal,Y.A., Berger,M.G., Mollica,L., Bay,J.O.,
            Omichinski,J.G. and Milot,E.
  TITLE     MNDA controls the expression of MCL-1 and BCL-2 in chronic
            lymphocytic leukemia cells
  JOURNAL   Exp Hematol 88, 68-82 (2020)
   PUBMED   32682001
  REMARK    GeneRIF: MNDA controls the expression of MCL-1 and BCL-2 in chronic
            lymphocytic leukemia cells.
REFERENCE   5  (bases 1 to 1716)
  AUTHORS   Wang,Z. and Cook,J.R.
  TITLE     IRTA1 and MNDA Expression in Marginal Zone Lymphoma: Utility in
            Differential Diagnosis and Implications for Classification
  JOURNAL   Am J Clin Pathol 151 (3), 337-343 (2019)
   PUBMED   30346478
  REMARK    GeneRIF: IRTA1 and MNDA are useful markers in the differential
            diagnosis of marginal zone lymphomas (MZLs).
REFERENCE   6  (bases 1 to 1716)
  AUTHORS   Dawson,M.J., Trapani,J.A., Briggs,R.C., Nicholl,J.K.,
            Sutherland,G.R. and Baker,E.
  TITLE     The closely linked genes encoding the myeloid nuclear
            differentiation antigen (MNDA) and IFI16 exhibit contrasting
            haemopoietic expression
  JOURNAL   Immunogenetics 41 (1), 40-43 (1995)
   PUBMED   7806273
REFERENCE   7  (bases 1 to 1716)
  AUTHORS   Briggs,R.C., Briggs,J.A., Ozer,J., Sealy,L., Dworkin,L.L.,
            Kingsmore,S.F., Seldin,M.F., Kaur,G.P., Athwal,R.S. and
            Dessypris,E.N.
  TITLE     The human myeloid cell nuclear differentiation antigen gene is one
            of at least two related interferon-inducible genes located on
            chromosome 1q that are expressed specifically in hematopoietic
            cells
  JOURNAL   Blood 83 (8), 2153-2162 (1994)
   PUBMED   7512843
REFERENCE   8  (bases 1 to 1716)
  AUTHORS   Briggs,J.A., Burrus,G.R., Stickney,B.D. and Briggs,R.C.
  TITLE     Cloning and expression of the human myeloid cell nuclear
            differentiation antigen: regulation by interferon alpha
  JOURNAL   J Cell Biochem 49 (1), 82-92 (1992)
   PUBMED   1644857
REFERENCE   9  (bases 1 to 1716)
  AUTHORS   Burrus,G.R., Briggs,J.A. and Briggs,R.C.
  TITLE     Characterization of the human myeloid cell nuclear differentiation
            antigen: relationship to interferon-inducible proteins
  JOURNAL   J Cell Biochem 48 (2), 190-202 (1992)
   PUBMED   1377701
REFERENCE   10 (bases 1 to 1716)
  AUTHORS   Ott,J. and Frater-Schroder,M.
  TITLE     Absence of linkage between transcobalamin II and ABO
  JOURNAL   Hum Genet 59 (2), 164-165 (1981)
   PUBMED   7327575
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB048114.1, M81750.1 and
            N29376.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002432.2.
            
            Summary: The myeloid cell nuclear differentiation antigen (MNDA) is
            detected only in nuclei of cells of the granulocyte-monocyte
            lineage. A 200-amino acid region of human MNDA is strikingly
            similar to a region in the proteins encoded by a family of
            interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and
            Ifi-203, that are not regulated in a cell- or tissue-specific
            fashion. The 1.8-kb MNDA mRNA, which contains an
            interferon-stimulated response element in the 5-prime untranslated
            region, was significantly upregulated in human monocytes exposed to
            interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS,
            CRP, and SPTA1. In its pattern of expression and/or regulation,
            MNDA resembles IFI16, suggesting that these genes participate in
            blood cell-specific responses to interferons. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.707397.1,
                                           SRR3476690.550752.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368141.5/ ENSP00000357123.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DB048114.1         51-77
            28-1694             M81750.1           1-1667
            1695-1716           N29376.1           13-34               c
FEATURES             Location/Qualifiers
     source          1..1716
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..1716
                     /gene="MNDA"
                     /gene_synonym="PYHIN3"
                     /note="myeloid cell nuclear differentiation antigen"
                     /db_xref="GeneID:4332"
                     /db_xref="HGNC:HGNC:7183"
                     /db_xref="MIM:159553"
     exon            1..207
                     /gene="MNDA"
                     /gene_synonym="PYHIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            208..492
                     /gene="MNDA"
                     /gene_synonym="PYHIN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1451
                     /gene="MNDA"
                     /gene_synonym="PYHIN3"
                     /note="epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="myeloid cell nuclear differentiation antigen"
                     /protein_id="NP_002423.1"
                     /db_xref="CCDS:CCDS1177.1"
                     /db_xref="GeneID:4332"
                     /db_xref="HGNC:HGNC:7183"
                     /db_xref="MIM:159553"
                     /translation="MVNEYKKILLLKGFELMDDYHFTSIKSLLAYDLGLTTKMQEEYN
                     RIKITDLMEKKFQGVACLDKLIELAKDMPSLKNLVNNLRKEKSKVAKKIKTQEKAPVK
                     KINQEEVGLAAPAPTARNKLTSEARGRIPVAQKRKTPNKEKTEAKRNKVSQEQSKPPG
                     PSGASTSAAVDHPPLPQTSSSTPSNTSFTPNQETQAQRQVDARRNVPQNDPVTVVVLK
                     ATAPFKYESPENGKSTMFHATVASKTQYFHVKVFDINLKEKFVRKKVITISDYSECKG
                     VMEIKEASSVSDFNQNFEVPNRIIEIANKTPKISQLYKQASGTMVYGLFMLQKKSVHK
                     KNTIYEIQDNTGSMDVVGSGKWHNIKCEKGDKLRLFCLQLRTVDRKLKLVCGSHSFIK
                     VIKAKKNKEGPMNVN"
     exon            493..629
                     /gene="MNDA"
                     /gene_synonym="PYHIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            630..797
                     /gene="MNDA"
                     /gene_synonym="PYHIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1214
                     /gene="MNDA"
                     /gene_synonym="PYHIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1403
                     /gene="MNDA"
                     /gene_synonym="PYHIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1716
                     /gene="MNDA"
                     /gene_synonym="PYHIN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1693..1698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MNDA"
                     /gene_synonym="PYHIN3"
                     /note="hexamer: AATAAA"
     polyA_site      1716
                     /gene="MNDA"
                     /gene_synonym="PYHIN3"
                     /note="major polyA site"
ORIGIN      
        1 agtgtaagaa ggccatctac aatcaagatt gagagtggct ctaacaagtg ccatttttcc
       61 ttgttagctt tcatttctca gccctttaca agattaaaat agtctgcagt ttaatctctc
      121 caaagcttta cggacagtga ttctgtccta aacaagacag tgactccagg atttctgaag
      181 actattgtgg aagaagcatc cattaaggcc aagctataac atcagaaatg gtgaatgaat
      241 acaagaaaat tcttttgctg aaaggatttg agctcatgga tgattatcat tttacatcaa
      301 ttaagtcctt actggcctat gatttaggac taactacaaa aatgcaagag gaatacaaca
      361 gaattaagat tacagatttg atggaaaaaa agttccaagg cgttgcctgt ctagacaaac
      421 taatagaact tgccaaagat atgccatcac ttaaaaacct tgttaacaat cttcgaaaag
      481 agaagtcaaa agttgctaag aaaattaaaa cacaagaaaa agctccagtg aaaaaaataa
      541 accaggaaga agtgggtctt gcggcacctg cacccaccgc aagaaacaaa ctgacatcgg
      601 aagcaagagg gaggattcct gtagctcaga aaagaaaaac tccaaacaaa gaaaagactg
      661 aagccaaaag gaataaggtg tcccaagagc agagtaagcc cccaggtccc tcaggagcca
      721 gcacatctgc agctgtggat catcccccac taccccagac ctcatcatca actccatcca
      781 acacttcgtt tactccgaat caggaaaccc aggcccaacg gcaggtggat gcaagaagaa
      841 atgttcccca aaacgaccca gtgacagtgg tggtactgaa agcaacagcg ccatttaaat
      901 acgagtcccc agaaaatggg aaaagcacaa tgtttcatgc tacagtggcc agtaagactc
      961 aatatttcca tgtgaaagtc ttcgacatca acttgaaaga gaaatttgta aggaagaagg
     1021 tcattaccat atctgattac tctgaatgta aaggagtaat ggaaataaag gaagcatcat
     1081 ctgtgtctga ctttaatcaa aattttgagg tcccaaacag aattatcgaa atagcaaata
     1141 aaactcccaa gatcagtcaa ctttacaagc aagcatctgg aacaatggtg tatgggttgt
     1201 ttatgttaca aaagaaaagc gtacacaaga agaacacaat ttatgaaata caggataata
     1261 caggatccat ggatgtagtg gggagtggaa aatggcacaa tatcaagtgt gagaaaggag
     1321 ataaacttcg actcttctgc cttcaactga gaacagttga ccgcaagctg aaactggtgt
     1381 gtggaagtca cagcttcatc aaggtcatca aggccaagaa aaacaaggaa ggaccaatga
     1441 atgttaattg aaatatgaaa gctgaaatgc aacaaacaac ttccgcttaa aacaattaag
     1501 ttgttaataa ctgtgatttt gtaaatttca gtaattcatt taaatgatgt ttcagtagat
     1561 atattctagc atattaagag cttttataac tgagttatag attagtttgc tttctggaat
     1621 aaaattttct tcttatactc ttcctttttt ttagatatta cattttgctt ttatgacatt
     1681 cacgaggcaa aaaataaaat atcttttttt gaagga
//
