LOCUS       NM_032117                929 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens meiotic nuclear divisions 1 (MND1), transcript variant
            1, mRNA.
ACCESSION   NM_032117
VERSION     NM_032117.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 929)
  AUTHORS   Fang,J., Zhen,J., Gong,Y., Ke,Y., Fu,B., Jiang,Y., Xie,J., Liu,Y.,
            Ding,Y., Huang,D. and Xiao,F.
  TITLE     MND1 functions as a potential prognostic biomarker associated with
            cell cycle and immune infiltration in kidney renal clear cell
            carcinoma
  JOURNAL   Aging (Albany NY) 14 (18), 7416-7442 (2022)
   PUBMED   36098680
  REMARK    GeneRIF: MND1 functions as a potential prognostic biomarker
            associated with cell cycle and immune infiltration in kidney renal
            clear cell carcinoma.
REFERENCE   2  (bases 1 to 929)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 929)
  AUTHORS   Zhang,Q., Shi,R., Bai,Y., Meng,L., Hu,J., Zhu,H., Liu,T., De,X.,
            Wang,S., Wang,J., Xu,L., Zhou,G. and Yin,R.
  TITLE     Meiotic nuclear divisions 1 (MND1) fuels cell cycle progression by
            activating a KLF6/E2F1 positive feedback loop in lung
            adenocarcinoma
  JOURNAL   Cancer Commun (Lond) 41 (6), 492-510 (2021)
   PUBMED   33734616
  REMARK    GeneRIF: Meiotic nuclear divisions 1 (MND1) fuels cell cycle
            progression by activating a KLF6/E2F1 positive feedback loop in
            lung adenocarcinoma.
REFERENCE   4  (bases 1 to 929)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 929)
  AUTHORS   Wei,J., Meng,G., Wu,J., Zhang,Q. and Zhang,J.
  TITLE     Genetic network and gene set enrichment analyses identify MND1 as
            potential diagnostic and therapeutic target gene for lung
            adenocarcinoma
  JOURNAL   Sci Rep 11 (1), 9430 (2021)
   PUBMED   33941804
  REMARK    GeneRIF: Genetic network and gene set enrichment analyses identify
            MND1 as potential diagnostic and therapeutic target gene for lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 929)
  AUTHORS   Dorosh,A., Tepla,O., Zatecka,E., Ded,L., Koci,K. and Peknicova,J.
  TITLE     Expression analysis of MND1/GAJ, SPATA22, GAPDHS and ACR genes in
            testicular biopsies from non-obstructive azoospermia (NOA) patients
  JOURNAL   Reprod Biol Endocrinol 11, 42 (2013)
   PUBMED   23675907
  REMARK    GeneRIF: Data indicate that the positive expression of studied
            genes fertilization rate for GAPDHS positive subset was 66%, ACR -
            71%, SPATA22 - 68%, MND1 - 70%, pregnancy rates were 8%, 6%, 18%
            and 36% respectively.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 929)
  AUTHORS   Chi,P., San Filippo,J., Sehorn,M.G., Petukhova,G.V. and Sung,P.
  TITLE     Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51
            recombinase
  JOURNAL   Genes Dev 21 (14), 1747-1757 (2007)
   PUBMED   17639080
REFERENCE   8  (bases 1 to 929)
  AUTHORS   Enomoto,R., Kinebuchi,T., Sato,M., Yagi,H., Kurumizaka,H. and
            Yokoyama,S.
  TITLE     Stimulation of DNA strand exchange by the human TBPIP/Hop2-Mnd1
            complex
  JOURNAL   J Biol Chem 281 (9), 5575-5581 (2006)
   PUBMED   16407260
  REMARK    GeneRIF: Data suggest that the human TBPIP/Hop2-Mnd1 complex may
            ensure proper pairing between homologous chromosomes through its
            stimulation of strand exchange during meiosis.
REFERENCE   9  (bases 1 to 929)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 929)
  AUTHORS   Tsubouchi,H. and Roeder,G.S.
  TITLE     The Mnd1 protein forms a complex with hop2 to promote homologous
            chromosome pairing and meiotic double-strand break repair
  JOURNAL   Mol Cell Biol 22 (9), 3078-3088 (2002)
   PUBMED   11940665
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM820228.1, AK312172.1, BU533354.1, AA542845.1 and AC013477.7.
            
            On May 17, 2019 this sequence version replaced NM_032117.3.
            
            Summary: The product of the MND1 gene associates with HOP2 (MIM
            608665) to form a stable heterodimeric complex that binds DNA and
            stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1
            (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1
            and HOP2 genes are indispensable for meiotic
            recombination.[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.601082.1, BC032142.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240488.8/ ENSP00000240488.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BM820228.1         40-41
            3-668               AK312172.1         1-666
            669-898             BU533354.1         364-593
            899-906             AA542845.1         11-18               c
            907-929             AC013477.7         156305-156327
FEATURES             Location/Qualifiers
     source          1..929
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..929
                     /gene="MND1"
                     /gene_synonym="GAJ"
                     /note="meiotic nuclear divisions 1"
                     /db_xref="GeneID:84057"
                     /db_xref="HGNC:HGNC:24839"
                     /db_xref="MIM:611422"
     exon            1..53
                     /gene="MND1"
                     /gene_synonym="GAJ"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..668
                     /gene="MND1"
                     /gene_synonym="GAJ"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homolog of yeast MND1; meiotic nuclear division protein 1
                     homolog; meiotic nuclear divisions 1 homolog"
                     /codon_start=1
                     /product="meiotic nuclear division protein 1 homolog
                     isoform 1"
                     /protein_id="NP_115493.1"
                     /db_xref="CCDS:CCDS3782.1"
                     /db_xref="GeneID:84057"
                     /db_xref="HGNC:HGNC:24839"
                     /db_xref="MIM:611422"
                     /translation="MSKKKGLSAEEKRTRMMEIFSETKDVFQLKDLEKIAPKEKGITA
                     MSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKHKLEVLESQLSEGSQKHAS
                     LQKSIEKAKIGRCETEERTRLAKELSSLRDQREQLKAEVEKYKDCDPQVVEEIRQANK
                     VAKEAANRWTDNIFAIKSWAKRKFGFEENKIDRTFGIPEDFDYID"
     exon            54..119
                     /gene="MND1"
                     /gene_synonym="GAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            120..177
                     /gene="MND1"
                     /gene_synonym="GAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            178..326
                     /gene="MND1"
                     /gene_synonym="GAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            327..401
                     /gene="MND1"
                     /gene_synonym="GAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            402..516
                     /gene="MND1"
                     /gene_synonym="GAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            517..561
                     /gene="MND1"
                     /gene_synonym="GAJ"
                     /inference="alignment:Splign:2.1.0"
     exon            562..929
                     /gene="MND1"
                     /gene_synonym="GAJ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      790..795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MND1"
                     /gene_synonym="GAJ"
                     /note="hexamer: AATAAA"
     polyA_site      807
                     /gene="MND1"
                     /gene_synonym="GAJ"
                     /note="major polyA site"
     regulatory      883..888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MND1"
                     /gene_synonym="GAJ"
                     /note="hexamer: AATAAA"
     polyA_site      903
                     /gene="MND1"
                     /gene_synonym="GAJ"
ORIGIN      
        1 ccctctcccc aagcgcgggc ccggccagcg gaagcccctg cgcccgcgcc atgtcaaaga
       61 aaaaaggact gagtgcagaa gaaaagagaa ctcgcatgat ggaaatattt tctgaaacaa
      121 aagatgtatt tcaattaaaa gacttggaga agattgctcc caaagagaaa ggcattactg
      181 ctatgtcagt aaaagaagtc cttcaaagct tagttgatga tggtatggtt gactgtgaga
      241 ggatcggaac ttctaattat tattgggctt ttccaagtaa agctcttcat gcaaggaaac
      301 ataagttgga ggttctggaa tctcagttgt ctgagggaag tcaaaagcat gcaagcctac
      361 agaaaagcat tgagaaagct aaaattggcc gatgtgaaac ggaagagcga accaggctag
      421 caaaagagct ttcttcactt cgagaccaaa gggaacagct aaaggcagaa gtagaaaaat
      481 acaaagactg tgatccgcaa gttgtggaag aaatacgcca agcaaataaa gtagccaaag
      541 aagctgctaa cagatggact gataacatat tcgcaataaa atcttgggcc aaaagaaaat
      601 ttgggtttga agaaaataaa attgatagaa cttttggaat tccagaagac tttgactaca
      661 tagactaaaa tattccatgg tggtgaagga tgtacaagct tgtgaatatg taaattttaa
      721 actattatct aactaagtgt actgaattgt cgtttgcctg taactgtgtt tatcatttta
      781 ttaatgttaa ataaagtgta aaatgcagat gttcttcacc ccttttggta gaacaaaagc
      841 aggatgataa ccatatcccc ccagtgctca tcaaagtagg acaataaaaa tccatccatc
      901 tcagtccagg cagatttaca aatgatttt
//
