LOCUS       NM_002430               7814 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens MN1 proto-oncogene, transcriptional regulator (MN1),
            mRNA.
ACCESSION   NM_002430
VERSION     NM_002430.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7814)
  AUTHORS   Hussain,S.I., Muhammad,N., Shah,S.A., Rehman,A.U., Khan,S.A.,
            Saleha,S., Khan,Y.M., Muhammad,N., Khan,S. and Wasif,N.
  TITLE     Variants in HCFC1 and MN1 genes causing intellectual disability in
            two Pakistani families
  JOURNAL   BMC Med Genomics 17 (1), 176 (2024)
   PUBMED   38956580
  REMARK    GeneRIF: Variants in HCFC1 and MN1 genes causing intellectual
            disability in two Pakistani families.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7814)
  AUTHORS   Ningombam,A., Verma,D., Kumar,R., Singh,J., Ali,M.S., Pandey,A.K.,
            Singh,I., Bakhshi,S., Sharma,A., Pushpam,D., Palanichamy,J.K.,
            Tanwar,P., Ranjan Singh,A. and Chopra,A.
  TITLE     Refinement of Risk-Stratification of Cytogenetically Normal Acute
            Myeloid Leukemia Adult Patients by MN1 Expression
  JOURNAL   Asian Pac J Cancer Prev 25 (7), 2283-2289 (2024)
   PUBMED   39068559
  REMARK    GeneRIF: Refinement of Risk-Stratification of Cytogenetically
            Normal Acute Myeloid Leukemia Adult Patients by MN1 Expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7814)
  AUTHORS   Yu,J.J., Wu,Q.Y., Ran,Q.C., Zhao,Y.Y., Yu,L.N., Cao,Q.X.,
            Chen,X.M., Li,W.Y. and Zhao,Z.J.
  TITLE     Distinctive Craniofacial and Oral Anomalies in MN1 C-terminal
            Truncation Syndrome
  JOURNAL   Chin J Dent Res 27 (1), 47-52 (2024)
   PUBMED   38546519
  REMARK    GeneRIF: Distinctive Craniofacial and Oral Anomalies in MN1
            C-terminal Truncation Syndrome.
            Review article
REFERENCE   4  (bases 1 to 7814)
  AUTHORS   Lehman,N.L.
  TITLE     Early ependymal tumor with MN1-BEND2 fusion: a mostly cerebral
            tumor of female children with a good prognosis that is distinct
            from classical astroblastoma
  JOURNAL   J Neurooncol 161 (3), 425-439 (2023)
   PUBMED   36604386
  REMARK    GeneRIF: Early ependymal tumor with MN1-BEND2 fusion: a mostly
            cerebral tumor of female children with a good prognosis that is
            distinct from classical astroblastoma.
            Review article
REFERENCE   5  (bases 1 to 7814)
  AUTHORS   Li,H.B., Huang,G., Tu,J., Lv,D.M., Jin,Q.L., Chen,J.K., Zou,Y.T.,
            Lee,D.F., Shen,J.N. and Xie,X.B.
  TITLE     METTL14-mediated epitranscriptome modification of MN1 mRNA promote
            tumorigenicity and all-trans-retinoic acid resistance in
            osteosarcoma
  JOURNAL   EBioMedicine 82, 104142 (2022)
   PUBMED   35810559
  REMARK    GeneRIF: METTL14-mediated epitranscriptome modification of MN1 mRNA
            promote tumorigenicity and all-trans-retinoic acid resistance in
            osteosarcoma.
REFERENCE   6  (bases 1 to 7814)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 7814)
  AUTHORS   van Wely,K.H., Molijn,A.C., Buijs,A., Meester-Smoor,M.A.,
            Aarnoudse,A.J., Hellemons,A., den Besten,P., Grosveld,G.C. and
            Zwarthoff,E.C.
  TITLE     The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in
            RAR-RXR-mediated transcription
  JOURNAL   Oncogene 22 (5), 699-709 (2003)
   PUBMED   12569362
REFERENCE   8  (bases 1 to 7814)
  AUTHORS   Gastier,J.M., Brody,T., Pulido,J.C., Businga,T., Sunden,S., Hu,X.,
            Maitra,S., Buetow,K.H., Murray,J.C., Sheffield,V.C., Boguski,M.,
            Duyk,G.M. and Hudson,T.J.
  TITLE     Development of a screening set for new (CAG/CTG)n dynamic mutations
  JOURNAL   Genomics 32 (1), 75-85 (1996)
   PUBMED   8786123
REFERENCE   9  (bases 1 to 7814)
  AUTHORS   Lekanne Deprez,R.H., Riegman,P.H., Groen,N.A., Warringa,U.L., van
            Biezen,N.A., Molijn,A.C., Bootsma,D., de Jong,P.J., Menon,A.G.,
            Kley,N.A. et al.
  TITLE     Cloning and characterization of MN1, a gene from chromosome 22q11,
            which is disrupted by a balanced translocation in a meningioma
  JOURNAL   Oncogene 10 (8), 1521-1528 (1995)
   PUBMED   7731706
REFERENCE   10 (bases 1 to 7814)
  AUTHORS   Buijs,A., Sherr,S., van Baal,S., van Bezouw,S., van der Plas,D.,
            Geurts van Kessel,A., Riegman,P., Lekanne Deprez,R., Zwarthoff,E.,
            Hagemeijer,A. et al.
  TITLE     Translocation (12;22) (p13;q11) in myeloproliferative disorders
            results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene
            on 22q11
  JOURNAL   Oncogene 10 (8), 1511-1519 (1995)
   PUBMED   7731705
  REMARK    Erratum:[Oncogene 1995 Aug 17;11(4):809]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031591.19 and X82209.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002430.2.
            
            Summary: Meningioma 1 (MN1) contains two sets of CAG repeats. It is
            disrupted by a balanced translocation (4;22) in a meningioma, and
            its inactivation may contribute to meningioma 32 pathogenesis.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X82209.2, SRR1660809.155500.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975, SAMN03465404
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302326.5/ ENSP00000304956.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AL031591.19        30208-30465         c
            259-2142            AL031591.19        28324-30207         c
            2143-5310           X82209.2           1883-5050
            5311-7814           X82209.2           5052-7555
FEATURES             Location/Qualifiers
     source          1..7814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.1"
     gene            1..7814
                     /gene="MN1"
                     /gene_synonym="CEBALID; dJ353E16.2; MGCR; MGCR1;
                     MGCR1-PEN"
                     /note="MN1 proto-oncogene, transcriptional regulator"
                     /db_xref="GeneID:4330"
                     /db_xref="HGNC:HGNC:7180"
                     /db_xref="MIM:156100"
     exon            1..4994
                     /gene="MN1"
                     /gene_synonym="CEBALID; dJ353E16.2; MGCR; MGCR1;
                     MGCR1-PEN"
                     /inference="alignment:Splign:2.1.0"
     exon            4995..7814
                     /gene="MN1"
                     /gene_synonym="CEBALID; dJ353E16.2; MGCR; MGCR1;
                     MGCR1-PEN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7792..7797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MN1"
                     /gene_synonym="CEBALID; dJ353E16.2; MGCR; MGCR1;
                     MGCR1-PEN"
                     /note="hexamer: AATAAA"
     polyA_site      7814
                     /gene="MN1"
                     /gene_synonym="CEBALID; dJ353E16.2; MGCR; MGCR1;
                     MGCR1-PEN"
                     /note="major polyA site"
ORIGIN      
        1 gttgctgctt ctcccggcgc tgggcgagag gcagacacag agaggggagc cgagaccctc
       61 ggaacgcccc acgcagagcc cccccgctag tcgggagagg ggtgcgcaga ccccccagag
      121 ctgcccccgc gcccccctcc ccccattccg ggctctgaga gcgcagcggg aacgccttag
      181 cctgctcgcc cggcgtggcc ccccgacccg cgtacgcccc cctccctcag gtccgagagg
      241 gactcgcgaa gcacctcagc gcggaggcag ggaaccggag ccttggagcg acccaacccc
      301 tcgtctcgct gccctcccgc gcctgcaacg gtgcgcggag actccggcga actcagacac
      361 ccaacggcgg agaacagaag cggcaggcgg cggacgtggc cgcgaagctg cgcgccgaac
      421 gcagcgcacc cgctgccgag cagaggagcc gcgcctttcc ccgaccctcg gctccagccc
      481 ccggcgcctg ccgcctcgca gcccctctgc gtcctcggct cgggggccgg caccggcgat
      541 gccgagcgga gcctccagtc ctccgacccg ctgaagaagc agcagccgct cgcccggagc
      601 ctacggggat tgtgcgagcg gatcgtgctc ggtggaggct cgggctgcgg ggcgcgggga
      661 ctccgggggg cggggggagg gaccgctctg tcggtgcccg gcgccagccg cggctttgaa
      721 gggtctccct cccctgccct tagcagctct gccacggact ccgggaggct gcgggcggcg
      781 tcctgagggc tccccagcag acccaatcgg acttgagaag gtgatcgctc tgctctccca
      841 acccccttcc ctccccattc cccccactta actttttgtc tccgttcatc cgcggcttcg
      901 tcccctcccc gcagacccac ccgcggctgt gacaaccgcc cggggcatgg gccccccaac
      961 acggctccta gaggccccgc ggcctcgcaa gatgtgagag gccctccccg ggcagaatcg
     1021 gagcttcagg agaggagcta ataccccgcc ccccgtccct cacatcaggc ggggtggagg
     1081 tgcgcgctga gcccccgcgg tgctgagcgt cccggagcgc ccaatcctgg gctggaacga
     1141 gtagctggcc ggaggcgcgc cgcggagagc cggctgtcat gccctattga tccccctctg
     1201 ccccccgcca agtatgtttg ggctggacca attcgagccc caggtcaaca gcaggaacgc
     1261 tggccagggc gagaggaact ttaacgagac cggactgagc atgaacaccc actttaaggc
     1321 cccggctttc cacactgggg ggccccctgg ccctgtggat cctgctatga gcgcgctggg
     1381 cgaacccccg atcttgggca tgaacatgga gccctacggc ttccacgcgc gcggccactc
     1441 ggagttgcac gcaggggggc tgcaagcgca gcctgtgcac ggcttctttg gcggccagca
     1501 gcctcaccac ggccacccgg gaagtcatca tccccaccag catcaccccc actttggggg
     1561 caacttcggt ggcccggacc ccggggcctc gtgcctgcac gggggtcgcc tgctcggcta
     1621 cggcggcgca gccggaggcc tgggcagcca gccgcccttc gccgagggct atgagcacat
     1681 ggcggagagc caggggcctg agagcttcgg cccgcagcga ccggggaacc tcccggactt
     1741 ccacagttca ggtgcctcca gccacgccgt gccggcccca tgcctgccgc tggaccagag
     1801 ccctaaccga gccgcctcct tccacggcct gccgtcctcc agcggctccg attcccacag
     1861 tctggagcca cggagggtga cgaaccaagg agccgtcgac tcgctggaat acaattaccc
     1921 gggcgaggcg ccctcgggac attttgacat gttttcgccc tctgactccg aagggcagct
     1981 gcctcattat gcagcgggtc gccaggttcc tgggggcgct ttcccgggcg cctcggccat
     2041 gcccagagct gcgggcatgg tgggcttgtc caaaatgcac gcccagccac cgcagcagca
     2101 gccccagcag cagcagcagc cccagcagca gcagcagcag catggtgtgt tctttgagag
     2161 gttcagtggg gccagaaaga tgcctgtggg tctggagccc tcagtgggct ccaggcaccc
     2221 gttaatgcag cctccccagc aggccccgcc accccctcag cagcagcccc cgcagcagcc
     2281 gccacagcag cagccgccgc cgccacccgg gcttctagtc cgacaaaatt cgtgcccgcc
     2341 tgcgctccct cggccccagc agggcgaggc gggcacgccc agcggcggcc tgcaggacgg
     2401 aggccccatg ctgcccagcc agcacgcgca attcgagtat cccatccacc ggctggagaa
     2461 ccggagcatg cacccttatt ccgagcctgt tttcagcatg cagcatcctc ctccgcagca
     2521 ggcgcccaac cagcggctgc agcatttcga cgcgcccccc tacatgaacg tggccaagag
     2581 gccgcgcttc gactttccgg gcagcgcggg agtggaccgc tgcgcttcgt ggaacggcag
     2641 catgcacaac ggcgctctgg ataatcacct ctccccttcc gcctacccag gcctacccgg
     2701 cgagttcaca ccgcctgtgc ccgacagctt cccttcgggg ccgcccctgc agcatccggc
     2761 cccggaccac cagtccctgc aacagcagca gcagcagcag cagcagcagc aacagcagca
     2821 gcagcagcag caacagcaac agcaacagca gcagcagcag cagcgccaaa acgcggccct
     2881 catgattaag cagatggcgt cgcggaatca gcagcagcgg ctgcgccagc ccaacctggc
     2941 tcagctaggc caccccgggg acgtgggcca gggcggcctg gtgcatggcg gcccggtggg
     3001 cggcttggcc cagccgaact ttgagcgcga aggcggcagc acgggcgccg ggcgtctggg
     3061 caccttcgag cagcaggcgc cgcacttggc gcaagagagc gcgtggttct caggtccgca
     3121 tccgccgccc ggagacctgc tgccccgtag gatgggcggc tcgggtctgc ccgctgactg
     3181 tggcccgcac gaccccagcc tggcgccccc tcctccgcct ggtggctcgg gggtgctgtt
     3241 ccggggccct ctgcaggagc cgatgaggat gcccggagag ggccacgtgc ccgcgctgcc
     3301 ttcaccgggc ctgcagttcg ggggcagtct gggaggcctg ggtcagctgc agtcgcccgg
     3361 ggcgggcgtg gggctcccca gcgctgcttc ggagcgccgg cccccgccgc cggactttgc
     3421 tacgtctgcg ctcgggggcc agccgggctt tccgtttggt gcagccggcc ggcagtccac
     3481 gccgcacagc ggtccaggcg tgaactcgcc ccccagcgcg ggagggggcg gtggcagctc
     3541 tggtggcggc ggtggcgggg gtgcctaccc gccgcagcct gatttccagc ccagccagcg
     3601 cacctcggcc agtaaattgg gcgcgctctc gctgggctcc ttcaacaagc ccagctccaa
     3661 ggacaacctg ttcggccaga gctgcctggc tgcgctctcc accgcttgcc agaacatgat
     3721 cgccagcctc ggggccccca acctcaacgt gaccttcaac aagaagaacc cgccagaggg
     3781 caagaggaaa ctgagccaga acgagaccga cggcgcggca gtggccggca acccgggctc
     3841 ggattacttc ccaggaggga ctgctcctgg ggccccagga cccggaggcc cgtccgggac
     3901 cagtagcagc ggctccaaag cctcggggcc gcccaaccct ccagcccagg gggacggcac
     3961 cagcctctcc cccaactaca ccctggaatc cacgtcgggg aatgacggca agccggtctc
     4021 cgggggcggc ggccggggac ggggtcgcag aaaaagggac agtggtcacg tgagccctgg
     4081 caccttcttt gacaagtact cggcggctcc ggacagcggg ggcgcacctg gggtgagccc
     4141 agggcagcag caagcgtcag gcgcagccgt cgggggaagc tccgcaggcg agacgcgcgg
     4201 ggcaccgacg ccccacgaaa aggcgctcac gtcgccatcc tgggggaagg gggctgagtt
     4261 gctcctgggg gatcagccgg acctcattgg gtccctggac ggcggggcca agtcggacag
     4321 tagttcgcca aacgtgggtg agttcgcctc ggacgaggtg agcacgagct acgccaatga
     4381 ggacgaggtg tcgtccagct ctgacaaccc ccaggcacta gttaaagcga gcaggagtcc
     4441 cctggtgacc ggctcgccca aactccctcc ccgtggggta ggcgccgggg aacacggacc
     4501 gaaggcgccc ccgcccgccc tcggcctggg catcatgtct aactctacct cgacccctga
     4561 cagctacggc ggcggtgggg gcccgggcca tccgggcact ccgggcctgg agcaggtccg
     4621 caccccgacg agcagcagcg gcgccccgcc acccgacgag atccaccccc tggagatcct
     4681 tcaggcgcag atccagctac agaggcagca gttcagcatc tccgaggacc agcctctggg
     4741 gctgaagggt ggcaagaagg gtgagtgcgc cgtcggggcc tcaggggcgc agaatggcga
     4801 cagcgagctg ggcagctgct gctccgaggc ggtcaagagc gccatgagca ccattgacct
     4861 ggactcgctg atggcagagc acagcgctgc ctggtacatg cccgctgaca aggccctggt
     4921 ggacagcgcg gacgacgaca agacgttggc gccctgggag aaggccaaac cccagaaccc
     4981 caacagcaaa gaagcccacg acctccctgc aaacaaggcc tcagcatccc agcctggcag
     5041 ccacttgcag tgcctgtctg tccactgcac agacgacgtg ggtgacgcca aggctcgagc
     5101 ctccgtgccc acctggcggt ccctgcattc tgacatctcc aacagatttg ggacattcgt
     5161 ggctgcccta acttgaatga caagaaagat cccctcctct accaggccct tcctctcccc
     5221 ctgtctgttt ccttccccct caaccttacc ccacccctct gttaatttga aagggccact
     5281 attgctgagt ggatgagttt tttttttttc tctaggttgg tacctgctta gtggcatatg
     5341 gaccggaaag ggttaattta aaggggggga acctcaaaag tttttttaaa aaagaaactt
     5401 gtctgccaca gtatgttacc agtgttaacc cttctgcagt tagcaaactt ttgcttaagc
     5461 ctttttcctc tagatactcc ccatgtttcg gtaatcttgg catacatttt ttagatgacc
     5521 tctttccttg ttttgttttc atgctgctgt atgtccaagt attgttattt cataataaga
     5581 caagagttgc tttctttttt attctttttc cttttcttac cccctcccct tttattttct
     5641 ttttgctttg ttcactgctt attaaaatgg aaatcctgga gaatagtagt tctggaatat
     5701 tgccgggtga aagtccaatt gtcatcacaa tgttatatat tgacacccca gtgtcatcag
     5761 tcaggcagga gccaaacaat gaatgcccct cttaggtatt ccgcctggga ttttgttttg
     5821 tctgttccct aagaaaatat attttcattc ctgcaaacac agtgctcagc cttcagttcc
     5881 cttccacttg agttctctct tctcctgctg gaagccgccc ctctctgcga tggacgtgag
     5941 gacgtgtcca gctctgctct gtgggaagga gttggaatgt tcgacagcag tgttttctct
     6001 ccttttctgg gcctcctcgc aaatgcccag gccctgcatt ttcacgctgt gctaagcagc
     6061 ctttggtctg catgggggat ggtgtgctcc cagcctgcag tctttggagc aaggctgctg
     6121 cccgtgcctt gggtgctgga gttggaggag gctgttctca gccctttccc ttttctgaaa
     6181 gctgttcctg gccgggcatc ccagggaaga aggaggggac tgcgtgtatc tcctccacct
     6241 ctcccattcc atccccagtc cagcctgggc aaccccaccc ctgggaggga tgaggcaccc
     6301 tcttgctcag cctgctcagc cttctctgag cctttgcagg gatctgcaga ctcctgaggg
     6361 ctagaggaca gagaaagaga atagaatgaa atgactttga ttcctgcgcc ttttagtttt
     6421 gaactctgga attcctctgc cccctcccca acattttttt ggaatctcac cctgttgcaa
     6481 aactagagcc atgtcccaag catctcacaa aggaataact gctctgagca gagatgagtg
     6541 gtggttggca ggggcaggca actttgggtg ctgctgatgc ctgcaaaagc catttatggc
     6601 ttgtggtggg gggcacatag attccccggt gggttagaca ggaagtaact gatatcactt
     6661 cacccaaata tataaccgtg atggttatct atttaatttc agtttttgtt aacgagcgtg
     6721 tcttactaaa acgctccact ttgagctccc ccaccccctc caggtcctca gagtttgcag
     6781 atctgggctt tctaaagcaa gtgacctgaa ggctctgggc tcaccataca acacccacgt
     6841 tgtttatttc aaagaacttt tcagcgaagg gagaggagct ttcagaaaaa cctcactctt
     6901 tcccctccct tctcccctct ttccttctgc cggtcctttt ggctggggtc tgagtctgcg
     6961 gttctcgcct gggcagtctt gacgaggagc aaaccccgcc ttcagagggc agacaaagca
     7021 ggtggcatga attgatcagc gagaaaggtg tgagccgagg cagttcctgc gttctgctac
     7081 aaaaggaatg gaaagggaag ggaatttccc cccaccatgg gctgtgggag agttgaccgt
     7141 attctgggca agactccatg acccctctga ttctgcagtg tacagctgtt tgagagcctc
     7201 atcattttac ttttgaaaca ggaatgattt ctccttaatt gcttaaggcc ggggagcaaa
     7261 gtgtcttaac ttctgtcttt gactttccca gcgttgagtc atcaacactt tgccaattag
     7321 ctcatggtcc tggcaacctc agaaacccct gaagttttaa aaactttctc gctccccacg
     7381 accccagaat gaaacagctt taaaaatagc cttaagcaaa aggatgttat ttcattaaat
     7441 ttggtttaat ggaaagaata aaagtaaatg aaaaacacac cctacacact agactccgaa
     7501 cactggtaat cagtactgca tagcaaactc tttgggaaag aaaacgaaaa tgttattgca
     7561 catgtaaaat atgaaaactt aactctgctg tgtgttaggc aatcctgtaa tcttttttga
     7621 ctcttaaaag aaattcattt ctgaaatgct tggttggaag actgtgacaa tagctcatga
     7681 aattgagtgt tatttttttc tttctttttt aaaaaaatat gtaaagtgca gtcttctgta
     7741 ttcctgcata ttgtatatac ctgtatatgt tttcctgagc agttaaataa caataaatat
     7801 gacgttaatg gtga
//
