LOCUS       NM_022362               3499 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens MMS19 homolog, cytosolic iron-sulfur assembly
            component (MMS19), transcript variant 1, mRNA.
ACCESSION   NM_022362
VERSION     NM_022362.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3499)
  AUTHORS   van Karnebeek,C.D.M., Tarailo-Graovac,M., Leen,R., Meinsma,R.,
            Correard,S., Jansen-Meijer,J., Prykhozhij,S.V., Pena,I.A., Ban,K.,
            Schock,S., Saxena,V., Pras-Raves,M.L., Drogemoller,B.I.,
            Grootemaat,A.E., van der Wel,N.N., Dobritzsch,D., Roseboom,W.,
            Schomakers,B.V., Jaspers,Y.R.J., Zoetekouw,L., Roelofsen,J.,
            Ferreira,C.R., van der Lee,R., Ross,C.J., Kochan,J., McIntyre,R.L.,
            van Klinken,J.B., van Weeghel,M., Kramer,G., Weschke,B.,
            Labrune,P., Willemsen,M.A., Riva,D., Garavaglia,B., Moeschler,J.B.,
            Filiano,J.J., Ekker,M., Berman,J.N., Dyment,D., Vaz,F.M.,
            Wasserman,W.W., Houtkooper,R.H. and van Kuilenburg,A.B.P.
  TITLE     CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype
            caused by cytosolic Fe-S cluster protein assembly disorders
  JOURNAL   Genet Med 26 (6), 101104 (2024)
   PUBMED   38411040
  REMARK    GeneRIF: CIAO1 and MMS19 deficiency: A lethal neurodegenerative
            phenotype caused by cytosolic Fe-S cluster protein assembly
            disorders.
REFERENCE   2  (bases 1 to 3499)
  AUTHORS   Ren,D., Li,L., Wang,S. and Zuo,Y.
  TITLE     The c-MYC transcription factor conduces to resistance to cisplatin
            by regulating MMS19 in bladder cancer cells
  JOURNAL   Tissue Cell 82, 102096 (2023)
   PUBMED   37201439
  REMARK    GeneRIF: The c-MYC transcription factor conduces to resistance to
            cisplatin by regulating MMS19 in bladder cancer cells.
REFERENCE   3  (bases 1 to 3499)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3499)
  AUTHORS   Kassube,S.A. and Thoma,N.H.
  TITLE     Structural insights into Fe-S protein biogenesis by the CIA
            targeting complex
  JOURNAL   Nat Struct Mol Biol 27 (8), 735-742 (2020)
   PUBMED   32632277
  REMARK    GeneRIF: Structural insights into Fe-S protein biogenesis by the
            CIA targeting complex.
REFERENCE   5  (bases 1 to 3499)
  AUTHORS   Horton,A.J., Brooker,J., Streitfeld,W.S., Flessa,M.E., Pillai,B.,
            Simpson,R., Clark,C.D., Gooz,M.B., Sutton,K.K., Foley,A.C. and
            Lee,K.H.
  TITLE     Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA
            Metabolism and Proliferation
  JOURNAL   Sci Rep 9 (1), 1738 (2019)
   PUBMED   30742009
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3499)
  AUTHORS   Hatfield,M.D., Reis,A.M., Obeso,D., Cook,J.R., Thompson,D.M.,
            Rao,M., Friedberg,E.C. and Queimado,L.
  TITLE     Identification of MMS19 domains with distinct functions in NER and
            transcription
  JOURNAL   DNA Repair (Amst) 5 (8), 914-924 (2006)
   PUBMED   16797255
  REMARK    GeneRIF: MMS19 HEAT repeat domain is essential for MMS19 function
            in NER and transcription, while domains A and B, within MMS19
            N-terminus, modulate the balance between DNA repair and
            transcription.
REFERENCE   7  (bases 1 to 3499)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3499)
  AUTHORS   Wu,X., Li,H. and Chen,J.D.
  TITLE     The human homologue of the yeast DNA repair and TFIIH regulator
            MMS19 is an AF-1-specific coactivator of estrogen receptor
  JOURNAL   J Biol Chem 276 (26), 23962-23968 (2001)
   PUBMED   11279242
REFERENCE   9  (bases 1 to 3499)
  AUTHORS   Queimado,L., Rao,M., Schultz,R.A., Koonin,E.V., Aravind,L.,
            Nardo,T., Stefanini,M. and Friedberg,E.C.
  TITLE     Cloning the human and mouse MMS19 genes and functional
            complementation of a yeast mms19 deletion mutant
  JOURNAL   Nucleic Acids Res 29 (9), 1884-1891 (2001)
   PUBMED   11328871
  REMARK    GeneRIF: Cloning of the human MMS19 genes and functional
            complementation in Saccharomyces cerevisiae
REFERENCE   10 (bases 1 to 3499)
  AUTHORS   Seroz,T., Winkler,G.S., Auriol,J., Verhage,R.A., Vermeulen,W.,
            Smit,B., Brouwer,J., Eker,A.P., Weeda,G., Egly,J.M. and
            Hoeijmakers,J.H.
  TITLE     Cloning of a human homolog of the yeast nucleotide excision repair
            gene MMS19 and interaction with transcription repair factor TFIIH
            via the XPB and XPD helicases
  JOURNAL   Nucleic Acids Res 28 (22), 4506-4513 (2000)
   PUBMED   11071939
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC382327.1, AK314374.1 and BC009396.2.
            
            On Nov 24, 2018 this sequence version replaced NM_022362.4.
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1
            and 4 encode the same protein.
            
            Sequence Note: A downstream start codon is selected for this RefSeq
            based on better conservation with homologous proteins. The use of
            an alternative upstream start codon, which is present in some
            species, including human, chimp and macaque (with a subsequent CDS
            frameshift in the latter species), would increase the protein
            length from 1030 aa to 1051 aa. The shorter protein is referred to
            in the literature, including PMIDs 11071939, 11279242 and 11328871.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF357881.1, SRR1803611.217037.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438925.7/ ENSP00000412698.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-538               DC382327.1         26-563
            539-2611            AK314374.1         524-2596
            2612-3499           BC009396.2         865-1752
FEATURES             Location/Qualifiers
     source          1..3499
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..3499
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="MMS19 homolog, cytosolic iron-sulfur assembly
                     component"
                     /db_xref="GeneID:64210"
                     /db_xref="HGNC:HGNC:13824"
                     /db_xref="MIM:614777"
     exon            1..150
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..3131
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homolog of yeast MMS19; MET18 homolog; MMS19-like (MET18
                     homolog, S. cerevisiae); MMS19 nucleotide excision repair
                     protein homolog; MMS19-like protein; MMS19 nucleotide
                     excision repair homolog; MMS19 cytosolic iron-sulfur
                     assembly component"
                     /codon_start=1
                     /product="MMS19 nucleotide excision repair protein homolog
                     isoform 1"
                     /protein_id="NP_071757.4"
                     /db_xref="CCDS:CCDS7464.1"
                     /db_xref="GeneID:64210"
                     /db_xref="HGNC:HGNC:13824"
                     /db_xref="MIM:614777"
                     /translation="MAAAAAVEAAAPMGALWGLVHDFVVGQQEGPADQVAADVKSGNY
                     TVLQVVEALGSSLENPEPRTRARAIQLLSQVLLHCHTLLLEKEVVHLILFYENRLKDH
                     HLVIPSVLQGLKALSLCVALPPGLAVSVLKAIFQEVHVQSLPQVDRHTVYNIITNFMR
                     TREEELKSLGADFTFGFIQVMDGEKDPRNLLVAFRIVHDLISRDYSLGPFVEELFEVT
                     SCYFPIDFTPPPNDPHGIQREDLILSLRAVLASTPRFAEFLLPLLIEKVDSEVLSAKL
                     DSLQTLNACCAVYGQKELKDFLPSLWASIRREVFQTASERVEAEGLAALHSLTACLSR
                     SVLRADAEDLLDSFLSNILQDCRHHLCEPDMKLVWPSAKLLQAAAGASARACDSVTSN
                     VLPLLLEQFHKHSQSSQRRTILEMLLGFLKLQQKWSYEDKDQRPLNGFKDQLCSLVFM
                     ALTDPSTQLQLVGIRTLTVLGAQPDLLSYEDLELAVGHLYRLSFLKEDSQSCRVAALE
                     ASGTLAALYPVAFSSHLVPKLAEELRVGESNLTNGDEPTQCSRHLCCLQALSAVSTHP
                     SIVKETLPLLLQHLWQVNRGNMVAQSSDVIAVCQSLRQMAEKCQQDPESCWYFHQTAI
                     PCLLALAVQASMPEKEPSVLRKVLLEDEVLAAMVSVIGTATTHLSPELAAQSVTHIVP
                     LFLDGNVSFLPENSFPSRFQPFQDGSSGQRRLIALLMAFVCSLPRNVEIPQLNQLMRE
                     LLELSCCHSCPFSSTAAAKCFAGLLNKHPAGQQLDEFLQLAVDKVEAGLGSGPCRSQA
                     FTLLLWVTKALVLRYHPLSSCLTARLMGLLSDPELGPAAADGFSLLMSDCTDVLTRAG
                     HAEVRIMFRQRFFTDNVPALVQGFHAAPQDVKPNYLKGLSHVLNRLPKPVLLPELPTL
                     LSLLLEALSCPDCVVQLSTLSCLQPLLLEAPQVMSLHVDTLVTKFLNLSSSPSMAVRI
                     AALQCMHALTRLPTPVLLPYKPQVIRALAKPLDDKKRLVRKEAVSARGEWFLLGSPGS
                     "
     exon            151..199
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            200..300
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            301..386
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            387..461
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            462..531
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            532..660
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            661..722
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            723..809
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            810..884
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            885..962
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1101
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1256
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1335
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1461
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1543
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1644
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1794
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1950
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2050
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2153
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2222
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2349
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2450
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2507
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2694
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2777
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2942
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3002
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3103
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3499
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3479..3484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="hexamer: AATAAA"
     polyA_site      3499
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="major polyA site"
ORIGIN      
        1 accgcccata tcccctccca cggtctctag ttcgcgttat ggccgctgcc gcggctgtgg
       61 aggcggcggc gcctatgggt gccctatggg gcctcgtgca cgacttcgtc gtgggtcagc
      121 aagagggccc cgctgaccag gtggctgcag atgtgaaatc tggcaactat acagtgttac
      181 aagttgtgga agcccttggg tcctctctag agaatccaga accccgaact cgggcacgag
      241 caatccagct tttgtcacag gtgctactcc actgtcacac cttgctcctg gagaaggaag
      301 tggtacacct gatactgttc tatgagaacc ggctgaagga ccatcatctt gtgatcccat
      361 ctgtcctgca gggtttgaag gcacttagcc tgtgtgtggc cctgccccca gggctggctg
      421 tttctgtgct taaagccatc ttccaggaag tgcatgtaca gtccctgcca caggtggacc
      481 gacacacagt ctacaatatc atcaccaatt ttatgcgaac ccgggaagaa gagctaaaga
      541 gcctaggagc tgacttcacc tttggcttca tccaggtgat ggatggggaa aaggatcccc
      601 gtaatcttct ggtggccttc cgcatcgtcc atgacctcat ctccagggac tatagcctgg
      661 gaccctttgt ggaggagttg tttgaagtga catcctgtta tttccctatc gattttaccc
      721 ctccacctaa tgatccccat ggtatccaga gagaagacct catcctgagt cttcgcgctg
      781 tgctggcttc tacaccacga tttgctgagt ttctgctgcc cctgttgatt gagaaagtgg
      841 attctgaggt tctgagtgcc aagttggatt ctctacagac tctgaatgct tgctgtgctg
      901 tgtatggaca gaaggaactg aaggacttcc tccccagcct ttgggcttct atccgcagag
      961 aggtgttcca gacggcaagt gagcgggtgg aggcagaggg cctggcggcc ctccactccc
     1021 tgactgcgtg tttgtctcgc tctgtgctga gggctgatgc tgaggacctc cttgactcct
     1081 tccttagcaa cattctacag gactgcaggc accacctgtg tgaaccggac atgaaactgg
     1141 tgtggcctag tgccaagctg ttgcaggcag ctgcaggtgc atctgcccgg gcctgtgact
     1201 ctgtcaccag caatgtactg cctttactgc tggaacagtt ccacaagcac agtcagagca
     1261 gccagcggcg gacaatcctt gaaatgctcc tgggtttctt gaagctgcag cagaaatgga
     1321 gctatgaaga caaagatcaa aggcctctga atggcttcaa ggaccagctg tgctcactgg
     1381 tattcatggc tctaacagac cccagcaccc agcttcagct tgttggcatc cgtacactga
     1441 cagtcttggg tgcccagcca gatctcctat cttatgagga cttggagctg gcagtgggtc
     1501 acctgtacag actgagcttc ctgaaggagg attcccagag ttgcagggtg gcagcactgg
     1561 aagcatcagg aaccctggct gctctctacc ctgtggcctt cagcagccac ctcgtaccca
     1621 agctcgctga ggagctgcgt gtaggggagt caaatttgac taacggagat gagcccaccc
     1681 aatgctcccg gcatctgtgc tgtctgcaag ccttgtcagc tgtatcaaca catcccagca
     1741 tcgtcaagga gacactgcct ctgctgctgc agcatctctg gcaagtgaac agagggaata
     1801 tggttgcaca atccagtgac gttattgctg tctgtcagag cctcagacag atggcagaaa
     1861 aatgtcagca ggaccctgag agttgctggt atttccacca gacagctata ccttgcctgc
     1921 ttgccttggc tgtgcaggcc tctatgccag agaaggagcc ctcagttctg agaaaagtac
     1981 tattggagga tgaggtgttg gctgccatgg tgtctgtcat tggcactgct acaacccacc
     2041 tgagccctga gttagctgcc cagagtgtga cacacattgt gcccctcttc ttggatggca
     2101 acgtgtcctt tctgcctgaa aacagcttcc cgagcagatt ccagccattc caggatggct
     2161 cctcagggca gaggcggctg attgcactgc ttatggcctt tgtctgctcc ctgcctcgaa
     2221 atgtggaaat ccctcagctg aaccaactca tgcgggagct tttggaactg agctgctgcc
     2281 acagctgccc cttttcttcc accgctgctg ccaagtgctt tgcaggactc ctcaacaagc
     2341 accctgcagg gcagcagctg gatgaattcc tacagctagc tgtggacaaa gtggaggctg
     2401 gcctgggctc tgggccctgt cgtagtcagg ccttcactct tcttctctgg gtaacaaagg
     2461 ccctagtgct cagataccat cctctcagct cctgccttac agcccggctc atgggcctcc
     2521 tgagtgaccc agaattaggt ccagcagcag ctgatggctt ctctctgctc atgtctgact
     2581 gcactgatgt gctgactcgt gctggccatg ccgaagtgcg gatcatgttc cgccagcggt
     2641 tcttcacaga taatgtgcct gctttggtcc agggcttcca tgctgctccc caagatgtga
     2701 agccaaacta cttgaagggt ctttctcatg tacttaacag gctgcccaag cctgtactct
     2761 tgccagagct gcccacgctt ctttccttgc tgctggaggc cctgtcctgc cctgactgtg
     2821 tggtgcagct ctccaccctc agctgccttc agcctcttct actggaagca ccccaagtca
     2881 tgagtcttca cgtggacacc ctcgtcacca agtttctgaa cctcagctct agcccttcca
     2941 tggctgtccg gatcgccgca ctgcagtgca tgcatgctct cactcgcctg cccacccctg
     3001 tgctgctgcc gtacaaacca caggtgattc gggccttagc caaacccctg gatgacaaga
     3061 agagactggt gcgcaaggaa gcagtgtcag ccagagggga gtggtttctg ttggggagcc
     3121 ctggcagctg agccctcagt cctggcctag actgttctga caatctaacc tgggattact
     3181 aactgttgag ccatcttccc caaagcaggg aaaccactgg tctctgactg cctttcccac
     3241 agacacagca caaatgctag gcctctgttg catggctgta caaagaacat aagagtccat
     3301 atttctagtg gatttgtaaa ataagtgtgt gtgagacact tgcgtttgaa gaaagatcta
     3361 gggtcctggg tctcttgcat ttatatgtca gaaaaggggc gatatgctgc tgaggggtga
     3421 gtgcatatga gtgtggccct gaggaccagg gctggcagat gttgtctacc tgctgaagaa
     3481 taaagatttc ttttggtaa
//
