LOCUS       NM_001351357            3497 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens MMS19 homolog, cytosolic iron-sulfur assembly
            component (MMS19), transcript variant 7, mRNA.
ACCESSION   NM_001351357 XM_017016523
VERSION     NM_001351357.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3497)
  AUTHORS   van Karnebeek,C.D.M., Tarailo-Graovac,M., Leen,R., Meinsma,R.,
            Correard,S., Jansen-Meijer,J., Prykhozhij,S.V., Pena,I.A., Ban,K.,
            Schock,S., Saxena,V., Pras-Raves,M.L., Drogemoller,B.I.,
            Grootemaat,A.E., van der Wel,N.N., Dobritzsch,D., Roseboom,W.,
            Schomakers,B.V., Jaspers,Y.R.J., Zoetekouw,L., Roelofsen,J.,
            Ferreira,C.R., van der Lee,R., Ross,C.J., Kochan,J., McIntyre,R.L.,
            van Klinken,J.B., van Weeghel,M., Kramer,G., Weschke,B.,
            Labrune,P., Willemsen,M.A., Riva,D., Garavaglia,B., Moeschler,J.B.,
            Filiano,J.J., Ekker,M., Berman,J.N., Dyment,D., Vaz,F.M.,
            Wasserman,W.W., Houtkooper,R.H. and van Kuilenburg,A.B.P.
  TITLE     CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype
            caused by cytosolic Fe-S cluster protein assembly disorders
  JOURNAL   Genet Med 26 (6), 101104 (2024)
   PUBMED   38411040
  REMARK    GeneRIF: CIAO1 and MMS19 deficiency: A lethal neurodegenerative
            phenotype caused by cytosolic Fe-S cluster protein assembly
            disorders.
REFERENCE   2  (bases 1 to 3497)
  AUTHORS   Ren,D., Li,L., Wang,S. and Zuo,Y.
  TITLE     The c-MYC transcription factor conduces to resistance to cisplatin
            by regulating MMS19 in bladder cancer cells
  JOURNAL   Tissue Cell 82, 102096 (2023)
   PUBMED   37201439
  REMARK    GeneRIF: The c-MYC transcription factor conduces to resistance to
            cisplatin by regulating MMS19 in bladder cancer cells.
REFERENCE   3  (bases 1 to 3497)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3497)
  AUTHORS   Kassube,S.A. and Thoma,N.H.
  TITLE     Structural insights into Fe-S protein biogenesis by the CIA
            targeting complex
  JOURNAL   Nat Struct Mol Biol 27 (8), 735-742 (2020)
   PUBMED   32632277
  REMARK    GeneRIF: Structural insights into Fe-S protein biogenesis by the
            CIA targeting complex.
REFERENCE   5  (bases 1 to 3497)
  AUTHORS   Horton,A.J., Brooker,J., Streitfeld,W.S., Flessa,M.E., Pillai,B.,
            Simpson,R., Clark,C.D., Gooz,M.B., Sutton,K.K., Foley,A.C. and
            Lee,K.H.
  TITLE     Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA
            Metabolism and Proliferation
  JOURNAL   Sci Rep 9 (1), 1738 (2019)
   PUBMED   30742009
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3497)
  AUTHORS   Hatfield,M.D., Reis,A.M., Obeso,D., Cook,J.R., Thompson,D.M.,
            Rao,M., Friedberg,E.C. and Queimado,L.
  TITLE     Identification of MMS19 domains with distinct functions in NER and
            transcription
  JOURNAL   DNA Repair (Amst) 5 (8), 914-924 (2006)
   PUBMED   16797255
  REMARK    GeneRIF: MMS19 HEAT repeat domain is essential for MMS19 function
            in NER and transcription, while domains A and B, within MMS19
            N-terminus, modulate the balance between DNA repair and
            transcription.
REFERENCE   7  (bases 1 to 3497)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3497)
  AUTHORS   Wu,X., Li,H. and Chen,J.D.
  TITLE     The human homologue of the yeast DNA repair and TFIIH regulator
            MMS19 is an AF-1-specific coactivator of estrogen receptor
  JOURNAL   J Biol Chem 276 (26), 23962-23968 (2001)
   PUBMED   11279242
REFERENCE   9  (bases 1 to 3497)
  AUTHORS   Queimado,L., Rao,M., Schultz,R.A., Koonin,E.V., Aravind,L.,
            Nardo,T., Stefanini,M. and Friedberg,E.C.
  TITLE     Cloning the human and mouse MMS19 genes and functional
            complementation of a yeast mms19 deletion mutant
  JOURNAL   Nucleic Acids Res 29 (9), 1884-1891 (2001)
   PUBMED   11328871
  REMARK    GeneRIF: Cloning of the human MMS19 genes and functional
            complementation in Saccharomyces cerevisiae
REFERENCE   10 (bases 1 to 3497)
  AUTHORS   Seroz,T., Winkler,G.S., Auriol,J., Verhage,R.A., Vermeulen,W.,
            Smit,B., Brouwer,J., Eker,A.P., Weeda,G., Egly,J.M. and
            Hoeijmakers,J.H.
  TITLE     Cloning of a human homolog of the yeast nucleotide excision repair
            gene MMS19 and interaction with transcription repair factor TFIIH
            via the XPB and XPD helicases
  JOURNAL   Nucleic Acids Res 28 (22), 4506-4513 (2000)
   PUBMED   11071939
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC382327.1, DB145487.1, BE382510.1, CO248418.1, AK314374.1 and
            BC009396.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001351357.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.258978.1,
                                           SRR18074969.3742257.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DC382327.1         26-54
            30-191              DB145487.1         1-162
            192-251             DC382327.1         266-325
            252-290             BE382510.1         41-79
            291-324             BE382510.1         81-114
            325-529             DC382327.1         352-556
            530-970             CO248418.1         200-640
            971-2609            AK314374.1         958-2596
            2610-3497           BC009396.2         865-1752
FEATURES             Location/Qualifiers
     source          1..3497
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..3497
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="MMS19 homolog, cytosolic iron-sulfur assembly
                     component"
                     /db_xref="GeneID:64210"
                     /db_xref="HGNC:HGNC:13824"
                     /db_xref="MIM:614777"
     exon            1..150
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            151..298
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            299..384
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            385..459
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            460..529
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     CDS             511..3129
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="isoform 7 is encoded by transcript variant 7;
                     homolog of yeast MMS19; MET18 homolog; MMS19-like (MET18
                     homolog, S. cerevisiae); MMS19 nucleotide excision repair
                     protein homolog; MMS19-like protein; MMS19 nucleotide
                     excision repair homolog; MMS19 cytosolic iron-sulfur
                     assembly component"
                     /codon_start=1
                     /product="MMS19 nucleotide excision repair protein homolog
                     isoform 7"
                     /protein_id="NP_001338286.1"
                     /db_xref="GeneID:64210"
                     /db_xref="HGNC:HGNC:13824"
                     /db_xref="MIM:614777"
                     /translation="MRTREEELKSLGADFTFGFIQVMDGEKDPRNLLVAFRIVHDLIS
                     RDYSLGPFVEELFEVTSCYFPIDFTPPPNDPHGIQREDLILSLRAVLASTPRFAEFLL
                     PLLIEKVDSEVLSAKLDSLQTLNACCAVYGQKELKDFLPSLWASIRREVFQTASERVE
                     AEGLAALHSLTACLSRSVLRADAEDLLDSFLSNILQDCRHHLCEPDMKLVWPSAKLLQ
                     AAAGASARACDSVTSNVLPLLLEQFHKHSQSSQRRTILEMLLGFLKLQQKWSYEDKDQ
                     RPLNGFKDQLCSLVFMALTDPSTQLQLVGIRTLTVLGAQPDLLSYEDLELAVGHLYRL
                     SFLKEDSQSCRVAALEASGTLAALYPVAFSSHLVPKLAEELRVGESNLTNGDEPTQCS
                     RHLCCLQALSAVSTHPSIVKETLPLLLQHLWQVNRGNMVAQSSDVIAVCQSLRQMAEK
                     CQQDPESCWYFHQTAIPCLLALAVQASMPEKEPSVLRKVLLEDEVLAAMVSVIGTATT
                     HLSPELAAQSVTHIVPLFLDGNVSFLPENSFPSRFQPFQDGSSGQRRLIALLMAFVCS
                     LPRNVEIPQLNQLMRELLELSCCHSCPFSSTAAAKCFAGLLNKHPAGQQLDEFLQLAV
                     DKVEAGLGSGPCRSQAFTLLLWVTKALVLRYHPLSSCLTARLMGLLSDPELGPAAADG
                     FSLLMSDCTDVLTRAGHAEVRIMFRQRFFTDNVPALVQGFHAAPQDVKPNYLKGLSHV
                     LNRLPKPVLLPELPTLLSLLLEALSCPDCVVQLSTLSCLQPLLLEAPQVMSLHVDTLV
                     TKFLNLSSSPSMAVRIAALQCMHALTRLPTPVLLPYKPQVIRALAKPLDDKKRLVRKE
                     AVSARGEWFLLGSPGS"
     exon            530..658
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            659..720
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            721..807
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            808..882
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            883..960
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1099
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1254
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1333
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1459
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1541
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1642
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1792
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1948
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2048
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2151
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2220
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2347
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2448
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2505
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2692
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2775
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2940
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3000
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3101
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3497
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3477..3482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="hexamer: AATAAA"
     polyA_site      3497
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="major polyA site"
ORIGIN      
        1 accgcccata tcccctccca cggtctctag ttcgcgttat ggccgctgcc gcggctgtgg
       61 aggcggcggc gcctatgggt gccctatggg gcctcgtgca cgacttcgtc gtgggtcagc
      121 aagagggccc cgctgaccag gtggctgcag gtcctctcta gagaatccag aaccccgaac
      181 tcgggcacga gcaatccagc ttttgtcaca ggtgctactc cactgtcaca ccttgctcct
      241 ggagaaggaa ggtactggtg tcactaatag gaatgtcttc ctggattgct gagcccagtg
      301 gtacacctga tactgttcta tgagaaccgg ctgaaggacc atcatcttgt gatcccatct
      361 gtcctgcagg gtttgaaggc acttagcctg tgtgtggccc tgcccccagg gctggctgtt
      421 tctgtgctta aagccatctt ccaggaagtg catgtacagt ccctgccaca ggtggaccga
      481 cacacagtct acaatatcat caccaatttt atgcgaaccc gggaagaaga gctaaagagc
      541 ctaggagctg acttcacctt tggcttcatc caggtgatgg atggggaaaa ggatccccgt
      601 aatcttctgg tggccttccg catcgtccat gacctcatct ccagggacta tagcctggga
      661 ccctttgtgg aggagttgtt tgaagtgaca tcctgttatt tccctatcga ttttacccct
      721 ccacctaatg atccccatgg tatccagaga gaagacctca tcctgagtct tcgcgctgtg
      781 ctggcttcta caccacgatt tgctgagttt ctgctgcccc tgttgattga gaaagtggat
      841 tctgaggttc tgagtgccaa gttggattct ctacagactc tgaatgcttg ctgtgctgtg
      901 tatggacaga aggaactgaa ggacttcctc cccagccttt gggcttctat ccgcagagag
      961 gtgttccaga cggcaagtga gcgggtggag gcagagggcc tggcggccct ccactccctg
     1021 actgcgtgtt tgtctcgctc tgtgctgagg gctgatgctg aggacctcct tgactccttc
     1081 cttagcaaca ttctacagga ctgcaggcac cacctgtgtg aaccggacat gaaactggtg
     1141 tggcctagtg ccaagctgtt gcaggcagct gcaggtgcat ctgcccgggc ctgtgactct
     1201 gtcaccagca atgtactgcc tttactgctg gaacagttcc acaagcacag tcagagcagc
     1261 cagcggcgga caatccttga aatgctcctg ggtttcttga agctgcagca gaaatggagc
     1321 tatgaagaca aagatcaaag gcctctgaat ggcttcaagg accagctgtg ctcactggta
     1381 ttcatggctc taacagaccc cagcacccag cttcagcttg ttggcatccg tacactgaca
     1441 gtcttgggtg cccagccaga tctcctatct tatgaggact tggagctggc agtgggtcac
     1501 ctgtacagac tgagcttcct gaaggaggat tcccagagtt gcagggtggc agcactggaa
     1561 gcatcaggaa ccctggctgc tctctaccct gtggccttca gcagccacct cgtacccaag
     1621 ctcgctgagg agctgcgtgt aggggagtca aatttgacta acggagatga gcccacccaa
     1681 tgctcccggc atctgtgctg tctgcaagcc ttgtcagctg tatcaacaca tcccagcatc
     1741 gtcaaggaga cactgcctct gctgctgcag catctctggc aagtgaacag agggaatatg
     1801 gttgcacaat ccagtgacgt tattgctgtc tgtcagagcc tcagacagat ggcagaaaaa
     1861 tgtcagcagg accctgagag ttgctggtat ttccaccaga cagctatacc ttgcctgctt
     1921 gccttggctg tgcaggcctc tatgccagag aaggagccct cagttctgag aaaagtacta
     1981 ttggaggatg aggtgttggc tgccatggtg tctgtcattg gcactgctac aacccacctg
     2041 agccctgagt tagctgccca gagtgtgaca cacattgtgc ccctcttctt ggatggcaac
     2101 gtgtcctttc tgcctgaaaa cagcttcccg agcagattcc agccattcca ggatggctcc
     2161 tcagggcaga ggcggctgat tgcactgctt atggcctttg tctgctccct gcctcgaaat
     2221 gtggaaatcc ctcagctgaa ccaactcatg cgggagcttt tggaactgag ctgctgccac
     2281 agctgcccct tttcttccac cgctgctgcc aagtgctttg caggactcct caacaagcac
     2341 cctgcagggc agcagctgga tgaattccta cagctagctg tggacaaagt ggaggctggc
     2401 ctgggctctg ggccctgtcg tagtcaggcc ttcactcttc ttctctgggt aacaaaggcc
     2461 ctagtgctca gataccatcc tctcagctcc tgccttacag cccggctcat gggcctcctg
     2521 agtgacccag aattaggtcc agcagcagct gatggcttct ctctgctcat gtctgactgc
     2581 actgatgtgc tgactcgtgc tggccatgcc gaagtgcgga tcatgttccg ccagcggttc
     2641 ttcacagata atgtgcctgc tttggtccag ggcttccatg ctgctcccca agatgtgaag
     2701 ccaaactact tgaagggtct ttctcatgta cttaacaggc tgcccaagcc tgtactcttg
     2761 ccagagctgc ccacgcttct ttccttgctg ctggaggccc tgtcctgccc tgactgtgtg
     2821 gtgcagctct ccaccctcag ctgccttcag cctcttctac tggaagcacc ccaagtcatg
     2881 agtcttcacg tggacaccct cgtcaccaag tttctgaacc tcagctctag cccttccatg
     2941 gctgtccgga tcgccgcact gcagtgcatg catgctctca ctcgcctgcc cacccctgtg
     3001 ctgctgccgt acaaaccaca ggtgattcgg gccttagcca aacccctgga tgacaagaag
     3061 agactggtgc gcaaggaagc agtgtcagcc agaggggagt ggtttctgtt ggggagccct
     3121 ggcagctgag ccctcagtcc tggcctagac tgttctgaca atctaacctg ggattactaa
     3181 ctgttgagcc atcttcccca aagcagggaa accactggtc tctgactgcc tttcccacag
     3241 acacagcaca aatgctaggc ctctgttgca tggctgtaca aagaacataa gagtccatat
     3301 ttctagtgga tttgtaaaat aagtgtgtgt gagacacttg cgtttgaaga aagatctagg
     3361 gtcctgggtc tcttgcattt atatgtcaga aaaggggcga tatgctgctg aggggtgagt
     3421 gcatatgagt gtggccctga ggaccagggc tggcagatgt tgtctacctg ctgaagaata
     3481 aagatttctt ttggtaa
//
