LOCUS       NM_001351356            3616 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens MMS19 homolog, cytosolic iron-sulfur assembly
            component (MMS19), transcript variant 6, mRNA.
ACCESSION   NM_001351356 XM_017016515
VERSION     NM_001351356.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3616)
  AUTHORS   van Karnebeek,C.D.M., Tarailo-Graovac,M., Leen,R., Meinsma,R.,
            Correard,S., Jansen-Meijer,J., Prykhozhij,S.V., Pena,I.A., Ban,K.,
            Schock,S., Saxena,V., Pras-Raves,M.L., Drogemoller,B.I.,
            Grootemaat,A.E., van der Wel,N.N., Dobritzsch,D., Roseboom,W.,
            Schomakers,B.V., Jaspers,Y.R.J., Zoetekouw,L., Roelofsen,J.,
            Ferreira,C.R., van der Lee,R., Ross,C.J., Kochan,J., McIntyre,R.L.,
            van Klinken,J.B., van Weeghel,M., Kramer,G., Weschke,B.,
            Labrune,P., Willemsen,M.A., Riva,D., Garavaglia,B., Moeschler,J.B.,
            Filiano,J.J., Ekker,M., Berman,J.N., Dyment,D., Vaz,F.M.,
            Wasserman,W.W., Houtkooper,R.H. and van Kuilenburg,A.B.P.
  TITLE     CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype
            caused by cytosolic Fe-S cluster protein assembly disorders
  JOURNAL   Genet Med 26 (6), 101104 (2024)
   PUBMED   38411040
  REMARK    GeneRIF: CIAO1 and MMS19 deficiency: A lethal neurodegenerative
            phenotype caused by cytosolic Fe-S cluster protein assembly
            disorders.
REFERENCE   2  (bases 1 to 3616)
  AUTHORS   Ren,D., Li,L., Wang,S. and Zuo,Y.
  TITLE     The c-MYC transcription factor conduces to resistance to cisplatin
            by regulating MMS19 in bladder cancer cells
  JOURNAL   Tissue Cell 82, 102096 (2023)
   PUBMED   37201439
  REMARK    GeneRIF: The c-MYC transcription factor conduces to resistance to
            cisplatin by regulating MMS19 in bladder cancer cells.
REFERENCE   3  (bases 1 to 3616)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3616)
  AUTHORS   Kassube,S.A. and Thoma,N.H.
  TITLE     Structural insights into Fe-S protein biogenesis by the CIA
            targeting complex
  JOURNAL   Nat Struct Mol Biol 27 (8), 735-742 (2020)
   PUBMED   32632277
  REMARK    GeneRIF: Structural insights into Fe-S protein biogenesis by the
            CIA targeting complex.
REFERENCE   5  (bases 1 to 3616)
  AUTHORS   Horton,A.J., Brooker,J., Streitfeld,W.S., Flessa,M.E., Pillai,B.,
            Simpson,R., Clark,C.D., Gooz,M.B., Sutton,K.K., Foley,A.C. and
            Lee,K.H.
  TITLE     Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA
            Metabolism and Proliferation
  JOURNAL   Sci Rep 9 (1), 1738 (2019)
   PUBMED   30742009
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3616)
  AUTHORS   Hatfield,M.D., Reis,A.M., Obeso,D., Cook,J.R., Thompson,D.M.,
            Rao,M., Friedberg,E.C. and Queimado,L.
  TITLE     Identification of MMS19 domains with distinct functions in NER and
            transcription
  JOURNAL   DNA Repair (Amst) 5 (8), 914-924 (2006)
   PUBMED   16797255
  REMARK    GeneRIF: MMS19 HEAT repeat domain is essential for MMS19 function
            in NER and transcription, while domains A and B, within MMS19
            N-terminus, modulate the balance between DNA repair and
            transcription.
REFERENCE   7  (bases 1 to 3616)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3616)
  AUTHORS   Wu,X., Li,H. and Chen,J.D.
  TITLE     The human homologue of the yeast DNA repair and TFIIH regulator
            MMS19 is an AF-1-specific coactivator of estrogen receptor
  JOURNAL   J Biol Chem 276 (26), 23962-23968 (2001)
   PUBMED   11279242
REFERENCE   9  (bases 1 to 3616)
  AUTHORS   Queimado,L., Rao,M., Schultz,R.A., Koonin,E.V., Aravind,L.,
            Nardo,T., Stefanini,M. and Friedberg,E.C.
  TITLE     Cloning the human and mouse MMS19 genes and functional
            complementation of a yeast mms19 deletion mutant
  JOURNAL   Nucleic Acids Res 29 (9), 1884-1891 (2001)
   PUBMED   11328871
  REMARK    GeneRIF: Cloning of the human MMS19 genes and functional
            complementation in Saccharomyces cerevisiae
REFERENCE   10 (bases 1 to 3616)
  AUTHORS   Seroz,T., Winkler,G.S., Auriol,J., Verhage,R.A., Vermeulen,W.,
            Smit,B., Brouwer,J., Eker,A.P., Weeda,G., Egly,J.M. and
            Hoeijmakers,J.H.
  TITLE     Cloning of a human homolog of the yeast nucleotide excision repair
            gene MMS19 and interaction with transcription repair factor TFIIH
            via the XPB and XPD helicases
  JOURNAL   Nucleic Acids Res 28 (22), 4506-4513 (2000)
   PUBMED   11071939
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC382327.1, DC323254.1, CO248418.1, AK314374.1 and BC009396.2.
            
            On Aug 14, 2020 this sequence version replaced NM_001351356.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.159298.1,
                                           SRR14038197.1773597.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               DC382327.1         26-266
            242-486             DC323254.1         242-486
            487-1089            CO248418.1         38-640
            1090-2728           AK314374.1         958-2596
            2729-3616           BC009396.2         865-1752
FEATURES             Location/Qualifiers
     source          1..3616
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..3616
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="MMS19 homolog, cytosolic iron-sulfur assembly
                     component"
                     /db_xref="GeneID:64210"
                     /db_xref="HGNC:HGNC:13824"
                     /db_xref="MIM:614777"
     exon            1..150
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..3248
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="isoform 6 is encoded by transcript variant 6;
                     homolog of yeast MMS19; MET18 homolog; MMS19-like (MET18
                     homolog, S. cerevisiae); MMS19 nucleotide excision repair
                     protein homolog; MMS19-like protein; MMS19 nucleotide
                     excision repair homolog; MMS19 cytosolic iron-sulfur
                     assembly component"
                     /codon_start=1
                     /product="MMS19 nucleotide excision repair protein homolog
                     isoform 6"
                     /protein_id="NP_001338285.1"
                     /db_xref="GeneID:64210"
                     /db_xref="HGNC:HGNC:13824"
                     /db_xref="MIM:614777"
                     /translation="MAAAAAVEAAAPMGALWGLVHDFVVGQQEGPADQVAADVKSGNY
                     TVLQVVEALGSSLENPEPRTRARAIQLLSQVLLHCHTLLLEKEGAESLIGKKEGRRKK
                     LPCTETERGSKAKRGNSACHRYQLVVHLILFYENRLKDHHLVIPSVLQGLKALSLCVA
                     LPPGLAVSVLKAIFQEVHVQSLPQVDRHTVYNIITNFMRTREEELKSLGADFTFGFIQ
                     VMDGEKDPRNLLVAFRIVHDLISRDYSLGPFVEELFEVTSCYFPIDFTPPPNDPHGIQ
                     REDLILSLRAVLASTPRFAEFLLPLLIEKVDSEVLSAKLDSLQTLNACCAVYGQKELK
                     DFLPSLWASIRREVFQTASERVEAEGLAALHSLTACLSRSVLRADAEDLLDSFLSNIL
                     QDCRHHLCEPDMKLVWPSAKLLQAAAGASARACDSVTSNVLPLLLEQFHKHSQSSQRR
                     TILEMLLGFLKLQQKWSYEDKDQRPLNGFKDQLCSLVFMALTDPSTQLQLVGIRTLTV
                     LGAQPDLLSYEDLELAVGHLYRLSFLKEDSQSCRVAALEASGTLAALYPVAFSSHLVP
                     KLAEELRVGESNLTNGDEPTQCSRHLCCLQALSAVSTHPSIVKETLPLLLQHLWQVNR
                     GNMVAQSSDVIAVCQSLRQMAEKCQQDPESCWYFHQTAIPCLLALAVQASMPEKEPSV
                     LRKVLLEDEVLAAMVSVIGTATTHLSPELAAQSVTHIVPLFLDGNVSFLPENSFPSRF
                     QPFQDGSSGQRRLIALLMAFVCSLPRNVEIPQLNQLMRELLELSCCHSCPFSSTAAAK
                     CFAGLLNKHPAGQQLDEFLQLAVDKVEAGLGSGPCRSQAFTLLLWVTKALVLRYHPLS
                     SCLTARLMGLLSDPELGPAAADGFSLLMSDCTDVLTRAGHAEVRIMFRQRFFTDNVPA
                     LVQGFHAAPQDVKPNYLKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDCVVQLST
                     LSCLQPLLLEAPQVMSLHVDTLVTKFLNLSSSPSMAVRIAALQCMHALTRLPTPVLLP
                     YKPQVIRALAKPLDDKKRLVRKEAVSARGEWFLLGSPGS"
     exon            151..199
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            200..300
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            301..417
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            418..503
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            504..578
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            579..648
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            649..777
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            778..839
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            840..926
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1001
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1079
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1218
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1373
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1452
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1578
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1660
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1761
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1911
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2067
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2167
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2270
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2339
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2466
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2567
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2624
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2811
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2894
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3059
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3119
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3220
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3616
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3596..3601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="hexamer: AATAAA"
     polyA_site      3616
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="major polyA site"
ORIGIN      
        1 accgcccata tcccctccca cggtctctag ttcgcgttat ggccgctgcc gcggctgtgg
       61 aggcggcggc gcctatgggt gccctatggg gcctcgtgca cgacttcgtc gtgggtcagc
      121 aagagggccc cgctgaccag gtggctgcag atgtgaaatc tggcaactat acagtgttac
      181 aagttgtgga agcccttggg tcctctctag agaatccaga accccgaact cgggcacgag
      241 caatccagct tttgtcacag gtgctactcc actgtcacac cttgctcctg gagaaggaag
      301 gagcagagag tttaataggc aagaaggaag ggaggaggaa gaagctcccc tgtacagaga
      361 cagagcgggg ctccaaagcc aagagaggga actccgcctg ccacagatac cagctagtgg
      421 tacacctgat actgttctat gagaaccggc tgaaggacca tcatcttgtg atcccatctg
      481 tcctgcaggg tttgaaggca cttagcctgt gtgtggccct gcccccaggg ctggctgttt
      541 ctgtgcttaa agccatcttc caggaagtgc atgtacagtc cctgccacag gtggaccgac
      601 acacagtcta caatatcatc accaatttta tgcgaacccg ggaagaagag ctaaagagcc
      661 taggagctga cttcaccttt ggcttcatcc aggtgatgga tggggaaaag gatccccgta
      721 atcttctggt ggccttccgc atcgtccatg acctcatctc cagggactat agcctgggac
      781 cctttgtgga ggagttgttt gaagtgacat cctgttattt ccctatcgat tttacccctc
      841 cacctaatga tccccatggt atccagagag aagacctcat cctgagtctt cgcgctgtgc
      901 tggcttctac accacgattt gctgagtttc tgctgcccct gttgattgag aaagtggatt
      961 ctgaggttct gagtgccaag ttggattctc tacagactct gaatgcttgc tgtgctgtgt
     1021 atggacagaa ggaactgaag gacttcctcc ccagcctttg ggcttctatc cgcagagagg
     1081 tgttccagac ggcaagtgag cgggtggagg cagagggcct ggcggccctc cactccctga
     1141 ctgcgtgttt gtctcgctct gtgctgaggg ctgatgctga ggacctcctt gactccttcc
     1201 ttagcaacat tctacaggac tgcaggcacc acctgtgtga accggacatg aaactggtgt
     1261 ggcctagtgc caagctgttg caggcagctg caggtgcatc tgcccgggcc tgtgactctg
     1321 tcaccagcaa tgtactgcct ttactgctgg aacagttcca caagcacagt cagagcagcc
     1381 agcggcggac aatccttgaa atgctcctgg gtttcttgaa gctgcagcag aaatggagct
     1441 atgaagacaa agatcaaagg cctctgaatg gcttcaagga ccagctgtgc tcactggtat
     1501 tcatggctct aacagacccc agcacccagc ttcagcttgt tggcatccgt acactgacag
     1561 tcttgggtgc ccagccagat ctcctatctt atgaggactt ggagctggca gtgggtcacc
     1621 tgtacagact gagcttcctg aaggaggatt cccagagttg cagggtggca gcactggaag
     1681 catcaggaac cctggctgct ctctaccctg tggccttcag cagccacctc gtacccaagc
     1741 tcgctgagga gctgcgtgta ggggagtcaa atttgactaa cggagatgag cccacccaat
     1801 gctcccggca tctgtgctgt ctgcaagcct tgtcagctgt atcaacacat cccagcatcg
     1861 tcaaggagac actgcctctg ctgctgcagc atctctggca agtgaacaga gggaatatgg
     1921 ttgcacaatc cagtgacgtt attgctgtct gtcagagcct cagacagatg gcagaaaaat
     1981 gtcagcagga ccctgagagt tgctggtatt tccaccagac agctatacct tgcctgcttg
     2041 ccttggctgt gcaggcctct atgccagaga aggagccctc agttctgaga aaagtactat
     2101 tggaggatga ggtgttggct gccatggtgt ctgtcattgg cactgctaca acccacctga
     2161 gccctgagtt agctgcccag agtgtgacac acattgtgcc cctcttcttg gatggcaacg
     2221 tgtcctttct gcctgaaaac agcttcccga gcagattcca gccattccag gatggctcct
     2281 cagggcagag gcggctgatt gcactgctta tggcctttgt ctgctccctg cctcgaaatg
     2341 tggaaatccc tcagctgaac caactcatgc gggagctttt ggaactgagc tgctgccaca
     2401 gctgcccctt ttcttccacc gctgctgcca agtgctttgc aggactcctc aacaagcacc
     2461 ctgcagggca gcagctggat gaattcctac agctagctgt ggacaaagtg gaggctggcc
     2521 tgggctctgg gccctgtcgt agtcaggcct tcactcttct tctctgggta acaaaggccc
     2581 tagtgctcag ataccatcct ctcagctcct gccttacagc ccggctcatg ggcctcctga
     2641 gtgacccaga attaggtcca gcagcagctg atggcttctc tctgctcatg tctgactgca
     2701 ctgatgtgct gactcgtgct ggccatgccg aagtgcggat catgttccgc cagcggttct
     2761 tcacagataa tgtgcctgct ttggtccagg gcttccatgc tgctccccaa gatgtgaagc
     2821 caaactactt gaagggtctt tctcatgtac ttaacaggct gcccaagcct gtactcttgc
     2881 cagagctgcc cacgcttctt tccttgctgc tggaggccct gtcctgccct gactgtgtgg
     2941 tgcagctctc caccctcagc tgccttcagc ctcttctact ggaagcaccc caagtcatga
     3001 gtcttcacgt ggacaccctc gtcaccaagt ttctgaacct cagctctagc ccttccatgg
     3061 ctgtccggat cgccgcactg cagtgcatgc atgctctcac tcgcctgccc acccctgtgc
     3121 tgctgccgta caaaccacag gtgattcggg ccttagccaa acccctggat gacaagaaga
     3181 gactggtgcg caaggaagca gtgtcagcca gaggggagtg gtttctgttg gggagccctg
     3241 gcagctgagc cctcagtcct ggcctagact gttctgacaa tctaacctgg gattactaac
     3301 tgttgagcca tcttccccaa agcagggaaa ccactggtct ctgactgcct ttcccacaga
     3361 cacagcacaa atgctaggcc tctgttgcat ggctgtacaa agaacataag agtccatatt
     3421 tctagtggat ttgtaaaata agtgtgtgtg agacacttgc gtttgaagaa agatctaggg
     3481 tcctgggtct cttgcattta tatgtcagaa aaggggcgat atgctgctga ggggtgagtg
     3541 catatgagtg tggccctgag gaccagggct ggcagatgtt gtctacctgc tgaagaataa
     3601 agatttcttt tggtaa
//
