LOCUS       NM_001289405            3568 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens MMS19 homolog, cytosolic iron-sulfur assembly
            component (MMS19), transcript variant 4, mRNA.
ACCESSION   NM_001289405
VERSION     NM_001289405.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3568)
  AUTHORS   van Karnebeek,C.D.M., Tarailo-Graovac,M., Leen,R., Meinsma,R.,
            Correard,S., Jansen-Meijer,J., Prykhozhij,S.V., Pena,I.A., Ban,K.,
            Schock,S., Saxena,V., Pras-Raves,M.L., Drogemoller,B.I.,
            Grootemaat,A.E., van der Wel,N.N., Dobritzsch,D., Roseboom,W.,
            Schomakers,B.V., Jaspers,Y.R.J., Zoetekouw,L., Roelofsen,J.,
            Ferreira,C.R., van der Lee,R., Ross,C.J., Kochan,J., McIntyre,R.L.,
            van Klinken,J.B., van Weeghel,M., Kramer,G., Weschke,B.,
            Labrune,P., Willemsen,M.A., Riva,D., Garavaglia,B., Moeschler,J.B.,
            Filiano,J.J., Ekker,M., Berman,J.N., Dyment,D., Vaz,F.M.,
            Wasserman,W.W., Houtkooper,R.H. and van Kuilenburg,A.B.P.
  TITLE     CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype
            caused by cytosolic Fe-S cluster protein assembly disorders
  JOURNAL   Genet Med 26 (6), 101104 (2024)
   PUBMED   38411040
  REMARK    GeneRIF: CIAO1 and MMS19 deficiency: A lethal neurodegenerative
            phenotype caused by cytosolic Fe-S cluster protein assembly
            disorders.
REFERENCE   2  (bases 1 to 3568)
  AUTHORS   Ren,D., Li,L., Wang,S. and Zuo,Y.
  TITLE     The c-MYC transcription factor conduces to resistance to cisplatin
            by regulating MMS19 in bladder cancer cells
  JOURNAL   Tissue Cell 82, 102096 (2023)
   PUBMED   37201439
  REMARK    GeneRIF: The c-MYC transcription factor conduces to resistance to
            cisplatin by regulating MMS19 in bladder cancer cells.
REFERENCE   3  (bases 1 to 3568)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3568)
  AUTHORS   Kassube,S.A. and Thoma,N.H.
  TITLE     Structural insights into Fe-S protein biogenesis by the CIA
            targeting complex
  JOURNAL   Nat Struct Mol Biol 27 (8), 735-742 (2020)
   PUBMED   32632277
  REMARK    GeneRIF: Structural insights into Fe-S protein biogenesis by the
            CIA targeting complex.
REFERENCE   5  (bases 1 to 3568)
  AUTHORS   Horton,A.J., Brooker,J., Streitfeld,W.S., Flessa,M.E., Pillai,B.,
            Simpson,R., Clark,C.D., Gooz,M.B., Sutton,K.K., Foley,A.C. and
            Lee,K.H.
  TITLE     Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA
            Metabolism and Proliferation
  JOURNAL   Sci Rep 9 (1), 1738 (2019)
   PUBMED   30742009
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3568)
  AUTHORS   Hatfield,M.D., Reis,A.M., Obeso,D., Cook,J.R., Thompson,D.M.,
            Rao,M., Friedberg,E.C. and Queimado,L.
  TITLE     Identification of MMS19 domains with distinct functions in NER and
            transcription
  JOURNAL   DNA Repair (Amst) 5 (8), 914-924 (2006)
   PUBMED   16797255
  REMARK    GeneRIF: MMS19 HEAT repeat domain is essential for MMS19 function
            in NER and transcription, while domains A and B, within MMS19
            N-terminus, modulate the balance between DNA repair and
            transcription.
REFERENCE   7  (bases 1 to 3568)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3568)
  AUTHORS   Wu,X., Li,H. and Chen,J.D.
  TITLE     The human homologue of the yeast DNA repair and TFIIH regulator
            MMS19 is an AF-1-specific coactivator of estrogen receptor
  JOURNAL   J Biol Chem 276 (26), 23962-23968 (2001)
   PUBMED   11279242
REFERENCE   9  (bases 1 to 3568)
  AUTHORS   Queimado,L., Rao,M., Schultz,R.A., Koonin,E.V., Aravind,L.,
            Nardo,T., Stefanini,M. and Friedberg,E.C.
  TITLE     Cloning the human and mouse MMS19 genes and functional
            complementation of a yeast mms19 deletion mutant
  JOURNAL   Nucleic Acids Res 29 (9), 1884-1891 (2001)
   PUBMED   11328871
  REMARK    GeneRIF: Cloning of the human MMS19 genes and functional
            complementation in Saccharomyces cerevisiae
REFERENCE   10 (bases 1 to 3568)
  AUTHORS   Seroz,T., Winkler,G.S., Auriol,J., Verhage,R.A., Vermeulen,W.,
            Smit,B., Brouwer,J., Eker,A.P., Weeda,G., Egly,J.M. and
            Hoeijmakers,J.H.
  TITLE     Cloning of a human homolog of the yeast nucleotide excision repair
            gene MMS19 and interaction with transcription repair factor TFIIH
            via the XPB and XPD helicases
  JOURNAL   Nucleic Acids Res 28 (22), 4506-4513 (2000)
   PUBMED   11071939
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359388.32, AF319947.1, AL355490.24 and BC009396.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001289405.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 4 encode the same protein
            (isoform 1).
            
            Sequence Note: A downstream start codon is selected for this RefSeq
            based on better conservation with homologous proteins. The use of
            an alternative upstream start codon, which is present in some
            species, including human, chimp and macaque (with a subsequent CDS
            frameshift in the latter species), would increase the protein
            length from 1030 aa to 1051 aa. The shorter protein is referred to
            in the literature, including PMIDs 11071939, 11279242 and 11328871.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF319947.1, SRR14038195.191260.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AL359388.32        11831-11868         c
            39-309              AF319947.1         5-275
            310-310             AL355490.24        182878-182878       c
            311-2680            AF319947.1         277-2646
            2681-3568           BC009396.2         865-1752
FEATURES             Location/Qualifiers
     source          1..3568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..3568
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="MMS19 homolog, cytosolic iron-sulfur assembly
                     component"
                     /db_xref="GeneID:64210"
                     /db_xref="HGNC:HGNC:13824"
                     /db_xref="MIM:614777"
     exon            1..99
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            100..219
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..3200
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="isoform 1 is encoded by transcript variant 4;
                     homolog of yeast MMS19; MET18 homolog; MMS19-like (MET18
                     homolog, S. cerevisiae); MMS19 nucleotide excision repair
                     protein homolog; MMS19-like protein; MMS19 nucleotide
                     excision repair homolog; MMS19 cytosolic iron-sulfur
                     assembly component"
                     /codon_start=1
                     /product="MMS19 nucleotide excision repair protein homolog
                     isoform 1"
                     /protein_id="NP_001276334.1"
                     /db_xref="CCDS:CCDS7464.1"
                     /db_xref="GeneID:64210"
                     /db_xref="HGNC:HGNC:13824"
                     /db_xref="MIM:614777"
                     /translation="MAAAAAVEAAAPMGALWGLVHDFVVGQQEGPADQVAADVKSGNY
                     TVLQVVEALGSSLENPEPRTRARAIQLLSQVLLHCHTLLLEKEVVHLILFYENRLKDH
                     HLVIPSVLQGLKALSLCVALPPGLAVSVLKAIFQEVHVQSLPQVDRHTVYNIITNFMR
                     TREEELKSLGADFTFGFIQVMDGEKDPRNLLVAFRIVHDLISRDYSLGPFVEELFEVT
                     SCYFPIDFTPPPNDPHGIQREDLILSLRAVLASTPRFAEFLLPLLIEKVDSEVLSAKL
                     DSLQTLNACCAVYGQKELKDFLPSLWASIRREVFQTASERVEAEGLAALHSLTACLSR
                     SVLRADAEDLLDSFLSNILQDCRHHLCEPDMKLVWPSAKLLQAAAGASARACDSVTSN
                     VLPLLLEQFHKHSQSSQRRTILEMLLGFLKLQQKWSYEDKDQRPLNGFKDQLCSLVFM
                     ALTDPSTQLQLVGIRTLTVLGAQPDLLSYEDLELAVGHLYRLSFLKEDSQSCRVAALE
                     ASGTLAALYPVAFSSHLVPKLAEELRVGESNLTNGDEPTQCSRHLCCLQALSAVSTHP
                     SIVKETLPLLLQHLWQVNRGNMVAQSSDVIAVCQSLRQMAEKCQQDPESCWYFHQTAI
                     PCLLALAVQASMPEKEPSVLRKVLLEDEVLAAMVSVIGTATTHLSPELAAQSVTHIVP
                     LFLDGNVSFLPENSFPSRFQPFQDGSSGQRRLIALLMAFVCSLPRNVEIPQLNQLMRE
                     LLELSCCHSCPFSSTAAAKCFAGLLNKHPAGQQLDEFLQLAVDKVEAGLGSGPCRSQA
                     FTLLLWVTKALVLRYHPLSSCLTARLMGLLSDPELGPAAADGFSLLMSDCTDVLTRAG
                     HAEVRIMFRQRFFTDNVPALVQGFHAAPQDVKPNYLKGLSHVLNRLPKPVLLPELPTL
                     LSLLLEALSCPDCVVQLSTLSCLQPLLLEAPQVMSLHVDTLVTKFLNLSSSPSMAVRI
                     AALQCMHALTRLPTPVLLPYKPQVIRALAKPLDDKKRLVRKEAVSARGEWFLLGSPGS
                     "
     exon            220..268
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            269..369
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            370..455
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            456..530
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            531..600
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            601..729
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            730..791
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            792..878
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            879..953
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1031
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1170
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1325
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1404
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1530
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1612
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1713
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1863
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2019
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2119
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2222
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2291
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2418
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2519
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2576
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2763
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2846
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..3011
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3071
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3172
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3568
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3548..3553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="hexamer: AATAAA"
     polyA_site      3568
                     /gene="MMS19"
                     /gene_synonym="CIAO4; hMMS19; MET18; MMS19L"
                     /note="major polyA site"
ORIGIN      
        1 ggtgcccgcg ccgccgccac cacccgcccc aggtgcgcat gtgaccgaca gcaccgcccc
       61 ctagggctgg gcctgatttt ctcattggct tcccccgtgt tcgcgttatg gccgctgccg
      121 cggctgtgga ggcggcggcg cctatgggtg ccctatgggg cctcgtgcac gacttcgtcg
      181 tgggtcagca agagggcccc gctgaccagg tggctgcaga tgtgaaatct ggcaactata
      241 cagtgttaca agttgtggaa gcccttgggt cctctctaga gaatccagaa ccccgaactc
      301 gggcacgagc aatccagctt ttgtcacagg tgctactcca ctgtcacacc ttgctcctgg
      361 agaaggaagt ggtacacctg atactgttct atgagaaccg gctgaaggac catcatcttg
      421 tgatcccatc tgtcctgcag ggtttgaagg cacttagcct gtgtgtggcc ctgcccccag
      481 ggctggctgt ttctgtgctt aaagccatct tccaggaagt gcatgtacag tccctgccac
      541 aggtggaccg acacacagtc tacaatatca tcaccaattt tatgcgaacc cgggaagaag
      601 agctaaagag cctaggagct gacttcacct ttggcttcat ccaggtgatg gatggggaaa
      661 aggatccccg taatcttctg gtggccttcc gcatcgtcca tgacctcatc tccagggact
      721 atagcctggg accctttgtg gaggagttgt ttgaagtgac atcctgttat ttccctatcg
      781 attttacccc tccacctaat gatccccatg gtatccagag agaagacctc atcctgagtc
      841 ttcgcgctgt gctggcttct acaccacgat ttgctgagtt tctgctgccc ctgttgattg
      901 agaaagtgga ttctgaggtt ctgagtgcca agttggattc tctacagact ctgaatgctt
      961 gctgtgctgt gtatggacag aaggaactga aggacttcct ccccagcctt tgggcttcta
     1021 tccgcagaga ggtgttccag acggcaagtg agcgggtgga ggcagagggc ctggcggccc
     1081 tccactccct gactgcgtgt ttgtctcgct ctgtgctgag ggctgatgct gaggacctcc
     1141 ttgactcctt ccttagcaac attctacagg actgcaggca ccacctgtgt gaaccggaca
     1201 tgaaactggt gtggcctagt gccaagctgt tgcaggcagc tgcaggtgca tctgcccggg
     1261 cctgtgactc tgtcaccagc aatgtactgc ctttactgct ggaacagttc cacaagcaca
     1321 gtcagagcag ccagcggcgg acaatccttg aaatgctcct gggtttcttg aagctgcagc
     1381 agaaatggag ctatgaagac aaagatcaaa ggcctctgaa tggcttcaag gaccagctgt
     1441 gctcactggt attcatggct ctaacagacc ccagcaccca gcttcagctt gttggcatcc
     1501 gtacactgac agtcttgggt gcccagccag atctcctatc ttatgaggac ttggagctgg
     1561 cagtgggtca cctgtacaga ctgagcttcc tgaaggagga ttcccagagt tgcagggtgg
     1621 cagcactgga agcatcagga accctggctg ctctctaccc tgtggccttc agcagccacc
     1681 tcgtacccaa gctcgctgag gagctgcgtg taggggagtc aaatttgact aacggagatg
     1741 agcccaccca atgctcccgg catctgtgct gtctgcaagc cttgtcagct gtatcaacac
     1801 atcccagcat cgtcaaggag acactgcctc tgctgctgca gcatctctgg caagtgaaca
     1861 gagggaatat ggttgcacaa tccagtgacg ttattgctgt ctgtcagagc ctcagacaga
     1921 tggcagaaaa atgtcagcag gaccctgaga gttgctggta tttccaccag acagctatac
     1981 cttgcctgct tgccttggct gtgcaggcct ctatgccaga gaaggagccc tcagttctga
     2041 gaaaagtact attggaggat gaggtgttgg ctgccatggt gtctgtcatt ggcactgcta
     2101 caacccacct gagccctgag ttagctgccc agagtgtgac acacattgtg cccctcttct
     2161 tggatggcaa cgtgtccttt ctgcctgaaa acagcttccc gagcagattc cagccattcc
     2221 aggatggctc ctcagggcag aggcggctga ttgcactgct tatggccttt gtctgctccc
     2281 tgcctcgaaa tgtggaaatc cctcagctga accaactcat gcgggagctt ttggaactga
     2341 gctgctgcca cagctgcccc ttttcttcca ccgctgctgc caagtgcttt gcaggactcc
     2401 tcaacaagca ccctgcaggg cagcagctgg atgaattcct acagctagct gtggacaaag
     2461 tggaggctgg cctgggctct gggccctgtc gtagtcaggc cttcactctt cttctctggg
     2521 taacaaaggc cctagtgctc agataccatc ctctcagctc ctgccttaca gcccggctca
     2581 tgggcctcct gagtgaccca gaattaggtc cagcagcagc tgatggcttc tctctgctca
     2641 tgtctgactg cactgatgtg ctgactcgtg ctggccatgc cgaagtgcgg atcatgttcc
     2701 gccagcggtt cttcacagat aatgtgcctg ctttggtcca gggcttccat gctgctcccc
     2761 aagatgtgaa gccaaactac ttgaagggtc tttctcatgt acttaacagg ctgcccaagc
     2821 ctgtactctt gccagagctg cccacgcttc tttccttgct gctggaggcc ctgtcctgcc
     2881 ctgactgtgt ggtgcagctc tccaccctca gctgccttca gcctcttcta ctggaagcac
     2941 cccaagtcat gagtcttcac gtggacaccc tcgtcaccaa gtttctgaac ctcagctcta
     3001 gcccttccat ggctgtccgg atcgccgcac tgcagtgcat gcatgctctc actcgcctgc
     3061 ccacccctgt gctgctgccg tacaaaccac aggtgattcg ggccttagcc aaacccctgg
     3121 atgacaagaa gagactggtg cgcaaggaag cagtgtcagc cagaggggag tggtttctgt
     3181 tggggagccc tggcagctga gccctcagtc ctggcctaga ctgttctgac aatctaacct
     3241 gggattacta actgttgagc catcttcccc aaagcaggga aaccactggt ctctgactgc
     3301 ctttcccaca gacacagcac aaatgctagg cctctgttgc atggctgtac aaagaacata
     3361 agagtccata tttctagtgg atttgtaaaa taagtgtgtg tgagacactt gcgtttgaag
     3421 aaagatctag ggtcctgggt ctcttgcatt tatatgtcag aaaaggggcg atatgctgct
     3481 gaggggtgag tgcatatgag tgtggccctg aggaccaggg ctggcagatg ttgtctacct
     3541 gctgaagaat aaagatttct tttggtaa
//
