LOCUS       NM_024756               4127 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens multimerin 2 (MMRN2), mRNA.
ACCESSION   NM_024756
VERSION     NM_024756.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4127)
  AUTHORS   Pellicani,R., Poletto,E., Andreuzzi,E., Paulitti,A., Doliana,R.,
            Bizzotto,D., Braghetta,P., Colladel,R., Tarticchio,G.,
            Sabatelli,P., Bucciotti,F., Bressan,G., Iozzo,R.V., Colombatti,A.,
            Bonaldo,P. and Mongiat,M.
  TITLE     Multimerin-2 maintains vascular stability and permeability
  JOURNAL   Matrix Biol 87, 11-25 (2020)
   PUBMED   31422156
  REMARK    GeneRIF: Multimerin-2 maintains vascular stability and
            permeability.
REFERENCE   2  (bases 1 to 4127)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4127)
  AUTHORS   Barbera,S., Nardi,F., Elia,I., Realini,G., Lugano,R., Santucci,A.,
            Tosi,G.M., Dimberg,A., Galvagni,F. and Orlandini,M.
  TITLE     The small GTPase Rab5c is a key regulator of trafficking of the
            CD93/Multimerin-2/beta1 integrin complex in endothelial cell
            adhesion and migration
  JOURNAL   Cell Commun Signal 17 (1), 55 (2019)
   PUBMED   31138217
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4127)
  AUTHORS   Andreuzzi,E., Capuano,A., Pellicani,R., Poletto,E., Doliana,R.,
            Maiero,S., Fornasarig,M., Magris,R., Colombatti,A., Cannizzaro,R.,
            Spessotto,P. and Mongiat,M.
  TITLE     Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer
            Associate with Altered Angiogenesis
  JOURNAL   Int J Mol Sci 19 (12), 3983 (2018)
   PUBMED   30544909
  REMARK    GeneRIF: Loss of Multimerin-2 and EMILIN-2 Expression in Gastric
            Cancer Associate with Altered Angiogenesis
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4127)
  AUTHORS   Lorenzon,E., Colladel,R., Andreuzzi,E., Marastoni,S., Todaro,F.,
            Schiappacassi,M., Ligresti,G., Colombatti,A. and Mongiat,M.
  TITLE     MULTIMERIN2 impairs tumor angiogenesis and growth by interfering
            with VEGF-A/VEGFR2 pathway
  JOURNAL   Oncogene 31 (26), 3136-3147 (2012)
   PUBMED   22020326
REFERENCE   6  (bases 1 to 4127)
  AUTHORS   Soltermann,A., Ossola,R., Kilgus-Hawelski,S., von Eckardstein,A.,
            Suter,T., Aebersold,R. and Moch,H.
  TITLE     N-glycoprotein profiling of lung adenocarcinoma pleural effusions
            by shotgun proteomics
  JOURNAL   Cancer 114 (2), 124-133 (2008)
   PUBMED   18327805
REFERENCE   7  (bases 1 to 4127)
  AUTHORS   Huber,M.A., Kraut,N., Schweifer,N., Dolznig,H., Peter,R.U.,
            Schubert,R.D., Scharffetter-Kochanek,K., Pehamberger,H. and
            Garin-Chesa,P.
  TITLE     Expression of stromal cell markers in distinct compartments of
            human skin cancers
  JOURNAL   J Cutan Pathol 33 (2), 145-155 (2006)
   PUBMED   16420310
REFERENCE   8  (bases 1 to 4127)
  AUTHORS   Leimeister,C., Steidl,C., Schumacher,N., Erhard,S. and Gessler,M.
  TITLE     Developmental expression and biochemical characterization of Emu
            family members
  JOURNAL   Dev Biol 249 (2), 204-218 (2002)
   PUBMED   12221002
REFERENCE   9  (bases 1 to 4127)
  AUTHORS   Christian,S., Ahorn,H., Novatchkova,M., Garin-Chesa,P., Park,J.E.,
            Weber,G., Eisenhaber,F., Rettig,W.J. and Lenter,M.C.
  TITLE     Molecular cloning and characterization of EndoGlyx-1, an
            EMILIN-like multisubunit glycoprotein of vascular endothelium
  JOURNAL   J Biol Chem 276 (51), 48588-48595 (2001)
   PUBMED   11559704
REFERENCE   10 (bases 1 to 4127)
  AUTHORS   Sanz-Moncasi,M.P., Garin-Chesa,P., Stockert,E., Jaffe,E.A.,
            Old,L.J. and Rettig,W.J.
  TITLE     Identification of a high molecular weight endothelial cell surface
            glycoprotein, endoGlyx-1, in normal and tumor blood vessels
  JOURNAL   Lab Invest 71 (3), 366-373 (1994)
   PUBMED   7933987
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025268.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_024756.2.
            
            Summary: This gene encodes a protein belonging to the member of
            elastin microfibril interface-located (EMILIN) protein family. This
            family member is an extracellular matrix glycoprotein that can
            interfere with tumor angiogenesis and growth. It serves as a
            transforming growth factor beta antagonist and can interfere with
            the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified
            on chromosome 6. [provided by RefSeq, Aug 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094744.1, AK023527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372027.10/ ENSP00000361097.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC025268.8         58912-59149
            239-367             AC025268.8         70838-70966
            368-474             AC025268.8         71051-71157
            475-555             AC025268.8         71259-71339
            556-729             AC025268.8         72092-72265
            730-2541            AC025268.8         72399-74210
            2542-4127           AC025268.8         79402-80987
FEATURES             Location/Qualifiers
     source          1..4127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.2"
     gene            1..4127
                     /gene="MMRN2"
                     /gene_synonym="EMILIN-3; EMILIN3; ENDOGLYX-1"
                     /note="multimerin 2"
                     /db_xref="GeneID:79812"
                     /db_xref="HGNC:HGNC:19888"
                     /db_xref="MIM:608925"
     exon            1..238
                     /gene="MMRN2"
                     /gene_synonym="EMILIN-3; EMILIN3; ENDOGLYX-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2924
                     /gene="MMRN2"
                     /gene_synonym="EMILIN-3; EMILIN3; ENDOGLYX-1"
                     /note="EMILIN-like protein EndoGlyx-1; elastin microfibril
                     interfacer 3; endoGlyx-1 p125/p140 subunit; elastin
                     microfibril interface located protein 3"
                     /codon_start=1
                     /product="multimerin-2 precursor"
                     /protein_id="NP_079032.2"
                     /db_xref="CCDS:CCDS7379.1"
                     /db_xref="GeneID:79812"
                     /db_xref="HGNC:HGNC:19888"
                     /db_xref="MIM:608925"
                     /translation="MILSLLFSLGGPLGWGLLGAWAQASSTSLSDLQSSRTPGVWKAE
                     AEDTGKDPVGRNWCPYPMSKLVTLLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYRMA
                     HKPVYQVKQKVLTSLAWRCCPGYTGPNCEHHDSMAIPEPADPGDSHQEPQDGPVSFKP
                     GHLAAVINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGH
                     EFPDRSLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRV
                     QDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVD
                     TKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARREE
                     ELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVIL
                     MEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQ
                     RDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRS
                     QVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSE
                     QTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSH
                     DAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFAT
                     QRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKE
                     AEPLVDIRVTGPVPGALGAALWEAGSPVAFYASFSEGTAALQTVKFNTTYINIGSSYF
                     PEHGYFRAPERGVYLFAVSVEFGPGPGTGQLVFGGHHRTPVCTTGQGSGSTATVFAMA
                     ELQKGERVWFELTQGSITKRSLSGTAFGGFLMFKT"
     exon            239..367
                     /gene="MMRN2"
                     /gene_synonym="EMILIN-3; EMILIN3; ENDOGLYX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..474
                     /gene="MMRN2"
                     /gene_synonym="EMILIN-3; EMILIN3; ENDOGLYX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..555
                     /gene="MMRN2"
                     /gene_synonym="EMILIN-3; EMILIN3; ENDOGLYX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..729
                     /gene="MMRN2"
                     /gene_synonym="EMILIN-3; EMILIN3; ENDOGLYX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..2541
                     /gene="MMRN2"
                     /gene_synonym="EMILIN-3; EMILIN3; ENDOGLYX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..4127
                     /gene="MMRN2"
                     /gene_synonym="EMILIN-3; EMILIN3; ENDOGLYX-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4107..4112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMRN2"
                     /gene_synonym="EMILIN-3; EMILIN3; ENDOGLYX-1"
                     /note="hexamer: AATAAA"
     polyA_site      4127
                     /gene="MMRN2"
                     /gene_synonym="EMILIN-3; EMILIN3; ENDOGLYX-1"
                     /note="major polyA site"
ORIGIN      
        1 aagacaacgt cactagcagt ttctggagct acttgccaag gctgagtgtg agctgagcct
       61 gccccaccac caagatgatc ctgagcttgc tgttcagcct tgggggcccc ctgggctggg
      121 ggctgctggg ggcatgggcc caggcttcca gtactagcct ctctgatctg cagagctcca
      181 ggacacctgg ggtctggaag gcagaggctg aggacaccgg caaggacccc gtaggacgta
      241 actggtgccc ctacccaatg tccaagctgg tcaccttact agctctttgc aaaacagaga
      301 aattcctcat ccactcgcag cagccgtgtc cgcagggagc tccagactgc cagaaagtca
      361 aagtcatgta ccgcatggcc cacaagccag tgtaccaggt caagcagaag gtgctgacct
      421 ctttggcctg gaggtgctgc cctggctaca cgggccccaa ctgcgagcac cacgattcca
      481 tggcaatccc tgagcctgca gatcctggtg acagccacca ggaacctcag gatggaccag
      541 tcagcttcaa acctggccac cttgctgcag tgatcaatga ggttgaggtg caacaggaac
      601 agcaggaaca tctgctggga gatctccaga atgatgtgca ccgggtggca gacagcctgc
      661 caggcctgtg gaaagccctg cctggtaacc tcacagctgc agtgatggaa gcaaatcaaa
      721 cagggcacga gttccctgat agatccttgg agcaggtgct gctaccccac gtggacacct
      781 tcctacaagt gcatttcagc cccatctgga ggagctttaa ccaaagcctg cacagcctta
      841 cccaggccat aagaaacctg tctcttgacg tggaggccaa ccgccaggcc atctccagag
      901 tccaggacag tgccgtggcc agggctgact tccaggagct tggtgccaaa tttgaggcca
      961 aggtccagga gaacactcag agagtgggtc agctgcgaca ggacgtggag gaccgcctgc
     1021 acgcccagca ctttaccctg caccgctcga tctcagagct ccaagccgat gtggacacca
     1081 aattgaagag gctgcacaag gctcaggagg ccccagggac caatggcagt ctggtgttgg
     1141 caacgcctgg ggctggggca aggcctgagc cggacagcct gcaggccagg ctgggccagc
     1201 tgcagaggaa cctctcagag ctgcacatga ccacggcccg cagggaggag gagttgcagt
     1261 acaccctgga ggacatgagg gccaccctga cccggcacgt ggatgagatc aaggaactgt
     1321 actccgaatc ggacgagact ttcgatcaga ttagcaaggt ggagcggcag gtggaggagc
     1381 tgcaggtgaa ccacacggcg ctccgtgagc tgcgcgtgat cctgatggag aagtctctga
     1441 tcatggagga gaacaaggag gaggtggagc ggcagctcct ggagctcaac ctcacgctgc
     1501 agcacctgca gggtggccat gccgacctca tcaagtacgt gaaggactgc aattgccaga
     1561 agctctattt agacctggac gtcatccggg agggccagag ggacgccacg cgtgccctgg
     1621 aggagaccca ggtgagcctg gacgagcggc ggcagctgga cggctcctcc ctgcaggccc
     1681 tgcagaacgc cgtggacgcc gtgtcgctgg ccgtggacgc gcacaaagcg gagggcgagc
     1741 gggcgcgggc ggccacgtcg cggctccgga gccaagtgca ggcgctggat gacgaggtgg
     1801 gcgcgctgaa ggcggccgcg gccgaggccc gccacgaggt gcgccagctg cacagcgcct
     1861 tcgccgccct gctggaggac gcgctgcggc acgaggcggt gctggccgcg ctcttcgggg
     1921 aggaggtgct ggaggagatg tctgagcaga cgccgggacc gctgcccctg agctacgagc
     1981 agatccgcgt ggccctgcag gacgccgcta gcgggctgca ggagcaggcg ctcggctggg
     2041 acgagctggc cgcccgagtg acggccctgg agcaggcctc ggagcccccg cggccggcag
     2101 agcacctgga gcccagccac gacgcgggcc gcgaggaggc cgccaccacc gccctggccg
     2161 ggctggcgcg ggagctccag agcctgagca acgacgtcaa gaatgtcggg cggtgctgcg
     2221 aggccgaggc cggggccggg gccgcctccc tcaacgcctc ccttcacggc ctccacaacg
     2281 cactcttcgc cactcagcgc agcttggagc agcaccagcg gctcttccac agcctctttg
     2341 ggaacttcca agggctcatg gaagccaacg tcagcctgga cctggggaag ctgcagacca
     2401 tgctgagcag gaaagggaag aagcagcaga aagacctgga agctccccgg aagagggaca
     2461 agaaggaagc ggagcctttg gtggacatac gggtcacagg gcctgtgcca ggtgccttgg
     2521 gcgcggcgct ctgggaggca ggatcccctg tggccttcta tgccagcttt tcagaaggga
     2581 cggctgccct gcagacagtg aagttcaaca ccacatacat caacattggc agcagctact
     2641 tccctgaaca tggctacttc cgagcccctg agcgtggtgt ctacctgttt gcagtgagcg
     2701 ttgaatttgg cccagggcca ggcaccgggc agctggtgtt tggaggtcac catcggactc
     2761 cagtctgtac cactgggcag gggagtggaa gcacagcaac ggtctttgcc atggctgagc
     2821 tgcagaaggg tgagcgagta tggtttgagt taacccaggg atcaataaca aagagaagcc
     2881 tgtcgggcac tgcatttggg ggcttcctga tgtttaagac ctgaacccca gccccaatct
     2941 gatcagacat catggactcg cccagctctc ctcggcctgg ggctctggcc aaggatgggc
     3001 tggaggtcat tcagttggtc tgtctcttcc ctggaaacct tctgcaaaga tggtgtggtg
     3061 tacgtggctt ccctgtaacc acatggggct tggccatttc tccatgatga gaaggactgg
     3121 aatgcttctc cgggcaggac atggtcctag gaagcctgaa ccttggcttg gcatgccttc
     3181 tcagacagca cggcctgggc tccaactctt caccacaccc tgtattctac aacttctttg
     3241 gtgttttgct cctcctgtgg ttggaaactt ctgtacaaca ctttaaactt ttctcttgct
     3301 tcctcttctc ttctccctta tcgtatgata gaaagacatt cttccccagg aggaatgttt
     3361 aaaatggagg caacattttg gccaacattg gaaagcacta gagggcaatg ggattaaacc
     3421 aacctgcttg gtctctatta gtcagtaatg aagacgacag cctggccaac caagggaaag
     3481 gaaattagta tctttagttt cagtcattcc ttgtaggata tggtttagct gtgcccccac
     3541 ctaaaatatc atcttgaatt gtaatcccta taatccccac atcaagggag agatcaggtg
     3601 gaggtaattg gatcttgggg gcggttcccc catgctgttc ttgtgatagt tctcacgaga
     3661 tctgatgatt ttataagttt gatagttcct cctgtgttca ttctccttcc tgccaccttg
     3721 tgaagatgcc ttggttcctc ttcactgtct gccatgattg taagtttcct gaggcctccc
     3781 cagccatgtg gaacagtgag tcaattaaac ctctttcctt tataaattat ccagtcttgg
     3841 gcaattcttg atagcagtgt gaaaatggac taatacactt gtgtttatct gtaatttaaa
     3901 tttcatgtct ttttctcctt gccttacata gggtaaagac caagaaatgc caaacgtgaa
     3961 ctaaaatatg tagggccttc aactttttta cttcctccag tatcttagga ccatcgtaat
     4021 tcttgttagc atctctaacc aggaggcagc tgagggagga gggaaagaag actgtaaaaa
     4081 tccccctcac taatgatcaa ctttggaata aagtgatgcc cttcaaa
//
