LOCUS       NM_002423               1119 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens matrix metallopeptidase 7 (MMP7), mRNA.
ACCESSION   NM_002423
VERSION     NM_002423.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1119)
  AUTHORS   Chien,H.J., Wang,Y.C., Chang,W.S., Hsieh,Y.H., Liu,Y.F., Yang,Y.C.,
            Chen,J.C., Bau,D.T. and Tsai,C.W.
  TITLE     Contribution of Matrix Metalloproteinase-7 Genotypes to
            Endometriosis Risk in Taiwan
  JOURNAL   Anticancer Res 44 (7), 3051-3058 (2024)
   PUBMED   38925847
  REMARK    GeneRIF: Contribution of Matrix Metalloproteinase-7 Genotypes to
            Endometriosis Risk in Taiwan.
REFERENCE   2  (bases 1 to 1119)
  AUTHORS   Yin,T., Chen,S., Zhou,R., Liu,W., Diao,M. and Li,L.
  TITLE     Relationships of serum MMP-7 and clinical characteristics in
            choledochal cyst children
  JOURNAL   BMC Surg 24 (1), 195 (2024)
   PUBMED   38914992
  REMARK    GeneRIF: Relationships of serum MMP-7 and clinical characteristics
            in choledochal cyst children.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1119)
  AUTHORS   Zhao,H., Tian,X., Wu,B., Lu,Y., Du,J., Peng,S. and Xiao,Y.
  TITLE     Neurotensin contributes to cholestatic liver disease potentially
            modulating matrix metalloprotease-7
  JOURNAL   Int J Biochem Cell Biol 170, 106567 (2024)
   PUBMED   38522506
  REMARK    GeneRIF: Neurotensin contributes to cholestatic liver disease
            potentially modulating matrix metalloprotease-7.
REFERENCE   4  (bases 1 to 1119)
  AUTHORS   Ash,S., Doyle,T.J., Choi,B., San Jose Estepar,R., Castro,V.,
            Enzer,N., Kalhan,R., Liu,G., Bowler,R., Wilson,D.O., San Jose
            Estepar,R., Rosas,I.O. and Washko,G.R.
  TITLE     Utility of peripheral protein biomarkers for the prediction of
            incident interstitial features: a multicentre retrospective cohort
            study
  JOURNAL   BMJ Open Respir Res 11 (1), e002219 (2024)
   PUBMED   38485250
  REMARK    GeneRIF: Utility of peripheral protein biomarkers for the
            prediction of incident interstitial features: a multicentre
            retrospective cohort study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1119)
  AUTHORS   Rohani,M.G. and Parks,W.C.
  TITLE     Matrix remodeling by MMPs during wound repair
  JOURNAL   Matrix Biol 44-46, 113-121 (2015)
   PUBMED   25770908
  REMARK    Review article
REFERENCE   6  (bases 1 to 1119)
  AUTHORS   Nguyen,Q., Murphy,G., Hughes,C.E., Mort,J.S. and Roughley,P.J.
  TITLE     Matrix metalloproteinases cleave at two distinct sites on human
            cartilage link protein
  JOURNAL   Biochem J 295 (Pt 2) (Pt 2), 595-598 (1993)
   PUBMED   7694569
REFERENCE   7  (bases 1 to 1119)
  AUTHORS   Marti,H.P., McNeil,L., Thomas,G., Davies,M. and Lovett,D.H.
  TITLE     Molecular characterization of a low-molecular-mass matrix
            metalloproteinase secreted by glomerular mesangial cells as PUMP-1
  JOURNAL   Biochem J 285 (Pt 3) (Pt 3), 899-905 (1992)
   PUBMED   1497627
REFERENCE   8  (bases 1 to 1119)
  AUTHORS   Miyazaki,K., Hattori,Y., Umenishi,F., Yasumitsu,H. and Umeda,M.
  TITLE     Purification and characterization of extracellular matrix-degrading
            metalloproteinase, matrin (pump-1), secreted from human rectal
            carcinoma cell line
  JOURNAL   Cancer Res 50 (24), 7758-7764 (1990)
   PUBMED   2253219
REFERENCE   9  (bases 1 to 1119)
  AUTHORS   Quantin,B., Murphy,G. and Breathnach,R.
  TITLE     Pump-1 cDNA codes for a protein with characteristics similar to
            those of classical collagenase family members
  JOURNAL   Biochemistry 28 (13), 5327-5334 (1989)
   PUBMED   2550050
REFERENCE   10 (bases 1 to 1119)
  AUTHORS   Muller,D., Quantin,B., Gesnel,M.C., Millon-Collard,R., Abecassis,J.
            and Breathnach,R.
  TITLE     The collagenase gene family in humans consists of at least four
            members
  JOURNAL   Biochem J 253 (1), 187-192 (1988)
   PUBMED   2844164
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB109660.1, BC003635.2 and
            X07819.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002423.4.
            
            Summary: This gene encodes a member of the peptidase M10 family of
            matrix metalloproteinases (MMPs). Proteins in this family are
            involved in the breakdown of extracellular matrix in normal
            physiological processes, such as embryonic development,
            reproduction, and tissue remodeling, as well as in disease
            processes, such as arthritis and metastasis. The encoded
            preproprotein is proteolytically processed to generate the mature
            protease. This secreted protease breaks down proteoglycans,
            fibronectin, elastin and casein and differs from most MMP family
            members in that it lacks a conserved C-terminal hemopexin domain.
            The enzyme is involved in wound healing, and studies in mice
            suggest that it regulates the activity of defensins in intestinal
            mucosa. The gene is part of a cluster of MMP genes on chromosome
            11. This gene exhibits elevated expression levels in multiple human
            cancers. [provided by RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.102394.1,
                                           SRR5189658.160444.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260227.5/ ENSP00000260227.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CB109660.1         8-23
            17-276              BC003635.2         1-260
            277-1004            X07819.1           257-984
            1005-1119           BC003635.2         989-1103
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.2"
     gene            1..1119
                     /gene="MMP7"
                     /gene_synonym="MMP-7; MPSL1; PUMP-1"
                     /note="matrix metallopeptidase 7"
                     /db_xref="GeneID:4316"
                     /db_xref="HGNC:HGNC:7174"
                     /db_xref="MIM:178990"
     exon            1..155
                     /gene="MMP7"
                     /gene_synonym="MMP-7; MPSL1; PUMP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..851
                     /gene="MMP7"
                     /gene_synonym="MMP-7; MPSL1; PUMP-1"
                     /EC_number="3.4.24.23"
                     /note="matrin; matrix metalloproteinase 7 (matrilysin,
                     uterine); uterine matrilysin; pump-1 protease; uterine
                     metalloproteinase; matrix metalloproteinase-7; matrix
                     metallopeptidase 7 (matrilysin, uterine)"
                     /codon_start=1
                     /product="matrilysin preproprotein"
                     /protein_id="NP_002414.1"
                     /db_xref="CCDS:CCDS8317.1"
                     /db_xref="GeneID:4316"
                     /db_xref="HGNC:HGNC:7174"
                     /db_xref="MIM:178990"
                     /translation="MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYL
                     YDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSP
                     KWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFAR
                     GAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGH
                     SLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK"
     exon            156..382
                     /gene="MMP7"
                     /gene_synonym="MMP-7; MPSL1; PUMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..531
                     /gene="MMP7"
                     /gene_synonym="MMP-7; MPSL1; PUMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..660
                     /gene="MMP7"
                     /gene_synonym="MMP-7; MPSL1; PUMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..822
                     /gene="MMP7"
                     /gene_synonym="MMP-7; MPSL1; PUMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1119
                     /gene="MMP7"
                     /gene_synonym="MMP-7; MPSL1; PUMP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1068..1073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP7"
                     /gene_synonym="MMP-7; MPSL1; PUMP-1"
                     /note="hexamer: AATAAA"
     regulatory      1091..1096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP7"
                     /gene_synonym="MMP-7; MPSL1; PUMP-1"
                     /note="hexamer: AATAAA"
     polyA_site      1097
                     /gene="MMP7"
                     /gene_synonym="MMP-7; MPSL1; PUMP-1"
     polyA_site      1119
                     /gene="MMP7"
                     /gene_synonym="MMP-7; MPSL1; PUMP-1"
                     /note="major polyA site"
ORIGIN      
        1 accaaatcaa ccataggtcc aagaacaatt gtctctggac ggcagctatg cgactcaccg
       61 tgctgtgtgc tgtgtgcctg ctgcctggca gcctggccct gccgctgcct caggaggcgg
      121 gaggcatgag tgagctacag tgggaacagg ctcaggacta tctcaagaga ttttatctct
      181 atgactcaga aacaaaaaat gccaacagtt tagaagccaa actcaaggag atgcaaaaat
      241 tctttggcct acctataact ggaatgttaa actcccgcgt catagaaata atgcagaagc
      301 ccagatgtgg agtgccagat gttgcagaat actcactatt tccaaatagc ccaaaatgga
      361 cttccaaagt ggtcacctac aggatcgtat catatactcg agacttaccg catattacag
      421 tggatcgatt agtgtcaaag gctttaaaca tgtggggcaa agagatcccc ctgcatttca
      481 ggaaagttgt atggggaact gctgacatca tgattggctt tgcgcgagga gctcatgggg
      541 actcctaccc atttgatggg ccaggaaaca cgctggctca tgcctttgcg cctgggacag
      601 gtctcggagg agatgctcac ttcgatgagg atgaacgctg gacggatggt agcagtctag
      661 ggattaactt cctgtatgct gcaactcatg aacttggcca ttctttgggt atgggacatt
      721 cctctgatcc taatgcagtg atgtatccaa cctatggaaa tggagatccc caaaatttta
      781 aactttccca ggatgatatt aaaggcattc agaaactata tggaaagaga agtaattcaa
      841 gaaagaaata gaaacttcag gcagaacatc cattcattca ttcattggat tgtatatcat
      901 tgttgcacaa tcagaattga taagcactgt tcctccactc catttagcaa ttatgtcacc
      961 cttttttatt gcagttggtt tttgaatgtc tttcactcct tttaaggata aactccttta
     1021 tggtgtgact gtgtcttatt catctatact tgcagtgggt agatgtcaat aaatgttaca
     1081 tacacaaata aataaaatgt ttattccatg gtaaattta
//
