LOCUS       NM_002422               1822 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens matrix metallopeptidase 3 (MMP3), mRNA.
ACCESSION   NM_002422
VERSION     NM_002422.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1822)
  AUTHORS   Billeson,K., Baldimtsi,E., Wahlberg,J. and Whiss,P.A.
  TITLE     Growth Differentiation Factor 15 and Matrix Metalloproteinase 3 in
            Plasma as Biomarkers for Neuropathy and Nephropathy in Type 1
            Diabetes
  JOURNAL   Int J Mol Sci 25 (13), 7328 (2024)
   PUBMED   39000435
  REMARK    GeneRIF: Growth Differentiation Factor 15 and Matrix
            Metalloproteinase 3 in Plasma as Biomarkers for Neuropathy and
            Nephropathy in Type 1 Diabetes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1822)
  AUTHORS   Xie,Y., Lin,T., Jin,Y., Berezowitz,A.G., Wang,X.L., Lu,J., Cai,Y.
            and Guzman,R.J.
  TITLE     Smooth muscle cell-specific matrix metalloproteinase 3 deletion
            reduces osteogenic transformation and medial artery calcification
  JOURNAL   Cardiovasc Res 120 (6), 658-670 (2024)
   PUBMED   38454645
  REMARK    GeneRIF: Smooth muscle cell-specific matrix metalloproteinase 3
            deletion reduces osteogenic transformation and medial artery
            calcification.
REFERENCE   3  (bases 1 to 1822)
  AUTHORS   Yin,Y., Zhang,Y., Zhang,X., Zhang,Q., Wang,J., Yang,T., Liang,C.,
            Li,W., Liu,J., Ma,X., Duan,J., Shi,W. and Tian,Y.
  TITLE     Association of MMP3, MMP14, and MMP25 gene polymorphisms with
            cerebral stroke risk: a case-control study
  JOURNAL   BMC Med Genomics 16 (1), 297 (2023)
   PUBMED   37986083
  REMARK    GeneRIF: Association of MMP3, MMP14, and MMP25 gene polymorphisms
            with cerebral stroke risk: a case-control study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1822)
  AUTHORS   Nehring,P., Gromadzka,G., Jastrzebski,M. and Przybylkowski,A.
  TITLE     Genetic Variants in Matrix Metalloproteinases MMP3 (rs3025058) and
            MMP9 (rs3918242) Associated with Colonic Diverticulosis
  JOURNAL   Medicina (Kaunas) 59 (11), 2031 (2023)
   PUBMED   38004080
  REMARK    GeneRIF: Genetic Variants in Matrix Metalloproteinases MMP3
            (rs3025058) and MMP9 (rs3918242) Associated with Colonic
            Diverticulosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1822)
  AUTHORS   Shih,M.L., Lee,J.C., Cheng,S.Y., Lawal,B., Ho,C.L., Wu,C.C.,
            Tzeng,D.T.W., Chen,J.H. and Wu,A.T.H.
  TITLE     Transcriptomic discovery of a theranostic signature
            (SERPINE1/MMP3/COL1A1/SPP1) for head and neck squamous cell
            carcinomas and identification of antrocinol as a candidate drug
  JOURNAL   Comput Biol Med 150, 106185 (2022)
   PUBMED   37859283
  REMARK    GeneRIF: Transcriptomic discovery of a theranostic signature
            (SERPINE1/MMP3/COL1A1/SPP1) for head and neck squamous cell
            carcinomas and identification of antrocinol as a candidate drug.
REFERENCE   6  (bases 1 to 1822)
  AUTHORS   Nagase,H., Enghild,J.J., Suzuki,K. and Salvesen,G.
  TITLE     Stepwise activation mechanisms of the precursor of matrix
            metalloproteinase 3 (stromelysin) by proteinases and
            (4-aminophenyl)mercuric acetate
  JOURNAL   Biochemistry 29 (24), 5783-5789 (1990)
   PUBMED   2383557
REFERENCE   7  (bases 1 to 1822)
  AUTHORS   Sirum,K.L. and Brinckerhoff,C.E.
  TITLE     Cloning of the genes for human stromelysin and stromelysin 2:
            differential expression in rheumatoid synovial fibroblasts
  JOURNAL   Biochemistry 28 (22), 8691-8698 (1989)
   PUBMED   2605216
REFERENCE   8  (bases 1 to 1822)
  AUTHORS   Quinones,S., Saus,J., Otani,Y., Harris,E.D. Jr. and Kurkinen,M.
  TITLE     Transcriptional regulation of human stromelysin
  JOURNAL   J Biol Chem 264 (14), 8339-8344 (1989)
   PUBMED   2785989
REFERENCE   9  (bases 1 to 1822)
  AUTHORS   Saus,J., Quinones,S., Otani,Y., Nagase,H., Harris,E.D. Jr. and
            Kurkinen,M.
  TITLE     The complete primary structure of human matrix metalloproteinase-3.
            Identity with stromelysin
  JOURNAL   J Biol Chem 263 (14), 6742-6745 (1988)
   PUBMED   3360803
REFERENCE   10 (bases 1 to 1822)
  AUTHORS   Whitham,S.E., Murphy,G., Angel,P., Rahmsdorf,H.J., Smith,B.J.,
            Lyons,A., Harris,T.J., Reynolds,J.J., Herrlich,P. and Docherty,A.J.
  TITLE     Comparison of human stromelysin and collagenase by cloning and
            sequence analysis
  JOURNAL   Biochem J 240 (3), 913-916 (1986)
   PUBMED   3030290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA982602.1, BC074815.2,
            AK223291.1 and AI628953.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002422.4.
            
            Summary: Proteins of the matrix metalloproteinase (MMP) family are
            involved in the breakdown of extracellular matrix in normal
            physiological processes, such as embryonic development,
            reproduction, and tissue remodeling, as well as in disease
            processes, such as arthritis and metastasis. Most MMP's are
            secreted as inactive proproteins which are activated when cleaved
            by extracellular proteinases. This gene encodes an enzyme which
            degrades fibronectin, laminin, collagens III, IV, IX, and X, and
            cartilage proteoglycans. The enzyme is thought to be involved in
            wound repair, progression of atherosclerosis, and tumor initiation.
            The gene is part of a cluster of MMP genes which localize to
            chromosome 11q22.3. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.9567.1,
                                           SRR5189667.122637.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146, SAMEA2467147
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299855.10/ ENSP00000299855.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DA982602.1         81-98
            19-1529             BC074815.2         1-1511
            1530-1817           AK223291.1         1529-1816
            1818-1822           AI628953.1         5-9                 c
FEATURES             Location/Qualifiers
     source          1..1822
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.2"
     gene            1..1822
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /note="matrix metallopeptidase 3"
                     /db_xref="GeneID:4314"
                     /db_xref="HGNC:HGNC:7173"
                     /db_xref="MIM:185250"
     exon            1..168
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1497
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /EC_number="3.4.24.17"
                     /note="proteoglycanase; matrix metalloproteinase 3
                     (stromelysin 1, progelatinase); transin-1; stromelysin-1"
                     /codon_start=1
                     /product="stromelysin-1 preproprotein"
                     /protein_id="NP_002413.1"
                     /db_xref="CCDS:CCDS8323.1"
                     /db_xref="GeneID:4314"
                     /db_xref="HGNC:HGNC:7173"
                     /db_xref="MIM:185250"
                     /translation="MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDL
                     KKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRT
                     FPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIM
                     ISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAH
                     EIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVP
                     TEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWP
                     SLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAI
                     SDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFF
                     TGSSQLEFDPNAKKVTHTLKSNSWLNC"
     exon            169..413
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..562
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..688
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..853
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..998
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1132
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1292
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1396
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1822
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1796..1801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /note="hexamer: AATAAA"
     polyA_site      1822
                     /gene="MMP3"
                     /gene_synonym="CHDS6; MMP-3; SL-1; STMY; STMY1; STR1"
                     /note="major polyA site"
ORIGIN      
        1 acaaggaggc aggcaagaca gcaaggcata gagacaacat agagctaagt aaagccagtg
       61 gaaatgaaga gtcttccaat cctactgttg ctgtgcgtgg cagtttgctc agcctatcca
      121 ttggatggag ctgcaagggg tgaggacacc agcatgaacc ttgttcagaa atatctagaa
      181 aactactacg acctcaaaaa agatgtgaaa cagtttgtta ggagaaagga cagtggtcct
      241 gttgttaaaa aaatccgaga aatgcagaag ttccttggat tggaggtgac ggggaagctg
      301 gactccgaca ctctggaggt gatgcgcaag cccaggtgtg gagttcctga tgttggtcac
      361 ttcagaacct ttcctggcat cccgaagtgg aggaaaaccc accttacata caggattgtg
      421 aattatacac cagatttgcc aaaagatgct gttgattctg ctgttgagaa agctctgaaa
      481 gtctgggaag aggtgactcc actcacattc tccaggctgt atgaaggaga ggctgatata
      541 atgatctctt ttgcagttag agaacatgga gacttttacc cttttgatgg acctggaaat
      601 gttttggccc atgcctatgc ccctgggcca gggattaatg gagatgccca ctttgatgat
      661 gatgaacaat ggacaaagga tacaacaggg accaatttat ttctcgttgc tgctcatgaa
      721 attggccact ccctgggtct ctttcactca gccaacactg aagctttgat gtacccactc
      781 tatcactcac tcacagacct gactcggttc cgcctgtctc aagatgatat aaatggcatt
      841 cagtccctct atggacctcc ccctgactcc cctgagaccc ccctggtacc cacggaacct
      901 gtccctccag aacctgggac gccagccaac tgtgatcctg ctttgtcctt tgatgctgtc
      961 agcactctga ggggagaaat cctgatcttt aaagacaggc acttttggcg caaatccctc
     1021 aggaagcttg aacctgaatt gcatttgatc tcttcatttt ggccatctct tccttcaggc
     1081 gtggatgccg catatgaagt tactagcaag gacctcgttt tcatttttaa aggaaatcaa
     1141 ttctgggcta tcagaggaaa tgaggtacga gctggatacc caagaggcat ccacacccta
     1201 ggtttccctc caaccgtgag gaaaatcgat gcagccattt ctgataagga aaagaacaaa
     1261 acatatttct ttgtagagga caaatactgg agatttgatg agaagagaaa ttccatggag
     1321 ccaggctttc ccaagcaaat agctgaagac tttccaggga ttgactcaaa gattgatgct
     1381 gtttttgaag aatttgggtt cttttatttc tttactggat cttcacagtt ggagtttgac
     1441 ccaaatgcaa agaaagtgac acacactttg aagagtaaca gctggcttaa ttgttgaaag
     1501 agatatgtag aaggcacaat atgggcactt taaatgaagc taataattct tcacctaagt
     1561 ctctgtgaat tgaaatgttc gttttctcct gcctgtgctg tgactcgagt cacactcaag
     1621 ggaacttgag cgtgaatctg tatcttgccg gtcattttta tgttattaca gggcattcaa
     1681 atgggctgct gcttagcttg caccttgtca catagagtga tctttcccaa gagaagggga
     1741 agcactcgtg tgcaacagac aagtgactgt atctgtgtag actatttgct tatttaataa
     1801 agacgatttg tcagttattt ta
//
