LOCUS       NM_024302               2462 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens matrix metallopeptidase 28 (MMP28), transcript variant
            1, mRNA.
ACCESSION   NM_024302
VERSION     NM_024302.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2462)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2462)
  AUTHORS   Morrell,E.D., Mikacenic,C., Gong,K.Q., Kosamo,S., Wurfel,M.M. and
            Manicone,A.M.
  TITLE     Alveolar MMP28 is associated with clinical outcomes and measures of
            lung injury in acute respiratory distress syndrome
  JOURNAL   Crit Care 24 (1), 141 (2020)
   PUBMED   32268921
  REMARK    GeneRIF: Increased bronchoalveolar lavage fluid MMP28
            concentrations were associated with increased % percentage alveolar
            neutrophils and total protein concentrations
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2462)
  AUTHORS   Wang,H., Wu,J.X., Chen,X.P., Zhang,Q., Wei,H.B., Wang,H.J., Yang,X.
            and Zhang,D.H.
  TITLE     Expression and Clinical Significance of MMP-28 in Bladder Cancer
  JOURNAL   Technol Cancer Res Treat 19, 1533033820974017 (2020)
   PUBMED   33191847
  REMARK    GeneRIF: Expression and Clinical Significance of MMP-28 in Bladder
            Cancer.
REFERENCE   4  (bases 1 to 2462)
  AUTHORS   Li,Y., Sun,Q., Jiang,M., Li,S., Zhang,J., Xu,Z., Guo,D., Gu,T.,
            Wang,B., Xiao,L., Zhou,T. and Zhuo,W.
  TITLE     KLF9 suppresses gastric cancer cell invasion and metastasis through
            transcriptional inhibition of MMP28
  JOURNAL   FASEB J 33 (7), 7915-7928 (2019)
   PUBMED   30913394
  REMARK    GeneRIF: Real-time PCR and dual-luciferase assay indicated that
            KLF9 directly inhibited MMP28 transcription.  Decreased invasion
            and metastasis capability of GC cells caused by ectopic KLF9
            expression could be rescued via reinforcing MMP28 expression in
            vivo. Collectively, our study indicates that KLF9 significantly
            suppresses GC cell invasion and metastasis through inhibiting MMP28
            transcription.
REFERENCE   5  (bases 1 to 2462)
  AUTHORS   Zhan,G., Wenhua,G., Jie,H., Xiang,Q., Lingzhi,C., Xue,X.,
            Xing-Xing,C., Qianli,Z., Weijian,H. and Hao,Z.
  TITLE     Potential roles of circulating matrix metalloproteinase-28 (MMP-28)
            in patients with atrial fibrillation
  JOURNAL   Life Sci 204, 15-19 (2018)
   PUBMED   29729262
  REMARK    GeneRIF: Circulating MMP-28 was elevated in atrial fibrillation
REFERENCE   6  (bases 1 to 2462)
  AUTHORS   Bar-Or,A., Nuttall,R.K., Duddy,M., Alter,A., Kim,H.J., Ifergan,I.,
            Pennington,C.J., Bourgoin,P., Edwards,D.R. and Yong,V.W.
  TITLE     Analyses of all matrix metalloproteinase members in leukocytes
            emphasize monocytes as major inflammatory mediators in multiple
            sclerosis
  JOURNAL   Brain 126 (Pt 12), 2738-2749 (2003)
   PUBMED   14506071
REFERENCE   7  (bases 1 to 2462)
  AUTHORS   Saarialho-Kere,U., Kerkela,E., Jahkola,T., Suomela,S., Keski-Oja,J.
            and Lohi,J.
  TITLE     Epilysin (MMP-28) expression is associated with cell proliferation
            during epithelial repair
  JOURNAL   J Invest Dermatol 119 (1), 14-21 (2002)
   PUBMED   12164918
  REMARK    GeneRIF: Epilysin (MMP-28) expression is associated with cell
            proliferation during epithelial repair.
REFERENCE   8  (bases 1 to 2462)
  AUTHORS   Illman,S.A., Keski-Oja,J. and Lohi,J.
  TITLE     Promoter characterization of the human and mouse epilysin (MMP-28)
            genes
  JOURNAL   Gene 275 (1), 185-194 (2001)
   PUBMED   11574168
REFERENCE   9  (bases 1 to 2462)
  AUTHORS   Lohi,J., Wilson,C.L., Roby,J.D. and Parks,W.C.
  TITLE     Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed
            in testis and keratinocytes and in response to injury
  JOURNAL   J Biol Chem 276 (13), 10134-10144 (2001)
   PUBMED   11121398
REFERENCE   10 (bases 1 to 2462)
  AUTHORS   Marchenko,G.N. and Strongin,A.Y.
  TITLE     MMP-28, a new human matrix metalloproteinase with an unusual
            cysteine-switch sequence is widely expressed in tumors
  JOURNAL   Gene 265 (1-2), 87-93 (2001)
   PUBMED   11255011
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK122604.1, AF330002.2 and
            AA813101.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024302.4.
            
            Summary: Proteins of the matrix metalloproteinase (MMP) family are
            involved in the breakdown of extracellular matrix for both normal
            physiological processes, such as embryonic development,
            reproduction and tissue remodeling, and disease processes, such as
            asthma and metastasis. This gene encodes a secreted enzyme that
            degrades casein. Its expression pattern suggests that it plays a
            role in tissue homeostasis and in wound repair. Alternative
            splicing of this gene results in multiple transcript variants.
            [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF330002.2, SRR1803612.76212.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2155770
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000605424.6/ ENSP00000473853.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AK122604.1         67-75
            10-2454             AF330002.2         1-2445
            2455-2462           AA813101.1         24-31               c
FEATURES             Location/Qualifiers
     source          1..2462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2462
                     /gene="MMP28"
                     /gene_synonym="EPILYSIN; MM28; MMP-25; MMP-28; MMP25"
                     /note="matrix metallopeptidase 28"
                     /db_xref="GeneID:79148"
                     /db_xref="HGNC:HGNC:14366"
                     /db_xref="MIM:608417"
     exon            1..375
                     /gene="MMP28"
                     /gene_synonym="EPILYSIN; MM28; MMP-25; MMP-28; MMP25"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1827
                     /gene="MMP28"
                     /gene_synonym="EPILYSIN; MM28; MMP-25; MMP-28; MMP25"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; matrix metalloproteinase-28; matrix
                     metalloprotease MMP25"
                     /codon_start=1
                     /product="matrix metalloproteinase-28 isoform 1
                     preproprotein"
                     /protein_id="NP_077278.1"
                     /db_xref="CCDS:CCDS74036.1"
                     /db_xref="GeneID:79148"
                     /db_xref="HGNC:HGNC:14366"
                     /db_xref="MIM:608417"
                     /translation="MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYG
                     YLNEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAW
                     AERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQ
                     LWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEAHF
                     DQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDV
                     LAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYCHSSFDAITVD
                     RQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGR
                     CWRFRGPKPVWGLPQLCRAGGLPRHPDAALFFPPLRRLILFKGARYYVLARGGLQVEP
                     YYPRSLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWM
                     GCWHANSGSALF"
     exon            376..455
                     /gene="MMP28"
                     /gene_synonym="EPILYSIN; MM28; MMP-25; MMP-28; MMP25"
                     /inference="alignment:Splign:2.1.0"
     exon            456..643
                     /gene="MMP28"
                     /gene_synonym="EPILYSIN; MM28; MMP-25; MMP-28; MMP25"
                     /inference="alignment:Splign:2.1.0"
     exon            644..868
                     /gene="MMP28"
                     /gene_synonym="EPILYSIN; MM28; MMP-25; MMP-28; MMP25"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1114
                     /gene="MMP28"
                     /gene_synonym="EPILYSIN; MM28; MMP-25; MMP-28; MMP25"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1264
                     /gene="MMP28"
                     /gene_synonym="EPILYSIN; MM28; MMP-25; MMP-28; MMP25"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1432
                     /gene="MMP28"
                     /gene_synonym="EPILYSIN; MM28; MMP-25; MMP-28; MMP25"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..2462
                     /gene="MMP28"
                     /gene_synonym="EPILYSIN; MM28; MMP-25; MMP-28; MMP25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2422..2427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP28"
                     /gene_synonym="EPILYSIN; MM28; MMP-25; MMP-28; MMP25"
                     /note="hexamer: AATAAA"
     polyA_site      2462
                     /gene="MMP28"
                     /gene_synonym="EPILYSIN; MM28; MMP-25; MMP-28; MMP25"
                     /note="major polyA site"
ORIGIN      
        1 ctccctccct cggtccccgg ggccggcgga cccgcgggca ggcactgccc gggctggacg
       61 acgtctggcc ggctcccggc gaagggcagc ggaggagcgg cccagagcgc gcagctaggg
      121 cactggcgaa accccgggac agtccctctc cgtgcggggg cggcgcagag cagtcccatc
      181 cccggggtcc cgggcgcggc tgactgccgg ctggttccct gcgcgcagta gctccccgag
      241 ccgggctgca ccggaggcgg cgagatggtc gcgcgcgtcg gcctcctgct gcgcgccctg
      301 cagctgctac tgtggggcca cctggacgcc cagcccgcgg agcgcggagg ccaggagctg
      361 cgcaaggagg cggaggcatt cctagagaag tacggatacc tcaatgaaca ggtccccaaa
      421 gctcccacct ccactcgatt cagcgatgcc atcagagcgt ttcagtgggt gtcccagcta
      481 cctgtcagcg gcgtgttgga ccgcgccacc ctgcgccaga tgactcgtcc ccgctgcggg
      541 gttacagata ccaacagtta tgcggcctgg gctgagagga tcagtgactt gtttgctaga
      601 caccggacca aaatgaggcg taagaaacgc tttgcaaagc aaggtaacaa atggtacaag
      661 cagcacctct cctaccgcct ggtgaactgg cctgagcatc tgccggagcc ggcagttcgg
      721 ggcgccgtgc gcgccgcctt ccagttgtgg agcaacgtct cagcgctgga gttctgggag
      781 gccccagcca caggccccgc tgacatccgg ctcaccttct tccaagggga ccacaacgat
      841 gggctgggca atgcctttga tggcccaggg ggcgccctgg cgcacgcctt cctgccccgc
      901 cgcggcgaag cgcacttcga ccaagatgag cgctggtccc tgagccgccg ccgcgggcgc
      961 aacctgttcg tggtgctggc gcacgagatc ggtcacacgc ttggcctcac ccactcgccc
     1021 gcgccgcgcg cgctcatggc gccctactac aagaggctgg gccgcgacgc gctgctcagc
     1081 tgggacgacg tgctggccgt gcagagcctg tatgggaagc ccctaggggg ctcagtggcc
     1141 gtccagctcc caggaaagct gttcactgac tttgagacct gggactccta cagcccccaa
     1201 ggaaggcgcc ctgaaacgca gggccctaaa tactgccact cttccttcga tgccatcact
     1261 gtagacaggc aacagcaact gtacattttt aaagggagcc atttctggga ggtggcagct
     1321 gatggcaacg tctcagagcc ccgtccactg caggaaagat gggtcgggct gccccccaac
     1381 attgaggctg cggcagtgtc attgaatgat ggagatttct acttcttcaa agggggtcga
     1441 tgctggaggt tccggggccc caagccagtg tggggtctcc cacagctgtg ccgggcaggg
     1501 ggcctgcccc gccatcctga cgccgccctc ttcttccctc ctctgcgccg cctcatcctc
     1561 ttcaagggtg cccgctacta cgtgctggcc cgagggggac tgcaagtgga gccctactac
     1621 ccccgaagtc tgcaggactg gggaggcatc cctgaggagg tcagcggcgc cctgccgagg
     1681 cccgatggct ccatcatctt cttccgagat gaccgctact ggcgcctcga ccaggccaaa
     1741 ctgcaggcaa ccacctcggg ccgctgggcc accgagctgc cctggatggg ctgctggcat
     1801 gccaactcgg ggagcgccct gttctgaagg cacctcctca cctcagaaac tggtggtgct
     1861 ctcagggcaa aatcatgttc cccacccccg gggcagaacc cctcttagaa gcctctgagt
     1921 ccctctgcag aagaccgggc agcaaagcct ccatctggaa gtctgtctgc ctttgttcct
     1981 tgaagaatgc agcattgtct ttgtctgtcc ccaccacatg gaggtggggg tgggatcaat
     2041 cttaggaaaa gcaaaaaagg gtcccagatc ccttggccct ttcctccgag gacttctatc
     2101 ctccccaggc ctttgtttct tcggctaaag gtacagttcc tttcaagagg taacagcact
     2161 gggatccaag cagggggatg aaaaactcag cagagaaatt cgagaccatt ttgcaagact
     2221 gtgcccttct cctcaggacc ccctggctca gttcttgaaa aacggtgtca tatttagtca
     2281 gaggccccac ccccaggaag catggatggg gatgaaggca caggcgtctc caacctcaga
     2341 ggccctttgt ggggtcagga cacagagtgg gagggagact gatgcaggcc taccagtccc
     2401 tggctttttg tctggggctg gaataaagag gtgccttcag ctggtgggcc gagaggcagg
     2461 aa
//
