LOCUS       NM_021801               1451 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens matrix metallopeptidase 26 (MMP26), transcript variant
            1, mRNA.
ACCESSION   NM_021801
VERSION     NM_021801.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1451)
  AUTHORS   Cheng,T., Li,F., Wei,R., Lv,M.Q., Zhou,Y., Dai,Y., Yuan,Y.,
            Jiang,G.Y., Ma,D. and Gao,Q.L.
  TITLE     MMP26: A potential biomarker for prostate cancer
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 37 (6), 891-894 (2017)
   PUBMED   29270749
  REMARK    GeneRIF: MMP26 is overexpressed in prostatic neoplasms patients,
            and can serve as a serum disease biomarker.
REFERENCE   2  (bases 1 to 1451)
  AUTHORS   Chen,C., Zhao,Y., Yu,Y., Li,R. and Qiao,J.
  TITLE     MiR-125b regulates endometrial receptivity by targeting MMP26 in
            women undergoing IVF-ET with elevated progesterone on HCG priming
            day
  JOURNAL   Sci Rep 6, 25302 (2016)
   PUBMED   27143441
  REMARK    GeneRIF: The luciferase report assay demonstrated that MMP26 is a
            target gene of miR-125b. And the expression profile of MMP26 showed
            an inverse relationship with miR-125b in vivo and in vitro.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1451)
  AUTHORS   Zhao,D., Lu,Y., Yang,C., Zhou,X. and Xu,Z.
  TITLE     Activation of FGF receptor signaling promotes invasion of
            non-small-cell lung cancer
  JOURNAL   Tumour Biol 36 (5), 3637-3642 (2015)
   PUBMED   25566961
  REMARK    GeneRIF: We found that only inhibition of JNK significantly
            decreased the activation of MMP26 in response to FGF1 stimulation,
            suggesting that activation of FGFR1 signaling may activate JNK to
            activate MMP26 in non-small-cell lung cancer
REFERENCE   4  (bases 1 to 1451)
  AUTHORS   Xu,X., Ma,J., Li,C., Zhao,W. and Xu,Y.
  TITLE     Regulation of chondrosarcoma invasion by MMP26
  JOURNAL   Tumour Biol 36 (1), 365-369 (2015)
   PUBMED   25262277
  REMARK    GeneRIF: Overexpression of MMP26 in SW1353 cells increased cell
            invasiveness, while inhibition of MMP26 decreased cell
            invasiveness.
REFERENCE   5  (bases 1 to 1451)
  AUTHORS   Yu,C., Wang,Z., Xu,X., Xiang,W. and Huang,X.
  TITLE     Circulating Hepatocellular Carcinoma Cells are Characterized by
            CXCR4 and MMP26
  JOURNAL   Cell Physiol Biochem 36 (6), 2393-2402 (2015)
   PUBMED   26279442
  REMARK    GeneRIF: MMP26+CXCR4+ cells may be circulating tumor cells in
            hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 1451)
  AUTHORS   Marchenko,G.N., Ratnikov,B.I., Rozanov,D.V., Godzik,A.,
            Deryugina,E.I. and Strongin,A.Y.
  TITLE     Characterization of matrix metalloproteinase-26, a novel
            metalloproteinase widely expressed in cancer cells of epithelial
            origin
  JOURNAL   Biochem J 356 (Pt 3), 705-718 (2001)
   PUBMED   11389678
REFERENCE   7  (bases 1 to 1451)
  AUTHORS   Uria,J.A. and Lopez-Otin,C.
  TITLE     Matrilysin-2, a new matrix metalloproteinase expressed in human
            tumors and showing the minimal domain organization required for
            secretion, latency, and activity
  JOURNAL   Cancer Res 60 (17), 4745-4751 (2000)
   PUBMED   10987280
REFERENCE   8  (bases 1 to 1451)
  AUTHORS   Park,H.I., Ni,J., Gerkema,F.E., Liu,D., Belozerov,V.E. and
            Sang,Q.X.
  TITLE     Identification and characterization of human endometase (Matrix
            metalloproteinase-26) from endometrial tumor
  JOURNAL   J Biol Chem 275 (27), 20540-20544 (2000)
   PUBMED   10801841
REFERENCE   9  (bases 1 to 1451)
  AUTHORS   de Coignac,A.B., Elson,G., Delneste,Y., Magistrelli,G., Jeannin,P.,
            Aubry,J.P., Berthier,O., Schmitt,D., Bonnefoy,J.Y. and Gauchat,J.F.
  TITLE     Cloning of MMP-26. A novel matrilysin-like proteinase
  JOURNAL   Eur J Biochem 267 (11), 3323-3329 (2000)
   PUBMED   10824119
REFERENCE   10 (bases 1 to 1451)
  AUTHORS   Nagase,H. and Woessner,J.F. Jr.
  TITLE     Matrix metalloproteinases
  JOURNAL   J Biol Chem 274 (31), 21491-21494 (1999)
   PUBMED   10419448
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090719.8, AC103710.2 and
            AC018375.8.
            
            On Jun 22, 2020 this sequence version replaced NM_021801.4.
            
            Summary: Proteins of the matrix metalloproteinase (MMP) family are
            involved in the breakdown of extracellular matrix in normal
            physiological processes, such as embryonic development,
            reproduction, and tissue remodeling, as well as in disease
            processes, such as arthritis and metastasis. The encoded
            preproprotein is proteolytically processed to generate the mature
            enzyme. This enzyme may degrade collagen type IV, fibronectin,
            fibrinogen, and beta-casein, and activate matrix
            metalloproteinase-9 by cleavage. The protein differs from most MMP
            family members in that it lacks a conserved C-terminal protein
            domain. The encoded protein may promote cell invasion in multiple
            human cancers. [provided by RefSeq, May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF291664.1, AF248646.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMN03267750,
                                    SAMN03267782 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000380390.6/ ENSP00000369753.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AC090719.8         3791-4052           c
            263-334             AC103710.2         81273-81344         c
            335-577             AC018375.8         48304-48546         c
            578-798             AC018375.8         46746-46966         c
            799-947             AC018375.8         45868-46016         c
            948-1073            AC018375.8         45118-45243         c
            1074-1235           AC018375.8         44489-44650         c
            1236-1451           AC018375.8         44185-44400         c
FEATURES             Location/Qualifiers
     source          1..1451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1451
                     /gene="MMP26"
                     /note="matrix metallopeptidase 26"
                     /db_xref="GeneID:56547"
                     /db_xref="HGNC:HGNC:14249"
                     /db_xref="MIM:605470"
     exon            1..262
                     /gene="MMP26"
                     /inference="alignment:Splign:2.1.0"
     exon            263..334
                     /gene="MMP26"
                     /inference="alignment:Splign:2.1.0"
     exon            335..577
                     /gene="MMP26"
                     /inference="alignment:Splign:2.1.0"
     CDS             479..1264
                     /gene="MMP26"
                     /EC_number="3.4.24.1"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; matrilysin 2; endometase; matrix
                     metalloproteinase-26; MMP-26"
                     /codon_start=1
                     /product="matrix metalloproteinase-26 isoform 1
                     preproprotein"
                     /protein_id="NP_068573.2"
                     /db_xref="CCDS:CCDS7752.1"
                     /db_xref="GeneID:56547"
                     /db_xref="HGNC:HGNC:14249"
                     /db_xref="MIM:605470"
                     /translation="MQLVILRVTIFLPWCFAVPVPPAADHKGWDFVEGYFHQFFLTKK
                     ESPLLTQETQTQLLQQFHRNGTDLLDMQMHALLHQPHCGVPDGSDTSISPGRCKWNKH
                     TLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAHED
                     GWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASDTGYNLFLVATHEIGHSLGLQH
                     SGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYGEKCSSDIP"
     exon            578..798
                     /gene="MMP26"
                     /inference="alignment:Splign:2.1.0"
     exon            799..947
                     /gene="MMP26"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1073
                     /gene="MMP26"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1235
                     /gene="MMP26"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1451
                     /gene="MMP26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1428..1433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP26"
                     /note="hexamer: AATAAA"
     polyA_site      1451
                     /gene="MMP26"
                     /note="major polyA site"
ORIGIN      
        1 agttctccta ttcctgaatt ttttccctat gttttctcct ggcagaagag gacctctttg
       61 tccaggggca gggctgatca ggggctgatt ccgcagctat agtagtacag aacctttctg
      121 caagtaagtt agtgaggttg agataactct ctctcacttg ctttgcatta atagattctc
      181 tgctgtgtgg gatgatcctt caaatagcag ggggcaggat caaataacct caccttccag
      241 acccaagaat tctgtgcaca agagtttctt acaaaatcgt cctatccagc atgcactttt
      301 ggatactctt tcaactcaga agtcaacata aagggtatgg atgatgacgc cactcacaga
      361 ttcaaagaaa gggcaaactg gcagagtgag tcattggatg ttgctggcac agctataaag
      421 atccagtggc ccaagttgtg tacctgaatt caagcagtgg gacaaatgag ggtttggcat
      481 gcagctcgtc atcttaagag ttactatctt cttgccctgg tgtttcgccg ttccagtgcc
      541 ccctgctgca gaccataaag gatgggactt tgttgagggc tatttccatc aatttttcct
      601 gaccaagaag gagtcgccac tccttaccca ggagacacaa acacagctcc tgcaacaatt
      661 ccatcggaat gggacagacc tacttgacat gcagatgcat gctctgctac accagcccca
      721 ctgtggggtg cctgatgggt ccgacacctc catctcgcca ggaagatgca agtggaataa
      781 gcacactcta acttacagga ttatcaatta cccacatgat atgaagccat ccgcagtgaa
      841 agacagtata tataatgcag tttccatctg gagcaatgtg acccctttga tattccagca
      901 agtgcagaat ggagatgcag acatcaaggt ttctttctgg cagtgggccc atgaagatgg
      961 ttggcccttt gatgggccag gtggtatctt aggccatgcc tttttaccaa attctggaaa
     1021 tcctggagtt gtccattttg acaagaatga acactggtca gcttcagaca ctggatataa
     1081 tctgttcctg gttgcaactc atgagattgg gcattctttg ggcctgcagc actctgggaa
     1141 tcagagctcc ataatgtacc ccacttactg gtatcacgac cctagaacct tccagctcag
     1201 tgccgatgat atccaaagga tccagcattt gtatggagaa aaatgttcat ctgacatacc
     1261 ttaatgttag cacagaggac ttattcaacc tgtcctttca gggagtttat tggaggatca
     1321 aagaactgaa agcactagag cagccttggg gactgctagg atgaagccct aaagaatgca
     1381 acctagtcag gttagctgaa ccgacactca aaacgctact gagtcacaat aaagattgtt
     1441 ttaaagagta a
//
