LOCUS       NM_022468               3674 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens matrix metallopeptidase 25 (MMP25), mRNA.
ACCESSION   NM_022468
VERSION     NM_022468.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3674)
  AUTHORS   Yin,Y., Zhang,Y., Zhang,X., Zhang,Q., Wang,J., Yang,T., Liang,C.,
            Li,W., Liu,J., Ma,X., Duan,J., Shi,W. and Tian,Y.
  TITLE     Association of MMP3, MMP14, and MMP25 gene polymorphisms with
            cerebral stroke risk: a case-control study
  JOURNAL   BMC Med Genomics 16 (1), 297 (2023)
   PUBMED   37986083
  REMARK    GeneRIF: Association of MMP3, MMP14, and MMP25 gene polymorphisms
            with cerebral stroke risk: a case-control study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3674)
  AUTHORS   Shirazkeytabar,K., Razavi,S.A., Abooshahab,R., Salehipour,P.,
            Akbarzadeh,M., Soroush,A., Hedayati,M. and Nasiri,S.
  TITLE     Elevated Plasma Levels of MT4-MMP and MT6-MMP; A New Observation in
            Patients with Thyroid Nodules
  JOURNAL   Arch Iran Med 26 (6), 338-345 (2023)
   PUBMED   38310435
  REMARK    GeneRIF: Elevated Plasma Levels of MT4-MMP and MT6-MMP; A New
            Observation in Patients with Thyroid Nodules.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3674)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3674)
  AUTHORS   de la Pena,S., Sampieri,C.L., Ochoa-Lara,M., Leon-Cordoba,K. and
            Remes-Troche,J.M.
  TITLE     Expression of the matrix metalloproteases 2, 14, 24, and 25 and
            tissue inhibitor 3 as potential molecular markers in advanced human
            gastric cancer
  JOURNAL   Dis Markers 2014, 285906 (2014)
   PUBMED   24669030
  REMARK    GeneRIF: In absolute mRNA levels, significant differences were
            found in expression of MMP2, MMP24, and MMP25 in gastric carcinoma
            compared with superficial gastritis.
REFERENCE   5  (bases 1 to 3674)
  AUTHORS   Peruzzi,G., Femnou,L., Gil-Krzewska,A., Borrego,F., Weck,J.,
            Krzewski,K. and Coligan,J.E.
  TITLE     Membrane-type 6 matrix metalloproteinase regulates the
            activation-induced downmodulation of CD16 in human primary NK cells
  JOURNAL   J Immunol 191 (4), 1883-1894 (2013)
   PUBMED   23851692
  REMARK    GeneRIF: IL-2-upregulated MT6 cell-surface expression correlates
            with CD16 downmodulation. MT6, sequestered in intracellular
            compartments in unstimulated NK cells, translocates to the
            effector-target cell interface of CD16-mediated immunological
            synapses.
REFERENCE   6  (bases 1 to 3674)
  AUTHORS   Velasco,G., Cal,S., Merlos-Suarez,A., Ferrando,A.A., Alvarez,S.,
            Nakano,A., Arribas,J. and Lopez-Otin,C.
  TITLE     Human MT6-matrix metalloproteinase: identification, progelatinase A
            activation, and expression in brain tumors
  JOURNAL   Cancer Res 60 (4), 877-882 (2000)
   PUBMED   10706098
REFERENCE   7  (bases 1 to 3674)
  AUTHORS   Pei,D.
  TITLE     Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase
            specifically expressed in the leukocyte lineage
  JOURNAL   Cell Res 9 (4), 291-303 (1999)
   PUBMED   10628838
REFERENCE   8  (bases 1 to 3674)
  AUTHORS   Nagase,H. and Woessner,J.F. Jr.
  TITLE     Matrix metalloproteinases
  JOURNAL   J Biol Chem 274 (31), 21491-21494 (1999)
   PUBMED   10419448
  REMARK    Review article
REFERENCE   9  (bases 1 to 3674)
  AUTHORS   Bernot,A., Heilig,R., Clepet,C., Smaoui,N., Da Silva,C.,
            Petit,J.L., Devaud,C., Chiannilkulchai,N., Fizames,C., Samson,D.,
            Cruaud,C., Caloustian,C., Gyapay,G., Delpech,M. and Weissenbach,J.
  TITLE     A transcriptional Map of the FMF region
  JOURNAL   Genomics 50 (2), 147-160 (1998)
   PUBMED   9653642
REFERENCE   10 (bases 1 to 3674)
  AUTHORS   Will,H., Atkinson,S.J., Butler,G.S., Smith,B. and Murphy,G.
  TITLE     The soluble catalytic domain of membrane type 1 matrix
            metalloproteinase cleaves the propeptide of progelatinase A and
            initiates autoproteolytic activation. Regulation by TIMP-2 and
            TIMP-3
  JOURNAL   J Biol Chem 271 (29), 17119-17123 (1996)
   PUBMED   8663332
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108134.3, AJ272137.1 and
            CB529891.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022468.4.
            
            Summary: Proteins of the matrix metalloproteinase (MMP) family are
            involved in the breakdown of extracellular matrix in normal
            physiological processes, such as embryonic development,
            reproduction, and tissue remodeling, as well as in disease
            processes, such as arthritis and metastasis. Most MMPs are secreted
            as inactive proproteins which are activated when cleaved by
            extracellular proteinases. However, the protein encoded by this
            gene is a member of the membrane-type MMP (MT-MMP) subfamily,
            attached to the plasma membrane via a glycosylphosphatidyl inositol
            anchor. In response to bacterial infection or inflammation, the
            encoded protein is thought to inactivate alpha-1 proteinase
            inhibitor, a major tissue protectant against proteolytic enzymes
            released by activated neutrophils, facilitating the
            transendothelial migration of neutrophils to inflammatory sites.
            The encoded protein may also play a role in tumor invasion and
            metastasis through activation of MMP2. The gene has previously been
            referred to as MMP20 but has been renamed MMP25. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ272137.1, AB042328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336577.9/ ENSP00000337816.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC108134.3         58085-58204
            121-151             AC108134.3         58205-58235
            152-3468            AJ272137.1         32-3348
            3469-3674           CB529891.1         12-217              c
FEATURES             Location/Qualifiers
     source          1..3674
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3674
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /note="matrix metallopeptidase 25"
                     /db_xref="GeneID:64386"
                     /db_xref="HGNC:HGNC:14246"
                     /db_xref="MIM:608482"
     exon            1..456
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..2046
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /note="membrane-type 6 matrix metalloproteinase; matrix
                     metalloproteinase 20; matrix metalloproteinase-like 1;
                     matrix metallopeptidase-like 1; leukolysin; matrix
                     metalloproteinase-25; membrane-type matrix
                     metalloproteinase 6"
                     /codon_start=1
                     /product="matrix metalloproteinase-25 preproprotein"
                     /protein_id="NP_071913.1"
                     /db_xref="CCDS:CCDS10492.1"
                     /db_xref="GeneID:64386"
                     /db_xref="HGNC:HGNC:14246"
                     /db_xref="MIM:608482"
                     /translation="MRLRLRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPP
                     PHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLV
                     RRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEV
                     DSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFG
                     SKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQ
                     QLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGNFDAIANIRGETFFF
                     KGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWV
                     FQDRQLEGGARPLTELGLPPGEEVDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGY
                     PRDLSLWEGAPPSPDDVTVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC
                     PAPSSGPRAPRPPKATPVSETCDCQCELNQAAGRWPAPIPLLLLPLLVGGVASR"
     exon            457..589
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /inference="alignment:Splign:2.1.0"
     exon            590..725
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /inference="alignment:Splign:2.1.0"
     exon            726..1018
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1195
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1280
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1363
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1516
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1774
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..3674
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3653..3658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /note="hexamer: AATAAA"
     polyA_site      3674
                     /gene="MMP25"
                     /gene_synonym="MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6;
                     MT-MMP6; MT6-MMP; MT6MMP; MTMMP6"
                     /note="major polyA site"
ORIGIN      
        1 acccagccct ccgctcgcgc ccggagagga ggggccgctg gcgcagcgcc ccgggacccc
       61 gagaggccgc cgcggcacat ccagacctcc gccgctcccg cgccctctca accatcctgg
      121 gattcccggg cccacccgac ccagcggcgc gaccctggcc ctccgggacc ctccgctgac
      181 tccaccgcgc acttcccggg acccccacac acatcccagc cctccggccg atccctccct
      241 actcggtgcc gggtgccccc cgccctctcc aggcccggat ctcctccccc aggtccccgg
      301 ggcggcccca gccaggcccc cttcgaaccc cgccggcggc ccgggctggg gcgcaccatg
      361 cggctgcggc tccggcttct ggcgctgctg cttctgctgc tggcaccgcc cgcgcgcgcc
      421 ccgaagccct cggcgcagga cgtgagcctg ggcgtggact ggctgactcg ctatggttac
      481 ctgccgccac cccaccctgc ccaggcccag ctgcagagcc ctgagaagtt gcgcgatgcc
      541 atcaaagtca tgcagaggtt cgcggggctg ccggagaccg gccgcatgga cccagggaca
      601 gtggccacca tgcgtaagcc ccgctgctcc ctgcctgacg tgctgggggt ggcggggctg
      661 gtcaggcggc gtcgccggta cgctctgagc ggcagcgtgt ggaagaagcg aaccctgaca
      721 tggagggtac gttccttccc ccagagctcc cagctgagcc aggagaccgt gcgggtcctc
      781 atgagctatg ccctgatggc ctggggcatg gagtcaggcc tcacatttca tgaggtggat
      841 tccccccagg gccaggagcc cgacatcctc atcgactttg cccgcgcctt ccaccaggac
      901 agctacccct tcgacgggtt ggggggcacc ctagcccatg ccttcttccc tggggagcac
      961 cccatctccg gggacactca ctttgacgat gaggagacct ggacttttgg gtcaaaagac
     1021 ggcgagggga ccgacctgtt tgccgtggct gtccatgagt ttggccacgc cctgggcctg
     1081 ggccactcct cagcccccaa ctccattatg aggcccttct accagggtcc ggtgggcgac
     1141 cctgacaagt accgcctgtc tcaggatgac cgcgatggcc tgcagcaact ctatgggaag
     1201 gcgccccaaa ccccatatga caagcccaca aggaaacccc tggctcctcc gccccagccc
     1261 ccggcctcgc ccacacacag cccatccttc cccatccctg atcgatgtga gggcaatttt
     1321 gacgccatcg ccaacatccg aggggaaact ttcttcttca aaggcccctg gttctggcgc
     1381 ctccagccct ccggacagct ggtgtccccg cgacccgcac ggctgcaccg cttctgggag
     1441 gggctgcccg cccaggtgag ggtggtgcag gccgcctatg ctcggcaccg agacggccga
     1501 atcctcctct ttagcgggcc ccagttctgg gtgttccagg accggcagct ggagggcggg
     1561 gcgcggccgc tcacggagct ggggctgccc ccgggagagg aggtggacgc cgtgttctcg
     1621 tggccacaga acgggaagac ctacctggtc cgcggccggc agtactggcg ctacgacgag
     1681 gcggcggcgc gcccggaccc cggctaccct cgcgacctga gcctctggga aggcgcgccc
     1741 ccctcccctg acgatgtcac cgtcagcaac gcaggtgaca cctacttctt caagggcgcc
     1801 cactactggc gcttccccaa gaacagcatc aagaccgagc cggacgcccc ccagcccatg
     1861 gggcccaact ggctggactg ccccgccccg agctctggtc cccgcgcccc caggcccccc
     1921 aaagcgaccc ccgtgtccga aacctgcgat tgtcagtgcg agctcaacca ggccgcagga
     1981 cgttggcctg ctcccatccc gctgctcctc ttgcccctgc tggtgggggg tgtagcctcc
     2041 cgctgatggg gggagccatc cagaccgaac agcgccctcc acggccgagt cccccgccgc
     2101 tggacctggt cgggggttgt gaggcgctgc ggaggcccct tgtctgttcc cacggacggg
     2161 ggctcgggcg cggactaagc aggggggatc tcccgcgcag gggcggcggc ggcggggacc
     2221 ggtcgcctgg cgctgggctc agtctcctca gggtctgaga ccccggcgct gccaccggaa
     2281 cccgccttca ggggcgcacg cgcgctggga ccatgcgtcg gtcgtcgccc ccgtcgttcc
     2341 ctcccggctg ccgccagggg gcggtcggac cccgcctccc gagcccgggg aggggcgggg
     2401 aggacaaggg gcgggcccgc ggcctcaccc ggagggacgg cagccccggt cgcgcgctgg
     2461 ccccgcagga ccttcctttt ccaggaagag ccagcttttc tcggagcgca gtcctgggac
     2521 tctccgcagc cccgccccgc ctggccactg cgtctggcat tcctgggtcg ttagaggaca
     2581 ggcctgactg cgaagctgtg ccttgcccct ctcccacccg cagtttctca ccccgttctg
     2641 ctcccacaag gcccccctac agtcactgcc acactggtgg ggacctggga cccagacccg
     2701 gaaccagccc agatatcacc cctgaggacc catgcgccac gtcctgggtg gtggaatcag
     2761 tggctggagg gacgaccctt gctctccagg ctgttaacct tttccgttgc tcccccgcca
     2821 cccacctcct cctccccagg ccacccaact tgggcacctc cctgggccca gaactgcctt
     2881 ccattcaatg gggaaccctt ctatccccaa gaaccccttc cctgcttgca ccctggagag
     2941 aacagcttga ctcccatcaa ctcaacgctg gtggaaagac agggaccgaa ccctggctca
     3001 ggcctggtca ttgcctcctc agcactccct cctgggaggc cttagctcta gagtgagggg
     3061 tgggtggaac ctgggggcac ctcgttcacc ctgtccccac tccccacagt tttaggatct
     3121 aaatgattgc ctctggaact attcttctag actatcccac atcagaatca ctgggaaatt
     3181 taagtttgca gatcccacac tcaccctgaa tcctcactca gggtggggtc aggaatctgc
     3241 attttaacta gtcgcgggga ttgtgggggg cagtagctgg ctgtttcgtg gcatttctgt
     3301 ggctctgcag tgttcctcca ccccaggacc aatatgttca ggccacaccg atggcctgaa
     3361 ccccatgggt agagtcactt aggggccact tcctaagttg ctgtccagcc tcagtgaccc
     3421 cctagtgctt cctggagctg aggctgtggg cggctgtccc agcaaccatg cgaggggttg
     3481 ccccagttgc tcatacaaac agatcagcat gaggacagaa ggcaggagac tttggtcagt
     3541 tacctgggaa ttctgggctg ccaggaaacg atttgggcct ctgtcagttt cttttccatg
     3601 tatgaggagg gggaaatttg tatattagaa acttattcat cccactcagg acaataaaaa
     3661 cgaatgtaca aaaa
//
