LOCUS       NM_006690               4376 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens matrix metallopeptidase 24 (MMP24), mRNA.
ACCESSION   NM_006690
VERSION     NM_006690.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4376)
  AUTHORS   Xu,M., Li,J., Xia,L., Du,Y., Wu,B., Shi,X., Tian,N., Pang,Y.,
            Yi,L., Chen,M., Song,W. and Dong,Z.
  TITLE     PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting
            MT5-MMP maturation
  JOURNAL   Exp Neurol 374, 114688 (2024)
   PUBMED   38216110
  REMARK    GeneRIF: PCSK6 exacerbates Alzheimer's disease pathogenesis by
            promoting MT5-MMP maturation.
REFERENCE   2  (bases 1 to 4376)
  AUTHORS   Pietrzak,J., Szmajda-Krygier,D., Wosiak,A., Swiechowski,R.,
            Michalska,K., Mirowski,M., Zebrowska-Nawrocka,M., Lochowski,M. and
            Balcerczak,E.
  TITLE     Changes in the expression of membrane type-matrix
            metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during
            treatment and their potential impact on the survival of patients
            with non-small cell lung cancer (NSCLC)
  JOURNAL   Biomed Pharmacother 146, 112559 (2022)
   PUBMED   35062057
  REMARK    GeneRIF: Changes in the expression of membrane type-matrix
            metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during
            treatment and their potential impact on the survival of patients
            with non-small cell lung cancer (NSCLC).
REFERENCE   3  (bases 1 to 4376)
  AUTHORS   Arnst,N., Belio-Mairal,P., Garcia-Gonzalez,L., Arnaud,L.,
            Greetham,L., Nivet,E., Rivera,S. and Dityatev,A.
  TITLE     Deficiency in MT5-MMP Supports Branching of Human iPSCs-Derived
            Neurons and Reduces Expression of GLAST/S100 in iPSCs-Derived
            Astrocytes
  JOURNAL   Cells 10 (7), 1705 (2021)
   PUBMED   34359875
  REMARK    GeneRIF: Deficiency in MT5-MMP Supports Branching of Human
            iPSCs-Derived Neurons and Reduces Expression of GLAST/S100 in
            iPSCs-Derived Astrocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4376)
  AUTHORS   Garcia-Gonzalez,L., Paumier,J.M., Louis,L., Pilat,D., Bernard,A.,
            Stephan,D., Jullien,N., Checler,F., Nivet,E., Khrestchatisky,M.,
            Baranger,K. and Rivera,S.
  TITLE     MT5-MMP controls APP and beta-CTF/C99 metabolism through
            proteolytic-dependent and -independent mechanisms relevant for
            Alzheimer's disease
  JOURNAL   FASEB J 35 (7), e21727 (2021)
   PUBMED   34117802
  REMARK    GeneRIF: MT5-MMP controls APP and beta-CTF/C99 metabolism through
            proteolytic-dependent and -independent mechanisms relevant for
            Alzheimer's disease.
REFERENCE   5  (bases 1 to 4376)
  AUTHORS   Okimoto,R.A., Breitenbuecher,F., Olivas,V.R., Wu,W., Gini,B.,
            Hofree,M., Asthana,S., Hrustanovic,G., Flanagan,J., Tulpule,A.,
            Blakely,C.M., Haringsma,H.J., Simmons,A.D., Gowen,K., Suh,J.,
            Miller,V.A., Ali,S., Schuler,M. and Bivona,T.G.
  TITLE     Inactivation of Capicua drives cancer metastasis
  JOURNAL   Nat Genet 49 (1), 87-96 (2017)
   PUBMED   27869830
  REMARK    GeneRIF: MMP24 overexpression is associated with lung cancer
            metastasis.
REFERENCE   6  (bases 1 to 4376)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   7  (bases 1 to 4376)
  AUTHORS   Romanic,A.M., Burns-Kurtis,C.L., Ao,Z., Arleth,A.J. and
            Ohlstein,E.H.
  TITLE     Upregulated expression of human membrane type-5 matrix
            metalloproteinase in kidneys from diabetic patients
  JOURNAL   Am J Physiol Renal Physiol 281 (2), F309-F317 (2001)
   PUBMED   11457723
REFERENCE   8  (bases 1 to 4376)
  AUTHORS   Nagase,H. and Woessner,J.F. Jr.
  TITLE     Matrix metalloproteinases
  JOURNAL   J Biol Chem 274 (31), 21491-21494 (1999)
   PUBMED   10419448
  REMARK    Review article
REFERENCE   9  (bases 1 to 4376)
  AUTHORS   Llano,E., Pendas,A.M., Freije,J.P., Nakano,A., Knauper,V.,
            Murphy,G. and Lopez-Otin,C.
  TITLE     Identification and characterization of human MT5-MMP, a new
            membrane-bound activator of progelatinase a overexpressed in brain
            tumors
  JOURNAL   Cancer Res 59 (11), 2570-2576 (1999)
   PUBMED   10363975
REFERENCE   10 (bases 1 to 4376)
  AUTHORS   Kinoh,H., Hayashita,H., Kajita,M., Okada,A. and Seiki,M.
  TITLE     Assignment of the genes for membrane-type-4 matrix
            metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human
            chromosome band 12q24.3 and membrane-type-5 matrix
            metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human
            chromosome band 20q11.2-->q12, respectively, by radiation hybrid
            and in situ hybridization
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 97-98 (1999)
   PUBMED   10640822
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121753.32, AB021227.1,
            BC047614.1 and R60687.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006690.3.
            
            Summary: This gene encodes a member of the peptidase M10 family of
            matrix metalloproteinases (MMPs). Proteins in this family are
            involved in the breakdown of extracellular matrix in normal
            physiological processes, such as embryonic development,
            reproduction, and tissue remodeling, as well as in disease
            processes, such as arthritis and metastasis. The encoded
            preproprotein is proteolytically processed to generate the mature
            protease. Unlike most MMPs, which are secreted, this protease is a
            member of the membrane-type MMP (MT-MMP) subfamily, contains a
            transmembrane domain and is expressed at the cell surface.
            Substrates of this protease include the proteins cadherin 2 and
            matrix metallopeptidase 2 (also known as 72 kDa type IV
            collagenase). The gene has previously been referred to as MMP25 but
            has been renamed matrix metallopeptidase 24 (MMP24). [provided by
            RefSeq, Oct 2019].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047614.1, SRR1660803.189864.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246186.8/ ENSP00000246186.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AL121753.32        36410-36455
            47-852              AB021227.1         1-806
            853-4374            BC047614.1         747-4268
            4375-4376           R60687.1           15-16               c
FEATURES             Location/Qualifiers
     source          1..4376
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..4376
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /note="matrix metallopeptidase 24"
                     /db_xref="GeneID:10893"
                     /db_xref="HGNC:HGNC:7172"
                     /db_xref="MIM:604871"
     exon            1..295
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1987
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /note="membrane-type 5 matrix metalloproteinase; matrix
                     metalloproteinase 24 (membrane-inserted); matrix
                     metalloproteinase-24; matrix metallopeptidase 24
                     (membrane-inserted); membrane-type matrix
                     metalloproteinase 5"
                     /codon_start=1
                     /product="matrix metalloproteinase-24 preproprotein"
                     /protein_id="NP_006681.1"
                     /db_xref="CCDS:CCDS46593.1"
                     /db_xref="GeneID:10893"
                     /db_xref="HGNC:HGNC:7172"
                     /db_xref="MIM:604871"
                     /translation="MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALC
                     CLPGAARAAAAAAGAGNRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALH
                     SAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTG
                     QKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEA
                     DIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDL
                     FLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLE
                     PTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFRG
                     EMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWV
                     FKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDP
                     GYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDW
                     MGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQ
                     FKNKTGPQPVTYYKRPVQEWV"
     exon            296..444
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            445..561
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            562..866
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1028
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1243
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1382
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1649
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..4376
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4358..4363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /note="hexamer: AATAAA"
     polyA_site      4376
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggcg gcgaaggcag gcgggccggg cgcgggcccc gccgccggga tgccgaggag
       61 ccggggcggc cgcgccgcgc cggggccgcc gccgccgccg ccgccgccgg gccaggcccc
      121 gcgctggagc cgctggcggg tccctgggcg gctgctgctg ctgctgctgc ccgcgctctg
      181 ctgcctcccg ggcgccgcgc gggcggcggc ggcggcggcg ggggcaggga accgggcagc
      241 ggtggcggtg gcggtggcgc gggcggacga ggcggaggcg cccttcgccg ggcagaactg
      301 gttaaagtcc tatggctatc tgcttcccta tgactcacgg gcatctgcgc tgcactcagc
      361 gaaggccttg cagtcggcag tctccactat gcagcagttt tacgggatcc cggtcaccgg
      421 tgtgttggat cagacaacga tcgagtggat gaagaaaccc cgatgtggtg tccctgatca
      481 cccccactta agccgtaggc ggagaaacaa gcgctatgcc ctgactggac agaagtggag
      541 gcaaaaacac atcacctaca gcattcacaa ctatacccca aaagtgggtg agctagacac
      601 gcggaaagct attcgccagg ctttcgatgt gtggcagaag gtgaccccac tgacctttga
      661 agaggtgcca taccatgaga tcaaaagtga ccggaaggag gcagacatca tgatcttttt
      721 tgcttctggt ttccatggcg acagctcccc atttgatgga gaagggggat tcctggccca
      781 tgcctacttc cctggcccag ggattggagg agacacccac tttgactccg atgagccatg
      841 gacgctagga aatgccaacc atgacgggaa cgacctcttc ctggtggctg tgcatgagct
      901 gggccacgcg ctgggactgg agcactccag cgaccccagc gccatcatgg cgcccttcta
      961 ccagtacatg gagacgcaca acttcaagct gccccaggac gatctccagg gcatccagaa
     1021 gatctatgga cccccagccg agcctctgga gcccacaagg ccactcccta cactccccgt
     1081 ccgcaggatc cactcaccat cggagaggaa acacgagcgc cagcccaggc cccctcggcc
     1141 gcccctcggg gaccggccat ccacaccagg caccaaaccc aacatctgtg acggcaactt
     1201 caacacagtg gccctcttcc ggggcgagat gtttgtcttt aaggatcgct ggttctggcg
     1261 tctgcgcaat aaccgagtgc aggagggcta ccccatgcag atcgagcagt tctggaaggg
     1321 cctgcctgcc cgcatcgacg cagcctatga aagggccgat gggagatttg tcttcttcaa
     1381 aggtgacaag tattgggtgt ttaaggaggt gacggtggag cctgggtacc cccacagcct
     1441 gggggagctg ggcagctgtt tgccccgtga aggcattgac acagctctgc gctgggaacc
     1501 tgtgggcaag acctactttt tcaaaggcga gcggtactgg cgctacagcg aggagcggcg
     1561 ggccacggac cctggctacc ctaagcccat caccgtgtgg aagggcatcc cacaggctcc
     1621 ccaaggagcc ttcatcagca aggaaggata ttacacctat ttctacaagg gccgggacta
     1681 ctggaagttt gacaaccaga aactgagcgt ggagccaggc tacccgcgca acatcctgcg
     1741 tgactggatg ggctgcaacc agaaggaggt ggagcggcgg aaggagcggc ggctgcccca
     1801 ggacgacgtg gacatcatgg tgaccatcaa cgatgtgccg ggctccgtga acgccgtggc
     1861 cgtggtcatc ccctgcatcc tgtccctctg catcctggtg ctggtctaca ccatcttcca
     1921 gttcaagaac aagacaggcc ctcagcctgt cacctactat aagcggccag tccaggaatg
     1981 ggtgtgagca gcccagagcc ctctctatcc acttggtctg gccagccagg cccttcctca
     2041 ccagggtctg aggggcagct ctggccagtg ctcaccaggg ccagcagggc cctaggctgg
     2101 ggtcgtacag ctgaagtggt gggtgcattg gcctaggctg agcgtggggc agggaattat
     2161 gggggctgtg ccccagggtg ggtgtctggc acccagctgc cagccttctg tcctgggcaa
     2221 actactccct acttaaggga ataggccagg ctccatccgg aggcagggac catgccagga
     2281 ggagcccctg tggtcacggc atcctgtggt gtccatgagg taccacagct ccactcctgg
     2341 ctggaaccca gcaccctctg tgggaagcca gcactagctc tcatccccca tccgggagat
     2401 accaccagtc ctggtcccct tttgccaaca cctgctggtc agatgtcccc ctacccccac
     2461 cccactgtcc tccaaggcta caggacccct gcttctgaca cagtgagcaa caagcctggg
     2521 tttccctgct ggcagacggc agatccctca ggaaacctgc tccacttgtc agggtctctt
     2581 cggagaccca ggatttaggg tcacatgctg caggcagggc tgtggcccag ctgggtctga
     2641 caaggaccca gctgtcacat cgtgaatatt taaatgtcct gtcactactg tcccattttg
     2701 caaaggctgc ttgaggcttt aggtgaacta gaggtgactg tcttggtgat gaggccagca
     2761 tagcggccct cccccaggcg acaaggacca aggtgctgct aaggccactc tagcgcccag
     2821 acaccccagt agctgagctc tgctcctatg gctacagagc tggggcagaa gctgacccca
     2881 tttctggagg aagatccgag tttgtgaccg tcctccactc ccctctattg tcactgtccc
     2941 cagctttgct ccagtctgtc acttgcagcc tggagctcag cctcaccagt taggtgaggc
     3001 agagatggct gcagggccaa cactggcaga gcctgggagt ccttcggaag gggaccaggg
     3061 cgtctgaagt gctcagtgcc cccactactc tgaggccgac tccagctact ctgaggccga
     3121 ctcaatctct cggctggaag cagtgttttc ccagagcttg gcccttgctg acctcgctca
     3181 ctgggcccat cttcccacac tgctcttaga aggacacccc taccggtagc agccccaagc
     3241 tgagggggct ccctttttga ccttcactgg cccgcccttc actgtctcca gcaggagttc
     3301 ctagggcttg gcctgccttg ctccacagta cggcggaggc agccctgctt gtcactgagg
     3361 agccctagac aaggccaatg ggttcatcaa tgcccactgg ctctctgcca aagccaaaaa
     3421 ggtgtcaggc agtctccagc gtgctggccg ggtctcggat gccacccctg ctcactgagc
     3481 ctgcatgggc cttgcccccg accctgtggt ctctgggatt ggggtcggct taccctgtag
     3541 cacagacagg gactcctgct gccctgggag ctgtctcaag caaaatctct tgtcccagag
     3601 gtgcccatgt gggtccgctg tgtcccctgt catcatcctt gttttttctc attttggcca
     3661 agggcaggct ccctgggaca ggcagggaac aactgcggag atattagtga ttcataggtt
     3721 tgtacagtgt tttatacttt gcaaagcact ttattagctc acacctgtcc actcacatga
     3781 aactcgtgtt aggccctggg aggccgacgg taactctcac cgtgccctca gatgaagcac
     3841 agagaggttg ttacttgccc gggccatcca gtgggctggc tgggtcttgt gtccccatct
     3901 gtggacccct ctagggtctg agatgagatg agaagtgtct cctgtatcca cctcttcctg
     3961 gcctcccttc ccccacttcc tggtccctgt ccactcctca ggttggtgct ctcacttctt
     4021 gaaagctcta ggcacccccg cctcccgcca ggctccccat tggctcctgg caggccagct
     4081 gagaatgaac aggagatgga ggcaggcagc ccaggctgca gaggtgaggg atgtggggcc
     4141 aggcccagag ggctcagcct agaggcttcc aatctcagat tctcctgcct gtggtcatct
     4201 gtttgtccat caccccagga cagggcagac agaggggcaa agcactgggg gccccagagc
     4261 ctagcttccc ctcagcctgg gggacatcac agcatttcag tgtcagtcac attttaaact
     4321 gatcagcctt tgtataatgt tttttaaatc atttctaaat aaaacagaaa tacaga
//
