LOCUS       NM_001355008            2363 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens MMP24-AS1-EDEM2 readthrough (MMP24-AS1-EDEM2), mRNA.
ACCESSION   NM_001355008
VERSION     NM_001355008.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2363)
  AUTHORS   Ninagawa,S., Okada,T., Sumitomo,Y., Kamiya,Y., Kato,K.,
            Horimoto,S., Ishikawa,T., Takeda,S., Sakuma,T., Yamamoto,T. and
            Mori,K.
  TITLE     EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first
            mannose trimming step
  JOURNAL   J Cell Biol 206 (3), 347-356 (2014)
   PUBMED   25092655
REFERENCE   2  (bases 1 to 2363)
  AUTHORS   Slominska-Wojewodzka,M., Pawlik,A., Sokolowska,I., Antoniewicz,J.,
            Wegrzyn,G. and Sandvig,K.
  TITLE     The role of EDEM2 compared with EDEM1 in ricin transport from the
            endoplasmic reticulum to the cytosol
  JOURNAL   Biochem J 457 (3), 485-496 (2014)
   PUBMED   24200403
REFERENCE   3  (bases 1 to 2363)
  AUTHORS   Mast,S.W., Diekman,K., Karaveg,K., Davis,A., Sifers,R.N. and
            Moremen,K.W.
  TITLE     Human EDEM2, a novel homolog of family 47 glycosidases, is involved
            in ER-associated degradation of glycoproteins
  JOURNAL   Glycobiology 15 (4), 421-436 (2005)
   PUBMED   15537790
  REMARK    Erratum:[Glycobiology. 2005 May;15(5):13G]
REFERENCE   4  (bases 1 to 2363)
  AUTHORS   Olivari,S., Galli,C., Alanen,H., Ruddock,L. and Molinari,M.
  TITLE     A novel stress-induced EDEM variant regulating endoplasmic
            reticulum-associated glycoprotein degradation
  JOURNAL   J Biol Chem 280 (4), 2424-2428 (2005)
   PUBMED   15579471
REFERENCE   5  (bases 1 to 2363)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   6  (bases 1 to 2363)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121753.32, AL356652.19 and AL135844.9.
            
            On Jun 2, 2019 this sequence version replaced NM_001355008.1.
            
            Summary: This record represents naturally-occurring readthrough
            transcription between upstream GeneID:101410538 (MMP24 antisense
            RNA 1) and the ER degradation enhancing alpha-mannosidase like
            protein 2 (EDEM2) gene. Readthrough transcripts may encode proteins
            similar to those encoded by the EDEM2 gene. [provided by RefSeq,
            Aug 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.22626.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 55741,
                                      101410538
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AL121753.32        87766-87842         c
            78-218              AL121753.32        81725-81865         c
            219-329             AL121753.32        45801-45911         c
            330-579             AL121753.32        27532-27781         c
            580-664             AL356652.19        25624-25708         c
            665-775             AL356652.19        6662-6772           c
            776-815             AL356652.19        4816-4855           c
            816-921             AL356652.19        2210-2315           c
            922-1047            AL135844.9         34644-34769         c
            1048-1259           AL135844.9         31502-31713         c
            1260-1401           AL135844.9         28406-28547         c
            1402-1526           AL135844.9         23015-23139         c
            1527-1671           AL135844.9         20654-20798         c
            1672-1793           AL135844.9         15362-15483         c
            1794-2363           AL135844.9         12128-12697         c
FEATURES             Location/Qualifiers
     source          1..2363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..2363
                     /gene="MMP24-AS1-EDEM2"
                     /note="MMP24-AS1-EDEM2 readthrough"
                     /db_xref="GeneID:111089941"
     exon            1..77
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            78..218
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            219..329
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..579
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            580..664
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            665..775
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             681..2294
                     /gene="MMP24-AS1-EDEM2"
                     /codon_start=1
                     /product="ER degradation-enhancing alpha-mannosidase-like
                     protein 2"
                     /protein_id="NP_001341937.1"
                     /db_xref="GeneID:111089941"
                     /translation="MFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDALDTL
                     LILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAG
                     WPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVE
                     FATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDS
                     YFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEA
                     YWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIE
                     SAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAET
                     VKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRL
                     KEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQARERKPA
                     KQKVPLLSCPSQPFTSKLALLGQVFLDSS"
     exon            776..815
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            816..921
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1047
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1259
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1401
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1526
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1671
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1793
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..2363
                     /gene="MMP24-AS1-EDEM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP24-AS1-EDEM2"
                     /note="hexamer: AATAAA"
     polyA_site      2363
                     /gene="MMP24-AS1-EDEM2"
                     /note="major polyA site"
ORIGIN      
        1 ctttccgctc caacgcacgg agggtgaggt cggtacgcgg tggtggcgtc acggcgccag
       61 ctcctcccga cgccgagatt gggtaactca aggcgtccct ggagtacact gaggataagt
      121 gtttgagaaa tgctgtctga aggaatgaag tcagtctatg acaacgtctc tctgccgtga
      181 atcattcctg cagatgaaaa agtgtgactt ggcagctgcc aatctaaaaa gggccctcag
      241 gatcgcccac aatgcccagc ttagcttctt gacaaacacc ttaatggcgc agcattgcct
      301 gttggctgcc atcggctctt gagtgggtgg agccggcgca cgtgcaggag ccaccagtgg
      361 tgcaggagca gttggggtcc atttcaagcc gcggtaaggc tggagatctc aagcgataat
      421 ggagagacag caaggcgcac gtggacggcg tgttcaccaa ttaccaaact ttttgacctg
      481 agcaactaga agaatggagt tgccattatt tgacacaaag aagactgcag gagggacagg
      541 tttgagtaga aatatgaaga gctcacccaa gtggatgtga tgaggacaca gaagcacaga
      601 acagggaact gagctgctca aagacatcca gctagtaaaa ggcagagctg ggactcatac
      661 ccagggagcg agtcaaggcc atgttctacc acgcctacga cagctacctg gagaatgcct
      721 ttcccttcga tgagctgcga cctctcacct gtgacgggca cgacacctgg ggcagttttt
      781 ctctgactct aattgatgca ctggacacct tgctgatttt ggggaatgtc tcagaattcc
      841 aaagagtggt tgaagtgctc caggacagcg tggactttga tattgatgtg aacgcctctg
      901 tgtttgaaac aaacattcga gtggtaggag gactcctgtc tgctcatctg ctctccaaga
      961 aggctggggt ggaagtagag gctggatggc cctgttccgg gcctctcctg agaatggctg
     1021 aggaggcggc ccgaaaactc ctcccagcct ttcagacccc cactggcatg ccatatggaa
     1081 cagtgaactt acttcatggc gtgaacccag gagagacccc tgtcacctgt acggcaggga
     1141 ttgggacctt cattgttgaa tttgccaccc tgagcagcct cactggtgac ccggtgttcg
     1201 aagatgtggc cagagtggct ttgatgcgcc tctgggagag ccggtcagat atcgggctgg
     1261 tcggcaacca cattgatgtg ctcactggca agtgggtggc ccaggacgca ggcatcgggg
     1321 ctggcgtgga ctcctacttt gagtacttgg tgaaaggagc catcctgctt caggataaga
     1381 agctcatggc catgttccta gagtataaca aagccatccg gaactacacc cgcttcgatg
     1441 actggtacct gtgggttcag atgtacaagg ggactgtgtc catgccagtc ttccagtcct
     1501 tggaggccta ctggcctggt cttcagagcc tcattggaga cattgacaat gccatgagga
     1561 ccttcctcaa ctactacact gtatggaagc agtttggggg gctcccggaa ttctacaaca
     1621 ttcctcaggg atacacagtg gagaagcgag agggctaccc acttcggcca gaacttattg
     1681 aaagcgcaat gtacctctac cgtgccacgg gggatcccac cctcctagaa ctcggaagag
     1741 atgctgtgga atccattgaa aaaatcagca aggtggagtg cggatttgca acaatcaaag
     1801 atctgcgaga ccacaagctg gacaaccgca tggagtcgtt cttcctggcc gagactgtga
     1861 aatacctcta cctcctgttt gacccaacca acttcatcca caacaatggg tccaccttcg
     1921 acgcggtgat caccccctat ggggagtgca tcctgggggc tggggggtac atcttcaaca
     1981 cagaagctca ccccatcgac cctgccgccc tgcactgctg ccagaggctg aaggaagagc
     2041 agtgggaggt ggaggacttg atgagggaat tctactctct caaacggagc aggtcgaaat
     2101 ttcagaaaaa cactgttagt tcggggccat gggaacctcc agcaaggcca ggaacactct
     2161 tctcaccaga aaaccatgac caggcaaggg agaggaagcc tgccaaacag aaggtcccac
     2221 ttctcagctg ccccagtcag cccttcacct ccaagttggc attactggga caggttttcc
     2281 tagactcctc ataaccactg gataattttt ttatttttat ttttttgagg ctaaactata
     2341 ataaattgct tttggctatc ata
//
