LOCUS       NM_002429               3236 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens matrix metallopeptidase 19 (MMP19), transcript variant
            1, mRNA.
ACCESSION   NM_002429 XM_001129299
VERSION     NM_002429.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3236)
  AUTHORS   Fan,Y., Zheng,C., Ma,R., Wang,J., Yang,S. and Ye,Q.
  TITLE     MMP19 Variants in Familial and Sporadic Idiopathic Pulmonary
            Fibrosis
  JOURNAL   Lung 201 (6), 571-580 (2023)
   PUBMED   37971547
  REMARK    GeneRIF: MMP19 Variants in Familial and Sporadic Idiopathic
            Pulmonary Fibrosis.
REFERENCE   2  (bases 1 to 3236)
  AUTHORS   Zhao,W., Wang,L., Yang,J., Chen,X., Guo,X., Xu,K., Wang,N.,
            Zhao,W., Xia,C., Lian,H., Rosas,I. and Yu,G.
  TITLE     Endothelial cell-derived MMP19 promotes pulmonary fibrosis by
            inducing E(nd)MT and monocyte infiltration
  JOURNAL   Cell Commun Signal 21 (1), 56 (2023)
   PUBMED   36915092
  REMARK    GeneRIF: Endothelial cell-derived MMP19 promotes pulmonary fibrosis
            by inducing E(nd)MT and monocyte infiltration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3236)
  AUTHORS   Horak,P., Suhaj,P., Matej,R. and Cervinkova,M.
  TITLE     Potential novel markers in IBD and CRC diagnostics. Are MMP-19 and
            RAGE promising candidates?
  JOURNAL   Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 166 (4),
            380-385 (2022)
   PUBMED   35352707
  REMARK    GeneRIF: Potential novel markers in IBD and CRC diagnostics. Are
            MMP-19 and RAGE promising candidates?
REFERENCE   4  (bases 1 to 3236)
  AUTHORS   Mueller,M.S., Mauch,S. and Sedlacek,R.
  TITLE     Structure of the human MMP-19 gene
  JOURNAL   Gene 252 (1-2), 27-37 (2000)
   PUBMED   10903435
REFERENCE   5  (bases 1 to 3236)
  AUTHORS   Murphy,G., Knauper,V., Cowell,S., Hembry,R., Stanton,H., Butler,G.,
            Freije,J., Pendas,A.M. and Lopez-Otin,C.
  TITLE     Evaluation of some newer matrix metalloproteinases
  JOURNAL   Ann N Y Acad Sci 878, 25-39 (1999)
   PUBMED   10415718
  REMARK    Review article
REFERENCE   6  (bases 1 to 3236)
  AUTHORS   Yang,M. and Kurkinen,M.
  TITLE     Cloning and characterization of a novel matrix metalloproteinase
            (MMP), CMMP, from chicken embryo fibroblasts. CMMP, Xenopus XMMP,
            and human MMP19 have a conserved unique cysteine in the catalytic
            domain
  JOURNAL   J Biol Chem 273 (28), 17893-17900 (1998)
   PUBMED   9651395
REFERENCE   7  (bases 1 to 3236)
  AUTHORS   Sedlacek,R., Mauch,S., Kolb,B., Schatzlein,C., Eibel,H.,
            Peter,H.H., Schmitt,J. and Krawinkel,U.
  TITLE     Matrix metalloproteinase MMP-19 (RASI-1) is expressed on the
            surface of activated peripheral blood mononuclear cells and is
            detected as an autoantigen in rheumatoid arthritis
  JOURNAL   Immunobiology 198 (4), 408-423 (1998)
   PUBMED   9562866
REFERENCE   8  (bases 1 to 3236)
  AUTHORS   Kolb,C., Mauch,S., Peter,H.H., Krawinkel,U. and Sedlacek,R.
  TITLE     The matrix metalloproteinase RASI-1 is expressed in synovial blood
            vessels of a rheumatoid arthritis patient
  JOURNAL   Immunol Lett 57 (1-3), 83-88 (1997)
   PUBMED   9232430
REFERENCE   9  (bases 1 to 3236)
  AUTHORS   Pendas,A.M., Knauper,V., Puente,X.S., Llano,E., Mattei,M.G.,
            Apte,S., Murphy,G. and Lopez-Otin,C.
  TITLE     Identification and characterization of a novel human matrix
            metalloproteinase with unique structural characteristics,
            chromosomal location, and tissue distribution
  JOURNAL   J Biol Chem 272 (7), 4281-4286 (1997)
   PUBMED   9020145
REFERENCE   10 (bases 1 to 3236)
  AUTHORS   Cossins,J., Dudgeon,T.J., Catlin,G., Gearing,A.J. and Clements,J.M.
  TITLE     Identification of MMP-18, a putative novel human matrix
            metalloproteinase
  JOURNAL   Biochem Biophys Res Commun 228 (2), 494-498 (1996)
   PUBMED   8920941
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023055.40.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002429.5.
            
            Summary: This gene encodes a member of a family of proteins that
            are involved in the breakdown of extracellular matrix in normal
            physiological processes, such as embryonic development,
            reproduction, and tissue remodeling, as well as in disease
            processes, such as arthritis and metastasis. The encoded protein is
            secreted as an inactive proprotein, which is activated upon
            cleavage by extracellular proteases. Alternative splicing results
            in multiple transcript variants for this gene. [provided by RefSeq,
            Jan 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1, also known as
            rasi-1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U37791.1, BC050368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322569.9/ ENSP00000313437.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AC023055.40        54890-55082         c
            194-279             AC023055.40        54499-54584         c
            280-410             AC023055.40        53252-53382         c
            411-626             AC023055.40        52813-53028         c
            627-872             AC023055.40        51642-51887         c
            873-1001            AC023055.40        50752-50880         c
            1002-1166           AC023055.40        49989-50153         c
            1167-1294           AC023055.40        49701-49828         c
            1295-3236           AC023055.40        47579-49520         c
FEATURES             Location/Qualifiers
     source          1..3236
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..3236
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /note="matrix metallopeptidase 19"
                     /db_xref="GeneID:4327"
                     /db_xref="HGNC:HGNC:7165"
                     /db_xref="MIM:601807"
     exon            1..193
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1633
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; matrix metalloproteinase-19; matrix
                     metalloproteinase-18; matrix metalloproteinase RASI;
                     matrix metalloproteinase-beta19"
                     /codon_start=1
                     /product="matrix metalloproteinase-19 isoform 1
                     preproprotein"
                     /protein_id="NP_002420.1"
                     /db_xref="CCDS:CCDS8895.1"
                     /db_xref="GeneID:4327"
                     /db_xref="HGNC:HGNC:7165"
                     /db_xref="MIM:601807"
                     /translation="MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEG
                     SNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLG
                     RWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHG
                     RQSSYCSNTFDGPGRVLAHADIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHAL
                     GLGHSRYSQALMAPVYEGYRPHFKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVP
                     PVPTEPSPMPDPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLP
                     GNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNRVEPNLDAALYWPLNQKV
                     FLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWR
                     LNQQLRVEKGYPRNISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTLSATETTFEY
                     "
     exon            194..279
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..410
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..626
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..872
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1001
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1166
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1294
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..3236
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2218..2223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /note="hexamer: AATAAA"
     polyA_site      2243
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /note="major polyA site"
     regulatory      3215..3220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
                     /note="hexamer: AATAAA"
     polyA_site      3236
                     /gene="MMP19"
                     /gene_synonym="CODA; MMP18; RASI-1"
ORIGIN      
        1 agaactgggg gtaagagccc ctctgcctag cactgctccc ccaaggctcc cagaaatctc
       61 aggtcagagg cacggacagc ctctggagct ctcgtctggt gggaccatga actgccagca
      121 gctgtggctg ggcttcctac tccccatgac agtctcaggc cgggtcctgg ggcttgcaga
      181 ggtggcgcct gtggactacc tgtcacaata tgggtaccta cagaagcctc tagaaggatc
      241 taataacttc aagccagaag atatcaccga ggctctgaga gcttttcagg aagcatctga
      301 acttccagtc tcaggtcagc tggatgatgc cacaagggcc cgcatgaggc agcctcgttg
      361 tggcctagag gatcccttca accagaagac ccttaaatac ctgttgctgg gccgctggag
      421 aaagaagcac ctgactttcc gcatcttgaa cctgccctcc acccttccac cccacacagc
      481 ccgggcagcc ctgcgtcaag ccttccagga ctggagcaat gtggctccct tgaccttcca
      541 agaggtgcag gctggtgcgg ctgacatccg cctctccttc catggccgcc aaagctcgta
      601 ctgttccaat acttttgatg ggcctgggag agtcctggcc catgccgaca tcccagagct
      661 gggcagtgtg cacttcgacg aagacgagtt ctggactgag gggacctacc gtggggtgaa
      721 cctgcgcatc attgcagccc atgaagtggg ccatgctctg gggcttgggc actcccgata
      781 ttcccaggcc ctcatggccc cagtctacga gggctaccgg ccccacttta agctgcaccc
      841 agatgatgtg gcagggatcc aggctctcta tggcaagaag agtccagtga taagggatga
      901 ggaagaagaa gagacagagc tgcccactgt gcccccagtg cccacagaac ccagtcccat
      961 gccagaccct tgcagtagtg aactggatgc catgatgctg gggccccgtg ggaagaccta
     1021 tgctttcaag ggggactatg tgtggactgt atcagattca ggaccgggcc ccttgttccg
     1081 agtgtctgcc ctttgggagg ggctccccgg aaacctggat gctgctgtct actcgcctcg
     1141 aacacaatgg attcacttct ttaagggaga caaggtgtgg cgctacatta atttcaagat
     1201 gtctcctggc ttccccaaga agctgaatag ggtagaacct aacctggatg cagctctcta
     1261 ttggcctctc aaccaaaagg tgttcctctt taagggctcc gggtactggc agtgggacga
     1321 gctagcccga actgacttca gcagctaccc caaaccaatc aagggtttgt ttacgggagt
     1381 gccaaaccag ccctcggctg ctatgagttg gcaagatggc cgagtctact tcttcaaggg
     1441 caaagtctac tggcgcctca accagcagct tcgagtagag aaaggctatc ccagaaatat
     1501 ttcccacaac tggatgcact gtcgtccccg gactatagac actaccccat caggtgggaa
     1561 taccactccc tcaggtacgg gcataacctt ggataccact ctctcagcca cagaaaccac
     1621 gtttgaatac tgactgctca cccacagaca caatcttgga cattaacccc tgaggctcca
     1681 ccacccaccc tttcatttcc cccccagaag cctaaggcct aatagctgaa tgaaatacct
     1741 gtctgctcag tagaaccttg caggtgctgt agcaggcgca agaccgtaga tctcaggcct
     1801 ctaacacttc caactccagc caccactttc ctgtgcattt tcactcctga gaagtgctcc
     1861 cctaactcag atcccctaac ttagatttgg cccccaactc catttcctgt ctgtcttaga
     1921 cagcccttcc aactgtgtca tctcttctct ggaggtcaat ggtggaggga gatgcctggg
     1981 tcctgttctt cctacataaa atgcaagaaa acagcatggc cagtaaactg agcaagggcc
     2041 ttggaatcct tgagaatcac atttatgtgc ttatgattac gggcaagcta attaaccttg
     2101 ttgaatctca gattccccat ttgcaacatt aggttaagac cagtactgca ggattgttgc
     2161 actaaatgaa atactgtatg tgaagtgcct ggcacagtgt ctggtacatt tgtgtttaat
     2221 aaaagctaac tccatgttca taagagagga ctgaacagct cttcctctag ctgtctggct
     2281 gtataactct tacagtagtc tgtataataa gggcatctct attagatctt taggggacag
     2341 aggatttgtc aagatggtta gctctttgtt ttggggtgca gagaaagaaa agagcagcaa
     2401 cagcagaggc tggactccct ggttcagtat ttaatgccat tttattcaca tgctcccatg
     2461 ttctccctcc ctcccattgt agccttgctg cccaggggag ggatatgtct tcctttatgc
     2521 atctgggaaa ccaggaacag accctgcgca ggagagtcag agggggaaga gttagaatgg
     2581 gtcagtggct ggaacaaagt tctggttaag gaggaaatta gtgccaccca cggtgagaag
     2641 cagagaaggc acttgcatcc tatgcagccc tgaagaccag gctcctttgg gcaaaaggca
     2701 agactctggc aggtgggtca atgctctctc cttggagcaa gaagccagct tttggggaag
     2761 gcaggtcctg aggcaggcac tgccctgtgg tcttccccag gttgaggaga gaagtggaag
     2821 ccccatggaa gacagtgctc ccagctgagg taggaggcgg aggtgggggt gggggtagtt
     2881 taagcctatg gggcccaggg ggaaaggcca aacagaaacc caactacccc ctaatgaagg
     2941 gcctggaggt tggggtatct tggagctcct cagagccctt cttcccatca aaaaggtatc
     3001 aaatgccttg gaagctccct gatcctacaa aacaaaaaaa tgcttatttt taccactgtg
     3061 aggcaagctg aggtgaacat ttaaaaggct atttcaagac gaggtgcggt ggctataatc
     3121 ctagcacttt gggaggctga agcaggagga tcacttgagc ccaggagttc aagaccagct
     3181 tgggcaacat agggagaccc tgtctctgca aaaaaataaa aacgaataca taaaaa
//
