LOCUS       NM_016155               2411 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens matrix metallopeptidase 17 (MMP17), transcript variant
            1, mRNA.
ACCESSION   NM_016155 XM_942715 XM_946329 XM_946330
VERSION     NM_016155.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2411)
  AUTHORS   Shirazkeytabar,K., Razavi,S.A., Abooshahab,R., Salehipour,P.,
            Akbarzadeh,M., Soroush,A., Hedayati,M. and Nasiri,S.
  TITLE     Elevated Plasma Levels of MT4-MMP and MT6-MMP; A New Observation in
            Patients with Thyroid Nodules
  JOURNAL   Arch Iran Med 26 (6), 338-345 (2023)
   PUBMED   38310435
  REMARK    GeneRIF: Elevated Plasma Levels of MT4-MMP and MT6-MMP; A New
            Observation in Patients with Thyroid Nodules.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2411)
  AUTHORS   Xiao,C., Wang,Y., Cheng,Q. and Fan,Y.
  TITLE     Increased expression of MMP17 predicts poor clinical outcomes in
            epithelial ovarian cancer patients
  JOURNAL   Medicine (Baltimore) 101 (34), e30279 (2022)
   PUBMED   36042626
  REMARK    GeneRIF: Increased expression of MMP17 predicts poor clinical
            outcomes in epithelial ovarian cancer patients.
REFERENCE   3  (bases 1 to 2411)
  AUTHORS   Yan,X., Cao,N., Chen,Y., Lan,H.Y., Cha,J.H., Yang,W.H. and
            Yang,M.H.
  TITLE     MT4-MMP promotes invadopodia formation and cell motility in FaDu
            head and neck cancer cells
  JOURNAL   Biochem Biophys Res Commun 522 (4), 1009-1014 (2020)
   PUBMED   31813546
  REMARK    GeneRIF: MT4-MMP promotes invadopodia formation and cell motility
            in FaDu head and neck cancer cells.
REFERENCE   4  (bases 1 to 2411)
  AUTHORS   Cervantes-Garduno,A., Zampedri,C., Espinosa,M., Maldonado,V.,
            Melendez-Zajgla,J. and Ceballos-Cancino,G.
  TITLE     MT4-MMP Modulates the Expression of miRNAs in Breast Cancer Cells
  JOURNAL   Arch Med Res 49 (7), 471-478 (2018)
   PUBMED   30792164
  REMARK    GeneRIF: In breast cancer cells, the overexpression of MT4-MMP
            modulates the expression of microRNAs involved in several
            biological processes associated with tumor formation and
            progression and with clinical relevance.
REFERENCE   5  (bases 1 to 2411)
  AUTHORS   Clemente,C., Rius,C., Alonso-Herranz,L., Martin-Alonso,M.,
            Pollan,A., Camafeita,E., Martinez,F., Mota,R.A., Nunez,V.,
            Rodriguez,C., Seiki,M., Martinez-Gonzalez,J., Andres,V., Ricote,M.
            and Arroyo,A.G.
  TITLE     MT4-MMP deficiency increases patrolling monocyte recruitment to
            early lesions and accelerates atherosclerosis
  JOURNAL   Nat Commun 9 (1), 910 (2018)
   PUBMED   29500407
  REMARK    GeneRIF: MT4-MMP targeting may constitute a novel strategy to boost
            patrolling monocyte activity in early inflammation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2411)
  AUTHORS   Kajita,M., Kinoh,H., Ito,N., Takamura,A., Itoh,Y., Okada,A.,
            Sato,H. and Seiki,M.
  TITLE     Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded
            by a novel major transcript: isolation of complementary DNA clones
            for human and mouse mt4-mmp transcripts
  JOURNAL   FEBS Lett 457 (3), 353-356 (1999)
   PUBMED   10471807
REFERENCE   7  (bases 1 to 2411)
  AUTHORS   Kolkenbrock,H., Essers,L., Ulbrich,N. and Will,H.
  TITLE     Biochemical characterization of the catalytic domain of
            membrane-type 4 matrix metalloproteinase
  JOURNAL   Biol Chem 380 (9), 1103-1108 (1999)
   PUBMED   10543448
REFERENCE   8  (bases 1 to 2411)
  AUTHORS   Nagase,H. and Woessner,J.F. Jr.
  TITLE     Matrix metalloproteinases
  JOURNAL   J Biol Chem 274 (31), 21491-21494 (1999)
   PUBMED   10419448
  REMARK    Review article
REFERENCE   9  (bases 1 to 2411)
  AUTHORS   Puente,X.S., Pendas,A.M., Llano,E. and Lopez-Otin,C.
  TITLE     Localization of the human membrane type 4-matrix metalloproteinase
            gene (MMP17) to chromosome 12q24
  JOURNAL   Genomics 54 (3), 578-579 (1998)
   PUBMED   9878265
REFERENCE   10 (bases 1 to 2411)
  AUTHORS   Puente,X.S., Pendas,A.M., Llano,E., Velasco,G. and Lopez-Otin,C.
  TITLE     Molecular cloning of a novel membrane-type matrix metalloproteinase
            from a human breast carcinoma
  JOURNAL   Cancer Res 56 (5), 944-949 (1996)
   PUBMED   8640782
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC131009.7.
            
            On Nov 23, 2018 this sequence version replaced NM_016155.6.
            
            Summary: This gene encodes a member of the peptidase M10 family and
            membrane-type subfamily of matrix metalloproteinases (MMPs).
            Proteins in this family are involved in the breakdown of
            extracellular matrix in normal physiological processes, such as
            embryonic development, reproduction, and tissue remodeling, as well
            as in disease processes, such as arthritis and metastasis. Members
            of this subfamily contain a transmembrane domain suggesting that
            these proteins are expressed at the cell surface rather than
            secreted. The encoded preproprotein is proteolytically processed to
            generate the mature protease. This protein is unique among the
            membrane-type matrix metalloproteinases in that it is anchored to
            the cell membrane via a glycosylphosphatidylinositol (GPI) anchor.
            Elevated expression of the encoded protein has been observed in
            osteoarthritis and multiple human cancers. [provided by RefSeq, Jan
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045610.1, AB021225.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360564.5/ ENSP00000353767.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AC131009.7         46044-46304
            262-394             AC131009.7         55846-55978
            395-524             AC131009.7         56263-56392
            525-808             AC131009.7         58224-58507
            809-985             AC131009.7         59275-59451
            986-1070            AC131009.7         61648-61732
            1071-1153           AC131009.7         62769-62851
            1154-1306           AC131009.7         62948-63100
            1307-1564           AC131009.7         67453-67710
            1565-2411           AC131009.7         68576-69422
FEATURES             Location/Qualifiers
     source          1..2411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..2411
                     /gene="MMP17"
                     /gene_synonym="MMP-17; MT4-MMP; MT4MMP; MTMMP4"
                     /note="matrix metallopeptidase 17"
                     /db_xref="GeneID:4326"
                     /db_xref="HGNC:HGNC:7163"
                     /db_xref="MIM:602285"
     exon            1..261
                     /gene="MMP17"
                     /gene_synonym="MMP-17; MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1914
                     /gene="MMP17"
                     /gene_synonym="MMP-17; MT4-MMP; MT4MMP; MTMMP4"
                     /EC_number="3.4.24.-"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; membrane-type matrix metalloproteinase 4;
                     matrix metalloproteinase 17 (membrane-inserted);
                     membrane-type-4 matrix metalloproteinase; matrix
                     metalloproteinase-17; MT-MMP 4; matrix metallopeptidase 17
                     (membrane-inserted)"
                     /codon_start=1
                     /product="matrix metalloproteinase-17 isoform 1 precursor"
                     /protein_id="NP_057239.4"
                     /db_xref="CCDS:CCDS31927.1"
                     /db_xref="GeneID:4326"
                     /db_xref="HGNC:HGNC:7163"
                     /db_xref="MIM:602285"
                     /translation="MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAP
                     RAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATL
                     ALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALM
                     YYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHT
                     AGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGD
                     PLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCST
                     HFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERT
                     SDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWAHNDRTYFFKDQL
                     YWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEV
                     APGYPQSTARDWLVCGDSQADGSVAAGVDAAEGPRAPPGQHDQSRSEDGYEVCSCTSG
                     ASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQALTL"
     exon            262..394
                     /gene="MMP17"
                     /gene_synonym="MMP-17; MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            395..524
                     /gene="MMP17"
                     /gene_synonym="MMP-17; MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            525..808
                     /gene="MMP17"
                     /gene_synonym="MMP-17; MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            809..985
                     /gene="MMP17"
                     /gene_synonym="MMP-17; MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1070
                     /gene="MMP17"
                     /gene_synonym="MMP-17; MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1153
                     /gene="MMP17"
                     /gene_synonym="MMP-17; MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1306
                     /gene="MMP17"
                     /gene_synonym="MMP-17; MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1564
                     /gene="MMP17"
                     /gene_synonym="MMP-17; MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..2411
                     /gene="MMP17"
                     /gene_synonym="MMP-17; MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2411
                     /gene="MMP17"
                     /gene_synonym="MMP-17; MT4-MMP; MT4MMP; MTMMP4"
                     /note="major polyA site"
ORIGIN      
        1 agtccggcgg gggcgccgcg gagagcggag ggcgccgggc tgcggaacgc gaagcggagg
       61 gcgcgggacc ctgcacgccg cccgcgggcc catgtgagcg ccatgcggcg ccgcgcagcc
      121 cggggacccg gcccgccgcc cccagggccc ggactctcgc ggctgccgct gccgctgctg
      181 ctgctgctgg cgctggggac ccgcgggggc tgcgccgcgc ccgcacccgc gccgcgcgcc
      241 gaggacctca gcctgggagt ggagtggcta agcaggttcg gttacctgcc cccggctgac
      301 cccacaacag ggcagctgca gacgcaagag gagctgtcta aggccatcac agccatgcag
      361 cagtttggtg gcctggaggc caccggcatc ctggacgagg ccaccctggc cctgatgaaa
      421 accccacgct gctccctgcc agacctccct gtcctgaccc aggctcgcag gagacgccag
      481 gctccagccc ccaccaagtg gaacaagagg aacctgtcgt ggagggtccg gacgttccca
      541 cgggactcac cactggggca cgacacggtg cgtgcactca tgtactacgc cctcaaggtc
      601 tggagcgaca ttgcgcccct gaacttccac gaggtggcgg gcagcgccgc cgacatccag
      661 atcgacttct ccaaggccga ccataacgac ggctacccct tcgacggccc cggcggcacc
      721 gtggcccacg ccttcttccc cggccaccac cacaccgccg gggacaccca ctttgacgat
      781 gacgaggcct ggaccttccg ctcctcggat gcccacggga tggacctgtt tgcagtggct
      841 gtccacgagt ttggccacgc cattgggtta agccatgtgg ccgctgcaca ctccatcatg
      901 cggccgtact accagggccc ggtgggtgac ccgctgcgct acgggctccc ctacgaggac
      961 aaggtgcgcg tctggcagct gtacggtgtg cgggagtctg tgtctcccac ggcgcagccc
     1021 gaggagcctc ccctgctgcc ggagccccca gacaaccggt ccagcgcccc gcccaggaag
     1081 gacgtgcccc acagatgcag cactcacttt gacgcggtgg cccagatccg gggtgaagct
     1141 ttcttcttca aaggcaagta cttctggcgg ctgacgcggg accggcacct ggtgtccctg
     1201 cagccggcac agatgcaccg cttctggcgg ggcctgccgc tgcacctgga cagcgtggac
     1261 gccgtgtacg agcgcaccag cgaccacaag atcgtcttct ttaaaggaga caggtactgg
     1321 gtgttcaagg acaataacgt agaggaagga tacccgcgcc ccgtctccga cttcagcctc
     1381 ccgcctggcg gcatcgacgc tgccttctcc tgggcccaca atgacaggac ttatttcttt
     1441 aaggaccagc tgtactggcg ctacgatgac cacacgaggc acatggaccc cggctacccc
     1501 gcccagagcc ccctgtggag gggtgtcccc agcacgctgg acgacgccat gcgctggtcc
     1561 gacggtgcct cctacttctt ccgtggccag gagtactgga aagtgctgga tggcgagctg
     1621 gaggtggcac ccgggtaccc acagtccacg gcccgggact ggctggtgtg tggagactca
     1681 caggccgatg gatctgtggc tgcgggcgtg gacgcggcag aggggccccg cgcccctcca
     1741 ggacaacatg accagagccg ctcggaggac ggttacgagg tctgctcatg cacctctggg
     1801 gcatcctctc ccccgggggc cccaggccca ctggtggctg ccaccatgct gctgctgctg
     1861 ccgccactgt caccaggcgc cctgtggaca gcggcccagg ccctgacgct atgacacaca
     1921 gcgcgagccc atgagaggac agaggcggtg ggacagcctg gccacagagg gcaaggactg
     1981 tgccggagtc cctgggggag gtgctggcgc gggatgagga cgggccaccc tggcaccgga
     2041 aggccagcag agggcactgt ccgccagggc tgggcaggct caggtggcaa ggacggagct
     2101 gtcccctagt gagggactgt gttgactgac gagccgaggg gtggccgctc cagaagggtg
     2161 cccagtcagg ccgcaccgcc gccagcctcc tccggccctg gagggagcat ctcgggctgg
     2221 gggcccaccc ctctctgtgc cggcgccacc aaccccaccc acactgctgc ctggtgctcc
     2281 cgccggccca cagggcctcc gtccccaggt ccccagtggg gcagccctcc ccacagacga
     2341 gccccccaca tggtgccgcg gcacgtcccc cctgtgacgc gttccagacc aacatgacct
     2401 ctccctgctt t
//
