LOCUS       NM_005941              11551 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens matrix metallopeptidase 16 (MMP16), mRNA.
ACCESSION   NM_005941
VERSION     NM_005941.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11551)
  AUTHORS   Lin,Y., Shi,J., Shi,B. and Jia,Z.
  TITLE     MMP16 as NSCL +/- P Susceptible Gene in Western Han Chinese
  JOURNAL   Cleft Palate Craniofac J 60 (12), 1625-1631 (2023)
   PUBMED   36120833
  REMARK    GeneRIF: MMP16 as NSCL +/- P Susceptible Gene in Western Han
            Chinese.
REFERENCE   2  (bases 1 to 11551)
  AUTHORS   Yan,P., Wang,J., Liu,H., Liu,X., Fu,R. and Feng,J.
  TITLE     M1 macrophage-derived exosomes containing miR-150 inhibit glioma
            progression by targeting MMP16
  JOURNAL   Cell Signal 108, 110731 (2023)
   PUBMED   37244635
  REMARK    GeneRIF: M1 macrophage-derived exosomes containing miR-150 inhibit
            glioma progression by targeting MMP16.
REFERENCE   3  (bases 1 to 11551)
  AUTHORS   Pietrzak,J., Szmajda-Krygier,D., Wosiak,A., Swiechowski,R.,
            Michalska,K., Mirowski,M., Zebrowska-Nawrocka,M., Lochowski,M. and
            Balcerczak,E.
  TITLE     Changes in the expression of membrane type-matrix
            metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during
            treatment and their potential impact on the survival of patients
            with non-small cell lung cancer (NSCLC)
  JOURNAL   Biomed Pharmacother 146, 112559 (2022)
   PUBMED   35062057
  REMARK    GeneRIF: Changes in the expression of membrane type-matrix
            metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during
            treatment and their potential impact on the survival of patients
            with non-small cell lung cancer (NSCLC).
REFERENCE   4  (bases 1 to 11551)
  AUTHORS   Zhang,Y., Zeng,S. and Wang,T.
  TITLE     Circular RNA hsa_circ_0002360 promotes non-small cell lung cancer
            progression through upregulating matrix metalloproteinase 16 and
            sponging multiple micorRNAs
  JOURNAL   Bioengineered 12 (2), 12767-12777 (2021)
   PUBMED   34747300
  REMARK    GeneRIF: Circular RNA hsa_circ_0002360 promotes non-small cell lung
            cancer progression through upregulating matrix metalloproteinase 16
            and sponging multiple micorRNAs.
REFERENCE   5  (bases 1 to 11551)
  AUTHORS   Duan,X.J., Zhang,X., Ding,N., Zhang,J.Y. and Chen,Y.P.
  TITLE     LncRNA NEAT1 regulates MMP-16 by targeting miR-200a/b to aggravate
            inflammation in asthma
  JOURNAL   Autoimmunity 54 (7), 439-449 (2021)
   PUBMED   34448644
  REMARK    GeneRIF: LncRNA NEAT1 regulates MMP-16 by targeting miR-200a/b to
            aggravate inflammation in asthma.
REFERENCE   6  (bases 1 to 11551)
  AUTHORS   Matsumoto,S., Katoh,M., Saito,S., Watanabe,T. and Masuho,Y.
  TITLE     Identification of soluble type of membrane-type matrix
            metalloproteinase-3 formed by alternatively spliced mRNA
  JOURNAL   Biochim Biophys Acta 1354 (2), 159-170 (1997)
   PUBMED   9396633
REFERENCE   7  (bases 1 to 11551)
  AUTHORS   Shofuda,K., Yasumitsu,H., Nishihashi,A., Miki,K. and Miyazaki,K.
  TITLE     Expression of three membrane-type matrix metalloproteinases
            (MT-MMPs) in rat vascular smooth muscle cells and characterization
            of MT3-MMPs with and without transmembrane domain
  JOURNAL   J Biol Chem 272 (15), 9749-9754 (1997)
   PUBMED   9092507
REFERENCE   8  (bases 1 to 11551)
  AUTHORS   Mattei,M.G., Roeckel,N., Olsen,B.R. and Apte,S.S.
  TITLE     Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene
            family, MMP14, MMP15, and MMP16, localize to human chromosomes 14,
            16, and 8, respectively
  JOURNAL   Genomics 40 (1), 168-169 (1997)
   PUBMED   9070935
REFERENCE   9  (bases 1 to 11551)
  AUTHORS   Sato,H., Tanaka,M., Takino,T., Inoue,M. and Seiki,M.
  TITLE     Assignment of the human genes for membrane-type-1, -2, and -3
            matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2,
            16q12.2-q21, and 8q21, respectively, by in situ hybridization
  JOURNAL   Genomics 39 (3), 412-413 (1997)
   PUBMED   9119382
REFERENCE   10 (bases 1 to 11551)
  AUTHORS   Takino,T., Sato,H., Shinagawa,A. and Seiki,M.
  TITLE     Identification of the second membrane-type matrix metalloproteinase
            (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a
            unique membrane-type subclass in the MMP family
  JOURNAL   J Biol Chem 270 (39), 23013-23020 (1995)
   PUBMED   7559440
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA575789.1, D83646.1,
            AC037450.6 and AL832595.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005941.4.
            
            Summary: Proteins of the matrix metalloproteinase (MMP) family are
            involved in the breakdown of extracellular matrix in normal
            physiological processes, such as embryonic development,
            reproduction, and tissue remodeling, as well as in disease
            processes, such as arthritis and metastasis. Most MMP's are
            secreted as inactive proproteins which are activated when cleaved
            by extracellular proteinases. The encoded protein activates MMP2 by
            cleavage. This gene was once referred to as MT-MMP2, but was
            renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2555629.1,
                                           SRR11853566.26704.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286614.11/ ENSP00000286614.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               DA575789.1         6-282
            278-1971            D83646.1           1-1694
            1972-6327           AC037450.6         85635-89990         c
            6328-6330           AL832595.1         6289-6291
            6331-11551          AC037450.6         80411-85631         c
FEATURES             Location/Qualifiers
     source          1..11551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..11551
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /note="matrix metallopeptidase 16"
                     /db_xref="GeneID:4325"
                     /db_xref="HGNC:HGNC:7162"
                     /db_xref="MIM:602262"
     exon            1..409
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..2101
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /EC_number="3.4.24.-"
                     /note="membrane-type-3 matrix metalloproteinase;
                     membrane-type matrix metalloproteinase 3; matrix
                     metalloproteinase-16; Putative transmembrane protein
                     C8orf57; MMP-16; MT3MMP; MTMMP3; MT-MMP 3; matrix
                     metallopeptidase 16 (membrane-inserted)"
                     /codon_start=1
                     /product="matrix metalloproteinase-16 precursor"
                     /protein_id="NP_005932.2"
                     /db_xref="CCDS:CCDS6246.1"
                     /db_xref="GeneID:4325"
                     /db_xref="HGNC:HGNC:7162"
                     /db_xref="MIM:602262"
                     /translation="MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVE
                     VWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG
                     VPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQ
                     NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGG
                     DTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNF
                     KLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPS
                     YPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSI
                     DAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGK
                     TYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYW
                     KFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIA
                     IVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV"
     exon            410..558
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            559..681
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            682..986
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1148
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1360
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1499
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1650
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1766
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..11551
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11534..11539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /note="hexamer: AATAAG"
     polyA_site      11551
                     /gene="MMP16"
                     /gene_synonym="C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP"
                     /note="major polyA site"
ORIGIN      
        1 gagccggaac cgccggtgaa cttaggcgcc acgttcccgg tgactgaccc cggaggatgg
       61 tgaacaggaa ctactgctga ccctgtcttc gccgctgcct ctcgggggct gccgagcgcg
      121 gggcccctgt ctcctcccct tgcccggctg tgggtgaacc tgcaggctcc ttacccaccc
      181 ggaggacttt tttttgaaag gaaacgaggg agggagggag agggagagag ggagaaaacg
      241 aaggggagct cgtccatcca ttgaagcaca gttcactatg atcttactca cattcagcac
      301 tggaagacgg ttggatttcg tgcatcattc gggggtgttt ttcttgcaaa ccttgctttg
      361 gattttatgt gctacagtct gcggaacgga gcagtatttc aatgtggagg tttggttaca
      421 aaagtacggc taccttccac cgactgaccc cagaatgtca gtgctgcgct ctgcagagac
      481 catgcagtct gccctagctg ccatgcagca gttctatggc attaacatga caggaaaagt
      541 ggacagaaac acaattgact ggatgaagaa gccccgatgc ggtgtacctg accagacaag
      601 aggtagctcc aaatttcata ttcgtcgaaa gcgatatgca ttgacaggac agaaatggca
      661 gcacaagcac atcacttaca gtataaagaa cgtaactcca aaagtaggag accctgagac
      721 tcgtaaagct attcgccgtg cctttgatgt gtggcagaat gtaactcctc tgacatttga
      781 agaagttccc tacagtgaat tagaaaatgg caaacgtgat gtggatataa ccattatttt
      841 tgcatctggt ttccatgggg acagctctcc ctttgatgga gagggaggat ttttggcaca
      901 tgcctacttc cctggaccag gaattggagg agatacccat tttgactcag atgagccatg
      961 gacactagga aatcctaatc atgatggaaa tgacttattt cttgtagcag tccatgaact
     1021 gggacatgct ctgggattgg agcattccaa tgaccccact gccatcatgg ctccatttta
     1081 ccagtacatg gaaacagaca acttcaaact acctaatgat gatttacagg gcatccagaa
     1141 gatatatggt ccacctgaca agattcctcc acctacaaga cctctaccga cagtgccccc
     1201 acaccgctct attcctccgg ctgacccaag gaaaaatgac aggccaaaac ctcctcggcc
     1261 tccaaccggc agaccctcct atcccggagc caaacccaac atctgtgatg ggaactttaa
     1321 cactctagct attcttcgtc gtgagatgtt tgttttcaag gaccagtggt tttggcgagt
     1381 gagaaacaac agggtgatgg atggataccc aatgcaaatt acttacttct ggcggggctt
     1441 gcctcctagt atcgatgcag tttatgaaaa tagcgacggg aattttgtgt tctttaaagg
     1501 taacaaatat tgggtgttca aggatacaac tcttcaacct ggttaccctc atgacttgat
     1561 aacccttgga agtggaattc cccctcatgg tattgattca gccatttggt gggaggacgt
     1621 cgggaaaacc tatttcttca agggagacag atattggaga tatagtgaag aaatgaaaac
     1681 aatggaccct ggctatccca agccaatcac agtctggaaa gggatccctg aatctcctca
     1741 gggagcattt gtacacaaag aaaatggctt tacgtatttc tacaaaggaa aggagtattg
     1801 gaaattcaac aaccagatac tcaaggtaga acctggatat ccaagatcca tcctcaagga
     1861 ttttatgggc tgtgatggac caacagacag agttaaagaa ggacacagcc caccagatga
     1921 tgtagacatt gtcatcaaac tggacaacac agccagcact gtgaaagcca tagctattgt
     1981 cattccctgc atcttggcct tatgcctcct tgtattggtt tacactgtgt tccagttcaa
     2041 gaggaaagga acaccccgcc acatactgta ctgtaaacgc tctatgcaag agtgggtgtg
     2101 atgtagggtt ttttcttctt tctttctttt gcaggagttt gtggtaactt gagattcaag
     2161 acaagagctg ttatgctgtt tcctagctag gagcaggctt gtggcagcct gattcggggc
     2221 tgacctttca aacccagagg gttgctggtc ctgcacatga gtggaaatac actcatgggg
     2281 aagcttccat gatgcacagt atctgctgtt cttcagtcct ttgtctttct ttgtcattca
     2341 gttctaggcc tttcctctgc acgctcaatg cccagtaaaa tttcaggatt aactaaagaa
     2401 gaggagaaaa agaagaaaag attcttctta aaagtttcta atgttatttt ccttctgaag
     2461 tctgagccca tttctggggg gagaaaaaaa aagcaaatca gaaaacccac ggtttttctt
     2521 tttttctttt tttctttttt tctttttttg ctttaaaaca aagggaaaaa agagtttaaa
     2581 caaaaaaccc acaattgaac ttccaggaaa gtgtgaagac ccaaaacagc tttgtctcca
     2641 aagaagatag ctctctgact gctttggata gtctcctacg caccattttg tcaggtggga
     2701 gatttggaat acacatgcag gacgttagac tgttgggaca gccattttcc aacaaccaag
     2761 gggccaaaat atctgcaata tagtaacagc cttaataata catccatttt tcgttttata
     2821 cagctgttct cagctatgtc ctcagtgttt catcgcattt atattcatag ctattttcaa
     2881 acacgacctt ttaattgttt ttgaagtatt tctaaacccc ttctttccac cttactcctc
     2941 catcattgtg ataatcttcc caagttgtat taggccattg ccccaggcct tccatgggtc
     3001 tgtcaggaat attcgttaca aagcagagca agaagcagta tgtctctgaa gtggattaca
     3061 gtggcagtta ttttacaagg atttgtgaca ctagtaacat acccgtgtaa ccctttgaga
     3121 actatcagac cagctttcag agtcttagga ttgtcggtct tgcgatctga taaattatag
     3181 aactgggcaa tggtaaaaac agtcacaagt tcaagaagtt caggttttta aaacagatat
     3241 cctataatgt catataattt ttaaatgatt tacaagacta cataaatgtg tttataacaa
     3301 acagaaatga tgttacttgc caaaattttt ctggcaaata aaaaaggtat tttattaaga
     3361 ttctcataaa tctgaaattt tatttgaaaa actgataata gcctaagtct tcttttcttt
     3421 tttttaggca tactgaattt ctgttttaaa atccattgca tgaaaattca atttgccttg
     3481 gtatatgcag ttagcattgc cattttaaaa atgaattaaa acggtgactc tgaagttgca
     3541 tgaatatcct ccagtgcatt acctattgca tgtccaccat agttctcaaa gggttagtgt
     3601 ggcttctggc atttagccgt ccatttgatc actgacagag ccaagagacc accaaagcat
     3661 ttcattgttg agtgtaattt gtcctaacag cagtattgtc attttcatgt gacctgcaga
     3721 gcaggtttgt atcaatattt ttttcctaga gaaaagtcag caactgacag acctctttat
     3781 tgatttttag gagctgcttc ttgcagtgaa aggctttaca gccactgggc tgtgaactta
     3841 ttagagatgg tcagaatgaa tgcaccccat gagtcagaca ttggctttgt gtgaaagcca
     3901 gctttgaggg gattagcttt tgaaacaatg aacagcttgc cttgaacttg attattgatc
     3961 tattgactgt cattaacaac aacttaaaca ttgtcttctg tgaaaatttt ccttgaagag
     4021 tcctgttcta tgtctttgcc ctttgacctt taacttgcaa actggcacaa actgaaggaa
     4081 atctggtgtt gcttctccat tggattagtt gttctctaaa acctagtaag catgagctgt
     4141 ttccttagag tggagagagt ggtgatggca gatctgcaga tggacacttt gctctttaca
     4201 tgcacactct gaaaatgccc tataggtaga agtgaatttt aatttcattt taatataatt
     4261 tcaagtctaa attcatcatt ttagtacaaa ttacaaaaac tataggaaaa aaaaaacctc
     4321 aaatacttga atggccagtg tggcttttat ataaagcagg aattttatac tagtaaaaat
     4381 ttcttactca tttgctaata cacatttcca gatgattttt aatgagtgta ggtatacatt
     4441 cttatttgga aatggatagt ttggctgcct tgaatttata tttatactca acgtagcatg
     4501 aaaattagaa tgccttttgg ttaaactaca tgtttatgat ttggttgggg aaaatatttt
     4561 ataattgtgg gtggcatgct gcaaagcctt gcagattgtt atttcttaca acctgagcgt
     4621 atatagtatg agcctaagaa aaaagaagag taagaaaaga agaatggctt tacagtaaaa
     4681 tatcatacaa tgcagacaat attttaagag gatattggag attatgtacg caagggccaa
     4741 gaaagcaaga aatgagaacc agagtcagcc ctgtagcttt acttcagtgc ttccattcta
     4801 gatgatgctg atattataaa gagttagtca ctgctgctaa gcatggagga ctatatacat
     4861 aagctcgttt atacagtgtt tgcttgtggg agggtttaat ccttttaggg ccttgatgtc
     4921 aagaaaaaaa taactggaaa ctatattttg ctaaagatag aaatgaggaa ctgtgtcatt
     4981 ttgggacatg tgcaaatcat tgaggaactc catcaccctg cattgaaaat tgattttttt
     5041 ttcctctaaa atgagaaaga aactgaataa gcaatctgtt gcctctttac tcattcatca
     5101 caatatcctg attcgtcata aggctatcag tatataaggg ctagaaaata atcatagcat
     5161 taagaaggaa ggagtctatc attatgcttg aattctggca aatgtcatga ataagggttg
     5221 ggtcatattt actttaatat gagacaagat ttatgtgata agcaaaggca tataaggctg
     5281 ctcttttgaa cagaacattt cagttatcag gctgtactat tacaagagat aagaagacaa
     5341 taaggacaat gtaatcacaa acagtgggat tccatttgtt tattgtacac cagctacttt
     5401 gtgggtatgg ttcctgactc ctcttctaca tgaggtttgg gaaaaaagtc tcaaaccaaa
     5461 tggaacagtg aaagggaaag taattcatct agcacataag aatagtgatt caaaaccaat
     5521 gcagaataaa tttccatggg tcaataacat aaggtgtcag ttcagtgtta ctagagatat
     5581 gcaaggcata aaatattttc atcaccccat cactaataac atgaaaagct cagacatagg
     5641 atttcccaaa ttgaaatgaa aacacattca tgcctgcaaa aataattctc cttctgcttc
     5701 atttctcatt actttatcta atataaacac aaatgtaaac aaggtaatgg tcttcatgta
     5761 aaatgaccat atagttaaga attttagtaa aatattgttg ttctgtgtat tattaaacaa
     5821 atgcaatgaa gtattaaaat agctgatcag tttgaatttc ctgtaaagca gtaattccgc
     5881 atcagaattg tagataaggt tgtgaattta ttgactcatt tcagaacagt gtctgttgac
     5941 atggcagtca gagcaggtga atacagatgc tctttctgat tgcaaaggtt atagagctaa
     6001 attagacagc attatgtgat actagcaaag acaacttctg ttataaatca gagggcaagg
     6061 cttttctgaa tcgatgtgat aaattactaa gtaatgatta ccaaaaataa ttactaagta
     6121 ataaaagata cagactggtt tactgaaata agcaagtgtt acatttaata attacctata
     6181 atcttttttt gttaacacat aagcaagtgt tacctttaat aattacctat aatctttttt
     6241 tgttaacaca taatttggcc atttcatata ctgtgtacct attttcattc cctctctgtg
     6301 ggtcattaaa aaacacaatg tggtggataa gaacattgtc caaacttcac tgctagttcc
     6361 aatacataga tgatggtgtg taaactggat tgtaggggta gtcatatttg caagttctac
     6421 atgttatgct aatatatcta gtatggtaca catacacgcc cacactttgt ggatcttaca
     6481 gtggaataaa tagtgtgtcc atattaacta aactcaaagt gctatctgaa gaggaatgga
     6541 tgttataagc agacagacag actgagttaa actgagtcat gaaaaaatat atattttaaa
     6601 gtttttggaa tcatttccag aaactaataa agggaattat ttactggtag tattgagtct
     6661 gtgagattgt agtatatact gaaacaatct tctggatggt ggtaaggtct tttttagcaa
     6721 acacagtaaa gagcttattt catttctgat gctttcaagg gcatattcca aagtatcaca
     6781 gatgtcaaat agaatatgct atataaacca aaaatgtgca tttcagatga cctattacag
     6841 caatctcagc caatatgtaa tatcacaaaa tgtgtcaagt caatcatata agaggatcta
     6901 atcattcggc tgtatttcat gtaccttcat gttgttgata tattgtgacc acaggaaata
     6961 ggtgccagag catatgcagt taagttacag gctccacgtt gcctaggagg gaatcataac
     7021 tacatcagaa aatttttaac agttatatct taaaaattag aattttatgt aataaataaa
     7081 gcggcaacca ggaatagcaa cgcaacaaat atgaaagcta attattatat ttagctttca
     7141 tatttatata atatgatgga aatggaggag gaaaaatgag tcttttgtta aatataaaga
     7201 caaactataa cactccttga taatacaact ggaaatttta ctttagcaag cataaaatag
     7261 tggaggaaaa aaatccaact tcaagctctt tgcactagtg atgattatgt gatatatcaa
     7321 tgtaatattt agccagtggt cattagatgt tactgtgctt aaacacatct gatactcatg
     7381 cattgcctta caggctaaaa atgtaagagg taggtgttca gtaacctcaa gttggaaaga
     7441 tatataatgt tagaatcccc tgagacaagc catttccctg aaatagaaat ttacctcaat
     7501 actcatgtaa tctaagacac ttggcgtagt agcaaagaag ttgccttcat gttctagtct
     7561 catctaattg tgacctttgt ctttcatgta cttctgaaat cattttccac tttttccact
     7621 ggtgtgattt tgaaacaatt ctgaaatatt tcaggtaaga ttaataacat ccaattacaa
     7681 atatatgttt caatatttta tacgtatgtc tactttgaaa gttaaaccaa tagtatagaa
     7741 agcctaagaa tgaacactga ttggacatac tcacagaaat taagggaaaa acacatattg
     7801 taaaattcct gtcaatgttt gagtagaata cagaagtaca tagcagtctt caatttttaa
     7861 acacaattat gggcttataa ctggacgtga catgcatcat ttattagaac aatattattt
     7921 atttatacta agtaaggata taagatcaca gaagcttagt gttataacgg agacttcaca
     7981 gacattcata actaatgttt tctaaggcaa ataagggcat aaaccagaac tcatggtcag
     8041 tgcagagtaa gtataaaaag ttatgtatga aagacattta tttatagaga tttctgagga
     8101 ttctatgcct tttcaactta aagatgagtg tgtcttagaa tttgttttat gcatcattgg
     8161 actggggatg atattcaaat gtgcactcag cgtgtcctca cattaaaggg cacattgaac
     8221 agtataggaa aatacatcat aaactagaat gttgtacaga ttcatataac tttcccatgt
     8281 gctctgctgt agagctgaat ttatatgccc ttaaaaaggg ataagaatca attaaatata
     8341 aatacggaaa tatacttatg ttaggtcact tagcttcaga gcaagatgtc attaaccttt
     8401 atttcacaga gaaaaactgg aagaaaagaa tggtgaacaa gaataaaatg ataaactttt
     8461 tggcttatag agatgtttct tgggaatttt ttccacttgt ttttatacat gaaaaaaata
     8521 tcagtcacaa tacagacatt tctgtagtat ttggtctgtg ggtaaactgg atcccaggca
     8581 gaatactttt tgacacaggc ctttttatac atgctttata tatgatgaag ctttggtgag
     8641 atgtgactgc atggtaggat gcattttcct aggataggat atggtgctgc ttgtacttgc
     8701 caccttttat atgaatgtat gtcgctacat tggcctgtct tgccaagaca tggttgaatg
     8761 aagcctggtg tgagctgtct atttgaaaag tcactaggat gcatgtttca tttgccgtta
     8821 cataatgcca atttgaacct gtttcctcta tatattaaca atccaattgt taagataaaa
     8881 tatactttgc ttgaatgaat gattttggta gtaatatgag cgttatcctt aaatcaatgt
     8941 tacaattttt gctattactg aaataccgtc acagaggcca cattattggc tgtctatacc
     9001 attgcctgag taaaattagg tttttaggtc tttttggcat ttacttcttt tacagctgat
     9061 gtggaatcaa ttattccttt atatgttcat aagtacaaaa tttcactatc ttaattactt
     9121 ccaaacaaac aatttccaag caagggtatg tgtgcctggt ttttctgctc ctccaattct
     9181 aagatcgtta tttgtttgcc ttctgtttct cacccaaaaa tacagatggt tgggaaagat
     9241 acatcttatt gagttgtcct atgcagtctc tgtctatatt tgcatttctt tctattccta
     9301 tcttgccttt tttttttttt tttacacaga tttggttttc ccttcccttt gtgaaaacca
     9361 gaattgagca gcattgtaca tcagagatgg tacccaggaa atgtctttgt tcctcagtat
     9421 ttttcgtcaa aacttccatg caaagacagt cccagcaaag ttgacataca tcccaacctc
     9481 tctcattggc ttttctaact ttttatagag ctattcccct gagaaaagtg aaatgctgag
     9541 tatgatgggt attgcctgtt gataggatag ctaaggaaat ttgcttttgg agaatgtatc
     9601 ttaaataatt atacaggaaa gtagtcacag tatagtgttc tgtttaaggt acatcatggg
     9661 tacataaatg cctaaaacct tcatcctttg gtctatttct ctgtaagtgt aaattacata
     9721 tatattagaa agagagatag aatcaaagaa ttaggggtgt tacagaggca gctttttgct
     9781 gccttggttt tgactgtatc agcatttcta ttgcagacct ctattttcag gggttttaga
     9841 gactcgacca taaaaatttg tttcaggctt aaaagttttg aaagattttt ttaggtatct
     9901 gattttaaac aaatagatct tgtttttata ttataggagg gaaataaatg gagtttacta
     9961 gttcaatttt gcgctaatat aacttttaat aaacttaact ttttaaacaa aaacataaaa
    10021 tctaattagt tcatagttgg ttgatgcttt tttaaaagaa tcaattattg accttgagaa
    10081 acttgcctgc ttcatcagta tagtaaccta tctttaagat attttaaaac gtgtatacct
    10141 ttattaacat tatcttgatt ccagcggtgg atcagtatga taatgcagat ttatgacatc
    10201 catataagct atctggtaat atagatttag gaatatatag tatatatgat acatatatat
    10261 atatatattt actagataga ttaaggagaa aaagctccca taaacttagt ttgtcaaata
    10321 aataccatat atttaaaaaa tgcacagaca tttatcattc agagtcagaa tgagattcaa
    10381 gtaattgcaa agggaagttg tctcttgggt aaacaataca cattttatag cttcttgtga
    10441 aactaatttt ttcctttcta tattgtggtt atgggaaagt aaaagaatta aaattaatac
    10501 agactttatt taaataacat taaactgtga agcagagaga aacgccagga aattaaatat
    10561 ttaggccatt atcttgtggt tgtctgacaa tacttcacct ttcttttaat tccccatgat
    10621 gttttcaatt atggagagag tattaaaatc tagatttaag tttctgcatt gttctcatta
    10681 cactcaacac tatttcatta agttcttgat aatatgtagt cttctgtgtg caaggaaaga
    10741 aataaataac acatttattt gctgaatgag ttttaaggtg tgcaagttgt agtgatgttt
    10801 ttcccacaca ggattctata cacttatacc atcttaaatc tggcattttt tttttcagat
    10861 agcttctact gacaaacaca aagcttgttt gtgtgcaaat ataaggctaa ataaatggtg
    10921 ctaaagtgta ttatgactgt cagataaaat caggcaaaat tttgtggtgc ttaaattaat
    10981 tttttcattg attttattga tcagtgcatt gaacagtgtt tattattcac aagttgtctt
    11041 ttattagtaa atcaaggcct catagcacat tgttaaataa agtggttgac tagtctatgt
    11101 aacagctcac caagctacta tctcttttaa ctccttataa tgttgcgtca ttaaaggtca
    11161 aggggtcatg ctattaatct cattgctata gaccattaac atgactgaac ttttccacaa
    11221 agtacttatg tttacaatgc tataaccctt tgactgctgc ggcaaccttt aaccacacaa
    11281 atgtcacaag ctagaatcat cagcatggtt cttgccatgg caatcaaaga gttaagggct
    11341 gtgcagtgat ttgttttgta tttattaatt tatatttatt ttgtttccat tcaaggaggg
    11401 gattaggggt ggggcagttt ttgtctgctg taagtgtctt aacctaggga agggttaaat
    11461 ggctttttat actattgcat cttctgtatt taccatcaat tcattgtgtt gtaattaaaa
    11521 gaaactgtca ataaataaga gaacagaaaa a
//
