LOCUS       NM_002428               4062 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens matrix metallopeptidase 15 (MMP15), mRNA.
ACCESSION   NM_002428
VERSION     NM_002428.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4062)
  AUTHORS   Mlynarczyk,G., Tokarzewicz,A., Gudowska-Sawczuk,M., Mroczko,B.,
            Novak,V., Novak,A., Mitura,P. and Romanowicz,L.
  TITLE     MMP-14 Exhibits Greater Expression, Content and Activity Compared
            to MMP-15 in Human Renal Carcinoma
  JOURNAL   Int J Mol Sci 25 (15), 8107 (2024)
   PUBMED   39125675
  REMARK    GeneRIF: MMP-14 Exhibits Greater Expression, Content and Activity
            Compared to MMP-15 in Human Renal Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4062)
  AUTHORS   Fakhari,S., Jalili,A., Nikkhoo,B., Ghaderi,B., Boshagh,M.A.,
            Mirzaie,S. and Moradzad,M.
  TITLE     MT2-MMP is differentially expressed in multiple myeloma cells and
            mediates their growth and progression
  JOURNAL   Cell Signal 92, 110248 (2022)
   PUBMED   35041985
  REMARK    GeneRIF: MT2-MMP is differentially expressed in multiple myeloma
            cells and mediates their growth and progression.
REFERENCE   3  (bases 1 to 4062)
  AUTHORS   Abdelrahman,H.A., Akawi,N., Al-Shamsi,A.M., Ali,A., Al-Jasmi,F.,
            John,A., Hertecant,J., Al-Gazali,L. and Ali,B.R.
  TITLE     Bi-allelic null variant in matrix metalloproteinase-15, causes
            congenital cardiac defect, cholestasis jaundice, and failure to
            thrive
  JOURNAL   Clin Genet 101 (4), 403-410 (2022)
   PUBMED   34988996
  REMARK    GeneRIF: Bi-allelic null variant in matrix metalloproteinase-15,
            causes congenital cardiac defect, cholestasis jaundice, and failure
            to thrive.
REFERENCE   4  (bases 1 to 4062)
  AUTHORS   Pietrzak,J., Szmajda-Krygier,D., Wosiak,A., Swiechowski,R.,
            Michalska,K., Mirowski,M., Zebrowska-Nawrocka,M., Lochowski,M. and
            Balcerczak,E.
  TITLE     Changes in the expression of membrane type-matrix
            metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during
            treatment and their potential impact on the survival of patients
            with non-small cell lung cancer (NSCLC)
  JOURNAL   Biomed Pharmacother 146, 112559 (2022)
   PUBMED   35062057
  REMARK    GeneRIF: Changes in the expression of membrane type-matrix
            metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during
            treatment and their potential impact on the survival of patients
            with non-small cell lung cancer (NSCLC).
REFERENCE   5  (bases 1 to 4062)
  AUTHORS   Hancock,D.B., Soler Artigas,M., Gharib,S.A., Henry,A.,
            Manichaikul,A., Ramasamy,A., Loth,D.W., Imboden,M., Koch,B.,
            McArdle,W.L., Smith,A.V., Smolonska,J., Sood,A., Tang,W.,
            Wilk,J.B., Zhai,G., Zhao,J.H., Aschard,H., Burkart,K.M.,
            Curjuric,I., Eijgelsheim,M., Elliott,P., Gu,X., Harris,T.B.,
            Janson,C., Homuth,G., Hysi,P.G., Liu,J.Z., Loehr,L.R., Lohman,K.,
            Loos,R.J., Manning,A.K., Marciante,K.D., Obeidat,M., Postma,D.S.,
            Aldrich,M.C., Brusselle,G.G., Chen,T.H., Eiriksdottir,G.,
            Franceschini,N., Heinrich,J., Rotter,J.I., Wijmenga,C.,
            Williams,O.D., Bentley,A.R., Hofman,A., Laurie,C.C., Lumley,T.,
            Morrison,A.C., Joubert,B.R., Rivadeneira,F., Couper,D.J.,
            Kritchevsky,S.B., Liu,Y., Wjst,M., Wain,L.V., Vonk,J.M.,
            Uitterlinden,A.G., Rochat,T., Rich,S.S., Psaty,B.M., O'Connor,G.T.,
            North,K.E., Mirel,D.B., Meibohm,B., Launer,L.J., Khaw,K.T.,
            Hartikainen,A.L., Hammond,C.J., Glaser,S., Marchini,J., Kraft,P.,
            Wareham,N.J., Volzke,H., Stricker,B.H., Spector,T.D.,
            Probst-Hensch,N.M., Jarvis,D., Jarvelin,M.R., Heckbert,S.R.,
            Gudnason,V., Boezen,H.M., Barr,R.G., Cassano,P.A., Strachan,D.P.,
            Fornage,M., Hall,I.P., Dupuis,J., Tobin,M.D. and London,S.J.
  TITLE     Genome-wide joint meta-analysis of SNP and SNP-by-smoking
            interaction identifies novel loci for pulmonary function
  JOURNAL   PLoS Genet 8 (12), e1003098 (2012)
   PUBMED   23284291
REFERENCE   6  (bases 1 to 4062)
  AUTHORS   d'Ortho,M.P., Will,H., Atkinson,S., Butler,G., Messent,A.,
            Gavrilovic,J., Smith,B., Timpl,R., Zardi,L. and Murphy,G.
  TITLE     Membrane-type matrix metalloproteinases 1 and 2 exhibit
            broad-spectrum proteolytic capacities comparable to many matrix
            metalloproteinases
  JOURNAL   Eur J Biochem 250 (3), 751-757 (1997)
   PUBMED   9461298
REFERENCE   7  (bases 1 to 4062)
  AUTHORS   Mattei,M.G., Roeckel,N., Olsen,B.R. and Apte,S.S.
  TITLE     Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene
            family, MMP14, MMP15, and MMP16, localize to human chromosomes 14,
            16, and 8, respectively
  JOURNAL   Genomics 40 (1), 168-169 (1997)
   PUBMED   9070935
REFERENCE   8  (bases 1 to 4062)
  AUTHORS   Sato,H., Tanaka,M., Takino,T., Inoue,M. and Seiki,M.
  TITLE     Assignment of the human genes for membrane-type-1, -2, and -3
            matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2,
            16q12.2-q21, and 8q21, respectively, by in situ hybridization
  JOURNAL   Genomics 39 (3), 412-413 (1997)
   PUBMED   9119382
REFERENCE   9  (bases 1 to 4062)
  AUTHORS   Takino,T., Sato,H., Shinagawa,A. and Seiki,M.
  TITLE     Identification of the second membrane-type matrix metalloproteinase
            (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a
            unique membrane-type subclass in the MMP family
  JOURNAL   J Biol Chem 270 (39), 23013-23020 (1995)
   PUBMED   7559440
REFERENCE   10 (bases 1 to 4062)
  AUTHORS   Will,H. and Hinzmann,B.
  TITLE     cDNA sequence and mRNA tissue distribution of a novel human matrix
            metalloproteinase with a potential transmembrane segment
  JOURNAL   Eur J Biochem 231 (3), 602-608 (1995)
   PUBMED   7649159
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC055428.1, AW161057.1,
            Z48482.1 and BC006412.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002428.3.
            
            Summary: This gene encodes a member of the peptidase M10 family and
            membrane-type subfamily of matrix metalloproteinases (MMPs).
            Proteins in this family are involved in the breakdown of
            extracellular matrix in normal physiological processes, such as
            embryonic development, reproduction, and tissue remodeling, as well
            as in disease processes, such as arthritis and metastasis. Members
            of this subfamily contain a transmembrane domain suggesting that
            these proteins are expressed at the cell surface rather than
            secreted. The encoded preproprotein is proteolytically processed to
            generate the mature protease. This protein may play a role in
            cancer progression. [provided by RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036495.1, Z48482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219271.4/ ENSP00000219271.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BC055428.1         191-198
            9-225               AW161057.1         1-217
            226-1430            BC055428.1         415-1619
            1431-3265           Z48482.1           882-2716
            3266-3471           BC006412.1         2574-2779
            3472-4062           Z48482.1           2922-3512
FEATURES             Location/Qualifiers
     source          1..4062
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..4062
                     /gene="MMP15"
                     /gene_synonym="MMP-15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2"
                     /note="matrix metallopeptidase 15"
                     /db_xref="GeneID:4324"
                     /db_xref="HGNC:HGNC:7161"
                     /db_xref="MIM:602261"
     exon            1..759
                     /gene="MMP15"
                     /gene_synonym="MMP-15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..908
                     /gene="MMP15"
                     /gene_synonym="MMP-15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1037
                     /gene="MMP15"
                     /gene_synonym="MMP-15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1345
                     /gene="MMP15"
                     /gene_synonym="MMP-15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1507
                     /gene="MMP15"
                     /gene_synonym="MMP-15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1761
                     /gene="MMP15"
                     /gene_synonym="MMP-15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1900
                     /gene="MMP15"
                     /gene_synonym="MMP-15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2051
                     /gene="MMP15"
                     /gene_synonym="MMP-15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2167
                     /gene="MMP15"
                     /gene_synonym="MMP-15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..4062
                     /gene="MMP15"
                     /gene_synonym="MMP-15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4041..4046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP15"
                     /gene_synonym="MMP-15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2"
                     /note="hexamer: AATAAA"
     polyA_site      4062
                     /gene="MMP15"
                     /gene_synonym="MMP-15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2"
                     /note="major polyA site"
ORIGIN      
        1 gaggagggct gggagcgccc ggagccgcgc tgaactcgcc ggggacgtcg ggcgcccgct
       61 ccttggctgg ctcgcttgct ctctcgctcg ctctctcggg tcggctccct gcgcctcctc
      121 ccgggactgc ttggggaccc gggcccggtc gggcgcggcg gcgagcagaa tccccgtgca
      181 ggaggcgcgc gctccgggca gcgcccggcc ccgggcatgg acagagggag ctgggcgcgc
      241 agggagcgcc gcgggaccgg gcggccggag cgctgagcca gacaaaggct ccggagttgc
      301 gcttgctctc gggagccggg ccccaggcgc tgggcgccga ggctgcggaa cctcgccggg
      361 ggcagctccg gtcggccccc tttcccgccg gctggttccg agctcccgga cctgccctgc
      421 ccgcttctcc tcgggcttgg gaatttgccg aggcgaccta ggcggctccg gcggggaccg
      481 ggagcccgag gtccgcggcg cgcctgccgg gccaggagcc agggagcgtc gcaagtttcc
      541 aaggcgcgtg cgaggatccg gcgtgcagtg ttccgagctg ggctgggcgc cgagagcatg
      601 ggcagcgacc cgagcgcgcc cggacggccg ggctggacgg gcagcctcct cggcgaccgg
      661 gaggaggcgg cgcggccgcg actgctgccg ctgctcctgg tgcttctggg ctgcctgggc
      721 cttggcgtag cggccgaaga cgcggaggtc catgccgaga actggctgcg gctttatggc
      781 tacctgcctc agcccagccg ccatatgtcc accatgcgtt ccgcccagat cttggcctcg
      841 gcccttgcag agatgcagcg cttctacggg atcccagtca ccggtgtgct cgacgaagag
      901 accaaggagt ggatgaagcg gccccgctgt ggggtgccag accagttcgg ggtacgagtg
      961 aaagccaacc tgcggcggcg tcggaagcgc tacgccctca ccgggaggaa gtggaacaac
     1021 caccatctga cctttagcat ccagaactac acggagaagt tgggctggta ccactcgatg
     1081 gaggcggtgc gcagggcctt ccgcgtgtgg gagcaggcca cgcccctggt cttccaggag
     1141 gtgccctatg aggacatccg gctgcggcga cagaaggagg ccgacatcat ggtactcttt
     1201 gcctctggct tccacggcga cagctcgccg tttgatggca ccggtggctt tctggcccac
     1261 gcctatttcc ctggccccgg cctaggcggg gacacccatt ttgacgcaga tgagccctgg
     1321 accttctcca gcactgacct gcatggaaac aacctcttcc tggtggcagt gcatgagctg
     1381 ggccacgcgc tggggctgga gcactccagc aaccccaatg ccatcatggc gccgttctac
     1441 cagtggaagg acgttgacaa cttcaagctg cccgaggacg atctccgtgg catccagcag
     1501 ctctacggta ccccagacgg tcagccacag cctacccagc ctctccccac tgtgacgcca
     1561 cggcggccag gccggcctga ccaccggccg ccccggcctc cccagccacc acccccaggt
     1621 gggaagccag agcggccccc aaagccgggc cccccagtcc agccccgagc cacagagcgg
     1681 cccgaccagt atggccccaa catctgcgac ggggactttg acacagtggc catgcttcgc
     1741 ggggagatgt tcgtgttcaa gggccgctgg ttctggcgag tccggcacaa ccgcgtcctg
     1801 gacaactatc ccatgcccat cgggcacttc tggcgtggtc tgcccggtga catcagtgct
     1861 gcctacgagc gccaagacgg tcgttttgtc tttttcaaag gtgaccgcta ctggctcttt
     1921 cgagaagcga acctggagcc cggctaccca cagccgctga ccagctatgg cctgggcatc
     1981 ccctatgacc gcattgacac ggccatctgg tgggagccca caggccacac cttcttcttc
     2041 caagaggaca ggtactggcg cttcaacgag gagacacagc gtggagaccc tgggtacccc
     2101 aagcccatca gtgtctggca ggggatccct gcctccccta aaggggcctt cctgagcaat
     2161 gacgcagcct acacctactt ctacaagggc accaaatact ggaaattcga caatgagcgc
     2221 ctgcggatgg agcccggcta ccccaagtcc atcctgcggg acttcatggg ctgccaggag
     2281 cacgtggagc caggcccccg atggcccgac gtggcccggc cgcccttcaa cccccacggg
     2341 ggtgcagagc ccggggcgga cagcgcagag ggcgacgtgg gggatgggga tggggacttt
     2401 ggggccgggg tcaacaagga cgggggcagc cgcgtggtgg tgcagatgga ggaggtggca
     2461 cggacggtga acgtggtgat ggtgctggtg ccactgctgc tgctgctctg cgtcctgggc
     2521 ctcacctacg cgctggtgca gatgcagcgc aagggtgcgc cacgtgtcct gctttactgc
     2581 aagcgctcgc tgcaggagtg ggtctgacca cccagcgctc ctgctaacgg tgctcagggg
     2641 gcgcctgtgg ttctgagatg gctcccaggg gctccctccg cccccaggta ggggcccctc
     2701 tcagccctca cacaccctgt ctgccccgcc ctcattattt atgtccaggt gtttgttttg
     2761 ttttgttttt ggcaccttac ttgaccattt gtttctgttt ccccgactgg ggcagggtgt
     2821 ttagaatttt ctaaatgtag ttctgctcca gacagggaat taggccccca tcatcctctg
     2881 gcttggccac agccagggga gcagaggggc agaggcccac attggaagag cagcacctcc
     2941 tcagcctgaa ccccagggct gtaactgcca ggctctcttt gcccagttgg agactgtctg
     3001 gcccccctgg tcccctcctt cccaagtgag tctctctggg ccttaggaag agccttccac
     3061 ccaggggcag ccccaggcca aaggggacct ggaagggagg tgggccgtgg cccttgagtc
     3121 cccattgagg cttggttcct tcccaatcca gtggacttcg cagtccactt ctgacagcct
     3181 cagtgaccct ggctccttgt gccagagaac ccagcccacc cccggcagca gcccccagct
     3241 cccacctccc cttgggccca cacctccttc cctctctgga gaaagggccc tgggcctgcc
     3301 tcaccacgga ccaaagggag tctgccaggg cccctctccc cagggaagca gcagcctcgc
     3361 ccctggcaga gatgcctccc tgagctagaa ccctctgttc cttccctgtg cctcctccct
     3421 ccctctccga ctcacaccac tagcctcagg ggtctgagct ccagctcctt tgggcttcag
     3481 ctgccagtgt cctgagcccc agggagaggg ggctggtggg tgcctaggcc tgggcagtgg
     3541 atggccgtga atgggtgccc acagtgtcag gcactgggca tgaggggttc ctcccctcca
     3601 gctccctgtg cccccagggt cctgggagga gagacactgg tggggatagg ccagccgcgc
     3661 atcagactgt gaaccccacg aaggagccca ttgtggccta agaggctgcc ctcctgtgct
     3721 cagccctgag gacagatgcc tccttcctct tttccttccc aaagcaagca agaggccgtg
     3781 gctgctgtgg gaaatggtac tgtacagctg gctctacttc cccatggccc tgagcgagtg
     3841 gagtctgcca cccaggatcc ccaaggcact tgagggggaa ggattctgct ggcctctgcg
     3901 agtggtttct tgtgcactgg caccaagtgc gggtccggca gcttctgccc cctgcagaac
     3961 cggagagcca gctaaggggt ggggctgcgg gggttccgtg tccaccccca tacatttatt
     4021 tctgtaaata atgtgcactg aataaattgt acagccggca aa
//
