LOCUS       NM_004995               3701 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens matrix metallopeptidase 14 (MMP14), mRNA.
ACCESSION   NM_004995
VERSION     NM_004995.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3701)
  AUTHORS   Mariappan,V., Shanmugam,L., Ranganathan Green,S., Easow,J.M.,
            Mutheneni,S.R., Thirugnanasambandhar Sivasubramanian,A. and
            Balakrishna Pillai,A.
  TITLE     Increased shedding of PECAM-1 associated with elevated serum MMP-14
            levels as new blood indicators of dengue disease manifestation
  JOURNAL   Infect Dis Now 54 (7), 104964 (2024)
   PUBMED   39181201
  REMARK    GeneRIF: Increased shedding of PECAM-1 associated with elevated
            serum MMP-14 levels as new blood indicators of dengue disease
            manifestation.
REFERENCE   2  (bases 1 to 3701)
  AUTHORS   Mlynarczyk,G., Tokarzewicz,A., Gudowska-Sawczuk,M., Mroczko,B.,
            Novak,V., Novak,A., Mitura,P. and Romanowicz,L.
  TITLE     MMP-14 Exhibits Greater Expression, Content and Activity Compared
            to MMP-15 in Human Renal Carcinoma
  JOURNAL   Int J Mol Sci 25 (15), 8107 (2024)
   PUBMED   39125675
  REMARK    GeneRIF: MMP-14 Exhibits Greater Expression, Content and Activity
            Compared to MMP-15 in Human Renal Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3701)
  AUTHORS   Li,X., Cao,Q., Xu,C., Wang,J., Pan,T., Liu,Q., Xie,P. and Hu,Z.
  TITLE     Exosomal lncRNA-MIAT promotes neovascularization via the
            miR-133a-3p/MMP-X1 axis in diabetic retinopathy
  JOURNAL   Exp Eye Res 243, 109912 (2024)
   PUBMED   38670210
  REMARK    GeneRIF: Exosomal lncRNA-MIAT promotes neovascularization via the
            miR-133a-3p/MMP-X1 axis in diabetic retinopathy.
REFERENCE   4  (bases 1 to 3701)
  AUTHORS   Liang,L., Wang,J., Guo,T., Huang,L., Wu,Y., Xu,R., Huang,T. and
            Ma,B.
  TITLE     Calreticulin regulates the expression of MMP14 and ADAR1 through
            EIF2AK2 signaling to promote the proliferation and progression of
            malignant melanoma cells
  JOURNAL   Neoplasma 71 (2), 180-192 (2024)
   PUBMED   38766853
  REMARK    GeneRIF: Calreticulin regulates the expression of MMP14 and ADAR1
            through EIF2AK2 signaling to promote the proliferation and
            progression of malignant melanoma cells.
REFERENCE   5  (bases 1 to 3701)
  AUTHORS   Lohi,J., Lehti,K., Valtanen,H., Parks,W.C. and Keski-Oja,J.
  TITLE     Structural analysis and promoter characterization of the human
            membrane-type matrix metalloproteinase-1 (MT1-MMP) gene
  JOURNAL   Gene 242 (1-2), 75-86 (2000)
   PUBMED   10721699
REFERENCE   6  (bases 1 to 3701)
  AUTHORS   Fernandez-Catalan,C., Bode,W., Huber,R., Turk,D., Calvete,J.J.,
            Lichte,A., Tschesche,H. and Maskos,K.
  TITLE     Crystal structure of the complex formed by the membrane type
            1-matrix metalloproteinase with the tissue inhibitor of
            metalloproteinases-2, the soluble progelatinase A receptor
  JOURNAL   EMBO J 17 (17), 5238-5248 (1998)
   PUBMED   9724659
REFERENCE   7  (bases 1 to 3701)
  AUTHORS   Pei,D. and Weiss,S.J.
  TITLE     Transmembrane-deletion mutants of the membrane-type matrix
            metalloproteinase-1 process progelatinase A and express intrinsic
            matrix-degrading activity
  JOURNAL   J Biol Chem 271 (15), 9135-9140 (1996)
   PUBMED   8621565
REFERENCE   8  (bases 1 to 3701)
  AUTHORS   Will,H. and Hinzmann,B.
  TITLE     cDNA sequence and mRNA tissue distribution of a novel human matrix
            metalloproteinase with a potential transmembrane segment
  JOURNAL   Eur J Biochem 231 (3), 602-608 (1995)
   PUBMED   7649159
REFERENCE   9  (bases 1 to 3701)
  AUTHORS   Takino,T., Sato,H., Yamamoto,E. and Seiki,M.
  TITLE     Cloning of a human gene potentially encoding a novel matrix
            metalloproteinase having a C-terminal transmembrane domain
  JOURNAL   Gene 155 (2), 293-298 (1995)
   PUBMED   7721107
REFERENCE   10 (bases 1 to 3701)
  AUTHORS   Okada,A., Bellocq,J.P., Rouyer,N., Chenard,M.P., Rio,M.C.,
            Chambon,P. and Basset,P.
  TITLE     Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed
            in stromal cells of human colon, breast, and head and neck
            carcinomas
  JOURNAL   Proc Natl Acad Sci U S A 92 (7), 2730-2734 (1995)
   PUBMED   7708715
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY075830.1, Z48481.1,
            AL135998.6 and BQ009340.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004995.3.
            
            Summary: Proteins of the matrix metalloproteinase (MMP) family are
            involved in the breakdown of extracellular matrix in normal
            physiological processes, such as embryonic development,
            reproduction, and tissue remodeling, as well as in disease
            processes, such as arthritis and metastasis. Most MMP's are
            secreted as inactive proproteins which are activated when cleaved
            by extracellular proteinases. However, the protein encoded by this
            gene is a member of the membrane-type MMP (MT-MMP) subfamily; each
            member of this subfamily contains a potential transmembrane domain
            suggesting that these proteins are expressed at the cell surface
            rather than secreted. This protein activates MMP2 protein, and this
            activity may be involved in tumor invasion. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312657.1, HE978355.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311852.11/ ENSP00000308208.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               HY075830.1         53-172
            121-2064            Z48481.1           1-1944
            2065-2065           AL135998.6         59062-59062         c
            2066-3537           Z48481.1           1946-3417
            3538-3543           BQ009340.1         16-21               c
            3544-3701           AL135998.6         57426-57583         c
FEATURES             Location/Qualifiers
     source          1..3701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..3701
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /note="matrix metallopeptidase 14"
                     /db_xref="GeneID:4323"
                     /db_xref="HGNC:HGNC:7160"
                     /db_xref="MIM:600754"
     exon            1..341
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1982
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /EC_number="3.4.24.80"
                     /note="membrane-type-1 matrix metalloproteinase; membrane
                     type 1 metalloprotease; matrix metalloproteinase-14;
                     matrix metallopeptidase 14 (membrane-inserted)"
                     /codon_start=1
                     /product="matrix metalloproteinase-14 preproprotein"
                     /protein_id="NP_004986.1"
                     /db_xref="CCDS:CCDS9577.1"
                     /db_xref="GeneID:4323"
                     /db_xref="HGNC:HGNC:7160"
                     /db_xref="MIM:600754"
                     /translation="MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGY
                     LPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAE
                     IKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFR
                     EVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSA
                     EPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDR
                     RGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMF
                     VFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDE
                     ASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYP
                     KNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC
                     PSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHG
                     TPRRLLYCQRSLLDKV"
     exon            342..490
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            491..613
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            614..921
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1083
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1244
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1383
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1534
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1650
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..3701
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2916
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
     regulatory      3684..3689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /note="hexamer: AATAAA"
     polyA_site      3701
                     /gene="MMP14"
                     /gene_synonym="MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP;
                     MT1MMP; MTMMP1; WNCHRS"
                     /note="major polyA site"
ORIGIN      
        1 agaccccagt tcgccgacta agcagaagaa agatcaaaaa ccggaaaaga ggagaagagc
       61 aaacaggcac tttgaggaac aatccccttt aactccaagc cgacagcggt ctaggaattc
      121 aagttcagtg cctaccgaag acaaaggcgc cccgagggag tggcggtgcg accccagggc
      181 gtgggcccgg ccgcggagcc cacactgccc ggctgacccg gtggtctcgg accatgtctc
      241 ccgccccaag acccccccgt tgtctcctgc tccccctgct cacgctcggc accgcgctcg
      301 cctccctcgg ctcggcccaa agcagcagct tcagccccga agcctggcta cagcaatatg
      361 gctacctgcc tcccggggac ctacgtaccc acacacagcg ctcaccccag tcactctcag
      421 cggccatcgc tgccatgcag aagttttacg gcttgcaagt aacaggcaaa gctgatgcag
      481 acaccatgaa ggccatgagg cgcccccgat gtggtgttcc agacaagttt ggggctgaga
      541 tcaaggccaa tgttcgaagg aagcgctacg ccatccaggg tctcaaatgg caacataatg
      601 aaatcacttt ctgcatccag aattacaccc ccaaggtggg cgagtatgcc acatacgagg
      661 ccattcgcaa ggcgttccgc gtgtgggaga gtgccacacc actgcgcttc cgcgaggtgc
      721 cctatgccta catccgtgag ggccatgaga agcaggccga catcatgatc ttctttgccg
      781 agggcttcca tggcgacagc acgcccttcg atggtgaggg cggcttcctg gcccatgcct
      841 acttcccagg ccccaacatt ggaggagaca cccactttga ctctgccgag ccttggactg
      901 tcaggaatga ggatctgaat ggaaatgaca tcttcctggt ggctgtgcac gagctgggcc
      961 atgccctggg gctcgagcat tccagtgacc cctcggccat catggcaccc ttttaccagt
     1021 ggatggacac ggagaatttt gtgctgcccg atgatgaccg ccggggcatc cagcaacttt
     1081 atgggggtga gtcagggttc cccaccaaga tgccccctca acccaggact acctcccggc
     1141 cttctgttcc tgataaaccc aaaaacccca cctatgggcc caacatctgt gacgggaact
     1201 ttgacaccgt ggccatgctc cgaggggaga tgtttgtctt caaggagcgc tggttctggc
     1261 gggtgaggaa taaccaagtg atggatggat acccaatgcc cattggccag ttctggcggg
     1321 gcctgcctgc gtccatcaac actgcctacg agaggaagga tggcaaattc gtcttcttca
     1381 aaggagacaa gcattgggtg tttgatgagg cgtccctgga acctggctac cccaagcaca
     1441 ttaaggagct gggccgaggg ctgcctaccg acaagattga tgctgctctc ttctggatgc
     1501 ccaatggaaa gacctacttc ttccgtggaa acaagtacta ccgtttcaac gaagagctca
     1561 gggcagtgga tagcgagtac cccaagaaca tcaaagtctg ggaagggatc cctgagtctc
     1621 ccagagggtc attcatgggc agcgatgaag tcttcactta cttctacaag gggaacaaat
     1681 actggaaatt caacaaccag aagctgaagg tagaaccggg ctaccccaag tcagccctga
     1741 gggactggat gggctgccca tcgggaggcc ggccggatga ggggactgag gaggagacgg
     1801 aggtgatcat cattgaggtg gacgaggagg gcggcggggc ggtgagcgcg gctgccgtgg
     1861 tgctgcccgt gctgctgctg ctcctggtgc tggcggtggg ccttgcagtc ttcttcttca
     1921 gacgccatgg gacccccagg cgactgctct actgccagcg ttccctgctg gacaaggtct
     1981 gacgcccacc gccggcccgc ccactcctac cacaaggact ttgcctctga aggccagtgg
     2041 cagcaggtgg tggtgggtgg gctgttccca tcgtcccgag ccccctcccc gcagcctcct
     2101 tgcttctctc tgtcccctgg ctggcctcct tcaccctgac cgcctccctc cctcctgccc
     2161 cggcattgca tcttccctag ataggtcccc tgagggctga gtgggagggc ggccctttcc
     2221 agcctctgcc cctcagggga accctgtagc tttgtgtctg tccagcccca tctgaatgtg
     2281 ttgggggctc tgcacttgaa ggcaggaccc tcagacctcg ctggtaaagg tcaaatgggg
     2341 tcatctgctc cttttccatc ccctgacata ccttaacctc tgaactctga cctcaggagg
     2401 ctctgggcac tccagccctg aaagccccag gtgtacccaa ttggcagcct ctcactactc
     2461 tttctggcta aaaggaatct aatcttgttg agggtagaga ccctgagaca gtgtgagggg
     2521 gtggggactg ccaagccacc ctaagacctt gggaggaaaa ctcagagagg gtcttcgttg
     2581 ctcagtcagt caagttcctc ggagatctgc ctctgcctca cctaccccag ggaacttcca
     2641 aggaaggagc ctgagccact ggggactaag tgggcagaag aaacccttgg cagccctgtg
     2701 cctctcgaat gttagccttg gatggggctt tcacagttag aagagctgaa accaggggtg
     2761 cagctgtcag gtagggtggg gccggtggga gaggcccggg tcagagccct gggggtgagc
     2821 ctgaaggcca cagagaaaga accttgccca aactcaggca gctggggctg aggcccaaag
     2881 gcagaacagc cagagggggc aggaggggac caaaaaggaa aatgaggacg tgcagcagca
     2941 ttggaaggct ggggccgggc aggccaggcc aagccaagca gggggccaca gggtgggctg
     3001 tggagctctc aggaagggcc ctgaggaagg cacacttgct cctgttggtc cctgtccttg
     3061 ctgcccaggc agcgtggagg ggaagggtag ggcagccaga gaaaggagca gagaaggcac
     3121 acaaacgagg aatgaggggc ttcacgagag gccacagggc ctggctggcc acgctgtccc
     3181 ggcctgctca ccatctcagt gaggggcagg agctggggct cgcttaggct gggtccacgc
     3241 ttccctggtg ccagcacccc tcaagcctgt ctcaccagtg gcctgccctc tcgctccccc
     3301 acccagccca cccattgaag tctccttggg ccaccaaagg tggtggccat ggtaccgggg
     3361 acttgggaga gtgagaccca gtggagggag caagaggaga gggatgtcgg gggggtgggg
     3421 cacggggtag gggaaatggg gtgaacggtg ctggcagttc ggctagattt ctgtcttgtt
     3481 tgtttttttg ttttgtttaa tgtatatttt tattataatt attatatatg aattccattc
     3541 aaatcgttcc tttttgttaa caaggggcat ggggaggggt gggggtgggg gggcagaggc
     3601 gtctgacccc aggaacctgc agggcggggc tgggtcggtg ccctctaagg acaattttga
     3661 ccttgttcaa cctttccaca aagaataaat tgtgtttcac a
//
