LOCUS       NM_002427               2714 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens matrix metallopeptidase 13 (MMP13), mRNA.
ACCESSION   NM_002427
VERSION     NM_002427.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2714)
  AUTHORS   Valeriano,A.T., Camara,L.S., Bernardes,V.F., Pais,F.S.,
            Araujo,F.M.G., Salim,A.C.M., Fernandes,G.D.R., Stussi,F.,
            Gomes,C.C., de Andrade Santos,P.P., de Souza,L.B., Gomez,R.S. and
            Diniz,M.G.
  TITLE     MMP13 Expression and Activity Suggest Its Role in Bone Resorption
            in Ameloblastomas
  JOURNAL   J Oral Pathol Med 53 (9), 577-583 (2024)
   PUBMED   39192690
  REMARK    GeneRIF: MMP13 Expression and Activity Suggest Its Role in Bone
            Resorption in Ameloblastomas.
REFERENCE   2  (bases 1 to 2714)
  AUTHORS   VAN Nguyen,S., Shamoun,L., Landerholm,K., Wagsater,D. and
            Dimberg,J.
  TITLE     Association of Clinicopathological Factors With MMP13 (rs2252070)
            Gene Polymorphism in Swedish Patients With Colorectal Cancer
  JOURNAL   In Vivo 38 (4), 1775-1782 (2024)
   PUBMED   38936942
  REMARK    GeneRIF: Association of Clinicopathological Factors With MMP13
            (rs2252070) Gene Polymorphism in Swedish Patients With Colorectal
            Cancer.
REFERENCE   3  (bases 1 to 2714)
  AUTHORS   Yu,J., Wang,W., Jiang,Z. and Liu,H.
  TITLE     TPX2 upregulates MMP13 to promote the progression of
            lipopolysaccharide-induced osteoarthritis
  JOURNAL   PeerJ 12, e17032 (2024)
   PUBMED   38770093
  REMARK    GeneRIF: TPX2 upregulates MMP13 to promote the progression of
            lipopolysaccharide-induced osteoarthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2714)
  AUTHORS   Luo,J., Zhou,J., Luo,J.Z., Wang,H.L., Zhao,X.L. and Zhou,R.D.
  TITLE     Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model
            by Reducing the Expression of Pdpn
  JOURNAL   Curr Med Sci 44 (2), 369-379 (2024)
   PUBMED   38619683
  REMARK    GeneRIF: Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a
            Mouse Model by Reducing the Expression of Pdpn.
REFERENCE   5  (bases 1 to 2714)
  AUTHORS   Mastalier Manolescu,B.S., Lazar,A.M., Tiplica,G.S., Zurac,S.A.,
            Rebosapca,A., Andreescu,B. and Popp,C.G.
  TITLE     MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis - key
            points in understanding the mechanisms and celerity of tumor
            dissemination
  JOURNAL   Rom J Morphol Embryol 65 (1), 45-52 (2024)
   PUBMED   38527983
  REMARK    GeneRIF: MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis
            - key points in understanding the mechanisms and celerity of tumor
            dissemination.
REFERENCE   6  (bases 1 to 2714)
  AUTHORS   Knauper,V., Will,H., Lopez-Otin,C., Smith,B., Atkinson,S.J.,
            Stanton,H., Hembry,R.M. and Murphy,G.
  TITLE     Cellular mechanisms for human procollagenase-3 (MMP-13) activation.
            Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to
            generate active enzyme
  JOURNAL   J Biol Chem 271 (29), 17124-17131 (1996)
   PUBMED   8663255
REFERENCE   7  (bases 1 to 2714)
  AUTHORS   Mitchell,P.G., Magna,H.A., Reeves,L.M., Lopresti-Morrow,L.L.,
            Yocum,S.A., Rosner,P.J., Geoghegan,K.F. and Hambor,J.E.
  TITLE     Cloning, expression, and type II collagenolytic activity of matrix
            metalloproteinase-13 from human osteoarthritic cartilage
  JOURNAL   J Clin Invest 97 (3), 761-768 (1996)
   PUBMED   8609233
REFERENCE   8  (bases 1 to 2714)
  AUTHORS   Knauper,V., Lopez-Otin,C., Smith,B., Knight,G. and Murphy,G.
  TITLE     Biochemical characterization of human collagenase-3
  JOURNAL   J Biol Chem 271 (3), 1544-1550 (1996)
   PUBMED   8576151
REFERENCE   9  (bases 1 to 2714)
  AUTHORS   Pendas,A.M., Matilla,T., Estivill,X. and Lopez-Otin,C.
  TITLE     The human collagenase-3 (CLG3) gene is located on chromosome
            11q22.3 clustered to other members of the matrix metalloproteinase
            gene family
  JOURNAL   Genomics 26 (3), 615-618 (1995)
   PUBMED   7607691
REFERENCE   10 (bases 1 to 2714)
  AUTHORS   Freije,J.M., Diez-Itza,I., Balbin,M., Sanchez,L.M., Blasco,R.,
            Tolivia,J. and Lopez-Otin,C.
  TITLE     Molecular cloning and expression of collagenase-3, a novel human
            matrix metalloproteinase produced by breast carcinomas
  JOURNAL   J Biol Chem 269 (24), 16766-16773 (1994)
   PUBMED   8207000
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292211.1, AK222748.1,
            X75308.1 and CA413743.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002427.3.
            
            Summary: This gene encodes a member of the peptidase M10 family of
            matrix metalloproteinases (MMPs). Proteins in this family are
            involved in the breakdown of extracellular matrix in normal
            physiological processes, such as embryonic development,
            reproduction, and tissue remodeling, as well as in disease
            processes, such as arthritis and metastasis. The encoded
            preproprotein is proteolytically processed to generate the mature
            protease. This protease cleaves type II collagen more efficiently
            than types I and III. It may be involved in articular cartilage
            turnover and cartilage pathophysiology associated with
            osteoarthritis. Mutations in this gene are associated with
            metaphyseal anadysplasia. This gene is part of a cluster of MMP
            genes on chromosome 11. [provided by RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X75308.1, AK222748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02400289 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260302.8/ ENSP00000260302.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1338              AK292211.1         3-1340
            1339-1916           AK222748.1         1341-1918
            1917-2327           X75308.1           1894-2304
            2328-2714           CA413743.1         20-406              c
FEATURES             Location/Qualifiers
     source          1..2714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.2"
     gene            1..2714
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /note="matrix metallopeptidase 13"
                     /db_xref="GeneID:4322"
                     /db_xref="HGNC:HGNC:7159"
                     /db_xref="MIM:600108"
     exon            1..147
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1443
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /EC_number="3.4.24.-"
                     /note="matrix metalloproteinase 13 (collagenase 3)"
                     /codon_start=1
                     /product="collagenase 3 preproprotein"
                     /protein_id="NP_002418.1"
                     /db_xref="CCDS:CCDS8324.1"
                     /db_xref="GeneID:4322"
                     /db_xref="HGNC:HGNC:7159"
                     /db_xref="MIM:600108"
                     /translation="MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLR
                     SYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVG
                     EYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGI
                     ADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFL
                     VAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPK
                     HPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRI
                     DAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTG
                     KTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQF
                     EYSIWSNRIVRVMPANSILWC"
     exon            148..389
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /inference="alignment:Splign:2.1.0"
     exon            390..538
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /inference="alignment:Splign:2.1.0"
     exon            539..664
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /inference="alignment:Splign:2.1.0"
     exon            665..826
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /inference="alignment:Splign:2.1.0"
     exon            827..944
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1078
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1238
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1342
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..2714
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1930..1935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /note="hexamer: AATAAT"
     polyA_site      1954
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
     regulatory      2692..2697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /note="hexamer: AATAAA"
     polyA_site      2714
                     /gene="MMP13"
                     /gene_synonym="CLG3; MANDP1; MDST; MMP-13"
                     /note="major polyA site"
ORIGIN      
        1 aacagtcccc aggcatcacc attcaagatg catccagggg tcctggctgc cttcctcttc
       61 ttgagctgga ctcattgtcg ggccctgccc cttcccagtg gtggtgatga agatgatttg
      121 tctgaggaag acctccagtt tgcagagcgc tacctgagat catactacca tcctacaaat
      181 ctcgcgggaa tcctgaagga gaatgcagca agctccatga ctgagaggct ccgagaaatg
      241 cagtctttct tcggcttaga ggtgactggc aaacttgacg ataacacctt agatgtcatg
      301 aaaaagccaa gatgcggggt tcctgatgtg ggtgaataca atgttttccc tcgaactctt
      361 aaatggtcca aaatgaattt aacctacaga attgtgaatt acacccctga tatgactcat
      421 tctgaagtcg aaaaggcatt caaaaaagcc ttcaaagttt ggtccgatgt aactcctctg
      481 aattttacca gacttcacga tggcattgct gacatcatga tctcttttgg aattaaggag
      541 catggcgact tctacccatt tgatgggccc tctggcctgc tggctcatgc ttttcctcct
      601 gggccaaatt atggaggaga tgcccatttt gatgatgatg aaacctggac aagtagttcc
      661 aaaggctaca acttgtttct tgttgctgcg catgagttcg gccactcctt aggtcttgac
      721 cactccaagg accctggagc actcatgttt cctatctaca cctacaccgg caaaagccac
      781 tttatgcttc ctgatgacga tgtacaaggg atccagtctc tctatggtcc aggagatgaa
      841 gaccccaacc ctaaacatcc aaaaacgcca gacaaatgtg acccttcctt atcccttgat
      901 gccattacca gtctccgagg agaaacaatg atctttaaag acagattctt ctggcgcctg
      961 catcctcagc aggttgatgc ggagctgttt ttaacgaaat cattttggcc agaacttccc
     1021 aaccgtattg atgctgcata tgagcaccct tctcatgacc tcatcttcat cttcagaggt
     1081 agaaaatttt gggctcttaa tggttatgac attctggaag gttatcccaa aaaaatatct
     1141 gaactgggtc ttccaaaaga agttaagaag ataagtgcag ctgttcactt tgaggataca
     1201 ggcaagactc tcctgttctc aggaaaccag gtctggagat atgatgatac taaccatatt
     1261 atggataaag actatccgag actaatagaa gaagacttcc caggaattgg tgataaagta
     1321 gatgctgtct atgagaaaaa tggttatatc tattttttca acggacccat acagtttgaa
     1381 tacagcatct ggagtaaccg tattgttcgc gtcatgccag caaattccat tttgtggtgt
     1441 taagtgtctt tttaaaaatt gttatttaaa tcctgaagag catttggggt aatacttcca
     1501 gaagtgcggg gtaggggaag aagagctatc aggagaaagc ttggttctgt gaacaagctt
     1561 cagtaagtta tctttgaata tgtagtatct atatgactat gcgtggctgg aaccacattg
     1621 aagaatgtta gagtaatgaa atggaggatc tctaaagagc atctgattct tgttgctgta
     1681 caaaagcaat ggttgatgat acttcccaca ccacaaatgg gacacatggt ctgtcaatga
     1741 gagcataatt taaaaatata tttataagga aattttacaa gggcataaag taaatacatg
     1801 catataatga ataaatcatt cttactaaaa agtataaaat agtatgaaaa tggaaatttg
     1861 ggagagccat acataaaaga aataaaccaa aggaaaatgt ctgtaataat agactgtaac
     1921 ttccaaataa ataattttca ttttgcactg aggatattca gatgtatgtg cccttcttca
     1981 cacagacact aacgaaatat caaagtcatt aaagacagga gacaaaagag cagtggtaag
     2041 aatagtagat gtggcctttg aattctgttt aattttcact tttggcaatg actcaaagtc
     2101 tgctctcata taagacaaat attcctttgc atattataaa ggataaagaa ggatgatgtc
     2161 tttttattaa aatatttcag gttcttcaga agtcacacat tacaaagtta aaattgttat
     2221 caaaatagtc taaggccatg gcatcccttt ttcataaatt atttgattat ttaagactaa
     2281 aagttgcatt ttaaccctat tttacctagc taattattta attgtccagt ttgtcttgga
     2341 tatataggct attttctaaa gacttgtata gcatgaaata aaatatatct tataaagtgg
     2401 aagtatgtat attaaaaaag agacatccaa attttttttt aaagcagtct actagattgt
     2461 gatcccttga gatatggaag gatgcctttt tttctctgca tttaaaaaaa tcccccagca
     2521 cttcccacag tgcctattga tacttgggga gggtgcttgg cacttattga atatatgatc
     2581 ggccatcaag ggaagaacta ttgtgctcag agacactgtt gataaaaact caggcaaaga
     2641 aaatgaaatg catatttgca aagtgtatta ggaagtgttt atgttgttta taataaaaat
     2701 atattttcaa caga
//
