LOCUS       NM_002425               1759 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens matrix metallopeptidase 10 (MMP10), mRNA.
ACCESSION   NM_002425
VERSION     NM_002425.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1759)
  AUTHORS   Verovenko,V., Tennstedt,S., Kleinecke,M., Kessler,T., Schunkert,H.,
            Erdmann,J., Ensminger,S. and Aherrahrou,Z.
  TITLE     Identification of a functional missense variant in the matrix
            metallopeptidase 10 (MMP10) gene in two families with premature
            myocardial infarction
  JOURNAL   Sci Rep 14 (1), 12212 (2024)
   PUBMED   38806571
  REMARK    GeneRIF: Identification of a functional missense variant in the
            matrix metallopeptidase 10 (MMP10) gene in two families with
            premature myocardial infarction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1759)
  AUTHORS   Ishimura,T., Ishii,A., Yamada,H., Osaki,K., Toda,N., Mori,K.P.,
            Ohno,S., Kato,Y., Handa,T., Sugioka,S., Ikushima,A., Nishio,H.,
            Yanagita,M. and Yokoi,H.
  TITLE     Matrix metalloproteinase-10 deficiency has protective effects
            against peritoneal inflammation and fibrosis via transcription
            factor NFkappaBeta pathway inhibition
  JOURNAL   Kidney Int 104 (5), 929-942 (2023)
   PUBMED   37652204
  REMARK    GeneRIF: Matrix metalloproteinase-10 deficiency has protective
            effects against peritoneal inflammation and fibrosis via
            transcription factor NFkappaBeta pathway inhibition.
REFERENCE   3  (bases 1 to 1759)
  AUTHORS   Zhao,Y., Zhang,Q., Zhang,X., Zhang,Y., Lu,Y., Ma,X., Li,W., Niu,X.,
            Zhang,G., Chang,M., Shi,W. and Tian,Y.
  TITLE     The roles of MMP8/MMP10 polymorphisms in ischemic stroke
            susceptibility
  JOURNAL   Brain Behav 12 (12), e2797 (2022)
   PUBMED   36282475
  REMARK    GeneRIF: The roles of MMP8/MMP10 polymorphisms in ischemic stroke
            susceptibility.
REFERENCE   4  (bases 1 to 1759)
  AUTHORS   Kudelski,J., Mlynarczyk,G., Gudowska-Sawczuk,M., Mroczko,B.,
            Darewicz,B., Bruczko-Goralewska,M. and Romanowicz,L.
  TITLE     Higher Content but Not Activity of Stromelysin-2 (MMP-10) in
            Comparison to Stromelysin-1 (MMP-3) in Human Renal Carcinoma
  JOURNAL   Int J Environ Res Public Health 19 (19), 12613 (2022)
   PUBMED   36231910
  REMARK    GeneRIF: Higher Content but Not Activity of Stromelysin-2 (MMP-10)
            in Comparison to Stromelysin-1 (MMP-3) in Human Renal Carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1759)
  AUTHORS   Tian,Y., Zheng,G., Xie,H., Guo,Y., Zeng,H., Fu,Y. and Liu,X.
  TITLE     Study on the Mechanism of circRNA-0024103 Reducing Endothelial Cell
            Injury by Regulating miR-363/MMP-10
  JOURNAL   Contrast Media Mol Imaging 2022, 1709325 (2022)
   PUBMED   35992547
  REMARK    GeneRIF: Study on the Mechanism of circRNA-0024103 Reducing
            Endothelial Cell Injury by Regulating miR-363/MMP-10.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1759)
  AUTHORS   Lichtinghagen,R., Helmbrecht,T., Arndt,B. and Boker,K.H.
  TITLE     Expression pattern of matrix metalloproteinases in human liver
  JOURNAL   Eur J Clin Chem Clin Biochem 33 (2), 65-71 (1995)
   PUBMED   7632822
REFERENCE   7  (bases 1 to 1759)
  AUTHORS   Fosang,A.J., Neame,P.J., Hardingham,T.E., Murphy,G. and
            Hamilton,J.A.
  TITLE     Cleavage of cartilage proteoglycan between G1 and G2 domains by
            stromelysins
  JOURNAL   J Biol Chem 266 (24), 15579-15582 (1991)
   PUBMED   1874716
REFERENCE   8  (bases 1 to 1759)
  AUTHORS   Jung,J.Y., Warter,S. and Rumpler,Y.
  TITLE     Localization of stromelysin 2 gene to the q22.3-23 region of
            chromosome 11 by in situ hybridization
  JOURNAL   Ann Genet 33 (1), 21-23 (1990)
   PUBMED   2369069
REFERENCE   9  (bases 1 to 1759)
  AUTHORS   Sirum,K.L. and Brinckerhoff,C.E.
  TITLE     Cloning of the genes for human stromelysin and stromelysin 2:
            differential expression in rheumatoid synovial fibroblasts
  JOURNAL   Biochemistry 28 (22), 8691-8698 (1989)
   PUBMED   2605216
REFERENCE   10 (bases 1 to 1759)
  AUTHORS   Muller,D., Quantin,B., Gesnel,M.C., Millon-Collard,R., Abecassis,J.
            and Breathnach,R.
  TITLE     The collagenase gene family in humans consists of at least four
            members
  JOURNAL   Biochem J 253 (1), 187-192 (1988)
   PUBMED   2844164
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313960.1 and BC002591.2.
            
            On Nov 22, 2018 this sequence version replaced NM_002425.2.
            
            Summary: This gene encodes a member of the peptidase M10 family of
            matrix metalloproteinases (MMPs). Proteins in this family are
            involved in the breakdown of extracellular matrix in normal
            physiological processes, such as embryonic development,
            reproduction, and tissue remodeling, as well as in disease
            processes, such as arthritis and metastasis. The encoded
            preproprotein is proteolytically processed to generate the mature
            protease. This secreted protease breaks down fibronectin, laminin,
            elastin, proteoglycan core protein, gelatins, and several types of
            collagen. The gene is part of a cluster of MMP genes on chromosome
            11. [provided by RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222601.1, SRR5189667.372209.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279441.9/ ENSP00000279441.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1468              AK313960.1         1-1468
            1469-1759           BC002591.2         1456-1746
FEATURES             Location/Qualifiers
     source          1..1759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.2"
     gene            1..1759
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /note="matrix metallopeptidase 10"
                     /db_xref="GeneID:4319"
                     /db_xref="HGNC:HGNC:7156"
                     /db_xref="MIM:185260"
     exon            1..142
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1468
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /EC_number="3.4.24.22"
                     /note="transin 2; matrix metalloproteinase 10 (stromelysin
                     2); matrix metalloprotease 10; stromelysin-2; MMP-10;
                     matrix metalloproteinase-10"
                     /codon_start=1
                     /product="stromelysin-2 preproprotein"
                     /protein_id="NP_002416.1"
                     /db_xref="CCDS:CCDS8321.1"
                     /db_xref="GeneID:4319"
                     /db_xref="HGNC:HGNC:7156"
                     /db_xref="MIM:185260"
                     /translation="MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNL
                     EKDVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSF
                     PGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMI
                     SFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHE
                     LGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPT
                     KSVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPS
                     LPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVS
                     DKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFS
                     GSSQFEFDPNARMVTHILKSNSWLHC"
     exon            143..384
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /inference="alignment:Splign:2.1.0"
     exon            385..533
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /inference="alignment:Splign:2.1.0"
     exon            534..659
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..824
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..969
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1103
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1263
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1367
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1759
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1728..1733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /note="hexamer: AATAAA"
     polyA_site      1759
                     /gene="MMP10"
                     /gene_synonym="SL-2; STMY2"
                     /note="major polyA site"
ORIGIN      
        1 agaagcccag tagacaaaga aggtaagggc agtgagaatg atgcatcttg cattccttgt
       61 gctgttgtgt ctgccagtct gctctgccta tcctctgagt ggggcagcaa aagaggagga
      121 ctccaacaag gatcttgccc agcaatacct agaaaagtac tacaacctcg aaaaggatgt
      181 gaaacagttt agaagaaagg acagtaatct cattgttaaa aaaatccaag gaatgcagaa
      241 gttccttggg ttggaggtga cagggaagct agacactgac actctggagg tgatgcgcaa
      301 gcccaggtgt ggagttcctg acgttggtca cttcagctcc tttcctggca tgccgaagtg
      361 gaggaaaacc caccttacat acaggattgt gaattataca ccagatttgc caagagatgc
      421 tgttgattct gccattgaga aagctctgaa agtctgggaa gaggtgactc cactcacatt
      481 ctccaggctg tatgaaggag aggctgatat aatgatctct tttgcagtta aagaacatgg
      541 agacttttac tcttttgatg gcccaggaca cagtttggct catgcctacc cacctggacc
      601 tgggctttat ggagatattc actttgatga tgatgaaaaa tggacagaag atgcatcagg
      661 caccaattta ttcctcgttg ctgctcatga acttggccac tccctggggc tctttcactc
      721 agccaacact gaagctttga tgtacccact ctacaactca ttcacagagc tcgcccagtt
      781 ccgcctttcg caagatgatg tgaatggcat tcagtctctc tacggacctc cccctgcctc
      841 tactgaggaa cccctggtgc ccacaaaatc tgttccttcg ggatctgaga tgccagccaa
      901 gtgtgatcct gctttgtcct tcgatgccat cagcactctg aggggagaat atctgttctt
      961 taaagacaga tatttttggc gaagatccca ctggaaccct gaacctgaat ttcatttgat
     1021 ttctgcattt tggccctctc ttccatcata tttggatgct gcatatgaag ttaacagcag
     1081 ggacaccgtt tttattttta aaggaaatga gttctgggcc atcagaggaa atgaggtaca
     1141 agcaggttat ccaagaggca tccataccct gggttttcct ccaaccataa ggaaaattga
     1201 tgcagctgtt tctgacaagg aaaagaagaa aacatacttc tttgcagcgg acaaatactg
     1261 gagatttgat gaaaatagcc agtccatgga gcaaggcttc cctagactaa tagctgatga
     1321 ctttccagga gttgagccta aggttgatgc tgtattacag gcatttggat ttttctactt
     1381 cttcagtgga tcatcacagt ttgagtttga ccccaatgcc aggatggtga cacacatatt
     1441 aaagagtaac agctggttac attgctaggc gagatagggg gaagacagat atgggtgttt
     1501 ttaataaatc taataattat tcatctaatg tattatgagc caaaatggtt aatttttcct
     1561 gcatgttctg tgactgaaga agatgagcct tgcagatatc tgcatgtgtc atgaagaatg
     1621 tttctggaat tcttcacttg cttttgaatt gcactgaaca gaattaagaa atactcatgt
     1681 gcaataggtg agagaatgta ttttcataga tgtgttatta cttcctcaat aaaaagtttt
     1741 attttgggcc tgttcctta
//
