LOCUS       NM_002421               1971 bp    mRNA    linear   PRI 02-MAR-2025
DEFINITION  Homo sapiens matrix metallopeptidase 1 (MMP1), transcript variant
            1, mRNA.
ACCESSION   NM_002421
VERSION     NM_002421.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1971)
  AUTHORS   Zhang,S., Cheng,L., Su,Y., Qian,Z., Wang,Z., Chen,C., Li,R.,
            Zhang,A., He,J., Mao,J., Wang,H. and Chen,J.
  TITLE     AGBL4 promotes malignant progression of glioblastoma via modulation
            of MMP-1 and inflammatory pathways
  JOURNAL   Front Immunol 15, 1420182 (2024)
   PUBMED   39007144
  REMARK    GeneRIF: AGBL4 promotes malignant progression of glioblastoma via
            modulation of MMP-1 and inflammatory pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1971)
  AUTHORS   Mastalier Manolescu,B.S., Lazar,A.M., Tiplica,G.S., Zurac,S.A.,
            Rebosapca,A., Andreescu,B. and Popp,C.G.
  TITLE     MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis - key
            points in understanding the mechanisms and celerity of tumor
            dissemination
  JOURNAL   Rom J Morphol Embryol 65 (1), 45-52 (2024)
   PUBMED   38527983
  REMARK    GeneRIF: MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis
            - key points in understanding the mechanisms and celerity of tumor
            dissemination.
REFERENCE   3  (bases 1 to 1971)
  AUTHORS   Xi,C., Song,Z., Cui,Q., Zhao,Y., Li,K. and Kang,H.
  TITLE     Elevated MMP1 Expression in Carcinoma-Associated Fibroblasts of
            Breast Cancer Contributes to Tumor Progression and Unfavorable
            Prognosis
  JOURNAL   Ann Clin Lab Sci 54 (1), 66-75 (2024)
   PUBMED   38514057
  REMARK    GeneRIF: Elevated MMP1 Expression in Carcinoma-Associated
            Fibroblasts of Breast Cancer Contributes to Tumor Progression and
            Unfavorable Prognosis.
REFERENCE   4  (bases 1 to 1971)
  AUTHORS   Chen,L.H., Li,C.H., Wang,S.C., Chiu,K.L., Wu,M.F., Yang,J.S.,
            Tsai,C.W., Chang,W.S., Hsia,T.C. and Bau,D.T.
  TITLE     Association of Matrix Metalloproteinase-1 Promoter Polymorphisms
            With Asthma Risk
  JOURNAL   In Vivo 38 (1), 365-371 (2024)
   PUBMED   38148093
  REMARK    GeneRIF: Association of Matrix Metalloproteinase-1 Promoter
            Polymorphisms With Asthma Risk.
REFERENCE   5  (bases 1 to 1971)
  AUTHORS   Rohani,M.G. and Parks,W.C.
  TITLE     Matrix remodeling by MMPs during wound repair
  JOURNAL   Matrix Biol 44-46, 113-121 (2015)
   PUBMED   25770908
  REMARK    Review article
REFERENCE   6  (bases 1 to 1971)
  AUTHORS   Desrochers,P.E., Mookhtiar,K., Van Wart,H.E., Hasty,K.A. and
            Weiss,S.J.
  TITLE     Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha
            1-antichymotrypsin by oxidatively activated human neutrophil
            metalloproteinases
  JOURNAL   J Biol Chem 267 (7), 5005-5012 (1992)
   PUBMED   1311327
REFERENCE   7  (bases 1 to 1971)
  AUTHORS   Desrochers,P.E., Jeffrey,J.J. and Weiss,S.J.
  TITLE     Interstitial collagenase (matrix metalloproteinase-1) expresses
            serpinase activity
  JOURNAL   J Clin Invest 87 (6), 2258-2265 (1991)
   PUBMED   1645757
REFERENCE   8  (bases 1 to 1971)
  AUTHORS   Templeton,N.S., Brown,P.D., Levy,A.T., Margulies,I.M., Liotta,L.A.
            and Stetler-Stevenson,W.G.
  TITLE     Cloning and characterization of human tumor cell interstitial
            collagenase
  JOURNAL   Cancer Res 50 (17), 5431-5437 (1990)
   PUBMED   2167156
REFERENCE   9  (bases 1 to 1971)
  AUTHORS   Clark,I.M. and Cawston,T.E.
  TITLE     Fragments of human fibroblast collagenase. Purification and
            characterization
  JOURNAL   Biochem J 263 (1), 201-206 (1989)
   PUBMED   2557822
REFERENCE   10 (bases 1 to 1971)
  AUTHORS   Brinckerhoff,C.E., Ruby,P.L., Austin,S.D., Fini,M.E. and White,H.D.
  TITLE     Molecular cloning of human synovial cell collagenase and selection
            of a single gene from genomic DNA
  JOURNAL   J Clin Invest 79 (2), 542-546 (1987)
   PUBMED   3027129
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC385245.1, BC013875.2 and
            AP000619.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002421.3.
            
            Summary: This gene encodes a member of the peptidase M10 family of
            matrix metalloproteinases (MMPs). Proteins in this family are
            involved in the breakdown of extracellular matrix in normal
            physiological processes, such as embryonic development,
            reproduction, and tissue remodeling, as well as in disease
            processes, such as arthritis and metastasis. The encoded
            preproprotein is proteolytically processed to generate the mature
            protease. This secreted protease breaks down the interstitial
            collagens, including types I, II, and III. The gene is part of a
            cluster of MMP genes on chromosome 11. Mutations in this gene are
            associated with chronic obstructive pulmonary disease (COPD).
            Alternative splicing results in multiple transcript variants, at
            least one of which encodes an isoform that is proteolytically
            processed. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X54925.1, AK024818.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315274.7/ ENSP00000322788.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DC385245.1         76-101
            27-715              BC013875.2         1-689
            716-716             AP000619.5         47113-47113         c
            717-1540            BC013875.2         691-1514
            1541-1541           AP000619.5         41877-41877         c
            1542-1971           BC013875.2         1516-1945
FEATURES             Location/Qualifiers
     source          1..1971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.2"
     gene            1..1971
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /note="matrix metallopeptidase 1"
                     /db_xref="GeneID:4312"
                     /db_xref="HGNC:HGNC:7155"
                     /db_xref="MIM:120353"
     exon            1..173
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1478
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /EC_number="3.4.24.7"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; fibroblast collagenase; matrix metalloprotease
                     1; matrix metallopeptidase 1 (interstitial collagenase)"
                     /codon_start=1
                     /product="interstitial collagenase isoform 1
                     preproprotein"
                     /protein_id="NP_002412.1"
                     /db_xref="CCDS:CCDS8322.1"
                     /db_xref="GeneID:4312"
                     /db_xref="HGNC:HGNC:7155"
                     /db_xref="MIM:120353"
                     /translation="MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNL
                     KNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVL
                     TEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIM
                     ISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAH
                     ELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPK
                     ACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEF
                     ADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFF
                     VANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPK
                     TKRILTLQKANSWFNCRKN"
     exon            174..418
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /inference="alignment:Splign:2.1.0"
     exon            419..567
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /inference="alignment:Splign:2.1.0"
     exon            568..693
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /inference="alignment:Splign:2.1.0"
     exon            694..849
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /inference="alignment:Splign:2.1.0"
     exon            850..967
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1101
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1264
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1368
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1971
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1942..1947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /note="hexamer: AATAAA"
     polyA_site      1971
                     /gene="MMP1"
                     /gene_synonym="CLG; CLGN"
                     /note="major polyA site"
ORIGIN      
        1 atattggagc agcaagaggc tgggaagcca tcacttacct tgcactgaga aagaagacaa
       61 aggccagtat gcacagcttt cctccactgc tgctgctgct gttctggggt gtggtgtctc
      121 acagcttccc agcgactcta gaaacacaag agcaagatgt ggacttagtc cagaaatacc
      181 tggaaaaata ctacaacctg aagaatgatg ggaggcaagt tgaaaagcgg agaaatagtg
      241 gcccagtggt tgaaaaattg aagcaaatgc aggaattctt tgggctgaaa gtgactggga
      301 aaccagatgc tgaaaccctg aaggtgatga agcagcccag atgtggagtg cctgatgtgg
      361 ctcagtttgt cctcactgag gggaaccctc gctgggagca aacacatctg acctacagga
      421 ttgaaaatta cacgccagat ttgccaagag cagatgtgga ccatgccatt gagaaagcct
      481 tccaactctg gagtaatgtc acacctctga cattcaccaa ggtctctgag ggtcaagcag
      541 acatcatgat atcttttgtc aggggagatc atcgggacaa ctctcctttt gatggacctg
      601 gaggaaatct tgctcatgct tttcaaccag gcccaggtat tggaggggat gctcattttg
      661 atgaagatga aaggtggacc aacaatttca gagagtacaa cttacatcgt gttgcagctc
      721 atgaactcgg ccattctctt ggactctccc attctactga tatcggggct ttgatgtacc
      781 ctagctacac cttcagtggt gatgttcagc tagctcagga tgacattgat ggcatccaag
      841 ccatatatgg acgttcccaa aatcctgtcc agcccatcgg cccacaaacc ccaaaagcgt
      901 gtgacagtaa gctaaccttt gatgctataa ctacgattcg gggagaagtg atgttcttta
      961 aagacagatt ctacatgcgc acaaatccct tctacccgga agttgagctc aatttcattt
     1021 ctgttttctg gccacaactg ccaaatgggc ttgaagctgc ttacgaattt gccgacagag
     1081 atgaagtccg gtttttcaaa gggaataagt actgggctgt tcagggacag aatgtgctac
     1141 acggataccc caaggacatc tacagctcct ttggcttccc tagaactgtg aagcatatcg
     1201 atgctgctct ttctgaggaa aacactggaa aaacctactt ctttgttgct aacaaatact
     1261 ggaggtatga tgaatataaa cgatctatgg atccaggtta tcccaaaatg atagcacatg
     1321 actttcctgg aattggccac aaagttgatg cagttttcat gaaagatgga tttttctatt
     1381 tctttcatgg aacaagacaa tacaaatttg atcctaaaac gaagagaatt ttgactctcc
     1441 agaaagctaa tagctggttc aactgcagga aaaattgaac attactaatt tgaatggaaa
     1501 acacatggtg tgagtccaaa gaaggtgttt tcctgaagaa ctgtctattt tctcagtcat
     1561 ttttaacctc tagagtcact gatacacaga atataatctt atttatacct cagtttgcat
     1621 atttttttac tatttagaat gtagcccttt ttgtactgat ataatttagt tccacaaatg
     1681 gtgggtacaa aaagtcaagt ttgtggctta tggattcata taggccagag ttgcaaagat
     1741 cttttccaga gtatgcaact ctgacgttga tcccagagag cagcttcagt gacaaacata
     1801 tcctttcaag acagaaagag acaggagaca tgagtctttg ccggaggaaa agcagctcaa
     1861 gaacacatgt gcagtcactg gtgtcaccct ggataggcaa gggataactc ttctaacaca
     1921 aaataagtgt tttatgtttg gaataaagtc aaccttgttt ctactgtttt a
//
