LOCUS       XM_047448157            5658 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens membrane metalloendopeptidase (MME),
            transcript variant X3, mRNA.
ACCESSION   XM_047448157
VERSION     XM_047448157.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5658
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..5658
                     /gene="MME"
                     /gene_synonym="CALLA; CD10; CMT2T; NEP; SCA43; SFE"
                     /note="membrane metalloendopeptidase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     mRNAs, 57 ESTs, 383 long SRA reads, 10 Proteins, and 99%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 12 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4311"
                     /db_xref="HGNC:HGNC:7154"
                     /db_xref="MIM:120520"
     CDS             136..2388
                     /gene="MME"
                     /gene_synonym="CALLA; CD10; CMT2T; NEP; SCA43; SFE"
                     /codon_start=1
                     /product="neprilysin isoform X1"
                     /protein_id="XP_047304113.1"
                     /db_xref="GeneID:4311"
                     /db_xref="HGNC:HGNC:7154"
                     /db_xref="MIM:120520"
                     /translation="MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVT
                     MIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSS
                     RYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKL
                     LPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIH
                     IDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKV
                     MELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTV
                     NISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRN
                     AFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREV
                     FIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYF
                     ENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFS
                     AQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVY
                     QYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNH
                     KQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSY
                     MNPEKKCRVW"
ORIGIN      
        1 tggtgagtcc caggagagcg agctgaggga gaaaggtcca aagggcgcga gcgcccaggg
       61 cgctgggagc ccgtgggacg ggcacgggga gggcagagcc agccgagggg agcggctgcc
      121 gggagatttt aggtgatggg caagtcagaa agtcagatgg atataactga tatcaacact
      181 ccaaagccaa agaagaaaca gcgatggact ccactggaga tcagcctctc ggtccttgtc
      241 ctgctcctca ccatcatagc tgtgacaatg atcgcactct atgcaaccta cgatgatggt
      301 atttgcaagt catcagactg cataaaatca gctgctcgac tgatccaaaa catggatgcc
      361 accactgagc cttgtacaga ctttttcaaa tatgcttgcg gaggctggtt gaaacgtaat
      421 gtcattcccg agaccagctc ccgttacggc aactttgaca ttttaagaga tgaactagaa
      481 gtcgttttga aagatgtcct tcaagaaccc aaaactgaag atatagtagc agtgcagaaa
      541 gcaaaagcat tgtacaggtc ttgtataaat gaatctgcta ttgatagcag aggtggagaa
      601 cctctactca aactgttacc agacatatat gggtggccag tagcaacaga aaactgggag
      661 caaaaatatg gtgcttcttg gacagctgaa aaagctattg cacaactgaa ttctaaatat
      721 gggaaaaaag tccttattaa tttgtttgtt ggcactgatg ataagaattc tgtgaatcat
      781 gtaattcata ttgaccaacc tcgacttggc ctcccttcta gagattacta tgaatgcact
      841 ggaatctata aagaggcttg tacagcatat gtggatttta tgatttctgt ggccagattg
      901 attcgtcagg aagaaagatt gcccatcgat gaaaaccagc ttgctttgga aatgaataaa
      961 gttatggaat tggaaaaaga aattgccaat gctacggcta aacctgaaga tcgaaatgat
     1021 ccaatgcttc tgtataacaa gatgacattg gcccagatcc aaaataactt ttcactagag
     1081 atcaatggga agccattcag ctggttgaat ttcacaaatg aaatcatgtc aactgtgaat
     1141 attagtatta caaatgagga agatgtggtt gtttatgctc cagaatattt aaccaaactt
     1201 aagcccattc ttaccaaata ttctgccaga gatcttcaaa atttaatgtc ctggagattc
     1261 ataatggatc ttgtaagcag cctcagccga acctacaagg agtccagaaa tgctttccgc
     1321 aaggcccttt atggtacaac ctcagaaaca gcaacttgga gacgttgtgc aaactatgtc
     1381 aatgggaata tggaaaatgc tgtggggagg ctttatgtgg aagcagcatt tgctggagag
     1441 agtaaacatg tggtcgagga tttgattgca cagatccgag aagtttttat tcagacttta
     1501 gatgacctca cttggatgga tgccgagaca aaaaagagag ctgaagaaaa ggccttagca
     1561 attaaagaaa ggatcggcta tcctgatgac attgtttcaa atgataacaa actgaataat
     1621 gagtacctcg agttgaacta caaagaagat gaatacttcg agaacataat tcaaaatttg
     1681 aaattcagcc aaagtaaaca actgaagaag ctccgagaaa aggtggacaa agatgagtgg
     1741 ataagtggag cagctgtagt caatgcattt tactcttcag gaagaaatca gatagtcttc
     1801 ccagccggca ttctgcagcc ccccttcttt agtgcccagc agtccaactc attgaactat
     1861 gggggcatcg gcatggtcat aggacacgaa atcacccatg gcttcgatga caatggcaga
     1921 aactttaaca aagatggaga cctcgttgac tggtggactc aacagtctgc aagtaacttt
     1981 aaggagcaat cccagtgcat ggtgtatcag tatggaaact tttcctggga cctggcaggt
     2041 ggacagcacc ttaatggaat taatacactg ggagaaaaca ttgctgataa tggaggtctt
     2101 ggtcaagcat acagagccta tcagaattat attaaaaaga atggcgaaga aaaattactt
     2161 cctggacttg acctaaatca caaacaacta tttttcttga actttgcaca ggtgtggtgt
     2221 ggaacctata ggccagagta tgcggttaac tccattaaaa cagatgtgca cagtccaggc
     2281 aatttcagga ttattgggac tttgcagaac tctgcagagt tttcagaagc ctttcactgc
     2341 cgcaagaatt catacatgaa tccagaaaag aagtgccggg tttggtgatc ttcaaaagaa
     2401 gcattgcagc ccttggctag acttgccaac accacagaaa tggggaattc tctaatcgaa
     2461 agaaaatggg ccctaggggt cactgtactg acttgagggt gattaacaga gagggcacca
     2521 tcacaataca gataacatta ggttgtccta gaaagggtgt ggagggagga agggggtcta
     2581 aggtctatca agtcaatcat ttctcactgt gtacataatg cttaatttct aaagataata
     2641 ttactgttta tttctgtttc tcatatggtc taccagtttg ctgatgtccc tagaaaacaa
     2701 tgcaaaacct ttgaggtaga ccaggatttc taatcaaaag ggaaaagaag atgttgaaga
     2761 atacagttag gcaccagaag aacagtaggt gacactatag tttaaaacac attgcctaac
     2821 tactagtttt tacttttatt tgcaacattt acagtccttc aaaatccttc caaagaattc
     2881 ttatacacat tggggccttg gagcttacat agttttaaac tcatttttgc catacatcag
     2941 ttattcattc tgtgatcatt tattttaagc actcttaaag caaaaaatga atgtctaaaa
     3001 ttgttttttg ttgtacctgc tttgactgat gctgagattc ttcaggcttc ctgcaatttt
     3061 ctaagcaatt tcttgctcta tctctcaaaa cttggtattt ttcagagatt tatataaatg
     3121 taaaaataat aatttttata tttaattatt aactacattt atgagtaact attattatag
     3181 gtaatcaatg aatattgaag tttcagctta aaataaacag ttgtgaacca agatctataa
     3241 agcgatatac agatgaaaat ttgagactat ttaaacttat aaatcatatt gatgaaaaga
     3301 tttaagcaca aactttaggg taaaaattgc cattggacag ttgtctagag atatatatac
     3361 ttgtggtttt caaattggac tttcaaaatt aaatctgtcc ctgagagtgt ctctgataaa
     3421 agggcaaatc tgcacctatg tagctctgca tctcctgtct tttcaggttt gtcatcagat
     3481 ggaaatattt tgataataaa ttgaaattgt gaactcattg ctccctaaga ctgtgacaac
     3541 tgtctaactt tagaagtgca tttctgaata gaaatgggag gcctctgatg gaccttctag
     3601 aattataagt cacaaagagt tctggaaaag aactgtttac tgcttgatag gaattcatct
     3661 tttgaggctt ctgttcctct cttttcctgt tgtattgact attttcgttc attacttgat
     3721 taagatttta caaaagagga gcacttccaa aattcttatt tttcctaaca aaagatgaaa
     3781 gcagggaatt tctatctaaa tgatgagtat tagttccctg tctcttgaaa aatgcccatt
     3841 tgcctttaaa aaaaaaagtt acagaaatac tataacatat gtacataaat tgcataaagc
     3901 ataagtatac agttcaataa acttaacttt aactgaacaa tggccctgta gccagcacct
     3961 gtaagaaaca gagcagtacc agcgctctaa aagcacctcc ttgtcacttt attactccca
     4021 gaacaacaac tatcctgact tctaatatca ttcactagct ttgcctggtt ttgtctttta
     4081 tgcagataga atcaatcagt atgtattctt ttgtgcctgg cttctttctc tcagccttac
     4141 atttgtgaga ttcctctgta ttgtgctgat tgtggatctt ttcattctca ttgcagaata
     4201 atgttctatt gtgggactta ttacaatttg ttcatcctat tgttgatggg cacttgagaa
     4261 ctttccattt tggcgctatt acaaatagtg caactatgaa tgtactgcat gttaccatct
     4321 tacttgagcc tttaatggac ttatttcttc aaatccttcc aaaaattatt ataagcattg
     4381 aaattatagt ttcaagccaa ctgtggatac ccttaccctt tcctccttta tcacaaccac
     4441 cgttacaagt atacttatat ttccctaaaa tacatttaaa acttacctaa gtgacatttg
     4501 tagttggagt aataggagct tccagctcta ataaaacagc tgtctctaac ttattttatt
     4561 tccatcatgt cagagcaggt gaagagccag aagtgaagag tgactagtac aaattataaa
     4621 aagccactag actcttcact gttagctttt taaaacatta ggctcccatc cctatggagg
     4681 aacaactctc cagtgcctgg atcccctctg tctacaaata taagattttc tgggcctaaa
     4741 ggatagatca aagtcaaaaa tagcaatgcc tccctatccc tcacacatcc agacatcatg
     4801 aattttacat ggtactcttg ttgagttctg tagagccttc tgatgtctct aaagcactac
     4861 cgattctttg gagttgtcac atcagataag acatatctct aattccatcc ataaatccag
     4921 ttctactatg gctgagttct ggtcaaagaa agaaagttta gaagctgaga cacaaagggt
     4981 tgggagctga tgaaactcac aaatgatggt aggaagaagc tctcgacaat acccgttggc
     5041 aaggagtctg cctccatgct gcagtgttcg agtggattgt aggtgcaaga tggaaaggat
     5101 tgtaggtgca agctgtccag agaaaagagt ccttgttcca gccctattct gccactcctg
     5161 acagggtgac cttgggtatt tgcaatattc ctttgggcct ctgcttctct cacctaaaaa
     5221 aagagaatta gattatattg gtggttctca gcaagagaag gagtatgtgt ccaatgctgc
     5281 cttcccatga atctgtctcc cagttatgaa tcagtgggca ggataaactg aaaactccca
     5341 tttacgtgtc tgaatcgagt gagacaaaat tttagtccaa ataacaagta ccaaagtttt
     5401 atcaagtttg ggtctgtgct gctgttactg ttaaccattt aagtggggca aaaccttgct
     5461 aattttctca aaagcattta tcattcttgt tgccacagct ggagctctca aactaaaaga
     5521 catttgttat tttggaaaga agaaagactc tattctcaaa gtttcctaat cagaaatttt
     5581 tatcagtttc cagtctcaaa aatacaaaat aaaaacaaac gtttttaata ctattgcttt
     5641 tatgcctagt caactctg
//
