LOCUS       NM_198403               2309 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens monocyte to macrophage differentiation associated 2
            (MMD2), transcript variant 2, mRNA.
ACCESSION   NM_198403 XM_166542 XM_353719
VERSION     NM_198403.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2309)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2309)
  AUTHORS   Jin,T., Xu,D., Ding,Q., Zhang,Y., Mao,C., Pan,Y., Wang,Z. and
            Chen,Y.
  TITLE     Identification of the topology and functional domains of PAQR10
  JOURNAL   Biochem J 443 (3), 643-653 (2012)
   PUBMED   22339580
  REMARK    GeneRIF: results of the present study indicate that Golgi
            localization is indispensable for PAQR10 to implement its
            regulatory functions in the Ras signalling cascade
REFERENCE   3  (bases 1 to 2309)
  AUTHORS   Kang,P., Lee,H.K., Glasgow,S.M., Finley,M., Donti,T., Gaber,Z.B.,
            Graham,B.H., Foster,A.E., Novitch,B.G., Gronostajski,R.M. and
            Deneen,B.
  TITLE     Sox9 and NFIA coordinate a transcriptional regulatory cascade
            during the initiation of gliogenesis
  JOURNAL   Neuron 74 (1), 79-94 (2012)
   PUBMED   22500632
REFERENCE   4  (bases 1 to 2309)
  AUTHORS   Jin,T., Ding,Q., Huang,H., Xu,D., Jiang,Y., Zhou,B., Li,Z.,
            Jiang,X., He,J., Liu,W., Zhang,Y., Pan,Y., Wang,Z., Thomas,W.G. and
            Chen,Y.
  TITLE     PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus
  JOURNAL   Cell Res 22 (4), 661-676 (2012)
   PUBMED   21968647
  REMARK    GeneRIF: Collectively, this study uncovers a new paradigm of
            spatial regulation of Ras signaling in the Golgi apparatus by
            PAQR10 and PAQR11.
REFERENCE   5  (bases 1 to 2309)
  AUTHORS   Nazari-Shafti,T.Z., Freisinger,E., Roy,U., Bulot,C.T., Senst,C.,
            Dupin,C.L., Chaffin,A.E., Srivastava,S.K., Mondal,D., Alt,E.U. and
            Izadpanah,R.
  TITLE     Mesenchymal stem cell derived hematopoietic cells are permissive to
            HIV-1 infection
  JOURNAL   Retrovirology 8 (1), 3 (2011)
   PUBMED   21226936
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2309)
  AUTHORS   McGovern,D.P., Jones,M.R., Taylor,K.D., Marciante,K., Yan,X.,
            Dubinsky,M., Ippoliti,A., Vasiliauskas,E., Berel,D., Derkowski,C.,
            Dutridge,D., Fleshner,P., Shih,D.Q., Melmed,G., Mengesha,E.,
            King,L., Pressman,S., Haritunians,T., Guo,X., Targan,S.R. and
            Rotter,J.I.
  CONSRTM   International IBD Genetics Consortium
  TITLE     Fucosyltransferase 2 (FUT2) non-secretor status is associated with
            Crohn's disease
  JOURNAL   Hum Mol Genet 19 (17), 3468-3476 (2010)
   PUBMED   20570966
  REMARK    GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 2309)
  AUTHORS   Gonez,L.J., Naselli,G., Banakh,I., Niwa,H. and Harrison,L.C.
  TITLE     Pancreatic expression and mitochondrial localization of the
            progestin-adipoQ receptor PAQR10
  JOURNAL   Mol Med 14 (11-12), 697-704 (2008)
   PUBMED   18769639
REFERENCE   8  (bases 1 to 2309)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC067905.1, AY424288.1,
            BC037881.1 and BC048346.1.
            
            On Jun 2, 2019 this sequence version replaced NM_198403.3.
            
            Summary: This gene encodes a member of the PAQR (progestin and
            adipoQ receptor) family. Members of this family are evolutionarily
            conserved with significant sequence identity to bacterial
            hemolysin-like proteins and are defined by a set of seven
            transmembrane domains. The protein encoded by this gene localizes
            to the Golgi apparatus to modulate Ras signaling. Alternative
            splicing results in multiple transcript variants and protein
            isoforms. [provided by RefSeq, Jun 2012].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region compared to variant 1. It encodes
            isoform 2 which is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.762929.1, BC067905.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401401.8/ ENSP00000384141.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               BC067905.1         27-223
            198-924             AY424288.1         133-859
            925-2229            BC037881.1         974-2278
            2230-2309           BC048346.1         2284-2363
FEATURES             Location/Qualifiers
     source          1..2309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..2309
                     /gene="MMD2"
                     /gene_synonym="PAQR10"
                     /note="monocyte to macrophage differentiation associated
                     2"
                     /db_xref="GeneID:221938"
                     /db_xref="HGNC:HGNC:30133"
                     /db_xref="MIM:614581"
     exon            1..217
                     /gene="MMD2"
                     /gene_synonym="PAQR10"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..911
                     /gene="MMD2"
                     /gene_synonym="PAQR10"
                     /note="isoform 2 is encoded by transcript variant 2;
                     progestin and adipoQ receptor family member X; monocyte to
                     macrophage differentiation factor 2; progestin and adipoQ
                     receptor family member 10; monocyte-to-macrophage
                     differentiation-associated protein 2"
                     /codon_start=1
                     /product="monocyte to macrophage differentiation factor 2
                     isoform 2"
                     /protein_id="NP_940685.3"
                     /db_xref="CCDS:CCDS47530.1"
                     /db_xref="GeneID:221938"
                     /db_xref="HGNC:HGNC:30133"
                     /db_xref="MIM:614581"
                     /translation="MFAPRLLDFQKTKYARFMNHRVPAHKRYQPTEYEHAANCATHAF
                     WIIPSILGSSNLYFLSDDDWETISAWIYGLGLCGLFVVSTVFHTISWKKSHLRMVEHC
                     LHMFDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASVGTIYVFFFHERYKLV
                     ELLCYVVMGFFPALVILSMPNTEGIWELVTGGVFYCLGMVFFKSDGRIPFAHAIWHLF
                     VAFGAGTHYYAIWRYLYLPSTLQTKVSK"
     exon            218..299
                     /gene="MMD2"
                     /gene_synonym="PAQR10"
                     /inference="alignment:Splign:2.1.0"
     exon            300..460
                     /gene="MMD2"
                     /gene_synonym="PAQR10"
                     /inference="alignment:Splign:2.1.0"
     exon            461..535
                     /gene="MMD2"
                     /gene_synonym="PAQR10"
                     /inference="alignment:Splign:2.1.0"
     exon            536..637
                     /gene="MMD2"
                     /gene_synonym="PAQR10"
                     /inference="alignment:Splign:2.1.0"
     exon            638..707
                     /gene="MMD2"
                     /gene_synonym="PAQR10"
                     /inference="alignment:Splign:2.1.0"
     exon            708..2309
                     /gene="MMD2"
                     /gene_synonym="PAQR10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2291..2296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMD2"
                     /gene_synonym="PAQR10"
                     /note="hexamer: ATTAAA"
     polyA_site      2309
                     /gene="MMD2"
                     /gene_synonym="PAQR10"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcctcc agctccggct cgggctccgg ctccggctcc gggcgccgac caggtcccct
       61 tggcccccgc cgcgcgccct ccaacctgct gctgccgccg ccgcgccccc caggctctgc
      121 cagctacccg cgctctgagc ccggggccag attcccatgg aagcgccgcg atgttcgccc
      181 cccggctgct ggatttccag aagacgaaat acgcgaggtt catgaaccac cgagtccctg
      241 cccacaagag gtaccagccc acagagtatg aacatgcggc caactgtgcc acccatgctt
      301 tctggatcat ccccagcatc ctgggcagct ccaacctcta cttcctgtcg gacgatgact
      361 gggagaccat ctctgcctgg atctacggcc tcggcctctg cggcctcttc gtggtgtcca
      421 ctgtgtttca caccatctcc tggaagaaga gccacctcag gatggtggaa cactgtctac
      481 acatgttcga ccggatggtc atctatttct tcatagcggc ttcctacgca ccctggctga
      541 accttcggga gctgggcccc tgggcctccc acatgcgctg gctggtctgg attatggctt
      601 ccgtgggcac catctatgtc ttcttcttcc atgagcggta caagcttgtg gagcttctct
      661 gctacgtcgt aatgggcttc ttccccgccc tggtcatcct ctccatgccc aacaccgagg
      721 gcatctggga gctggtgacc ggaggggtct tctactgcct gggcatggtc ttcttcaaga
      781 gtgacgggag gatccccttt gcccacgcca tctggcatct ctttgtagca tttggtgctg
      841 gtacccacta ctatgccatc tggaggtacc tctatctgcc cagcaccctg cagaccaagg
      901 tgtccaaatg aggtgaccca gacttgagag gtcgtttggg ctttaggagt ggagcacgtt
      961 tctgtgaacg ttaacccaga gcacagcgcc aaggcctgtc ttccctttat tgggtagagt
     1021 tcttgatggc tccaaggtga cttctggtga cagccagatc atccctcgag tccccagcga
     1081 gaaagaaagc atttagccat tcttacagag gagaaattaa ccctgtaatg tgtttctatt
     1141 ttagatgagt gtttcctaat acaagcaaca ttaacatctt cagaaaagga agcaggcatg
     1201 gtcctggaaa attggggaat gacgggccaa tctgtgtttc ctaaggtcct gaagaatctg
     1261 gcaaagagtc ctgtgggttg tttatacctg ggtggccagg gcctccctct ctgttaccaa
     1321 agtccaggct ggcgaattgt ctctggttca gggaaagggg acagcccagc ttgaagatga
     1381 gggatggtga atggctgtga ccatggcaga catcaccaat caagtgcagc acatgggtga
     1441 tgtcagaatt cttcccagca cagtgttctg ggcagccagt accaatcaat ttggcactca
     1501 tgatgggacc tctttgccct tcctgtctgg tgtgctctga aatgggataa tggccagagt
     1561 agctgaaaat ctccaaatgg gcatttgcat gcctatctcc tcatctcccc ctcccttttg
     1621 ggaaactcct ggagtaggca gtttgggggc ggtagaggga aactgaggcg cacacccatg
     1681 cagcccctga tgttctgttc caccgtagtt gattctcagt agagttggga atgaggatgc
     1741 tgttacttgg ccatttcttc ccatctccaa aaatccagag acattacgag agctattcat
     1801 tcataagatg gggcaaacag cccccaggca cttgctccct gctccatact taaggtttgt
     1861 gatgccaaca tttggattct ctcttggtgc caatcagtgg ctgttagagg ctactcaggt
     1921 gtaccccaaa cagaaggcac atggatctgg ggcgactgtt ccaggtcctc ccaacctctg
     1981 aagtgctcag tagcccaaca acaaggctgc tgggggcctg ttcttcagcc cccgtcaggg
     2041 cggggccagc ctctctgtcc aatgctgcct ggacatttac tggggaggtg agtagcaggc
     2101 ccagctccag gatctgaatt ggaatctcag attctctgga taaagaatct gtctcaagtc
     2161 aggaggtcct cattctgcga ctcccaacca gggtggagtg ggcacagaca ggatgcctta
     2221 tgcttatctc tagcacattc cagggggttc cagggttcct gcacctggaa tccagtgtgt
     2281 ccaagccagt attaaattat ctcaacaca
//
