LOCUS       NM_012329               2569 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens monocyte to macrophage differentiation associated
            (MMD), mRNA.
ACCESSION   NM_012329
VERSION     NM_012329.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2569)
  AUTHORS   Phadnis,V.V., Snider,J., Varadharajan,V., Ramachandiran,I.,
            Deik,A.A., Lai,Z.W., Kunchok,T., Eaton,E.N., Sebastiany,C.,
            Lyakisheva,A., Vaccaro,K.D., Allen,J., Yao,Z., Wong,V., Geng,B.,
            Weiskopf,K., Clish,C.B., Brown,J.M., Stagljar,I., Weinberg,R.A. and
            Henry,W.S.
  TITLE     MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated
            phosphatidylinositol remodeling and susceptibility to ferroptosis
  JOURNAL   Cell Rep 42 (9), 113023 (2023)
   PUBMED   37691145
  REMARK    GeneRIF: MMD collaborates with ACSL4 and MBOAT7 to promote
            polyunsaturated phosphatidylinositol remodeling and susceptibility
            to ferroptosis.
REFERENCE   2  (bases 1 to 2569)
  AUTHORS   Lin,Y., Huang,M., Wang,S., You,X., Zhang,L. and Chen,Y.
  TITLE     PAQR11 modulates monocyte-to-macrophage differentiation and
            pathogenesis of rheumatoid arthritis
  JOURNAL   Immunology 163 (1), 60-73 (2021)
   PUBMED   33421113
  REMARK    GeneRIF: PAQR11 modulates monocyte-to-macrophage differentiation
            and pathogenesis of rheumatoid arthritis.
REFERENCE   3  (bases 1 to 2569)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2569)
  AUTHORS   Eudy,A.M., Voora,D., Myers,R.A. and Clowse,M.E.B.
  TITLE     Effect of aspirin response signature gene expression on preterm
            birth and preeclampsia among women with lupus: a pilot study
  JOURNAL   Lupus 28 (14), 1640-1647 (2019)
   PUBMED   31684818
  REMARK    GeneRIF: Expression of PBX1 and MMD was higher in the second
            trimester among lupus patients who experienced a poor pregnancy
            outcome compared to those who did not.  The pilot study identified
            two candidate genes that are reflective of the platelet function
            response to aspirin.
REFERENCE   5  (bases 1 to 2569)
  AUTHORS   Tan,X., Banerjee,P., Guo,H.F., Ireland,S., Pankova,D., Ahn,Y.H.,
            Nikolaidis,I.M., Liu,X., Zhao,Y., Xue,Y., Burns,A.R., Roybal,J.,
            Gibbons,D.L., Zal,T., Creighton,C.J., Ungar,D., Wang,Y. and
            Kurie,J.M.
  TITLE     Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi
            compaction process through scaffolding protein PAQR11
  JOURNAL   J Clin Invest 127 (1), 117-131 (2017)
   PUBMED   27869652
  REMARK    GeneRIF: high PAQR11 levels were correlated with
            epithelial-to-mesenchymal transition (EMT) and shorter survival in
            human cancers, and PAQR11 was found to be essential for tumor cell
            migration and metastasis in EMT-driven lung adenocarcinoma models.
REFERENCE   6  (bases 1 to 2569)
  AUTHORS   Jin,T., Ding,Q., Huang,H., Xu,D., Jiang,Y., Zhou,B., Li,Z.,
            Jiang,X., He,J., Liu,W., Zhang,Y., Pan,Y., Wang,Z., Thomas,W.G. and
            Chen,Y.
  TITLE     PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus
  JOURNAL   Cell Res 22 (4), 661-676 (2012)
   PUBMED   21968647
  REMARK    GeneRIF: this study uncovers a new paradigm of spatial regulation
            of Ras signaling in the Golgi apparatus by PAQR10 and PAQR11.
REFERENCE   7  (bases 1 to 2569)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (bases 1 to 2569)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2569)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
REFERENCE   10 (bases 1 to 2569)
  AUTHORS   Rehli,M., Krause,S.W., Schwarzfischer,L., Kreutz,M. and
            Andreesen,R.
  TITLE     Molecular cloning of a novel macrophage maturation-associated
            transcript encoding a protein with several potential transmembrane
            domains
  JOURNAL   Biochem Biophys Res Commun 217 (2), 661-667 (1995)
   PUBMED   7503749
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY424289.1, X85750.1, N40480.1
            and BC026324.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012329.2.
            
            Summary: This protein is expressed by in vitro differentiated
            macrophages but not freshly isolated monocytes. Although sequence
            analysis identifies seven potential transmembrane domains, this
            protein has little homology to G-protein receptors and it has not
            been positively identified as a receptor. A suggested alternative
            function is that of an ion channel protein in maturing macrophages.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026324.1, AY424289.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262065.8/ ENSP00000262065.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1900              AY424289.1         126-2025
            1901-1938           X85750.1           1843-1880
            1939-1939           N40480.1           14-14
            1940-2569           BC026324.1         2055-2684
FEATURES             Location/Qualifiers
     source          1..2569
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..2569
                     /gene="MMD"
                     /gene_synonym="MMA; MMD1; PAQR11"
                     /note="monocyte to macrophage differentiation associated"
                     /db_xref="GeneID:23531"
                     /db_xref="HGNC:HGNC:7153"
                     /db_xref="MIM:604467"
     exon            1..166
                     /gene="MMD"
                     /gene_synonym="MMA; MMD1; PAQR11"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..857
                     /gene="MMD"
                     /gene_synonym="MMA; MMD1; PAQR11"
                     /note="macrophage maturation-associated; progestin and
                     adipoQ receptor family member XI; monocyte to macrophage
                     differentiation protein; progestin and adipoQ receptor
                     family member 11"
                     /codon_start=1
                     /product="monocyte to macrophage differentiation factor"
                     /protein_id="NP_036461.2"
                     /db_xref="CCDS:CCDS11586.1"
                     /db_xref="GeneID:23531"
                     /db_xref="HGNC:HGNC:7153"
                     /db_xref="MIM:604467"
                     /translation="MRFKNRFQRFMNHRAPANGRYKPTCYEHAANCYTHAFLIVPAIV
                     GSALLHRLSDDCWEKITAWIYGMGLCALFIVSTVFHIVSWKKSHLRTVEHCFHMCDRM
                     VIYFFIAASYAPWLNLRELGPLASHMRWFIWLMAAGGTIYVFLYHEKYKVVELFFYLT
                     MGFSPALVVTSMNNTDGLQELACGGLIYCLGVVFFKSDGIIPFAHAIWHLFVATAAAV
                     HYYAIWKYLYRSPTDFMRHL"
     exon            167..248
                     /gene="MMD"
                     /gene_synonym="MMA; MMD1; PAQR11"
                     /inference="alignment:Splign:2.1.0"
     exon            249..409
                     /gene="MMD"
                     /gene_synonym="MMA; MMD1; PAQR11"
                     /inference="alignment:Splign:2.1.0"
     exon            410..484
                     /gene="MMD"
                     /gene_synonym="MMA; MMD1; PAQR11"
                     /inference="alignment:Splign:2.1.0"
     exon            485..586
                     /gene="MMD"
                     /gene_synonym="MMA; MMD1; PAQR11"
                     /inference="alignment:Splign:2.1.0"
     exon            587..656
                     /gene="MMD"
                     /gene_synonym="MMA; MMD1; PAQR11"
                     /inference="alignment:Splign:2.1.0"
     exon            657..2569
                     /gene="MMD"
                     /gene_synonym="MMA; MMD1; PAQR11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2551..2556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MMD"
                     /gene_synonym="MMA; MMD1; PAQR11"
                     /note="hexamer: AATAAA"
     polyA_site      2569
                     /gene="MMD"
                     /gene_synonym="MMA; MMD1; PAQR11"
                     /note="major polyA site"
ORIGIN      
        1 actccgaccc tacccggccg aagggttccg ctggacacgc aggcggcctc cggagcagcc
       61 caagcccatg agggccgcgc gcccggccgc cggtgctgac gagacggagc tcctggcccc
      121 cgaggaggag cagaggatca atgcggttca agaatcgatt ccagcggttc atgaaccatc
      181 gagctccagc caatggccgc tacaagccaa cttgctatga acatgctgct aactgttaca
      241 cacacgcatt cctcattgtt ccggccatcg tgggcagtgc cctcctccat cggctgtctg
      301 atgactgctg ggaaaagata acagcatgga tttatggaat gggactctgt gccctcttca
      361 tcgtttctac agtatttcac attgtatcat ggaaaaagag ccacttaagg acagtggagc
      421 attgttttca catgtgtgat agaatggtta tctatttctt cattgctgct tcttatgctc
      481 catggttaaa tcttcgtgaa cttggacccc tggcatctca tatgcgttgg tttatctggc
      541 tcatggcagc tggaggaacc atttatgtat ttctctacca tgaaaaatat aaggtggttg
      601 aactcttttt ctatctcaca atgggattct ctccagcctt ggtggtgaca tcaatgaaca
      661 acaccgatgg acttcaggaa cttgcctgtg ggggcttaat ttattgcttg ggagttgtgt
      721 tcttcaagag tgatggcatc attccatttg cccacgccat ctggcacctg tttgtggcca
      781 cggcagctgc agtgcattac tacgccattt ggaaatacct ttaccgaagt cctacggact
      841 ttatgcggca tttatgacca atctgtacta attctccaaa ccagtattat ttcaattatg
      901 gcacttggga gtggggtgag agctaaacat tgcacaggga aagaaaaaaa ataactgcac
      961 tgactttata tcttttgaat ataattactg tgaaagtata aaggctgtgt tctggaattt
     1021 tctgcctcac agcaaataaa taaggtagtg aattaattat tcattccatt ccactatcat
     1081 gaaggactct gaatagactt ggccaactga tgtttacaaa ccagactttt atattttaat
     1141 tttacagatt ttactacatg atttttctaa attactatgt caggttgtaa aagtcagtgc
     1201 aataacaaac cttccttttt aagaagaaaa ttgtttctat tactttccca ttcactaggt
     1261 aaagaatcat ggacagaact tacactactt tttaccatgt ttcatcttgg cataacatgg
     1321 ttctttttta aatagaaact ttagtttttt gtaaattttt aaaaaaatat ttcattgata
     1381 tgcatctctg caggtcctca ttcatgttgt aaatttttgc agcaagcagt caacattcca
     1441 caaacgaaca aacattatac ctcttctgat agttttatta agcatggaga aattgccaat
     1501 ttttaaaaac tgcagttttc caaacttttc tgccaacctc ttactctgaa ttcagtgctg
     1561 ctttgggaca tatacttgac ctagcttggt ttaccagtga tggaaaagta ttttgatatc
     1621 attaactttt tcaaaagatc caactttttc tctatgcctt tgccacattc tcttcagggt
     1681 ctctttccac agtggataaa tgttttttct gtattatgac agtattgttg tgatggccat
     1741 ctgctggaaa ctcctgaaga gcattatgta ttacagtgag cagttgtatt gcctgtttgg
     1801 tgcccaatgg ttaagtcatt gtcacttagc tttatattgt cagtttgata tttattttaa
     1861 attgtggaac tagatgcata aattcacatt tctgcctttc ctttgcatct tctcatatat
     1921 tgtgtttttt tttttttttc ctagaaaaaa tatttaaagc attgtttgac aggtagaaac
     1981 tcatgtatct gtagtccatg agttatatcc tggctcagtg gagtgatatt tatgtattat
     2041 ttttactttt ctctcagtgt cttatattaa gattaacatg ttgttaatag ttgctttgtt
     2101 gattaatctc tcttgttggt gttttaataa atgaaatagg cttgccttta gatcgggtgc
     2161 tgatattgcc tgtttcctag taatgggctg atcaaatgat cagtggaatt cttggtttga
     2221 tgataacctt attaattgaa attttttact gatgtggctt taaaagaggt ttattttgta
     2281 tatgtttaga actctctgat tttgatgaat tatatgggaa tgagaaacag aagaagtggt
     2341 atttgctggc gagttaaata ggcaaggtac ccagtgataa caccaaccaa accactccta
     2401 tctgcatgat tctgaacatc tggatgcctg ttgttttact gtgtatattt tatttttaat
     2461 atattaactt tgtggattca tttaaggtct actcaaaagt aacactgtca aaaccactaa
     2521 tatgtatgta aaaattgtgc tgtatactac aataaagttg ttacttgga
//
