LOCUS       NM_001507               1239 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens motilin receptor (MLNR), mRNA.
ACCESSION   NM_001507
VERSION     NM_001507.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Sadig,R.R., Allende,A., Hall,G., Tran,D., Madigan,M.C., Watson,S.L.
            and Ooi,K.G.
  TITLE     Motilin Receptor Expression Found in the Human Main and Accessory
            Lacrimal Glands
  JOURNAL   Ocul Immunol Inflamm 30 (7-8), 1553-1558 (2022)
   PUBMED   33974477
  REMARK    GeneRIF: Motilin Receptor Expression Found in the Human Main and
            Accessory Lacrimal Glands.
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   Kawamura,T., Matsuura,B., Miyake,T., Abe,M., Ikeda,Y. and Hiasa,Y.
  TITLE     Effects of Motilin Receptor Agonists and Ghrelin in Human motilin
            receptor Transgenic Mice
  JOURNAL   Int J Mol Sci 20 (7), 1521 (2019)
   PUBMED   30934667
  REMARK    GeneRIF: human motilin receptor transgenic (Tg) mice were tested
            with experiments evaluating the effects of motilin, erythromycin
            (EM), and ghrelin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1239)
  AUTHORS   Utsunomiya,S., Matsuura,B., Ueda,T., Miyake,T., Furukawa,S.,
            Kumagi,T., Ikeda,Y., Abe,M., Hiasa,Y. and Onji,M.
  TITLE     Critical residues in the transmembrane helical bundle domains of
            the human motilin receptor for erythromycin binding and activity
  JOURNAL   Regul Pept 180, 17-25 (2013)
   PUBMED   23142315
  REMARK    GeneRIF: data support important roles of new regions in the TM
            domains of the motilin receptor for erythromycin action, suggesting
            differential mechanisms of actions by peptidyl and non-peptidyl
            ligands
REFERENCE   4  (bases 1 to 1239)
  AUTHORS   Nunoi,H., Matsuura,B., Utsunomiya,S., Ueda,T., Miyake,T.,
            Furukawa,S., Kumagi,T., Ikeda,Y., Abe,M., Hiasa,Y. and Onji,M.
  TITLE     A relationship between motilin and growth hormone secretagogue
            receptors
  JOURNAL   Regul Pept 176 (1-3), 28-35 (2012)
   PUBMED   22465164
  REMARK    GeneRIF: The data suggested that in species expressing both
            motilin-MR and ghrelin-GHSR, there is a compensatory relationship
            in vivo.
REFERENCE   5  (bases 1 to 1239)
  AUTHORS   Yokoyama,K., Urashima,M., Ohkido,I., Kono,T., Yoshida,T.,
            Muramatsu,M., Niu,T. and Hosoya,T.
  TITLE     L-type voltage-dependent calcium channel alpha subunit 1C is a
            novel candidate gene associated with secondary hyperparathyroidism:
            an application of haplotype-based analysis for multiple linked
            single nucleotide polymorphisms
  JOURNAL   Nephron Clin Pract 115 (4), c237-c243 (2010)
   PUBMED   20424473
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1239)
  AUTHORS   Thielemans,L., Depoortere,I., Van Assche,G., Bender,E. and
            Peeters,T.L.
  TITLE     Demonstration of a functional motilin receptor in TE671 cells from
            human cerebellum
  JOURNAL   Brain Res 895 (1-2), 119-128 (2001)
   PUBMED   11259768
REFERENCE   7  (bases 1 to 1239)
  AUTHORS   Smith,R.G., Leonard,R., Bailey,A.R., Palyha,O., Feighner,S.,
            Tan,C., Mckee,K.K., Pong,S.S., Griffin,P. and Howard,A.
  TITLE     Growth hormone secretagogue receptor family members and ligands
  JOURNAL   Endocrine 14 (1), 9-14 (2001)
   PUBMED   11322507
  REMARK    Review article
REFERENCE   8  (bases 1 to 1239)
  AUTHORS   Miller,P., Roy,A., St-Pierre,S., Dagenais,M., Lapointe,R. and
            Poitras,P.
  TITLE     Motilin receptors in the human antrum
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 278 (1), G18-G23 (2000)
   PUBMED   10644557
REFERENCE   9  (bases 1 to 1239)
  AUTHORS   Feighner,S.D., Tan,C.P., McKee,K.K., Palyha,O.C., Hreniuk,D.L.,
            Pong,S.S., Austin,C.P., Figueroa,D., MacNeil,D., Cascieri,M.A.,
            Nargund,R., Bakshi,R., Abramovitz,M., Stocco,R., Kargman,S.,
            O'Neill,G., Van Der Ploeg,L.H., Evans,J., Patchett,A.A., Smith,R.G.
            and Howard,A.D.
  TITLE     Receptor for motilin identified in the human gastrointestinal
            system
  JOURNAL   Science 284 (5423), 2184-2188 (1999)
   PUBMED   10381885
REFERENCE   10 (bases 1 to 1239)
  AUTHORS   McKee,K.K., Tan,C.P., Palyha,O.C., Liu,J., Feighner,S.D.,
            Hreniuk,D.L., Smith,R.G., Howard,A.D. and Van der Ploeg,L.H.
  TITLE     Cloning and characterization of two human G protein-coupled
            receptor genes (GPR38 and GPR39) related to the growth hormone
            secretagogue and neurotensin receptors
  JOURNAL   Genomics 46 (3), 426-434 (1997)
   PUBMED   9441746
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY603964.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Motilin is a 22 amino acid peptide hormone expressed
            throughout the gastrointestinal (GI) tract. The protein encoded by
            this gene is a motilin receptor which is a member of the G-protein
            coupled receptor 1 family. This member is a multi-pass
            transmembrane protein, and is an important therapeutic target for
            the treatment of hypomotility disorders. [provided by RefSeq, Aug
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY603964.1, SRR9304717.525095.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000218721.1/ ENSP00000218721.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1239              AY603964.1         1-1239
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..1239
                     /gene="MLNR"
                     /gene_synonym="GPR38; MTLR1"
                     /note="motilin receptor"
                     /db_xref="GeneID:2862"
                     /db_xref="HGNC:HGNC:4495"
                     /db_xref="MIM:602885"
     CDS             1..1239
                     /gene="MLNR"
                     /gene_synonym="GPR38; MTLR1"
                     /note="G protein-coupled receptor 38"
                     /codon_start=1
                     /product="motilin receptor"
                     /protein_id="NP_001498.1"
                     /db_xref="CCDS:CCDS9414.1"
                     /db_xref="GeneID:2862"
                     /db_xref="HGNC:HGNC:4495"
                     /db_xref="MIM:602885"
                     /translation="MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAV
                     CLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSR
                     PWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIA
                     VLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSP
                     PSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWS
                     SRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQ
                     YFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAG
                     DTGGDTVGYTETSANVKTMG"
     exon            1..901
                     /gene="MLNR"
                     /gene_synonym="GPR38; MTLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1239
                     /gene="MLNR"
                     /gene_synonym="GPR38; MTLR1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggcagcc cctggaacgg cagcgacggc cccgaggggg cgcgggagcc gccgtggccc
       61 gcgctgccgc cttgcgacga gcgccgctgc tcgccctttc ccctgggggc gctggtgccg
      121 gtgaccgctg tgtgcctgtg cctgttcgtc gtcggggtga gcggcaacgt ggtgaccgtg
      181 atgctgatcg ggcgctaccg ggacatgcgg accaccacca acttgtacct gggcagcatg
      241 gccgtgtccg acctactcat cctgctcggg ctgccgttcg acctgtaccg cctctggcgc
      301 tcgcggccct gggtgttcgg gccgctgctc tgccgcctgt ccctctacgt gggcgagggc
      361 tgcacctacg ccacgctgct gcacatgacc gcgctcagcg tcgagcgcta cctggccatc
      421 tgccgcccgc tccgcgcccg cgtcttggtc acccggcgcc gcgtccgcgc gctcatcgct
      481 gtgctctggg ccgtggcgct gctctctgcc ggtcccttct tgttcctggt gggcgtcgag
      541 caggaccccg gcatctccgt agtcccgggc ctcaatggca ccgcgcggat cgcctcctcg
      601 cctctcgcct cgtcgccgcc tctctggctc tcgcgggcgc caccgccgtc cccgccgtcg
      661 gggcccgaga ccgcggaggc cgcggcgctg ttcagccgcg aatgccggcc gagccccgcg
      721 cagctgggcg cgctgcgtgt catgctgtgg gtcaccaccg cctacttctt cctgcccttt
      781 ctgtgcctca gcatcctcta cgggctcatc gggcgggagc tgtggagcag ccggcggccg
      841 ctgcgaggcc cggccgcctc ggggcgggag agaggccacc ggcagaccgt ccgcgtcctg
      901 ctggtggtgg ttctggcatt tataatttgc tggttgccct tccacgttgg cagaatcatt
      961 tacataaaca cggaagattc gcggatgatg tacttctctc agtactttaa catcgtcgct
     1021 ctgcaacttt tctatctgag cgcatctatc aacccaatcc tctacaacct catttcaaag
     1081 aagtacagag cggcggcctt taaactgctg ctcgcaagga agtccaggcc gagaggcttc
     1141 cacagaagca gggacactgc gggggaagtt gcaggggaca ctggaggaga cacggtgggc
     1201 tacaccgaga caagcgctaa cgtgaagacg atgggataa
//
