LOCUS       NM_002418                558 bp    mRNA    linear   PRI 15-MAR-2023
DEFINITION  Homo sapiens motilin (MLN), transcript variant 1, mRNA.
ACCESSION   NM_002418
VERSION     NM_002418.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 558)
  AUTHORS   Arslan B, Dogan G, Orenay-Boyacioglu S, Caliskan M and Elevli M.
  TITLE     Serotonin, ghrelin, and motilin gene/receptor/transporter
            polymorphisms in childhood functional constipation
  JOURNAL   Rev Assoc Med Bras (1992) 69 (2), 279-284 (2023)
   PUBMED   36888769
  REMARK    GeneRIF: Serotonin, ghrelin, and motilin gene/receptor/transporter
            polymorphisms in childhood functional constipation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 558)
  AUTHORS   Mori H, Verbeure W, Tanemoto R, Sosoranga ER and Jan Tack.
  TITLE     Physiological functions and potential clinical applications of
            motilin
  JOURNAL   Peptides 160, 170905 (2023)
   PUBMED   36436612
  REMARK    GeneRIF: Physiological functions and potential clinical
            applications of motilin.
            Review article
REFERENCE   3  (bases 1 to 558)
  AUTHORS   Ulusoy E, Arslan N, Kume T, Ulgenalp A, Cirali C, Bozkaya O and
            Ercal D.
  TITLE     Serum motilin levels and motilin gene polymorphisms in children
            with functional constipation
  JOURNAL   Minerva Pediatr (Torino) 73 (5), 420-425 (2021)
   PUBMED   27706119
  REMARK    GeneRIF: Serum motilin levels and motilin gene polymorphisms in
            children with functional constipation.
REFERENCE   4  (bases 1 to 558)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 558)
  AUTHORS   Wu GJ, Cai XD, Xing J, Zhong GH and Chen JDZ.
  TITLE     Circulating motilin, ghrelin, and GLP-1 and their correlations with
            gastric slow waves in patients with chronic kidney disease
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 313 (2), R149-R157 (2017)
   PUBMED   28566304
  REMARK    GeneRIF: Hemodialysis improves upper GI symptoms and gastric slow
            waves in CKD patients. An increase in ghrelin and a decrease in
            GLP-1 might be involved in the HD-induced improvement in gastric
            slow waves.
REFERENCE   6  (bases 1 to 558)
  AUTHORS   Daikh DI, Douglass JO and Adelman JP.
  TITLE     Structure and expression of the human motilin gene
  JOURNAL   DNA 8 (8), 615-621 (1989)
   PUBMED   2574660
REFERENCE   7  (bases 1 to 558)
  AUTHORS   Yano H, Seino Y, Fujita J, Yamada Y, Inagaki N, Takeda J, Bell GI,
            Eddy RL, Fan YS, Byers MG et al.
  TITLE     Exon-intron organization, expression, and chromosomal localization
            of the human motilin gene
  JOURNAL   FEBS Lett 249 (2), 248-252 (1989)
   PUBMED   2737284
REFERENCE   8  (bases 1 to 558)
  AUTHORS   Dea D, Boileau G, Poitras P and Lahaie RG.
  TITLE     Molecular heterogeneity of human motilinlike immunoreactivity
            explained by the processing of prepromotilin
  JOURNAL   Gastroenterology 96 (3), 695-703 (1989)
   PUBMED   2914635
REFERENCE   9  (bases 1 to 558)
  AUTHORS   Seino Y, Tanaka K, Takeda J, Takahashi H, Mitani T, Kurono M,
            Kayano T, Koh G, Fukumoto H, Yano H et al.
  TITLE     Sequence of an intestinal cDNA encoding human motilin precursor
  JOURNAL   FEBS Lett 223 (1), 74-76 (1987)
   PUBMED   3666144
REFERENCE   10 (bases 1 to 558)
  AUTHORS   Sjolund,K., Sanden,G., Hakanson,R. and Sundler,F.
  TITLE     Endocrine cells in human intestine: an immunocytochemical study
  JOURNAL   Gastroenterology 85 (5), 1120-1130 (1983)
   PUBMED   6194039
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC069675.1, Y00695.1 and
            AL158049.11.
            
            On Nov 23, 2018 this sequence version replaced NM_002418.2.
            
            Summary: This gene encodes a small peptide hormone that is secreted
            by cells of the small intestine to regulate gastrointestinal
            contractions and motility. Proteolytic processing of the secreted
            protein produces the mature peptide and a byproduct referred to as
            motilin-associated peptide (MAP). Three transcript variants
            encoding different preproprotein isoforms but the same mature
            peptide have been found for this gene. [provided by RefSeq, May
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00695.1, BC069675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000430124.7/ ENSP00000388825.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               BC069675.1         9-109
            102-511             Y00695.1           99-508
            512-512             AL158049.11        45996-45996         c
            513-558             Y00695.1           509-554
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..558
                     /gene="MLN"
                     /note="motilin"
                     /db_xref="GeneID:4295"
                     /db_xref="HGNC:HGNC:7141"
                     /db_xref="MIM:158270"
     exon            1..51
                     /gene="MLN"
                     /inference="alignment:Splign:2.1.0"
     exon            52..175
                     /gene="MLN"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..406
                     /gene="MLN"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; promotilin; prepromotilin"
                     /codon_start=1
                     /product="promotilin isoform 1 preproprotein"
                     /protein_id="NP_002409.1"
                     /db_xref="CCDS:CCDS4786.1"
                     /db_xref="GeneID:4295"
                     /db_xref="HGNC:HGNC:7141"
                     /db_xref="MIM:158270"
                     /translation="MVSRKAVAALLVVHVAAMLASQTEAFVPIFTYGELQRMQEKERN
                     KGQKKSLSVWQRSGEEGPVDPAEPIREEENEMIKLTAPLEIGMRMNSRQLEKYPATLE
                     GLLSEMLPQHAAK"
     exon            176..292
                     /gene="MLN"
                     /inference="alignment:Splign:2.1.0"
     exon            293..395
                     /gene="MLN"
                     /inference="alignment:Splign:2.1.0"
     exon            396..558
                     /gene="MLN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      539..544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLN"
                     /note="hexamer: AATAAA"
     polyA_site      558
                     /gene="MLN"
                     /note="major polyA site"
ORIGIN      
        1 agaagacaag cagagagact cctccagacc cactcagacc acgtgcacgc cctccaagat
       61 ggtatcccgt aaggctgtgg ctgctctgct ggtggtgcat gtagctgcca tgctggcctc
      121 ccagacggaa gccttcgtcc ccatcttcac ctatggcgaa ctccagagga tgcaggaaaa
      181 ggaacggaat aaagggcaaa agaaatccct gagtgtatgg cagaggtctg gggaggaagg
      241 tcctgtagac cctgcggagc ccatcaggga agaagaaaac gaaatgatca agctgactgc
      301 tcctctggaa attggaatga ggatgaactc cagacagctg gaaaagtacc cggccaccct
      361 ggaagggctg ctgagtgaga tgcttcccca gcatgcagcc aagtgatggc cacgctgggg
      421 agaaggtgga cagatttggg aggcccctcc tgcccaagtg aggccctggg aatttacaga
      481 gcctgccagc tgggcttgga aggaaaacac cctttccaaa gcaaattccc ctccagcaaa
      541 taaagcatga aatataca
//
