LOCUS       NM_005937               7839 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MLLT6, PHD finger containing (MLLT6), mRNA.
ACCESSION   NM_005937
VERSION     NM_005937.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7839)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7839)
  AUTHORS   Sreevalsan,S., Doring,M., Paszkowski-Rogacz,M., Brux,M., Blanck,C.,
            Meyer,M., Momburg,F., Buchholz,F. and Theis,M.
  TITLE     MLLT6 maintains PD-L1 expression and mediates tumor immune
            resistance
  JOURNAL   EMBO Rep 21 (12), e50155 (2020)
   PUBMED   33063451
  REMARK    GeneRIF: MLLT6 maintains PD-L1 expression and mediates tumor immune
            resistance.
REFERENCE   3  (bases 1 to 7839)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 7839)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 7839)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 7839)
  AUTHORS   Chen,L., Wu,H., Pochynyuk,O.M., Reisenauer,M.R., Zhang,Z.,
            Huang,L., Zaika,O.L., Mamenko,M., Zhang,W., Zhou,Q., Liu,M., Xia,Y.
            and Zhang,W.
  TITLE     Af17 deficiency increases sodium excretion and decreases blood
            pressure
  JOURNAL   J Am Soc Nephrol 22 (6), 1076-1086 (2011)
   PUBMED   21546577
REFERENCE   7  (bases 1 to 7839)
  AUTHORS   Reisenauer,M.R., Anderson,M., Huang,L., Zhang,Z., Zhou,Q.,
            Kone,B.C., Morris,A.P., Lesage,G.D., Dryer,S.E. and Zhang,W.
  TITLE     AF17 competes with AF9 for binding to Dot1a to up-regulate
            transcription of epithelial Na+ channel alpha
  JOURNAL   J Biol Chem 284 (51), 35659-35669 (2009)
   PUBMED   19864429
  REMARK    GeneRIF: AF17 competes with AF9 to bind Dot1a, decreases Dot1a
            nuclear expression by possibly facilitating its nuclear export, and
            relieves Dot1a.AF9-mediated repression of alpha-ENaC and other
            target genes.
REFERENCE   8  (bases 1 to 7839)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   9  (bases 1 to 7839)
  AUTHORS   Pan,J.L., Xue,Y.Q., Jiang,H.Y., He,J., Wang,W. and Wu,Y.F.
  TITLE     [Application of reverse transcription-multiplex nested PCR to
            detect MLL rearrangement in AML-M4/M5]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22 (4), 444-446 (2005)
   PUBMED   16086288
  REMARK    GeneRIF: In the Acute Myeloid Leukemia patients, detected MLL
            rearrangements consisting of MLL/AF6, MLL/AF9, MLL/AF17 , MLL/ELL
            and MLL partial tandem duplication. MLL rearrangement include
            chromosome translocation and partial tandem duplication.
REFERENCE   10 (bases 1 to 7839)
  AUTHORS   Prasad,R., Leshkowitz,D., Gu,Y., Alder,H., Nakamura,T., Saito,H.,
            Huebner,K., Berger,R., Croce,C.M. and Canaani,E.
  TITLE     Leucine-zipper dimerization motif encoded by the AF17 gene fused to
            ALL-1 (MLL) in acute leukemia
  JOURNAL   Proc Natl Acad Sci U S A 91 (17), 8107-8111 (1994)
   PUBMED   8058765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006449.19, KF456275.1 and AB209633.1.
            
            On May 17, 2019 this sequence version replaced NM_005937.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB209633.1, U07932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621332.5/ ENSP00000479910.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               AC006449.19        150276-150598
            324-347             KF456275.1         1-24
            348-372             AC006449.19        150623-150647
            373-2562            AB209633.1         1-2190
            2563-2563           AC006449.19        165422-165422
            2564-5843           AB209633.1         2192-5471
            5844-7839           AC006449.19        172803-174798
FEATURES             Location/Qualifiers
     source          1..7839
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..7839
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /note="MLLT6, PHD finger containing"
                     /db_xref="GeneID:4302"
                     /db_xref="HGNC:HGNC:7138"
                     /db_xref="MIM:600328"
     exon            1..469
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..3642
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /note="Myeloid/lymphoid or mixed-lineage leukemia,
                     translocated to, 6; myeloid/lymphoid or mixed-lineage
                     leukemia (trithorax homolog); translocated to, 6;
                     ALL1-fused gene from chromosome 17 protein; MLLT6, PHD
                     finger domain containing; myeloid/lymphoid or
                     mixed-lineage leukemia (trithorax homolog, Drosophila);
                     translocated to, 6; myeloid/lymphoid or mixed-lineage
                     leukemia; translocated to, 6; KMT2A/MLLT6 fusion;
                     KMT2A-MLLT6 fusion protein; MLLT6/KMT2A fusion"
                     /codon_start=1
                     /product="protein AF-17"
                     /protein_id="NP_005928.2"
                     /db_xref="CCDS:CCDS11327.1"
                     /db_xref="GeneID:4302"
                     /db_xref="HGNC:HGNC:7138"
                     /db_xref="MIM:600328"
                     /translation="MKEMVGGCCVCSDERGWAENPLVYCDGHACSVAVHQACYGIVQV
                     PTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLT
                     MEPIVLQYVPHDRFNKTCYICEEQGRESKAASGACMTCNRHGCRQAFHVTCAQMAGLL
                     CEEEVLEVDNVKYCGYCKYHFSKMKTSRHSSGGGGGGAGGGGGSMGGGGSGFISGRRS
                     RSASPSTQQEKHPTHHERGQKKSRKDKERLKQKHKKRPESPPSILTPPVVPTADKVSS
                     SASSSSHHEASTQETSESSRESKGKKSSSHSLSHKGKKLSSGKGVSSFTSASSSSSSS
                     SSSSGGPFQPAVSSLQSSPDFSAFPKLEQPEEDKYSKPTAPAPSAPPSPSAPEPPKAD
                     LFEQKVVFSGFGPIMRFSTTTSSSGRARAPSPGDYKSPHVTGSGASAGTHKRMPALSA
                     TPVPADETPETGLKEKKHKASKRSRHGPGRPKGSRNKEGTGGPAAPSLPSAQLAGFTA
                     TAASPFSGGSLVSSGLGGLSSRTFGPSGSLPSLSLESPLLGAGIYTSNKDPISHSGGM
                     LRAVCSTPLSSSLLGPPGTSALPRLSRSPFTSTLPSSSASISTTQVFSLAGSTFSLPS
                     THIFGTPMGAVNPLLSQAESSHTEPDLEDCSFRCRGTSPQESLSSMSPISSLPALFDQ
                     TASAPCGGGQLDPAAPGTTNMEQLLEKQGDGEAGVNIVEMLKALHALQKENQRLQEQI
                     LSLTAKKERLQILNVQLSVPFPALPAALPAANGPVPGPYGLPPQAGSSDSLSTSKSPP
                     GKSSLGLDNSLSTSSEDPHSGCPSRSSSSLSFHSTPPPLPLLQQSPATLPLALPGAPA
                     PLPPQPQNGLGRAPGAAGLGAMPMAEGLLGGLAGSGGLPLNGLLGGLNGAAAPNPASL
                     SQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQQLQQLLASPQLTPEHQTVVYQMIQ
                     QIQQKRELQRLQMAGGSQLPMASLLAGSSTPLLSAGTPGLLPTASAPPLLPAGALVAP
                     SLGNNTSLMAAAAAAAAVAAAGGPPVLTAQTNPFLSLSGAEGSGGGPKGGTADKGASA
                     NQEKG"
     exon            470..549
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            550..604
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            605..714
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            715..818
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            819..912
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1080
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1179
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1396
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..2011
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2193
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2302
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2369
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2515
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2713
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2802
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..3152
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3243
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3600
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     exon            3601..7839
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5198..5203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /note="hexamer: AAGAAA"
     polyA_site      5236
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /note="major polyA site"
     regulatory      5473..5478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /note="hexamer: AAGAAA"
     polyA_site      5478
                     /gene="MLLT6"
                     /gene_synonym="AF17"
                     /note="major polyA site"
     polyA_site      5493
                     /gene="MLLT6"
                     /gene_synonym="AF17"
ORIGIN      
        1 gccactcggc gcctcccccg ccgggctcgg gctacgcggc ggcggggcgg ccctaggagc
       61 cgggcgagcg gcgcggaggg ggcgagcccg gcgtgcgagt ctcattgttg tggggggggc
      121 ccgtcggggc atgagggcga gagcacggcg gggggggcgg ccagacagag cgagcgagga
      181 ggaggaggag gaggacgcgg aggaggagga aggaggaggc aaagaaaaga agcggcggcg
      241 gcggagggag aggaggaggg ggcgaggagg cgcgcggccc cccgctccct ccctcccccc
      301 tgacccccga cccccgccgg ccggcccccc gccccagccc cggagggagc tcatgggagt
      361 atgaaggaga tggtaggagg ctgctgcgta tgttcggacg agaggggctg ggccgagaac
      421 ccgctggtct actgcgatgg gcacgcgtgc agcgtggccg tccaccaagc ttgctatggc
      481 atcgttcagg tgccaacggg accctggttc tgccggaaat gtgaatctca ggagcgagca
      541 gccagggtga ggtgtgagct gtgcccacac aaagacgggg cattgaagag gactgataat
      601 ggaggctggg cacacgtggt gtgtgccctc tacatccccg aggtgcaatt tgccaacgtg
      661 ctcaccatgg agcccatcgt gctgcagtac gtgcctcatg atcgcttcaa caagacctgt
      721 tacatctgcg aggagcaggg ccgggagagc aaggcggcct cgggagcctg catgacctgt
      781 aaccgccatg gatgtcgaca agctttccac gtcacctgtg cccaaatggc aggcttgctg
      841 tgtgaggaag aagtgctgga ggtggacaac gtcaagtact gcggctactg caaataccac
      901 ttcagcaaga tgaagacatc ccggcacagc agcgggggag gcggaggagg cgctggagga
      961 ggaggtggca gcatgggggg aggtggcagt ggtttcatct ctgggaggag aagccggtca
     1021 gcctcaccat ccacgcagca ggagaagcac cccacccacc acgagagggg ccagaagaag
     1081 agtcgaaagg acaaagaacg ccttaagcag aagcacaaga agcggcctga gtcgcccccc
     1141 agcatcctca ccccgcccgt ggtccccact gctgacaagg tctcctcctc ggcttcctct
     1201 tcctcccacc acgaggccag cacgcaggag acctctgaga gcagcaggga gtcaaagggg
     1261 aaaaagtctt ccagccatag cctgagtcat aaagggaaga aactgagcag tgggaaaggt
     1321 gtgagcagtt ttacctccgc ctcctcttct tcctcctcct cttcctcctc ctctgggggg
     1381 cccttccagc ctgcagtctc gtccctgcag agctcccctg acttctctgc attccccaag
     1441 ctggagcagc cagaggagga caagtactcc aagcccacag cccccgcccc ttcagcccct
     1501 ccttctccct cagctcccga gccccccaag gctgaccttt ttgagcagaa ggtggtcttc
     1561 tctggctttg ggcccatcat gcgcttctcc accaccacct ccagctcagg ccgggcccgg
     1621 gcgccctccc ctggggacta taagtctccc cacgtcacgg ggtctggggc ctcggcaggc
     1681 acccacaaac ggatgcccgc actgagtgcc acccctgtgc ctgctgatga gacccctgag
     1741 acaggcctga aggagaagaa gcacaaagcc agcaagagga gccgccatgg gccaggccgt
     1801 cccaagggca gccggaacaa ggagggcact gggggcccag ctgccccatc cttgcccagt
     1861 gcccagctgg ctggctttac cgccactgct gcctcaccct tctctggagg ttccctggtc
     1921 agctccggcc tgggaggtct gtcctcccga acctttgggc cttctgggag cttgcccagc
     1981 ttgagcctgg agtccccctt actaggggca ggcatctaca ccagtaataa ggaccccatc
     2041 tcccacagtg gcgggatgct gcgggctgtc tgcagcaccc ctctctcctc cagcctcctg
     2101 gggcccccag ggacctcggc cctgccccgc ctcagccgct ccccgttcac cagcaccctc
     2161 ccctcctctt ctgcttctat ctccaccact caggtgtttt ctctggctgg ctctaccttt
     2221 agcctccctt ctacccacat ctttggaacc cccatgggtg ccgttaatcc cctcctctcc
     2281 caagctgaga gcagccacac agagccagac ctggaggact gcagcttccg gtgtcggggg
     2341 acctcccctc aggagagtct gtcttccatg tcccccatca gcagcctccc cgcactcttc
     2401 gaccagacag cctctgcacc ctgtgggggc ggccagttag acccggcggc cccagggacg
     2461 actaacatgg agcagcttct ggagaagcag ggcgacgggg aggccggcgt caacatcgtg
     2521 gagatgctga aggcgctgca cgcgctgcag aaggagaacc agcggctgca agagcagatc
     2581 ctgagcctga cggccaaaaa ggagcggctg cagattctca acgtgcagct ctctgtgccc
     2641 ttccctgccc tgcctgctgc cctgcctgcc gccaacggcc ctgtccctgg gccctatggc
     2701 ctgcctcccc aagccggcag cagcgactcc ttgagcacca gcaagagccc tccgggaaag
     2761 agcagcctcg gcctggacaa ctcgctgtcc acttcttctg aggacccaca ctcaggctgc
     2821 ccgagccgca gcagctcgtc gctgtccttc cacagcacgc ccccaccgct gcccctcctc
     2881 cagcagagcc ctgccactct gcccctggcc ctgcctgggg cccctgcccc actcccgccc
     2941 cagccgcaga acgggttggg ccgggcaccc ggggcagcgg ggctgggggc catgcccatg
     3001 gctgaggggc tgttgggggg gctggcaggc agtgggggcc tgcccctcaa tgggctcctt
     3061 ggggggttga atggggccgc tgcccccaac cccgcaagct tgagccaggc tggcggggcc
     3121 cccacgctgc agctgccagg ctgtctcaac agccttacag agcagcagag acatctcctt
     3181 cagcagcaag agcagcagct ccagcaactc cagcagctcc tggcctcccc gcagctgacc
     3241 ccggaacacc agactgttgt ctaccagatg atccagcaga tccagcagaa acgggagctg
     3301 cagcgcctgc agatggctgg gggctcccag ctgcccatgg ccagcctgct ggcaggaagc
     3361 tccaccccgc tgctgtctgc gggtacccct ggcctgctgc ccacagcgtc tgctccaccc
     3421 ctgctgcccg ctggagccct agtggctccc tcgcttggca acaacacaag tctcatggcc
     3481 gcagcagctg cagctgcagc agtagcagca gcaggcggac ctccagtcct cactgcccag
     3541 accaacccct tcctcagcct gtcgggagca gagggcagtg gcggtggccc caaaggaggg
     3601 accgctgaca aaggagcctc agccaaccag gaaaaaggct aaatccaccc ttacccctcc
     3661 tgaccccccc aagtggaggg aacagatcct ggcctgaggg gtcctagcct ggagcaggcg
     3721 cctgcgccca gaccctggag agccttgacc cagagcctgt gctgaggtcc agggagtgtg
     3781 gagagctcct ggtgtcgagg actgagactg agaggggagc cccctccatc tggccccctt
     3841 ccctttccgc actgtccgct ttgtgaggct cagaggaagg acagtctgca agcccgccta
     3901 ggaggtccat ccccagcaaa tgttttggag gtccccccag agagcagagt gggccatggc
     3961 agaagtaggg ggttggttgg acctgtcaca tgaaatggat cagcacttga atggggagaa
     4021 gtggagggag aggccctggg cctgtccctg cggggaaatc ttttatggaa gaagggctgg
     4081 acccacttta cctgcagttt cttcccagct cgggcagatg gcagaaggga ccccttggac
     4141 tttttctcgc catccctccc cccagcgcag gggcacaagc tgagcttgta aaagcccaca
     4201 gatgttgggg gctggagaag gggcaggaga gcatcacact cagccccagc ctcctcaacc
     4261 tcttggggcc ccgtgatggg gaggagaggg caggtgcggg gaggctctgg ccttccttgg
     4321 tgccccgccc tttgtttgca ctattggact taggagtgcc gagggtgggg agatggagct
     4381 gcccgtctca gtgtgtgagt gtgtgtgtgc gtgcatgtgt gtgtgtgtgt gtgtgtgtgt
     4441 gtgtgtctgt ctgcctgtct ctctcctcct ggacccaggg cagccaaggg cagggatagg
     4501 cgcagtggtc agatgaagca gcgccagaga ggggacctcc cagctcttat ttgcaccctc
     4561 cccacctcac caactttggt ccctctctgg gggcatgaat ggttaacaaa caccagagca
     4621 gtactccaat attggagagt cgctgggggc acagggcttt gaatcagggt agtatcctgc
     4681 cttccctccc ctgaccccac atggtctcag ggccccctta gggcccccta ccccactgat
     4741 agcttcctcc ttctctggca caaggggagc cccagggctt gggggagggc gtaaggtggg
     4801 gggaaatgcc actgctttta gcaaaagcct ccctcccaga attagccagc ttgcctcctg
     4861 caccccaccc ccaccaacca ggggagccac taagctgact aacaactgtc ccctcaccca
     4921 ccagctattt ccccagggta gagtgggcaa ttctcacctt caaagagtcc ccgcctgccc
     4981 aggcctttgg cacagaggct gagtggacag tcaggagaga ggcgagaggc aaggcgaagc
     5041 ctgtgtccct gtttcagttg cactggggtt ggagcccagg gtaggggttt ccagcttccc
     5101 caggctccgg ccttgtcagt ctctttgcat gtgtggattt ttctgtgtgt gtttctgttt
     5161 gggtttttgt tgttgggttt tttttttttt tttaataaag aaaagaagat gtgtatattt
     5221 ttggcaacga cagaaacgta gtgcagatat atttttgcct gtgctgctca actgtttttt
     5281 ttttctgata ctgaaaataa tattaatatt cctgttgata agactttgta agatgttagg
     5341 gagctgataa tggagggggg tgggaatcct tcaaaggcaa tttcttaggc acttgcaagg
     5401 gcttggggga gggggaggca gttgtgatga cctcagaaat actcactttt tattaatgct
     5461 aaatatgtta gaaagaaatg atagcattca gcattttatt cttcttaatc tattaagctg
     5521 tgtaactccc tgccccaaac cactgaaaag aaaagtaacc ttcaggccag gcgcggtggc
     5581 tcacgcctgt aatcccaaca ctttgggagg ctgaggcggg cggatcactt aaggtcagga
     5641 gttcaagacc agcctggcca acatggtgaa accccgtctc tatcaaaaat tagccgggca
     5701 tggtggcacg tgcctgtaat cccagctact tgggaggctg aggcacgaga attgcttgaa
     5761 cccaggaggc tgaggctgca gtgagccaag attgtgccac tgcactccag cctgtgtgag
     5821 agagtgagac tctgtctcaa aagagaaaaa aaaagaaaag taaccttcag agattcttag
     5881 aagagttgct cattcacacc cacgcccttg cccaaggctg gcccacttag agcgaaactt
     5941 aacttttgtc tggatgggaa gagaagtaag tctaccccga ggttgccatg ttgaagagtg
     6001 agaggtccaa gtgattctgt gcattgaaac caagacaccc cacccagaac acttcttccc
     6061 tccctcagcc caaaccaaag gctggggttc tcatctccaa gtggctgttc tccaactttc
     6121 ccaagccgct tgcattcccc agactggact actgtggcgg ttaggttaga tttgaagacg
     6181 gggcccaggc tgggtatgaa cgggtgcagc cctcttctcc tcttcccccc cacatctctc
     6241 atgagagagg tagtggcatt tccttctcag ggagcttcaa tgggaaaggt ctcgaaagct
     6301 tcaggaggag cagaatacca acgcaggggg atggctgtaa cgatctcacc gtctcctaac
     6361 ctcagtccct tttttgagag tgaatggtgg agggtgggaa gggacccaga tttgtagatc
     6421 tctttgtctg ggggagggga aggatgtggt ttgcagagcg gaagcagagt ttggaaacgc
     6481 atgagagcag agcttcgtgt gttcccaccc tcagtgagga ggtgtgagtg ggtgagcatg
     6541 tggagttggg tgttcccacc ctcagtgagg aggtgtgagt gggggtgcat atagaggcag
     6601 tgcctgctgt ggggtcacaa ctggtgcatg ccagcgccaa agggacctgt ctttaggggt
     6661 catttcagcc agctcctccc atcacagatg acagctccaa gcctagaagg ggctcagtga
     6721 cagggccagg acaagccctc aggactgtgg cctcctggcc cttggttccc ctgccccaca
     6781 acatggtctc cacatggctg gctggctggc tgtccctgtg tgtgtgtgac acacggtgtg
     6841 agtgcagggc tgtgcccggg gtgggagggt gtctatgtgg cactgactgt cttagctcag
     6901 agctggtgga tcctctccat ggacaatgac actttaagga ttgtcttggt ttgtttttcc
     6961 tatttgtggg gtattttccc cctcaggctc ctgggtctgc tgctgcctca aggtgtcctg
     7021 accttgaggc tgatgagggg acccctgcct gtttccccca tactgagttc tagggaggtg
     7081 ctcaccccag actcttagga agggtctaga gaaatgagag gagcccaagc caggggccag
     7141 ctccgagaaa gggtaacctc cacgcttctc tctcccaaat tggaaatgaa gacaggtttt
     7201 caaaggcaca ggctccccct gccagcttct aggatcttcc ttggtgtgca atgggccagt
     7261 taggggtagg cagcttgcac ccagttctcc tttatctcaa cttattttcc tggggagagg
     7321 tgcctagagg gattgaggta acttcaactg ggaattccaa ggaaggtggg caagtagcct
     7381 tggctctctc ccaccatgtc catcaggatt gagagtgtgt ctagctcccg accactttgt
     7441 cttgacctac tgaaaagttg ggaactgagg ggtgccttca ttcccctttg ttcactttct
     7501 ccagctcaac ttgggacttg ggtggtggga ctggagacct cacccctgct cccgtcccgc
     7561 cccctttcta tcccaacctg tttccatgta gcagaccctt cctagggagc agggagggga
     7621 agccacagat tgcaaaccca ggggctcctt tttcattctt tctaaaacct tgatatcctc
     7681 agcccaaagg cgatgccccc ctgccacctc caagcctgga attgtgcata acccggatct
     7741 tgtatctttg tataacggat gttatttgta cgaagggcag ttcgtaaaca gcacttgttc
     7801 ttttaataaa agaatgtttt gcaaaaaaaa aaaaaaaaa
//
