LOCUS       NM_004529               6724 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens MLLT3 super elongation complex subunit (MLLT3),
            transcript variant 1, mRNA.
ACCESSION   NM_004529
VERSION     NM_004529.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6724)
  AUTHORS   Yang,Z., Zhang,G., Zhao,R., Tian,T., Zhi,J., Wei,G., Roeder,R.G.,
            Jing,L. and Yu,M.
  TITLE     MLL-AF9 regulates transcriptional initiation in mixed lineage
            leukemic cells
  JOURNAL   J Biol Chem 300 (8), 107566 (2024)
   PUBMED   39002676
  REMARK    GeneRIF: MLL-AF9 regulates transcriptional initiation in mixed
            lineage leukemic cells.
REFERENCE   2  (bases 1 to 6724)
  AUTHORS   Tariq,M., Shahab,S., Saeed,J.R., Hussain,Z., Zaidi,U., Farzana,T.
            and Ahmad,S.
  TITLE     Impact of MLL::AF9 Gene Rearrangement on Survival of Acute Myeloid
            Leukaemia Patients: An Insight into Pakistani Population
  JOURNAL   J Coll Physicians Surg Pak 34 (4), 424-428 (2024)
   PUBMED   38576284
  REMARK    GeneRIF: Impact of MLL::AF9 Gene Rearrangement on Survival of Acute
            Myeloid Leukaemia Patients: An Insight into Pakistani Population.
REFERENCE   3  (bases 1 to 6724)
  AUTHORS   He,X., Zhong,X., Fang,Y., Hu,Z., Chen,Z., Wang,Y., Huang,H.,
            Zhao,S., Li,D. and Wei,P.
  TITLE     AF9 sustains glycolysis in colorectal cancer via H3K9ac-mediated
            PCK2 and FBP1 transcription
  JOURNAL   Clin Transl Med 13 (8), e1352 (2023)
   PUBMED   37565737
  REMARK    GeneRIF: AF9 sustains glycolysis in colorectal cancer via
            H3K9ac-mediated PCK2 and FBP1 transcription.
REFERENCE   4  (bases 1 to 6724)
  AUTHORS   Bilgin,N., Moesgaard,L., Rahman,M.M., Turkmen,V.A., Kongsted,J. and
            Mecinovic,J.
  TITLE     Molecular Recognition of Methacryllysine and Crotonyllysine by the
            AF9 YEATS Domain
  JOURNAL   Int J Mol Sci 24 (8), 7002 (2023)
   PUBMED   37108167
  REMARK    GeneRIF: Molecular Recognition of Methacryllysine and
            Crotonyllysine by the AF9 YEATS Domain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6724)
  AUTHORS   Liu,X.X., Pan,X.A., Gao,M.G., Kong,J., Jiang,H., Chang,Y.J.,
            Zhang,X.H., Wang,Y., Liu,K.Y., Chen,Z., Zhao,X.S. and Huang,X.J.
  TITLE     The adverse impact of ecotropic viral integration site-1 (EVI1)
            overexpression on the prognosis of acute myeloid leukemia with
            KMT2A gene rearrangement in different risk stratification subtypes
  JOURNAL   Int J Lab Hematol 45 (2), 195-203 (2023)
   PUBMED   36358022
  REMARK    GeneRIF: The adverse impact of ecotropic viral integration site-1
            (EVI1) overexpression on the prognosis of acute myeloid leukemia
            with KMT2A gene rearrangement in different risk stratification
            subtypes.
REFERENCE   6  (bases 1 to 6724)
  AUTHORS   Hemenway,C.S., de Erkenez,A.C. and Gould,G.C.
  TITLE     The polycomb protein MPc3 interacts with AF9, an MLL fusion partner
            in t(9;11)(p22;q23) acute leukemias
  JOURNAL   Oncogene 20 (29), 3798-3805 (2001)
   PUBMED   11439343
REFERENCE   7  (bases 1 to 6724)
  AUTHORS   Garcia-Cuellar,M.P., Zilles,O., Schreiner,S.A., Birke,M.,
            Winkler,T.H. and Slany,R.K.
  TITLE     The ENL moiety of the childhood leukemia-associated MLL-ENL
            oncoprotein recruits human Polycomb 3
  JOURNAL   Oncogene 20 (4), 411-419 (2001)
   PUBMED   11313972
REFERENCE   8  (bases 1 to 6724)
  AUTHORS   Huynh,K.D., Fischle,W., Verdin,E. and Bardwell,V.J.
  TITLE     BCoR, a novel corepressor involved in BCL-6 repression
  JOURNAL   Genes Dev 14 (14), 1810-1823 (2000)
   PUBMED   10898795
REFERENCE   9  (bases 1 to 6724)
  AUTHORS   Iida,S., Seto,M., Yamamoto,K., Komatsu,H., Tojo,A., Asano,S.,
            Kamada,N., Ariyoshi,Y., Takahashi,T. and Ueda,R.
  TITLE     MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a
            serine/proline rich protein homologous to MLLT1 on 19p13
  JOURNAL   Oncogene 8 (11), 3085-3092 (1993)
   PUBMED   8414510
REFERENCE   10 (bases 1 to 6724)
  AUTHORS   Nakamura,T., Alder,H., Gu,Y., Prasad,R., Canaani,O., Kamada,N.,
            Gale,R.P., Lange,B., Crist,W.M., Nowell,P.C. et al.
  TITLE     Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities
            in acute leukemia share sequence homology and/or common motifs
  JOURNAL   Proc Natl Acad Sci U S A 90 (10), 4631-4635 (1993)
   PUBMED   8506309
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036089.1, L13744.1 and AL512635.8.
            
            On Nov 23, 2018 this sequence version replaced NM_004529.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L13744.1, BX649194.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380338.9/ ENSP00000369695.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-759               BC036089.1         8-766
            760-2927            L13744.1           712-2879
            2928-6724           AL512635.8         159166-162962       c
FEATURES             Location/Qualifiers
     source          1..6724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..6724
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /note="MLLT3 super elongation complex subunit"
                     /db_xref="GeneID:4300"
                     /db_xref="HGNC:HGNC:7136"
                     /db_xref="MIM:159558"
     exon            1..255
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1950
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /note="isoform a is encoded by transcript variant 1;
                     myeloid/lymphoid or mixed-lineage leukemia (trithorax
                     homolog); translocated to, 3; protein AF-9; ALL1-fused
                     gene from chromosome 9 protein; myeloid/lymphoid or
                     mixed-lineage leukemia (trithorax homolog, Drosophila);
                     translocated to, 3; myeloid/lymphoid or mixed-lineage
                     leukemia translocated to chromosome 3 protein; YEATS
                     domain-containing protein 3; myeloid/lymphoid or
                     mixed-lineage leukemia; translocated to 3; KMT2A/MLLT3
                     fusion protein"
                     /codon_start=1
                     /product="protein AF-9 isoform a"
                     /protein_id="NP_004520.2"
                     /db_xref="CCDS:CCDS6494.1"
                     /db_xref="GeneID:4300"
                     /db_xref="HGNC:HGNC:7136"
                     /db_xref="MIM:159558"
                     /translation="MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNI
                     QHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDY
                     DLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSS
                     SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAF
                     KEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQ
                     DKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVK
                     MGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSF
                     TPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSLSDG
                     SDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELV
                     ELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSG
                     TS"
     exon            256..436
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /inference="alignment:Splign:2.1.0"
     exon            437..519
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /inference="alignment:Splign:2.1.0"
     exon            520..663
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /inference="alignment:Splign:2.1.0"
     exon            664..1368
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1444
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1574
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1674
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1746
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1818
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..6724
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2739..2744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /note="hexamer: AATAAA"
     polyA_site      2766
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /note="major polyA site"
     regulatory      4466..4471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /note="hexamer: AATAAA"
     polyA_site      4489
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /note="major polyA site"
     regulatory      5989..5994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /note="hexamer: TATAAA"
     polyA_site      6013
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
     polyA_site      6171
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
     polyA_site      6216
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
     polyA_site      6226
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
     regulatory      6702..6707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
                     /note="hexamer: AATACA"
     polyA_site      6724
                     /gene="MLLT3"
                     /gene_synonym="AF9; YEATS3"
ORIGIN      
        1 aatcatcttc tttaccctgg agctgctgct gctgctgctg cttttgcttt tggggctgag
       61 tttaataagc gagcgagcga gcaagcgagc gcggggggaa aaaggcagag aatgtccgcc
      121 atctaccctc cgctcctggg cgcgctctca ttcatagcag cctcttcatg aattacagct
      181 gagggggggc ggaggagggg ggggtaccac acaacacccc agcaaacctc cgggccccca
      241 ggcatggcta gctcgtgtgc cgtgcaggtg aagctggagc tggggcaccg cgcccaggtg
      301 aggaaaaaac ccaccgtgga gggcttcacc cacgactgga tggtgttcgt acgcggtccg
      361 gagcacagta acatacagca ctttgtggag aaagtcgtct tccacttgca cgaaagcttt
      421 cctaggccaa aaagagtgtg caaagatcca ccttacaaag tagaagaatc tgggtatgct
      481 ggtttcattt tgccaattga agtttatttt aaaaacaagg aagaacctag gaaagtccgc
      541 tttgattatg acttattcct gcatcttgaa ggccatccac cagtgaatca cctccgctgt
      601 gaaaagctaa ctttcaacaa ccccacagag gactttagga gaaagttgct gaaggcagga
      661 ggggacccta ataggagtat tcataccagc agcagcagca gcagcagcag tagcagcagc
      721 agcagcagca gcagcagcag cagtagcagc agcagcagca gcagcagcag cagcagtagc
      781 agcagcagta gcagcagcag cagcagcagt agtaccagtt tttcaaagcc tcacaaatta
      841 atgaaggagc acaaggaaaa accttctaaa gactccagag aacataaaag tgccttcaaa
      901 gaaccttcca gggatcacaa caaatcttcc aaagaatcct ctaagaaacc caaagaaaat
      961 aaaccactga aagaagagaa aatagttcct aagatggcct tcaaggaacc taaacccatg
     1021 tcaaaagagc caaaaccaga tagtaactta ctcaccatca ccagtggaca agataagaag
     1081 gctcctagta aaaggccgcc catttcagat tctgaagaac tctcagccaa aaaaaggaaa
     1141 aagagtagct cagaggcttt atttaaaagt ttttctagcg caccaccact gatactcact
     1201 tgttctgctg acaaaaaaca gataaaagat aaatctcatg tcaagatggg aaaggtcaaa
     1261 attgaaagtg agacatcaga gaagaagaaa tcaacgttac cgccatttga tgatattgtg
     1321 gatcccaatg attcagatgt ggaggagaat atatcctcta aatctgattc tgaacaaccc
     1381 agtcctgcca gctccagctc cagctccagc tccagcttca caccatccca gaccaggcaa
     1441 caaggtcctt tgaggtctat aatgaaagat ctgcattctg atgacaatga ggaggaatca
     1501 gatgaagtgg aggataacga caatgactct gaaatggaga ggcctgtaaa tagaggaggc
     1561 agccgaagtc gcagagttag cttaagtgat ggcagcgata gtgaaagcag ttctgcttct
     1621 tcacccctac atcacgaacc tccaccaccc ttactaaaaa ccaacaacaa ccagattctt
     1681 gaagtgaaaa gtccaataaa gcaaagcaaa tcagataagc aaataaagaa tggtgaatgt
     1741 gacaaggcat acctagatga actggtagag cttcacagaa ggttaatgac attgagagaa
     1801 agacacattc tgcagcagat cgtgaacctt atagaagaaa ctggacactt tcatatcaca
     1861 aacacaacat ttgattttga tctttgctcg ctggacaaaa ccacagtccg taaactacag
     1921 agttacctgg aaacatctgg aacatcctga ggatataaca actggatgca tcaagaacta
     1981 ttgtgttttt tttttttggt tttttttttt tttggttgtg attttttgtt cttgttgttt
     2041 atatgaaaac actcaaaatg atgcaaccaa aagggaaaaa ataaaaatca aacaaccttc
     2101 agctttattt ttctttaaag ccagtcatca tctcttgata aaggagaggt taaagcaaac
     2161 cagcctcagc ggaccactct tctctccaag gaaatccccg ggaagagtta gcctggatag
     2221 ccttgaaaac aaacaaatca aacacaacac aagaaaactc aaagaatgtg tatggtatca
     2281 tgtatctctc tgtggtggtt cattccacag gacgaatgca tattcaacac actgccttat
     2341 tacataactg atctatttat tatcgcatac agatattcta agtcgttgag ggaatgacac
     2401 catcagacat tataagtact tggtcccgtg gatgctcttt caatgcagca cccttgccat
     2461 cccaagccca gtgaccttac tcgtataccg tgccactttc caccaacttt ttccaagtcc
     2521 tttaactcgt tgcagtctgt attttccacc ttttgttttt ccagttccag gacacagatt
     2581 atcaactggg gggaccaaat agccaccttg attttcttct ttgtggtctt tttcctgaaa
     2641 gttggggccc agtccttggc tgtatccatg taatgatctt ggaccatggt agaaaatgca
     2701 ccaaatagga tcatatgaat tgctgtctag ccttagtcaa taaacttgta ggacttttaa
     2761 acaaaagtgt acctgtaaat gtcctgaatc cagcattgtt gagctgtcat caacattctt
     2821 gtgtctgttt tactgttaca atattaggtg aatatggaag taaaggcatt ccacaggatc
     2881 atcatttaaa aaaaaagaat tctggtcctg ttttctaaaa aaaaaaactg ttgtagaaat
     2941 tcttaatttg gatctattta ttagtcagag tttcagcttt cttcagctgc cagtgtgtta
     3001 ctcatcttta tcctaaaaat ctggaatcag agatttttgt ttgttcacat atgattctct
     3061 tagacacttt tatatttgaa aaaattaaaa tctttctttg gggaaaaatt cttggttatt
     3121 ctgccataac agattatgta ttaacttgta gattcagtgg ttcaatacct gtttagttgc
     3181 ttgctaatat ttccagaagg atttcttgta ttggtgaaag acggttgggg atggggggat
     3241 ttttttgttc ttgttgtacc cttgttttga aactagaaat ctgtcctgtg gcatgcaaaa
     3301 gaaagcaaat tatttttaaa agaaaaaaac caaagtactt ttggtgtcat tattccatct
     3361 tctccataag tggagaaatg aaaagtaaga acagctcatc ttcaaagttt ttactagaaa
     3421 ttcagccgaa aagaagagaa atgaagaaat acttctggat ccaaaggttc gtcactggat
     3481 cagccttaag aaagtctcta tgtgtgctaa tagaccagta tctcccttgt ttgttcccat
     3541 gccagatgct gtcttttcat acagagatta actagtgtct gtacagaaaa tggtctttcc
     3601 agacccattc ttttgggcag ttatataaat gcagattgat aatggagtta tttctgcatt
     3661 ttaaaaaggg gattttttac actgtttctt tctatccaaa gaaactattt ttcctttaaa
     3721 aaattataat acagccatgc tccttgtaaa ttatttctct gaagcgtcct cccagaggac
     3781 aagtgtactt tctcaataat gttatgattc ttaatgacga ttggcatgaa ccgtacttga
     3841 agcatttgtt gtattgtcca cttcttgatg tgcagagaaa ctttgagtca ttttggacat
     3901 taggtgattg atgaattgtg tggtttcagt tgcgttttgt ttttaacttt atagctggaa
     3961 ggggagggta atgtttatat ggaaatgttg caaattttta aaatatttta aaatttctaa
     4021 ctgctaacac atattctgat caagccagaa gtttatgtga tttaatatat ctgtgtagtt
     4081 taactagaaa cgtatatatg tagtttgggc catttttatt tctgtaacta aattgtgggg
     4141 caaaaaatat gatttgccaa tgtaaaaatt ttttccttta agttactaac caagaagcta
     4201 ggtaagataa gaaatgacca aacaaaaata atgataagaa ggacagctat tatatgataa
     4261 actttagact tgaaaattag gtaataaagt taatttcttc agaatatcct aaaatgtaag
     4321 tttgtaaatt gataaagttc agaaaaactt atccatcttc tactcatcaa gatagcaaag
     4381 taagtttttc acaaaattaa gactgagagt tacgttattt tttttgaagt ggtaatcttg
     4441 ctctcatcta atttttaaat acagaaataa aaagatccct ttgaattaat ttcaagtagt
     4501 tttaatacct ctcttaaagt aaccccttca gttctgtcac atttatatac acccaacttt
     4561 gaagcctatt aagaatatct ttgacatgtg agtaccctaa cagtggctct ggtttcttaa
     4621 gcacaaaggg aaaatggcag ggtttaattt ctttggtgta catatataaa tagatgtttc
     4681 aaataaaatt aattgggtaa atgtgaatat ggtttgaacc agccagagta tgataaactt
     4741 ttaaaaaatt tttcctcagt gatcagccag gggaaaaaat atatgtacag agctcctgcc
     4801 cctctgcccc cttataactt agcttttgcc tctggttttg cagcaggatg tgtgttggtg
     4861 ggtttggggt tccttctgtc ttcggatgta acagtcatgt tagcaacaat attttgcagt
     4921 tacttcacca tcctcagcat aatctgcctc tctctcaatc ttaatacaga caaataggta
     4981 tgtctataaa tgcgttcata tagtgtcaag gtagggaaga ctataaaaac ttcagatcag
     5041 gaaaaaaata tctcttaaga gagtgtctta aacattttaa attgctaggc aatttaaatc
     5101 tctctaatct gaatattcac cttttggtgg aaagagccag taatattggt tttcttccac
     5161 taaaaagttt cttcaaaatt tttttttttt tttttttttt tttttttttg ccgatatctt
     5221 ttacaggccc acctaatctt taaaaaaaag agaagaaaca attttaggcc tgtataacat
     5281 cctatttact acttcaagct ccacaaatgt agttaatata tttgtttaag agagacttta
     5341 ctcttaaatg ttttaacttt gcctacttaa tggagttgga tgtccagtgt tggaaacagt
     5401 cagtgtctgt ttggtggctc gtgtttattt ttgtcactgt agaagtgatc tgctctggag
     5461 taatttgctg tatgcttatt actttccacc tttagcgttt tgtgtactaa tgctatgtac
     5521 tgctcctata tttatatata catatatata tatatataca catatatatt atcagagtaa
     5581 tcttgctttg gactgttgct ctaaaactat gaatatgatg tagagactac tacagctgca
     5641 gtgaatgtta aggagtcaat tcccatggtt tagtttagtc tcgggctgga agtctacatc
     5701 ttttgacctc ttttgtttta tatgatgctt tttattatgt aggcactgcc atccctgaat
     5761 attccttgta aagatgcagt gaagaagtca atttaaaagg aagacaaagc caccgctgtc
     5821 tgtaaactgt aaatgtgtat tttggcactt gtactccagt attctgaaaa tagagttatg
     5881 atggaaatgc tgacagatcc ttaatggtgg ccagagctac catgcagtgc aaaaataaat
     5941 taagtgaaaa tgtattattg agattaacag tgcaaggcca atacatttta taaatctgtc
     6001 agtatctttt taatggactg tgtatgtgta gttatgttga aagatacatt gtgtatgtgt
     6061 acatgctttt gtgtgaattc aaggcacact gtaagatgta tttcccttct ctaaaatcca
     6121 tgttgaaatg taagtacaga ttgatagaaa taggtgtttt acttaaactc atataatctg
     6181 tttcagcacc ttttttaaaa tgtataattg tactgatttg ctgagagtca tttgaccaaa
     6241 gtttggcttt attttgcata caggaaaaat tagcccctag ccttttctca agaagtgatg
     6301 ctgtttctaa agaagaatag atggggagat ctgagacatc cagagagagg acaatgtgtc
     6361 caaaaccagc tgaaggcaga gagtccatgc ctcattcatt ttaggagtcc ctcatgtcta
     6421 acaccatctt ctgtgtccta aagccagtat atatataata tttttaaaac tctgcaaaga
     6481 ttggaacaag aagtggtggg atacattttt tggcataaac tgggctatgt gtgcccggta
     6541 ttttttcttt cccccctatt tctttggagg gttttgttca gaaacaatgt gctatagcca
     6601 gagagagtcg atcttacaaa gtccctgcat ttactttcac agcaagaact gctaccttga
     6661 ttagacagga aggagaacaa ctactacaac aaagagaata aaatacattc agtttggtaa
     6721 ataa
//
