LOCUS       NM_006818               2483 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens MLLT11 transcription factor 7 cofactor (MLLT11), mRNA.
ACCESSION   NM_006818
VERSION     NM_006818.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2483)
  AUTHORS   Proestling,K., Husslein,H., Hudson,Q.J., Witzmann-Stern,M.,
            Widmar,B., Bago-Horvath,Z., Sandrieser,L., Perricos,A., Wenzl,R.
            and Yotova,I.
  TITLE     MLLT11 Regulates Endometrial Stroma Cell Adhesion, Proliferation
            and Survival in Ectopic Lesions of Women with Advanced
            Endometriosis
  JOURNAL   Int J Mol Sci 25 (1), 439 (2023)
   PUBMED   38203610
  REMARK    GeneRIF: MLLT11 Regulates Endometrial Stroma Cell Adhesion,
            Proliferation and Survival in Ectopic Lesions of Women with
            Advanced Endometriosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2483)
  AUTHORS   Liu,X., Bai,W., Li,J., Ma,J., Liu,Y., Wang,Z., Hu,L., Li,Z.,
            Papukashvili,D., Rcheulishvili,N., Wang,F. and Lu,X.
  TITLE     MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of
            MDA-MB-231 Breast Cancer Cells
  JOURNAL   Breast J 2023, 6282654 (2023)
   PUBMED   38075552
  REMARK    GeneRIF: MLLT11 siRNA Inhibits the Migration and Promotes the
            Apoptosis of MDA-MB-231 Breast Cancer Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2483)
  AUTHORS   Liao,J., Chen,H., Qi,M., Wang,J. and Wang,M.
  TITLE     MLLT11-TRIL complex promotes the progression of endometrial cancer
            through PI3K/AKT/mTOR signaling pathway
  JOURNAL   Cancer Biol Ther 23 (1), 211-224 (2022)
   PUBMED   35253622
REFERENCE   4  (bases 1 to 2483)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 2483)
  AUTHORS   Manyisa,N., Schrauwen,I., de Souza Rios,L.A., Mowla,S.,
            Tekendo-Ngongang,C., Popel,K., Esoh,K., Bharadwaj,T.,
            Nouel-Saied,L.M., Acharya,A., Nasir,A., Wonkam-Tingang,E., Kock,C.,
            Dandara,C., Leal,S.M. and Wonkam,A.
  TITLE     A Monoallelic Variant in REST Is Associated with Non-Syndromic
            Autosomal Dominant Hearing Impairment in a South African Family
  JOURNAL   Genes (Basel) 12 (11), 1765 (2021)
   PUBMED   34828371
  REMARK    GeneRIF: A Monoallelic Variant in REST Is Associated with
            Non-Syndromic Autosomal Dominant Hearing Impairment in a South
            African Family.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2483)
  AUTHORS   Strunk,C.J., Platzbecker,U., Thiede,C., Schaich,M., Illmer,T.,
            Kang,Z., Leahy,P., Li,C., Xie,X., Laughlin,M.J., Lazarus,H.M.,
            Gerson,S.L., Bunting,K.D., Ehninger,G. and Tse,W.
  TITLE     Elevated AF1q expression is a poor prognostic marker for adult
            acute myeloid leukemia patients with normal cytogenetics
  JOURNAL   Am J Hematol 84 (5), 308-309 (2009)
   PUBMED   19396856
  REMARK    GeneRIF: high AF1q expression is a poor prognostic marker for adult
            patients with normal cytogenetics acute myeloid leukemia
REFERENCE   7  (bases 1 to 2483)
  AUTHORS   Co,N.N., Tsang,W.P., Wong,T.W., Cheung,H.H., Tsang,T.Y., Kong,S.K.
            and Kwok,T.T.
  TITLE     Oncogene AF1q enhances doxorubicin-induced apoptosis through
            BAD-mediated mitochondrial apoptotic pathway
  JOURNAL   Mol Cancer Ther 7 (10), 3160-3168 (2008)
   PUBMED   18852119
  REMARK    GeneRIF: The study provides the first evidence that AF1q plays a
            critical role in the regulation of apoptosis and drug resistance.
REFERENCE   8  (bases 1 to 2483)
  AUTHORS   Chang,X.Z., Li,D.Q., Hou,Y.F., Wu,J., Lu,J.S., Di,G.H., Jin,W.,
            Ou,Z.L., Shen,Z.Z. and Shao,Z.M.
  TITLE     Identification of the functional role of AF1Q in the progression of
            breast cancer
  JOURNAL   Breast Cancer Res Treat 111 (1), 65-78 (2008)
   PUBMED   17929166
  REMARK    GeneRIF: overexpression of AF1Q leads to more progression in human
            breast cancer
REFERENCE   9  (bases 1 to 2483)
  AUTHORS   Lin,H.J., Shaffer,K.M., Sun,Z., Jay,G., He,W.W. and Ma,W.
  TITLE     AF1q, a differentially expressed gene during neuronal
            differentiation, transforms HEK cells into neuron-like cells
  JOURNAL   Brain Res Mol Brain Res 131 (1-2), 126-130 (2004)
   PUBMED   15530661
  REMARK    GeneRIF: The ectopic expression of human AF1q triggered the
            expression of the neuronal marker TuJ1 in non-neuronal human
            embryonic kidney (HEK) cells.
REFERENCE   10 (bases 1 to 2483)
  AUTHORS   Tse,W., Zhu,W., Chen,H.S. and Cohen,A.
  TITLE     A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is
            specifically expressed in leukemic and immature hematopoietic cells
  JOURNAL   Blood 85 (3), 650-656 (1995)
   PUBMED   7833468
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590133.32.
            
            On Jul 27, 2019 this sequence version replaced NM_006818.3.
            
            Summary: The gene variously symbolized ALL1, HRX, or MLL located on
            11q23 has been demonstrated to be fused with a number of
            translocation partners in cases of leukemia. t(1;11)(q21;q23)
            translocations that fused the MLL gene to a gene on chromosomal
            band 1q21 in 2 infants with acute myelomonocytic leukemia have been
            demonstrated. The N-terminal portion of the MLL gene is critical
            for leukemogenesis in translocations involving band 11q23. This
            gene encodes 90 amino acids. It was found to be highly expressed in
            the thymus but not in peripheral lymphoid tissues. In contrast to
            its restricted distribution in normal hematopoietic tissue, this
            gene was expressed in all leukemic cell lines tested. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.137394.1, BC022448.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368921.5/ ENSP00000357917.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AL590133.32        146590-146746
            158-2483            AL590133.32        153412-155737
FEATURES             Location/Qualifiers
     source          1..2483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2483
                     /gene="MLLT11"
                     /gene_synonym="AF1Q"
                     /note="MLLT11 transcription factor 7 cofactor"
                     /db_xref="GeneID:10962"
                     /db_xref="HGNC:HGNC:16997"
                     /db_xref="MIM:604684"
     exon            1..157
                     /gene="MLLT11"
                     /gene_synonym="AF1Q"
                     /inference="alignment:Splign:2.1.0"
     exon            158..2483
                     /gene="MLLT11"
                     /gene_synonym="AF1Q"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..436
                     /gene="MLLT11"
                     /gene_synonym="AF1Q"
                     /note="ALL1 fused gene from chromosome 1q;
                     myeloid/lymphoid or mixed-lineage leukemia (trithorax
                     homolog, Drosophila); translocated to, 11;
                     myeloid/lymphoid or mixed-lineage leukemia; translocated
                     to, 11"
                     /codon_start=1
                     /product="protein AF1q"
                     /protein_id="NP_006809.1"
                     /db_xref="CCDS:CCDS982.1"
                     /db_xref="GeneID:10962"
                     /db_xref="HGNC:HGNC:16997"
                     /db_xref="MIM:604684"
                     /translation="MRDPVSSQYSSFLFWRMPIPELDLSELEGLGLSDTATYKVKDSS
                     VGKMIGQATAADQEKNPEGDGLLEYSTFNFWRAPIASIHSFELDLL"
     regulatory      1414..1419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLLT11"
                     /gene_synonym="AF1Q"
                     /note="hexamer: AATAAA"
     polyA_site      1433
                     /gene="MLLT11"
                     /gene_synonym="AF1Q"
                     /note="major polyA site"
     regulatory      2465..2470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLLT11"
                     /gene_synonym="AF1Q"
                     /note="hexamer: AATAAA"
     polyA_site      2483
                     /gene="MLLT11"
                     /gene_synonym="AF1Q"
ORIGIN      
        1 gaactgacag actcagtcac tgaagaggga aaaggagtga gaagacaaag ccgtcaaagc
       61 cccaacagct ttgtatttct ccagcccggc gcagaccccg gagctcccga ggcactccct
      121 ccatctttgg aacacgccag taattgattg ataacaggaa gctatgaggg accctgtgag
      181 tagccagtac agttcctttc ttttctggag gatgcccatc ccagaactgg atctgtcgga
      241 gctggaaggc ctgggtctgt cagatacagc cacctacaag gtcaaagaca gcagcgttgg
      301 caaaatgatc gggcaagcaa ctgcagcaga ccaggagaaa aaccctgaag gtgatggcct
      361 ccttgagtac agcaccttca acttctggag agctcccatt gccagcatcc actccttcga
      421 actggacttg ctctaaggcc aagacttctc tctcccatca ccttgccctc attgtcttcc
      481 ctctcaagcc ccttcctttc cactcctttc ccattttaat cttgttctct ccctactgtg
      541 ttggtggtgc tgatgaatct gccagagttg agttctatgt atttatttat ctatctgtct
      601 actccatttc tctcaaaagc cctcaagtca caaagtaaat ggttcaagca atggagtact
      661 gggtcacagg gattcctcct ttccccccca aatattaact ccagaaacta ggcctgactg
      721 gggacacctg agagtagtat agtagtgcaa aatggaagac tgatttttga ctctattata
      781 atcagcttca gagattcctt aaaccttcct aatttcctgc tccagggcag taaacacaaa
      841 tatttcttca aggggtgatg aaaacctcgg aagttttaat ttgaggttat ctgctacgaa
      901 acagtatttc taaaaggcta aagtgataag tctcttgctt ttttttgatc ctgctcttat
      961 attctttttt ttcctcagag aaatcaggag ggtagttaga ggtataaaac aggaggaaat
     1021 attatggaaa atgaaaatag ggaaaataat tgaatcattt tagaagtagc taatttcttt
     1081 tctcaaaaga gtgtcccttc ttcacaccta ctcactttac aactttgctc ctaactgtgg
     1141 gttgaaaact ctagctaaag aaagttatca aatcttaaca tgcattccta ctattatgat
     1201 agtttttaag gtttcaattc aatcttctga acggcataag tcctatttta gccttacctc
     1261 ctgcatttgc aatacgtaat actgatcagt gggcacagtt cttcagctac attgagaccc
     1321 tgaaatgaac aattatattc tgactcgaca tcttgtcccc aatccttcca aaaatattga
     1381 tggtgatttg tgctaccatt tactcgttta tttaataaag acattcaatc ccaggactgg
     1441 agtctaattt tctctcttca caagaaaagc cacagaaatc tgagaaatta gccttgcttt
     1501 cacacttagc ttatacatct tttttttctt ttttattttt gagacagggt cccactctgt
     1561 cacccaggct ggagtgcagt ggcggggatc accgctcact gcaacctcca cccaccaggg
     1621 tcaagggatc ctcccacctc aggctcccag gtagctggga ttacaggcgc ctgccaccag
     1681 gcctggttaa tttttgtatt tttcatagag acggggtttc accatgttgg ccaggctggt
     1741 ctctaactcc tgacctcagg tgatctgccc gccttagcct ctcaaagtgc tgagattaca
     1801 ggcgtgagcc actgagcccg gcctcatttt atctttctat aataatattc aacttagagg
     1861 aagaatgatt tgagtagcat ttagacatta gatggtgaac ttcgcattga acagataatg
     1921 aaagggcaaa atcaacttaa aattagaaaa gtagttaggg agacaggtac aaccactctt
     1981 ctgcttgccc actgactacc aacattatat ttcaggtaat aattctccta ggtgcctaag
     2041 aagataaacg aattcactca aatatgttat ctgcttaact tctggttttt gtgtgcctgc
     2101 tataggaaag cactgagcca aacagaatgt aaacgggaat gagacaagac tccaactctc
     2161 aaaagagaaa ctgtaaatac caatatggat aggacagaat tgggcagtgt actataaata
     2221 aggatgacac tataccctaa ataaggatga tctagagaag tccccaggtg ggagaaaaaa
     2281 agacaaatcc tccctctagg ccatgaaaag cccacatcta aagacggtcc cagtctaacg
     2341 aagaatgggg ccaggaagga taagtagtgc gtccttttct atttttactg agttttgaag
     2401 ggccccttca gagtccttca gccatggcaa ttggtgggtg gagacaggga tcaactgttt
     2461 ggtaaataaa gtgactaaat gga
//
