LOCUS       NM_001324296             870 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens MLLT10 histone lysine methyltransferase DOT1L cofactor
            (MLLT10), transcript variant 7, mRNA.
ACCESSION   NM_001324296
VERSION     NM_001324296.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 870)
  AUTHORS   Klein,B.J., Deshpande,A., Cox,K.L., Xuan,F., Zandian,M.,
            Barbosa,K., Khanal,S., Tong,Q., Zhang,Y., Zhang,P., Sinha,A.,
            Bohlander,S.K., Shi,X., Wen,H., Poirier,M.G., Deshpande,A.J. and
            Kutateladze,T.G.
  TITLE     The role of the PZP domain of AF10 in acute leukemia driven by AF10
            translocations
  JOURNAL   Nat Commun 12 (1), 4130 (2021)
   PUBMED   34226546
  REMARK    GeneRIF: The role of the PZP domain of AF10 in acute leukemia
            driven by AF10 translocations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Ugurlu-Cimen,D., Odluyurt,D., Sevinc,K., Ozkan-Kucuk,N.E.,
            Ozcimen,B., Demirtas,D., Enustun,E., Aztekin,C., Philpott,M.,
            Oppermann,U., Ozlu,N. and Onder,T.T.
  TITLE     AF10 (MLLT10) prevents somatic cell reprogramming through
            regulation of DOT1L-mediated H3K79 methylation
  JOURNAL   Epigenetics Chromatin 14 (1), 32 (2021)
   PUBMED   34215314
  REMARK    GeneRIF: AF10 (MLLT10) prevents somatic cell reprogramming through
            regulation of DOT1L-mediated H3K79 methylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 870)
  AUTHORS   Chen,B.R., Deshpande,A., Barbosa,K., Kleppe,M., Lei,X., Yeddula,N.,
            Vela,P.S., Campos,A.R., Wechsler-Reya,R.J., Bagchi,A.,
            Meshinchi,S., Eaves,C., Jeremias,I., Haferlach,T., Frank,D.A.,
            Ronai,Z., Chanda,S., Armstrong,S.A., Adams,P.D., Levine,R.L. and
            Deshpande,A.J.
  TITLE     A JAK/STAT-mediated inflammatory signaling cascade drives
            oncogenesis in AF10-rearranged AML
  JOURNAL   Blood 137 (24), 3403-3415 (2021)
   PUBMED   33690798
  REMARK    GeneRIF: A JAK/STAT-mediated inflammatory signaling cascade drives
            oncogenesis in AF10-rearranged AML.
REFERENCE   5  (bases 1 to 870)
  AUTHORS   Deutsch,J.L. and Heath,J.L.
  TITLE     MLLT10 in benign and malignant hematopoiesis
  JOURNAL   Exp Hematol 87, 1-12 (2020)
   PUBMED   32569758
  REMARK    GeneRIF: MLLT10 in benign and malignant hematopoiesis.
            Review article
REFERENCE   6  (bases 1 to 870)
  AUTHORS   de Bruijn,D.R., dos Santos,N.R., Thijssen,J., Balemans,M.,
            Debernardi,S., Linder,B., Young,B.D. and Geurts van Kessel,A.
  TITLE     The synovial sarcoma associated protein SYT interacts with the
            acute leukemia associated protein AF10
  JOURNAL   Oncogene 20 (25), 3281-3289 (2001)
   PUBMED   11423977
REFERENCE   7  (bases 1 to 870)
  AUTHORS   Lillington,D.M., Jaju,R.J., Shankar,A.G., Neat,M., Kearney,L.,
            Young,B.D. and Saha,V.
  TITLE     Cytogenetic and molecular evidence of marrow involvement in
            extramedullary acute myeloid leukaemia
  JOURNAL   Br J Haematol 110 (3), 547-551 (2000)
   PUBMED   10997963
REFERENCE   8  (bases 1 to 870)
  AUTHORS   Linder,B., Newman,R., Jones,L.K., Debernardi,S., Young,B.D.,
            Freemont,P., Verrijzer,C.P. and Saha,V.
  TITLE     Biochemical analyses of the AF10 protein: the extended
            LAP/PHD-finger mediates oligomerisation
  JOURNAL   J Mol Biol 299 (2), 369-378 (2000)
   PUBMED   10860745
REFERENCE   9  (bases 1 to 870)
  AUTHORS   Silliman,C.C., McGavran,L., Wei,Q., Miller,L.A., Li,S. and
            Hunger,S.P.
  TITLE     Alternative splicing in wild-type AF10 and CALM cDNAs and in
            AF10-CALM and CALM-AF10 fusion cDNAs produced by the
            t(10;11)(p13-14;q14-q21) suggests a potential role for truncated
            AF10 polypeptides
  JOURNAL   Leukemia 12 (9), 1404-1410 (1998)
   PUBMED   9737689
REFERENCE   10 (bases 1 to 870)
  AUTHORS   Chaplin,T., Ayton,P., Bernard,O.A., Saha,V., Della Valle,V.,
            Hillion,J., Gregorini,A., Lillington,D., Berger,R. and Young,B.D.
  TITLE     A novel class of zinc finger/leucine zipper genes identified from
            the molecular cloning of the t(10;11) translocation in acute
            leukemia
  JOURNAL   Blood 85 (6), 1435-1441 (1995)
   PUBMED   7888665
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358780.22.
            
            On Aug 13, 2020 this sequence version replaced NM_001324296.1.
            
            Summary: This gene encodes a transcription factor and has been
            identified as a partner gene involved in several chromosomal
            rearrangements resulting in various leukemias. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (7), as well as variants 5 and 6,
            encodes isoform e.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.61980.1,
                                           SRR1163655.434132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AL358780.22        65258-65343
            87-246              AL358780.22        66147-66306
            247-326             AL358780.22        70335-70414
            327-870             AL358780.22        88145-88688
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.31"
     gene            1..870
                     /gene="MLLT10"
                     /gene_synonym="AF10"
                     /note="MLLT10 histone lysine methyltransferase DOT1L
                     cofactor"
                     /db_xref="GeneID:8028"
                     /db_xref="HGNC:HGNC:16063"
                     /db_xref="MIM:602409"
     exon            1..86
                     /gene="MLLT10"
                     /gene_synonym="AF10"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..626
                     /gene="MLLT10"
                     /gene_synonym="AF10"
                     /note="isoform e is encoded by transcript variant 7; type
                     I AF10 protein; ALL1-fused gene from chromosome 10
                     protein; type III AF10 protein; type IV AF10 protein;
                     myeloid/lymphoid or mixed-lineage leukemia (trithorax
                     homolog, Drosophila); translocated to, 10;
                     myeloid/lymphoid or mixed-lineage leukemia; translocated
                     to, 10"
                     /codon_start=1
                     /product="protein AF-10 isoform e"
                     /protein_id="NP_001311225.1"
                     /db_xref="CCDS:CCDS55707.1"
                     /db_xref="GeneID:8028"
                     /db_xref="HGNC:HGNC:16063"
                     /db_xref="MIM:602409"
                     /translation="MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDG
                     HGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVMVCNSCWLASSENVTPGYIEHH
                     CACASPHPRCLVSNVPPVSGALMHCFWACLTTAAFFGPQSFTTCHMSFLVSRDILFYI
                     YGFMPFISVVIWRFKKERW"
     exon            87..246
                     /gene="MLLT10"
                     /gene_synonym="AF10"
                     /inference="alignment:Splign:2.1.0"
     exon            247..326
                     /gene="MLLT10"
                     /gene_synonym="AF10"
                     /inference="alignment:Splign:2.1.0"
     exon            327..870
                     /gene="MLLT10"
                     /gene_synonym="AF10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      842..847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLLT10"
                     /gene_synonym="AF10"
                     /note="hexamer: AATAAA"
     polyA_site      870
                     /gene="MLLT10"
                     /gene_synonym="AF10"
                     /note="major polyA site"
ORIGIN      
        1 atgcttcatt acacccttca tggaagctgg cacactcgcc ccaccctcgt tttccacggg
       61 ccagtcttgg aggaaaaggc cagcagatgg tctctagcga ccggcccgtg tcactggagg
      121 acgaggtctc ccatagtatg aaggagatga ttggaggctg ttgcgtttgc tcagacgaga
      181 gaggctgggc cgagaacccg ctggtttatt gcgacgggca cggctgcagc gtcgcggtgc
      241 atcaagcttg ctatggcatt gttcaagtac ccactggacc gtggttttgc aggaaatgtg
      301 aatctcagga gagagcagcc agagtgatgg tatgcaattc ctgttggtta gcctcatctg
      361 aaaacgtcac tcctggatac atagaacatc actgcgcatg tgcatctccc cacccccgat
      421 gcctggtgtc taacgttcct ccagtttctg gtgctctgat gcattgcttt tgggcttgtc
      481 ttactacagc agctttcttc ggtcctcagt catttaccac ttgtcatatg tcctttctag
      541 tttccaggga tattcttttt tatatttatg gctttatgcc atttatctca gttgtcattt
      601 ggcgtttcaa gaaggagagg tggtagtgtt taagtggaat taactacttg tgtttctgat
      661 gtggtctttt atatttctta cagggttttg ttttaccaag tactagtctt cagtctatcc
      721 tgtttacttg attttttccc actcaactca caaacatttt tgaatcatct catgaattct
      781 gctttccatt tacatttttg cccttttgtc ttttcctctt cgctgttaaa cttcctgaaa
      841 aaataaaact agttgattca cttcttcaaa
//
