LOCUS       NM_005934               4532 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens MLLT1 super elongation complex subunit (MLLT1), mRNA.
ACCESSION   NM_005934
VERSION     NM_005934.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4532)
  AUTHORS   Tan,L., Wang,L., Liu,J. and Yu,Y.
  TITLE     Circvrk1 downregulation attenuates brain microvascular endothelial
            cell damage induced by oxygen-glucose deprivation through
            modulating the miR-150-5p/MLLT1 axis
  JOURNAL   Exp Brain Res 241 (3), 781-791 (2023)
   PUBMED   36735043
  REMARK    GeneRIF: Circvrk1 downregulation attenuates brain microvascular
            endothelial cell damage induced by oxygen-glucose deprivation
            through modulating the miR-150-5p/MLLT1 axis.
REFERENCE   2  (bases 1 to 4532)
  AUTHORS   Hu,H., Saha,N., Yang,Y., Ahmad,E., Lachowski,L., Shrestha,U.,
            Premkumar,V., Ropa,J., Chen,L., Teahan,B., Grigsby,S.,
            Marschalek,R., Nikolovska-Coleska,Z. and Muntean,A.G.
  TITLE     The ENL YEATS epigenetic reader domain critically links MLL-ENL to
            leukemic stem cell frequency in t(11;19) Leukemia
  JOURNAL   Leukemia 37 (1), 190-201 (2023)
   PUBMED   36435883
  REMARK    GeneRIF: The ENL YEATS epigenetic reader domain critically links
            MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia.
REFERENCE   3  (bases 1 to 4532)
  AUTHORS   Yan,F., Li,J., Milosevic,J., Petroni,R., Liu,S., Shi,Z., Yuan,S.,
            Reynaga,J.M., Qi,Y., Rico,J., Yu,S., Liu,Y., Rokudai,S.,
            Palmisiano,N., Meyer,S.E., Sung,P.J., Wan,L., Lan,F., Garcia,B.A.,
            Stanger,B.Z., Sykes,D.B. and Blanco,M.A.
  TITLE     KAT6A and ENL Form an Epigenetic Transcriptional Control Module to
            Drive Critical Leukemogenic Gene-Expression Programs
  JOURNAL   Cancer Discov 12 (3), 792-811 (2022)
   PUBMED   34853079
  REMARK    GeneRIF: KAT6A and ENL Form an Epigenetic Transcriptional Control
            Module to Drive Critical Leukemogenic Gene-Expression Programs.
REFERENCE   4  (bases 1 to 4532)
  AUTHORS   Kabra,A. and Bushweller,J.
  TITLE     The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) -
            Multimodal Transcriptional Switches With Roles in Normal
            Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer
  JOURNAL   J Mol Biol 434 (1), 167117 (2022)
   PUBMED   34174329
  REMARK    GeneRIF: The Intrinsically Disordered Proteins MLLT3 (AF9) and
            MLLT1 (ENL) - Multimodal Transcriptional Switches With Roles in
            Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer.
            Review article
REFERENCE   5  (bases 1 to 4532)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4532)
  AUTHORS   Lavau,C., Luo,R.T., Du,C. and Thirman,M.J.
  TITLE     Retrovirus-mediated gene transfer of MLL-ELL transforms primary
            myeloid progenitors and causes acute myeloid leukemias in mice
  JOURNAL   Proc Natl Acad Sci U S A 97 (20), 10984-10989 (2000)
   PUBMED   10995463
REFERENCE   7  (bases 1 to 4532)
  AUTHORS   Thirman,M.J., Levitan,D.A., Kobayashi,H., Simon,M.C. and
            Rowley,J.D.
  TITLE     Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1)
            in acute myeloid leukemia
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 12110-12114 (1994)
   PUBMED   7991593
REFERENCE   8  (bases 1 to 4532)
  AUTHORS   Rubnitz,J.E., Morrissey,J., Savage,P.A. and Cleary,M.L.
  TITLE     ENL, the gene fused with HRX in t(11;19) leukemias, encodes a
            nuclear protein with transcriptional activation potential in
            lymphoid and myeloid cells
  JOURNAL   Blood 84 (6), 1747-1752 (1994)
   PUBMED   8080983
REFERENCE   9  (bases 1 to 4532)
  AUTHORS   Yamamoto,K., Seto,M., Komatsu,H., Iida,S., Akao,Y., Kojima,S.,
            Kodera,Y., Nakazawa,S., Ariyoshi,Y., Takahashi,T. et al.
  TITLE     Two distinct portions of LTG19/ENL at 19p13 are involved in
            t(11;19) leukemia
  JOURNAL   Oncogene 8 (10), 2617-2625 (1993)
   PUBMED   8378076
REFERENCE   10 (bases 1 to 4532)
  AUTHORS   Tkachuk,D.C., Kohler,S. and Cleary,M.L.
  TITLE     Involvement of a homolog of Drosophila trithorax by 11q23
            chromosomal translocations in acute leukemias
  JOURNAL   Cell 71 (4), 691-700 (1992)
   PUBMED   1423624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011471.6, D14539.1 and BC047008.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005934.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D14539.1, L04285.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252674.9/ ENSP00000252674.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC011471.6         143779-143805       c
            28-1957             D14539.1           1-1930
            1958-2552           AC011471.6         76191-76785         c
            2553-4532           BC047008.1         61-2040
FEATURES             Location/Qualifiers
     source          1..4532
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4532
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /note="MLLT1 super elongation complex subunit"
                     /db_xref="GeneID:4298"
                     /db_xref="HGNC:HGNC:7134"
                     /db_xref="MIM:159556"
     exon            1..203
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1871
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /note="myeloid/lymphoid or mixed-lineage leukemia
                     (trithorax homolog); translocated to, 1; myeloid/lymphoid
                     or mixed-lineage leukemia; translocated to, 1; ENL/MLL
                     fusion; MLLT1/MLL fusion; CTC-503J8.6; MLL/ENL fusion
                     protein; myeloid/lymphoid or mixed-lineage leukemia
                     (trithorax homolog, Drosophila); translocated to, 1; YEATS
                     domain-containing protein 1"
                     /codon_start=1
                     /product="protein ENL"
                     /protein_id="NP_005925.2"
                     /db_xref="CCDS:CCDS12160.1"
                     /db_xref="GeneID:4298"
                     /db_xref="HGNC:HGNC:7134"
                     /db_xref="MIM:159556"
                     /translation="MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDI
                     QHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTY
                     DLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPM
                     LPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKEL
                     EREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPP
                     PPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKS
                     STRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFE
                     PSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADS
                     SLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMA
                     LRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSCLEAVAT"
     exon            204..384
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..467
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..611
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..737
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1301
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1389
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1498
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1598
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1670
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1742
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..4532
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4511..4516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /note="hexamer: AATAAA"
     polyA_site      4532
                     /gene="MLLT1"
                     /gene_synonym="ENL; LTG19; YEATS1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgacccg ggctggcggt ggtttccggt tccgcggggc tggcgggcga gcgggcggcc
       61 gggatcggcg gcggcggcgg cggcggcggc gcttgacaga caatgagggc ggcggggcgg
      121 cgttgagcgg cggcggcggc ggcggcggcg gcgagcgacg cggggcccgg gggcggggcg
      181 gggcgccagc catggacaat cagtgcaccg tccaggtgag gttagagctg gggcatcgcg
      241 cccaactgcg caagaagccc accacggagg ggttcactca cgactggatg gtgtttgtcc
      301 gcggccccga gcaatgtgac atccagcact tcgtggagaa ggtggtcttc tggctgcacg
      361 acagcttccc caagcccaga cgcgtgtgca aggagccccc ctacaaagta gaggagtcgg
      421 ggtacgctgg cttcatcatg cccatcgagg tgcacttcaa aaacaaggag gagccgagga
      481 aggtctgctt cacctacgac ctgttcctga acctggaagg caacccgccc gtgaaccacc
      541 tgcgctgcga gaagctcacc ttcaacaacc ccaccacgga gttccggtac aagctcctgc
      601 gggccggcgg ggtgatggta atgcccgaag gagcagacac ggtgtccagg cccagtcccg
      661 actaccccat gttacccaca attccactct ctgccttctc tgaccccaag aagaccaaac
      721 catcccacgg ctccaaggac gccaacaagg agagcagcaa gacctccaag ccacacaagg
      781 tgaccaagga gcaccgggag cggccccgca aagactccga gagcaagagc tcctccaagg
      841 agctggagcg tgagcaggcc aaaagctcca aggacacctc gcggaagctg ggcgagggcc
      901 ggctgcccaa ggaggagaag gcgccaccgc ccaaggctgc cttcaaggaa cccaagatgg
      961 ccctgaaaga gaccaagctg gaaagcacgt cccccaaggg tgggccccca cccccacccc
     1021 cacccccacc ccgggcttcc agcaagcggc cggccaccgc cgactcgcca aagcccagcg
     1081 ccaagaagca gaagaagagc agctcgaagg ggtcccggag tgctccaggc acctcgcccc
     1141 gcacctcctc ctcctcctcc ttctcggaca agaagccggc caaggacaag agcagcacca
     1201 gaggggagaa ggtgaaggcc gagagtgagc cccgggaggc caaaaaggcc ctggaggtgg
     1261 aggagtccaa ctcagaggac gaggcctcct tcaagtccga gtctgcccag tcaagcccgt
     1321 ccaactccag ctccagctca gactccagct cagactcaga cttcgagcca tcccagaacc
     1381 acagccaagg acccctgcgc tccatggtgg aggacctgca gtccgaggag tccgacgagg
     1441 acgactcttc gtcaggcgag gaggctgccg gcaagaccaa cccggggagg gactccaggt
     1501 tgagcttcag cgacagcgag agtgacaaca gcgccgactc ctccctgccc agccgtgagc
     1561 ccccaccccc ccagaagcca cccccgccca acagcaaggt gtcaggccgg aggagccccg
     1621 agtcctgcag caagcctgag aagatcctca agaagggcac ctacgacaag gcctacacgg
     1681 atgagctggt ggagctacac cggaggctga tggcgctgcg ggagcgcaac gtgctgcagc
     1741 agattgtgaa tctgatcgag gagactggcc acttcaatgt caccaacacc accttcgact
     1801 tcgacctctt ctccctggac gagaccaccg tgcgcaaact gcagagctgc ctggaggccg
     1861 tggccacatg accctgggcc gcgtgccggg cccccaccgc cggggtcctg ggaggctgca
     1921 gccaggcctc gcctgccctc ctctcccgtc tcgcctgccc gcagcactgc cttagcgaca
     1981 gccctgtcct cgcccgcaca gcccgctgca ctttcctcgg cggctccctg cccactctcc
     2041 ccgctccatc gccaggagcc ctggggccgg gctgggccac acgggagccg ccccccgggc
     2101 tctctgggct cccctcagag agcggctggt gttgaaggca gctctgggca gagacagggc
     2161 cgggggcccc tcgcccagcc ttgggaccag cccccactgc tcggcgggct gtgcggcgtc
     2221 gctgccccag cctttctgag cagcggatcg acggctgggg ggcatctcca gcctcccgaa
     2281 tggttcagaa cacaccctcc gcccaccctg gacctcagaa ggccctgcct gtgtgtctgc
     2341 gtcgtcctcc gtgtagacct agcgccggct cctccccggc tcgcgctgcg ctggggtctg
     2401 tgctgtatag ttctctctat tatatatgtg tgtgcactgt ctggtcaaga gcagtgtcca
     2461 tgtgcgtttc tgtggcagca gtgcacgtgg ggtgggtggg gggtgcgtac ggtggggctt
     2521 gtaggttaag atgtctctgc ggtggtgtgg ggctggaggc cgagccaggc acggcagctg
     2581 gccctctcca ggcgcatgga ggaattctcc ctttgccgtt ccaaggatgc cgccgcctcc
     2641 taccggggct cccggggggg tcagccaaca ctacaaaggg cagcgagtcc tcagggcgcc
     2701 cgggagccac cagtctgctc tcgggctcta ctcagactag cgccaacagt ctccgcggac
     2761 agactcgcat cagccgccct ggggctcggc ctcctcccat aggctcctct tcctctcttt
     2821 cattcaagtc ttcaaacttt gaaaaaaata tgagcttttg ccaaataaga cgggatagtt
     2881 tatggagttt tctgaggcgc attgaactct ggtcagcccc tcgagcgtgg gctcggccat
     2941 cagcaggccc ggtgggttgg ccgggctggc cctcccaggc tgcctttctc tctggtcgcg
     3001 gcctggcccg ccccggcctc caccgccgca attcatgctg gtgccgcgcc cgcagcccca
     3061 ctcctggtat gcctgagatt ctccaggggc caagccggtc ctccttcccg gcccactctt
     3121 ccagggccag gacgctcccg cggagccagc ccatcgtggc tgggggtccc aggggctgga
     3181 ggcctgcctg gttagcctct gtttcccaga cattgactcg aggcgcctcc agtcctctca
     3241 accccctgac tttcaagtcc tttcaagtcc ttgtgccctg accaagttat gaggaaaaga
     3301 gggctgaggg cctggaggtg ggctcgcacc ccctcgaacc cacctagatg tctcctcctc
     3361 cccagcctat gagttcagac ttggggggct ccatctgtcc ctccctgagg tccctcatct
     3421 tgtccctgct ctgattctgt cagcagatcc tgaacactcc ttggtgggga cccatgcctc
     3481 caaggctgcc cccaatgcca gctgtcctgg ggaaactccc cagaactctc ggggaaaggc
     3541 ccgagaacct tcggaggaag cctccgggac tcctcgccac ctgctctgtt tctctcccgg
     3601 ccccactgcc ttcaggtatc aggaagaggg caggcccctg tgccccctct ccccttccca
     3661 gggcggccaa caatactcca ccatggggcg cttcctttct tctctggaaa ctaagacatt
     3721 ggactgaagg aactggcctg aggggggctg accgggggcc cgtgctgctg ggagctctac
     3781 gcacaagagg ccgccggggt cacggacagg aacctcagcc cagggtgctg gcctttctcc
     3841 ttcgcaggag tcccccaaaa tccacacagc gactcgagca gccttccact cagccagagg
     3901 agggtcgggc tcccccgcct gctctcggtg gtggcgtctg gcccttcctg ccgtttccaa
     3961 ggcctccgga agcaccaacc cagttctcag ttacctcctc tggccggaag gcctcacgtt
     4021 gtcctccaga gctgctctgg gcccagggct ggctccgtga ccacctgatg gacgtgctgg
     4081 gcagcatggg ctcccaaggc agcatcccca gctgctctcc caccccaccc cagctgcccg
     4141 gcggctgggc ccacgagggc tctggggaca cttccatagg aaaggggcct ggcactttgt
     4201 gattgccacg tgtttcctgt taagccgcct gcccccagtg caaatctctg tgttttgctc
     4261 tctcctgaac aaaaatgtaa accgacgccg gaaagcaaat ggtatcgaat acctttcttg
     4321 cccataaggg tttttacaaa gaacgtgtct cactaggaac taggacactc atcggcccga
     4381 gaccaactcc tggataaaag gaataaggag aatcgtgttt gtaacgagtt acaggattgt
     4441 ttctttcctg gattttaaac ttttgttaaa ttgtgaaatt atggaggagt tttatagaaa
     4501 aaaaaagtga aataaagtca gatgggaaag ca
//
