LOCUS       XM_047431269            3683 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens mutL homolog 3 (MLH3), transcript variant
            X15, mRNA.
ACCESSION   XM_047431269
VERSION     XM_047431269.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     gene            1..3683
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /note="mutL homolog 3; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 1 mRNA, 5 ESTs, 494 long
                     SRA reads, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 40 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
     CDS             152..3625
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /codon_start=1
                     /product="DNA mismatch repair protein Mlh3 isoform X9"
                     /protein_id="XP_047287225.1"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
                     /translation="MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVR
                     VNMETFQVQVIDNGFGMGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIAD
                     MASAVEISSKKNRTMKTFVKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRK
                     CMDPRLEFEKVRQRIEALSLMHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLG
                     KSQKLREISFKYKEFELSGYISSEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKES
                     IICKPKNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWD
                     TLLFCIQEGVKMFLKQEKLFVELSGEDIKEFSEDNGFSLFDATLQKRVTSDERSNFQE
                     ACNNILDSYEMFNLQSKAVKRKTTAENVNTQSSRDSEATRKNTNDAFLYIYESGGPGH
                     SKMTEPSLQNKDSSCSESKMLEQETIVASEAGENEKHKKSFLEHSSLENPCGTSLEMF
                     LSPFQTPCHFEESGQDLEIWKESTTVNGMAANILKNNRIQNQPKRFKDATEVGCQPLP
                     FATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGRVKLCSTGFITHVVQNEKTKSTETE
                     HSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLASTLSKESGQLPNKKNCRTNISYG
                     LENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWYRHVSNDSRKTDKLIGFSKPI
                     VRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTTNLSLQVEPDILLKDKNRL
                     ENSDVCKITTMEHSDSDSSCQPASHILNSEKFPFSKDEDCLEQQMPSLRESPMTLKEL
                     SLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELPNSDSSRKDSKLCSV
                     LTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTTENCVISETPLVL
                     PYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGICFQSEESKARA
                     CSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTKDLTTVAVD
                     VVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQSLFSEWD
                     NPVFARYPESF"
ORIGIN      
        1 gtgggcacgc acgagcctca agatccaagg tgcgcgcgtc ggcgtccgag gcggttggtg
       61 tcggagaatt tgttaagcgg gactccaggc aattatttcc agtcagagaa ggaaaccagt
      121 gcctggcatt ctcaccatct ttctacctac catgatcaag tgcttgtcag ttgaagtaca
      181 agccaaattg cgttctggtt tggccataag ctccttgggc caatgtgttg aggaacttgc
      241 cctcaacagt attgatgctg aagcaaaatg tgtggctgtc agggtgaata tggaaacctt
      301 ccaagttcaa gtgatagaca atggatttgg gatggggagt gatgatgtag agaaagtggg
      361 aaatcgttat ttcaccagta aatgccactc ggtacaggac ttggagaatc caaggtttta
      421 tggtttccga ggagaggcct tggcaaatat tgctgacatg gccagtgctg tggaaatttc
      481 gtccaagaaa aacaggacaa tgaaaacttt tgtgaaactg tttcagagtg gaaaagccct
      541 gaaagcttgt gaagctgatg tgactagagc aagcgctggg actactgtaa cagtgtataa
      601 cctattttac cagcttcctg taaggaggaa atgcatggac cctagactgg agtttgagaa
      661 ggttaggcag agaatagaag ctctctcact catgcaccct tccatttctt tctctttgag
      721 aaatgatgtt tctggttcca tggttcttca gctccctaaa accaaagacg tatgttcccg
      781 attttgtcaa atttatggat tgggaaagtc ccaaaagcta agagaaataa gttttaaata
      841 taaagagttt gagcttagtg gctatatcag ctctgaagca cattacaaca agaatatgca
      901 gtttttgttt gtgaacaaaa gactagtttt aaggacaaag ctacataaac tcattgactt
      961 tttattaagg aaagaaagta ttatatgcaa gccaaagaat ggtcccacca gtaggcaaat
     1021 gaattcaagt cttcggcacc ggtctacccc agaactctat ggcatatatg taattaatgt
     1081 gcagtgccaa ttctgtgagt atgatgtgtg catggagcca gccaaaactc tgattgaatt
     1141 tcagaactgg gacactctct tgttttgcat tcaggaagga gtgaaaatgt ttttaaagca
     1201 agaaaaatta tttgtggaat tatcaggtga ggatattaag gaatttagtg aagataatgg
     1261 ttttagttta tttgatgcta ctcttcagaa gcgtgtgact tccgatgaga ggagcaattt
     1321 ccaggaagca tgtaataata ttttagattc ctatgagatg tttaatttgc agtcaaaagc
     1381 tgtgaaaaga aaaactactg cagaaaacgt aaacacacag agttctaggg attcagaagc
     1441 taccagaaaa aatacaaatg atgcattttt gtacatttat gaatcaggtg gtccaggcca
     1501 tagcaaaatg acagagccat ctttacaaaa caaagacagc tcttgctcag aatcaaagat
     1561 gttagaacaa gagacaattg tagcatcaga agctggagaa aatgagaaac ataaaaaatc
     1621 tttcctggaa catagctctt tagaaaatcc gtgtggaacc agtttagaaa tgtttttaag
     1681 cccttttcag acaccatgtc actttgagga gagtgggcag gatctagaaa tatggaaaga
     1741 aagtactact gttaatggca tggctgccaa catcttgaaa aataatagaa ttcagaatca
     1801 accaaagaga tttaaagatg ctactgaagt gggatgccag cctctgcctt ttgcaacaac
     1861 attatgggga gtacatagtg ctcagacaga gaaagagaaa aaaaaagaat ctagcaattg
     1921 tggaagaaga aatgttttta gttatgggcg agttaaatta tgttccactg gctttataac
     1981 tcatgtagta caaaatgaaa aaactaaatc aactgaaaca gaacattcat ttaaaaatta
     2041 tgttagacct ggtcccacac gtgcccaaga aacatttgga aatagaacac gtcattcagt
     2101 tgaaactcca gacatcaaag atttagccag cactttaagt aaagaatctg gtcaattgcc
     2161 caacaaaaaa aattgcagaa cgaatataag ttatgggcta gagaatgaac ctacagcaac
     2221 ttatacaatg ttttctgctt ttcaggaagg tagcaaaaaa tcacaaacag attgcatatt
     2281 atctgataca tccccctctt tcccctggta tagacacgtt tccaatgata gtaggaaaac
     2341 agataaatta attggtttct ccaaaccaat cgtccgtaag aagctaagct tgagttcaca
     2401 gctaggatct ttagagaagt ttaagaggca atatgggaag gttgaaaatc ctctggatac
     2461 agaagtagag gaaagtaatg gagtcactac caatctcagt cttcaagttg aacctgacat
     2521 tctgctgaag gacaagaacc gcttagagaa ctctgatgtt tgtaaaatca ctactatgga
     2581 gcatagtgat tcagatagta gttgtcaacc agcaagccac atccttaact cagagaagtt
     2641 tccattctcc aaggatgaag attgtttaga acaacagatg cctagtttga gagaaagtcc
     2701 tatgaccctg aaggagttat ctctctttaa tagaaaacct ttggaccttg agaagtcatc
     2761 tgaatcacta gcctctaaat tatccagact gaagggttcc gaaagagaaa ctcaaacaat
     2821 ggggatgatg agtcgtttta atgaacttcc aaattcagat tccagtagga aagacagcaa
     2881 gttgtgcagt gtgttaacac aagatttttg tatgttattt aacaacaagc atgaaaaaac
     2941 agagaatggt gtcatcccaa catcagattc tgccacacag gataattcct ttaataaaaa
     3001 tagtaaaaca cattctaaca gcaatacaac agagaactgt gtgatatcag aaactccttt
     3061 ggtattgccc tataataatt ctaaagttac cggtaaagat tcagatgttc ttatcagagc
     3121 ctcagaacaa cagataggaa gtcttgactc tcccagtgga atgttaatga atccggtaga
     3181 agatgccaca ggtgaccaaa atggaatttg ttttcagagt gaggaatcta aagcaagagc
     3241 ttgttctgaa actgaagagt caaacacgtg ttgttcagat tggcagcggc atttcgatgt
     3301 agccctggga agaatggttt atgtcaacaa aatgactgga ctcagcacat tcattgcccc
     3361 aactgaggac attcaggctg cttgtactaa agacctgaca actgtggctg tggatgttgt
     3421 acttgagaat gggtctcagt acaggtgtca accttttaga agcgaccttg ttcttccttt
     3481 ccttccgaga gctcgagcag agaggactgt gatgagacag gataacagag atactgtgga
     3541 tgatactgtt agtagcgaat cgcttcagtc tttgttctca gaatgggaca atccagtatt
     3601 tgcccgttat ccagagtctt tctaggttgc tgttgatgta agcagtggcc aggctgagag
     3661 cttagcagtt aaaattcaca aca
//
