LOCUS       XM_047431265            7584 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens mutL homolog 3 (MLH3), transcript variant
            X10, mRNA.
ACCESSION   XM_047431265
VERSION     XM_047431265.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7584
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     gene            1..7584
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /note="mutL homolog 3; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 26 ESTs, 386 long SRA
                     reads, and 100% coverage of the annotated genomic feature
                     by RNAseq alignments, including 33 samples with support
                     for all annotated introns"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
     CDS             93..4277
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /codon_start=1
                     /product="DNA mismatch repair protein Mlh3 isoform X4"
                     /protein_id="XP_047287221.1"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
                     /translation="MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVR
                     VNMETFQVQVIDNGFGMGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIAD
                     MASAVEISSKKNRTMKTFVKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRK
                     CMDPRLEFEKVRQRIEALSLMHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLG
                     KSQKLREISFKYKEFELSGYISSEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKES
                     IICKPKNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWD
                     TLLFCIQEGVKMFLKQEKLFVELSGEDIKEFSEDNGFSLFDATLQKRVTSDERSNFQE
                     ACNNILDSYEMFNLQSKAVKRKTTAENVNTQSSRDSEATRKNTNDAFLYIYESGGPGH
                     SKMTEPSLQNKDSSCSESKMLEQETIVASEAGENEKHKKSFLEHSSLENPCGTSLEMF
                     LSPFQTPCHFEESGQDLEIWKESTTVNGMAANILKNNRIQNQPKRFKDATEVGCQPLP
                     FATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGRVKLCSTGFITHVVQNEKTKSTETE
                     HSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLASTLSKESGQLPNKKNCRTNISYG
                     LENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWYRHVSNDSRKTDKLIGFSKPI
                     VRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTTNLSLQVEPDILLKDKNRL
                     ENSDVCKITTMEHSDSDSSCQPASHILNSEKFPFSKDEDCLEQQMPSLRESPMTLKEL
                     SLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELPNSDSSRKDSKLCSV
                     LTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTTENCVISETPLVL
                     PYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGICFQSEESKARA
                     CSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTKDLTTVAVD
                     VVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQSLFSEWD
                     NPVFARYPEVLQQVDNKFIACLMSTKTEENGEADSYEKQQAQGSGRKKLLSSTLIPPL
                     EITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRS
                     TVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCR
                     LIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAEC
                     DTRQSLQQSMPPCEPP"
ORIGIN      
        1 gtgggcacgc acgagcctca agatccaagg caattatttc cagtcagaga aggaaaccag
       61 tgcctggcat tctcaccatc tttctaccta ccatgatcaa gtgcttgtca gttgaagtac
      121 aagccaaatt gcgttctggt ttggccataa gctccttggg ccaatgtgtt gaggaacttg
      181 ccctcaacag tattgatgct gaagcaaaat gtgtggctgt cagggtgaat atggaaacct
      241 tccaagttca agtgatagac aatggatttg ggatggggag tgatgatgta gagaaagtgg
      301 gaaatcgtta tttcaccagt aaatgccact cggtacagga cttggagaat ccaaggtttt
      361 atggtttccg aggagaggcc ttggcaaata ttgctgacat ggccagtgct gtggaaattt
      421 cgtccaagaa aaacaggaca atgaaaactt ttgtgaaact gtttcagagt ggaaaagccc
      481 tgaaagcttg tgaagctgat gtgactagag caagcgctgg gactactgta acagtgtata
      541 acctatttta ccagcttcct gtaaggagga aatgcatgga ccctagactg gagtttgaga
      601 aggttaggca gagaatagaa gctctctcac tcatgcaccc ttccatttct ttctctttga
      661 gaaatgatgt ttctggttcc atggttcttc agctccctaa aaccaaagac gtatgttccc
      721 gattttgtca aatttatgga ttgggaaagt cccaaaagct aagagaaata agttttaaat
      781 ataaagagtt tgagcttagt ggctatatca gctctgaagc acattacaac aagaatatgc
      841 agtttttgtt tgtgaacaaa agactagttt taaggacaaa gctacataaa ctcattgact
      901 ttttattaag gaaagaaagt attatatgca agccaaagaa tggtcccacc agtaggcaaa
      961 tgaattcaag tcttcggcac cggtctaccc cagaactcta tggcatatat gtaattaatg
     1021 tgcagtgcca attctgtgag tatgatgtgt gcatggagcc agccaaaact ctgattgaat
     1081 ttcagaactg ggacactctc ttgttttgca ttcaggaagg agtgaaaatg tttttaaagc
     1141 aagaaaaatt atttgtggaa ttatcaggtg aggatattaa ggaatttagt gaagataatg
     1201 gttttagttt atttgatgct actcttcaga agcgtgtgac ttccgatgag aggagcaatt
     1261 tccaggaagc atgtaataat attttagatt cctatgagat gtttaatttg cagtcaaaag
     1321 ctgtgaaaag aaaaactact gcagaaaacg taaacacaca gagttctagg gattcagaag
     1381 ctaccagaaa aaatacaaat gatgcatttt tgtacattta tgaatcaggt ggtccaggcc
     1441 atagcaaaat gacagagcca tctttacaaa acaaagacag ctcttgctca gaatcaaaga
     1501 tgttagaaca agagacaatt gtagcatcag aagctggaga aaatgagaaa cataaaaaat
     1561 ctttcctgga acatagctct ttagaaaatc cgtgtggaac cagtttagaa atgtttttaa
     1621 gcccttttca gacaccatgt cactttgagg agagtgggca ggatctagaa atatggaaag
     1681 aaagtactac tgttaatggc atggctgcca acatcttgaa aaataataga attcagaatc
     1741 aaccaaagag atttaaagat gctactgaag tgggatgcca gcctctgcct tttgcaacaa
     1801 cattatgggg agtacatagt gctcagacag agaaagagaa aaaaaaagaa tctagcaatt
     1861 gtggaagaag aaatgttttt agttatgggc gagttaaatt atgttccact ggctttataa
     1921 ctcatgtagt acaaaatgaa aaaactaaat caactgaaac agaacattca tttaaaaatt
     1981 atgttagacc tggtcccaca cgtgcccaag aaacatttgg aaatagaaca cgtcattcag
     2041 ttgaaactcc agacatcaaa gatttagcca gcactttaag taaagaatct ggtcaattgc
     2101 ccaacaaaaa aaattgcaga acgaatataa gttatgggct agagaatgaa cctacagcaa
     2161 cttatacaat gttttctgct tttcaggaag gtagcaaaaa atcacaaaca gattgcatat
     2221 tatctgatac atccccctct ttcccctggt atagacacgt ttccaatgat agtaggaaaa
     2281 cagataaatt aattggtttc tccaaaccaa tcgtccgtaa gaagctaagc ttgagttcac
     2341 agctaggatc tttagagaag tttaagaggc aatatgggaa ggttgaaaat cctctggata
     2401 cagaagtaga ggaaagtaat ggagtcacta ccaatctcag tcttcaagtt gaacctgaca
     2461 ttctgctgaa ggacaagaac cgcttagaga actctgatgt ttgtaaaatc actactatgg
     2521 agcatagtga ttcagatagt agttgtcaac cagcaagcca catccttaac tcagagaagt
     2581 ttccattctc caaggatgaa gattgtttag aacaacagat gcctagtttg agagaaagtc
     2641 ctatgaccct gaaggagtta tctctcttta atagaaaacc tttggacctt gagaagtcat
     2701 ctgaatcact agcctctaaa ttatccagac tgaagggttc cgaaagagaa actcaaacaa
     2761 tggggatgat gagtcgtttt aatgaacttc caaattcaga ttccagtagg aaagacagca
     2821 agttgtgcag tgtgttaaca caagattttt gtatgttatt taacaacaag catgaaaaaa
     2881 cagagaatgg tgtcatccca acatcagatt ctgccacaca ggataattcc tttaataaaa
     2941 atagtaaaac acattctaac agcaatacaa cagagaactg tgtgatatca gaaactcctt
     3001 tggtattgcc ctataataat tctaaagtta ccggtaaaga ttcagatgtt cttatcagag
     3061 cctcagaaca acagatagga agtcttgact ctcccagtgg aatgttaatg aatccggtag
     3121 aagatgccac aggtgaccaa aatggaattt gttttcagag tgaggaatct aaagcaagag
     3181 cttgttctga aactgaagag tcaaacacgt gttgttcaga ttggcagcgg catttcgatg
     3241 tagccctggg aagaatggtt tatgtcaaca aaatgactgg actcagcaca ttcattgccc
     3301 caactgagga cattcaggct gcttgtacta aagacctgac aactgtggct gtggatgttg
     3361 tacttgagaa tgggtctcag tacaggtgtc aaccttttag aagcgacctt gttcttcctt
     3421 tccttccgag agctcgagca gagaggactg tgatgagaca ggataacaga gatactgtgg
     3481 atgatactgt tagtagcgaa tcgcttcagt ctttgttctc agaatgggac aatccagtat
     3541 ttgcccgtta tccagaggtt ctccagcaag tagataacaa gtttattgcc tgtttgatga
     3601 gcactaagac tgaagagaat ggcgaggcag attcctacga gaagcaacag gcacaaggct
     3661 ctggtcggaa aaaattactg tcttctactc taattcctcc gctagagata acagtgacag
     3721 aggaacaaag gagactctta tggtgttacc acaaaaatct ggaagatctg ggccttgaat
     3781 ttgtatttcc agacactagt gattctctgg tccttgtggg aaaagtacca ctatgttttg
     3841 tggaaagaga agccaatgaa cttcggagag gaagatctac tgtgaccaag agtattgtgg
     3901 aggaatttat ccgagaacaa ctggagctac tccagaccac cggaggcatc caagggacat
     3961 tgccactgac tgtccagaag gtgttggcat cccaagcctg ccatggggcc attaagttta
     4021 atgatggcct gagcttacag gaaagttgcc gccttattga agctctgtcc tcatgccagc
     4081 tgccattcca gtgtgctcac gggagacctt ctatgctgcc gttagctgac atagaccact
     4141 tggaacagga aaaacagatt aaacccaacc tcactaaact tcgcaaaatg gcccaggcct
     4201 ggcgtctctt tggaaaagca gagtgtgata caaggcagag cctgcagcaa tccatgcctc
     4261 cctgtgagcc accatgagaa cagaatcact ggtctaaaag gaacaaaggg atgttcactg
     4321 tatgcctctg agcagagagc agcagcagca ggtaccagca cggccctgac tgaatcagcc
     4381 cagtgtccct gagcagctta gacagcaggg ctctctgtat cagtctttct tgagcagatg
     4441 attcccctag ttgagtagcc agatgaaatt caagcctaaa gacaattcat tcatttgcat
     4501 ccatgggcac agaaggttgc tatatagtat ctaccttttg ctacttattt aatgataaaa
     4561 tttaatgaca gtttgattgg ttgcttggtt tgttatttga agggtgtgat ttttgttttt
     4621 gtacagtttt ttttcaagct tcacatttgc gtgtatctaa ttcagctgat gctcaagtcc
     4681 aaggggtagt ctgccttccc aggctgcccc cagggtttct gcactggtcc cctcttttcc
     4741 cttcagtctt cttcacttcc ctatgctgct gcttcatgtg ctacatctca gacttaaaga
     4801 gtttctctac tacagtgaaa acattctcta gggtctttca tcaggccttt agttatttta
     4861 gggataaaaa ctattgataa aaaggacaag gatagaacag agaaaattta aagtcctgtt
     4921 ccgggttttt tgttatgttt tctttaaaaa ctcagagact gatgttcaat atcccaaacc
     4981 agtaaaatgg tgaaaatact atgagcttgt tttttaaaat atgatttttt ttggtacttt
     5041 ataaagtatc tctttatgtg aaagcaattg tcatatcaaa acacagcata catacgttca
     5101 acctaaccaa atatctttac actttttctt tcaggagaca agggttcttt gggtcccttt
     5161 caaacggtat cttggtgtta ttacattatg cctatctatt gcccttataa tatcacttgg
     5221 gaccaggact gatcgttctg caaatgcttg ttatgccatt ctcaatctat ttttcccgca
     5281 ccttttcaca tgatttgtgg ttaataggac tcaacagact aaaattgcat agtagaaaaa
     5341 aaatgcaaaa agccagctgg taatgtttat tgcaactggg gtgctataca attagtaaga
     5401 tgatgcaatg agaatttcta cttttgtatt tcctgaccag cctgctcaaa gtggctttta
     5461 tatcaattga atgattttcc tcatttttta atacaggaaa ccaattcgtg ctcatggaag
     5521 aaaagttcct ttgccagcag ccttgaagtg aatcttacag gagcaatgaa agtattgcat
     5581 tcattagcgt ctgccccaga gaaggttcag agaaaacctt cacttgtttt caaggggatc
     5641 cttgtagatt tacgtaattg gaatcctgaa gaacaggccc tactgtctaa aaaatggctt
     5701 ttattcttct aaatacatat aaacggatgt tttatagatg ggaagacatg accttagaaa
     5761 ggagagagtt ttcagaggat ttgccaggct gtcaggggct ctgcctccag gcccagtgtg
     5821 gcagtgtggc ctcagggcct ccgcctccct gcttgagggc tgcatggagg ccaactgtcc
     5881 tgggagttgt aaaaatcttt taaggccaga ccaatttgag ggattttaaa aagtgtctca
     5941 gtgcctctta tgatttcaga aggttttgct atatgtaatc ccaactactg ttttcttgag
     6001 agtagcagag gattagaaaa agtcctccat aaattatgta accggccttc ctgactagcc
     6061 tgactcaagc aatgtaagag ataattattc tgttttcata atttataagt gtgggggcat
     6121 gcctcagcat aaaaacaacc tattagggaa aaatatctaa tagattacct ttatcgcctg
     6181 ttagggtttt atgttgtttt taactcagat gccataagaa caaagataca tgtaatttat
     6241 aatagtaatc attaatacct atattgtgct ttaaggttta caaaataatt tttctcatac
     6301 tttatcttag tttagtttct tgacagtcca tgaggtaagg tggtagcttt atcaccattt
     6361 tacaaagtgg gaaacgaagg ttcctcttag gaacctagtt gtcacctttg tataataaaa
     6421 cttcgaagct cggagctgtt aactggtttg ctgaaggctt agctgtaaga gccagaattc
     6481 agacccaggt ctgagtgact tcaaactgca cagtccttcc cattattacc catatgctat
     6541 cccttatatt tttaatttat taggaattca ttcatttata aacttggtga ttcaccttta
     6601 ttagattctg gtcgctgaag gctttagtaa cttcagagta aaacttgaga gatgagatgt
     6661 aaaatgcagc cattcttgag agttcctttt tctgtaacat tcatcaacac ttcattgaga
     6721 agtgaaggtt cctatggctg tctctacctt caagaggctt agctttagtc actgagaaag
     6781 acaaggaaac taatgataga atatagtagc ttcttctggc gttaggtatc acagagtcac
     6841 agctagttac agctagccct ttattattga aagaagagga gctagcagtc ccactatcag
     6901 aattaagact agagatggta ataggagcta gtatcagaaa agcttaaggc aaagcataaa
     6961 gtgtaggcta gaatgaagct ggagaatggg gagggggctt gggtaacatc cagaacctgg
     7021 ctggggacct ggaactacat gagatgtaag aatggagagg ttctagcagt cagaggtcag
     7081 gtacaaatga acagctggga tctgcgcatg gcagacagtg aaaaaaccca ggcaagcaaa
     7141 atggtcagag cagaaagggg cccaaggcca cgttcttgag atgtggaggg ggctgaggaa
     7201 gccacgccaa gtaaggacag atgcagctca gcagttccta gcgagccctg acaagccagc
     7261 tcagctgaag cttcgggtgg gagccagtca tggcacagtg gagtgaagga agagcagttt
     7321 caggcaccca aaacctgacc cccacgacct gttttccacc tgaagagcca cccattccat
     7381 ccaaaccctt ggcaaaagtc tgctaacaga gagaaccggc cagtatgctg gccagtcgcg
     7441 atcatgcctg tctttaccct ctaagctgaa gctgctcatc aacggtgaga tggcaaaaag
     7501 gtgggtccag aagaggggaa aagaagggag tctgtgaaaa caaaatgctg aagaatctgc
     7561 atcaaataaa cccttccttc cttc
//
