LOCUS       NM_001040108            7820 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens mutL homolog 3 (MLH3), transcript variant 1, mRNA.
ACCESSION   NM_001040108
VERSION     NM_001040108.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7820)
  AUTHORS   Khailany,R.A. and Ozaslan,M.
  TITLE     Exonic sequencing and MLH3 gene expression analysis of breast
            cancer patients
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (3), 35-43 (2021)
   PUBMED   34933735
  REMARK    GeneRIF: Exonic sequencing and MLH3 gene expression analysis of
            breast cancer patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7820)
  AUTHORS   Nawaz,S., Ullah,M.I., Hamid,B.S., Nargis,J., Nawaz,M., Hussain,S.
            and Ahmad,W.
  TITLE     A loss-of-function variant in DNA mismatch repair gene MLH3
            underlies severe oligozoospermia
  JOURNAL   J Hum Genet 66 (7), 725-730 (2021)
   PUBMED   33517345
  REMARK    GeneRIF: A loss-of-function variant in DNA mismatch repair gene
            MLH3 underlies severe oligozoospermia.
REFERENCE   3  (bases 1 to 7820)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7820)
  AUTHORS   Rahman,M.M., Mohiuddin,M., Shamima Keka,I., Yamada,K., Tsuda,M.,
            Sasanuma,H., Andreani,J., Guerois,R., Borde,V., Charbonnier,J.B.
            and Takeda,S.
  TITLE     Genetic evidence for the involvement of mismatch repair proteins,
            PMS2 and MLH3, in a late step of homologous recombination
  JOURNAL   J Biol Chem 295 (51), 17460-17475 (2020)
   PUBMED   33453991
  REMARK    GeneRIF: Genetic evidence for the involvement of mismatch repair
            proteins, PMS2 and MLH3, in a late step of homologous
            recombination.
REFERENCE   5  (bases 1 to 7820)
  AUTHORS   Cannavo,E., Sanchez,A., Anand,R., Ranjha,L., Hugener,J., Adam,C.,
            Acharya,A., Weyland,N., Aran-Guiu,X., Charbonnier,J.B.,
            Hoffmann,E.R., Borde,V., Matos,J. and Cejka,P.
  TITLE     Regulation of the MLH1-MLH3 endonuclease in meiosis
  JOURNAL   Nature 586 (7830), 618-622 (2020)
   PUBMED   32814904
  REMARK    GeneRIF: Regulation of the MLH1-MLH3 endonuclease in meiosis.
            Erratum:[Nature. 2021 Feb;590(7844):E29. doi:
            10.1038/s41586-020-03111-9.. PMID: 33469227]
REFERENCE   6  (bases 1 to 7820)
  AUTHORS   Lipkin,S.M., Wang,V., Stoler,D.L., Anderson,G.R., Kirsch,I.,
            Hadley,D., Lynch,H.T. and Collins,F.S.
  TITLE     Germline and somatic mutation analyses in the DNA mismatch repair
            gene MLH3: Evidence for somatic mutation in colorectal cancers
  JOURNAL   Hum Mutat 17 (5), 389-396 (2001)
   PUBMED   11317354
REFERENCE   7  (bases 1 to 7820)
  AUTHORS   Kondo,E., Horii,A. and Fukushige,S.
  TITLE     The interacting domains of three MutL heterodimers in man: hMLH1
            interacts with 36 homologous amino acid residues within hMLH3,
            hPMS1 and hPMS2
  JOURNAL   Nucleic Acids Res 29 (8), 1695-1702 (2001)
   PUBMED   11292842
REFERENCE   8  (bases 1 to 7820)
  AUTHORS   Lipkin,S.M., Wang,V., Jacoby,R., Banerjee-Basu,S., Baxevanis,A.D.,
            Lynch,H.T., Elliott,R.M. and Collins,F.S.
  TITLE     MLH3: a DNA mismatch repair gene associated with mammalian
            microsatellite instability
  JOURNAL   Nat Genet 24 (1), 27-35 (2000)
   PUBMED   10615123
REFERENCE   9  (bases 1 to 7820)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
REFERENCE   10 (bases 1 to 7820)
  AUTHORS   Idos,G. and Valle,L.
  TITLE     Lynch Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301390
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA805814.1, AB039667.1,
            AL049780.4 and BX090851.1.
            
            On Dec 27, 2019 this sequence version replaced NM_001040108.1.
            
            Summary: This gene is a member of the MutL-homolog (MLH) family of
            DNA mismatch repair (MMR) genes. MLH genes are implicated in
            maintaining genomic integrity during DNA replication and after
            meiotic recombination. The protein encoded by this gene functions
            as a heterodimer with other family members. Somatic mutations in
            this gene frequently occur in tumors exhibiting microsatellite
            instability, and germline mutations have been linked to hereditary
            nonpolyposis colorectal cancer type 7 (HNPCC7). Several
            alternatively spliced transcript variants have been identified, but
            the full-length nature of only two transcript variants has been
            determined. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2612854.1,
                                           SRR14038192.3759035.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355774.7/ ENSP00000348020.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               DA805814.1         66-216
            152-2626            AB039667.1         1-2475
            2627-2627           AL049780.4         114574-114574
            2628-4485           AB039667.1         2477-4334
            4486-7523           AL049780.4         144645-147682
            7524-7820           BX090851.1         1-297
FEATURES             Location/Qualifiers
     source          1..7820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..7820
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /note="mutL homolog 3"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
     exon            1..88
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            89..3431
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..4513
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     mismatch repair protein MLH3"
                     /codon_start=1
                     /product="DNA mismatch repair protein Mlh3 isoform 1"
                     /protein_id="NP_001035197.1"
                     /db_xref="CCDS:CCDS32123.1"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
                     /translation="MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVR
                     VNMETFQVQVIDNGFGMGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIAD
                     MASAVEISSKKNRTMKTFVKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRK
                     CMDPRLEFEKVRQRIEALSLMHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLG
                     KSQKLREISFKYKEFELSGYISSEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKES
                     IICKPKNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWD
                     TLLFCIQEGVKMFLKQEKLFVELSGEDIKEFSEDNGFSLFDATLQKRVTSDERSNFQE
                     ACNNILDSYEMFNLQSKAVKRKTTAENVNTQSSRDSEATRKNTNDAFLYIYESGGPGH
                     SKMTEPSLQNKDSSCSESKMLEQETIVASEAGENEKHKKSFLEHSSLENPCGTSLEMF
                     LSPFQTPCHFEESGQDLEIWKESTTVNGMAANILKNNRIQNQPKRFKDATEVGCQPLP
                     FATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGRVKLCSTGFITHVVQNEKTKSTETE
                     HSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLASTLSKESGQLPNKKNCRTNISYG
                     LENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWYRHVSNDSRKTDKLIGFSKPI
                     VRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTTNLSLQVEPDILLKDKNRL
                     ENSDVCKITTMEHSDSDSSCQPASHILNSEKFPFSKDEDCLEQQMPSLRESPMTLKEL
                     SLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELPNSDSSRKDSKLCSV
                     LTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTTENCVISETPLVL
                     PYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGICFQSEESKARA
                     CSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTKDLTTVAVD
                     VVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQSLFSEWD
                     NPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNKFIACLM
                     STKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLIPP
                     LEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGR
                     STVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESC
                     RLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAE
                     CDTRQSLQQSMPPCEPP"
     exon            3432..3530
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..3616
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3721
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3794
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3866
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3867..3978
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4138
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4139..4162
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4163..4241
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4242..4393
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4394..7820
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4790..4795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /note="hexamer: GATAAA"
     polyA_site      4812
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /note="major polyA site"
     regulatory      6650..6655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /note="hexamer: AATAAA"
     polyA_site      6670
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
     regulatory      7801..7806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /note="hexamer: AATAAA"
     polyA_site      7820
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
ORIGIN      
        1 gtgggcacgc acgagcctca agatccaagg tgcgcgcgtc ggcgtccgag gcggttggtg
       61 tcggagaatt tgttaagcgg gactccaggc aattatttcc agtcagagaa ggaaaccagt
      121 gcctggcatt ctcaccatct ttctacctac catgatcaag tgcttgtcag ttgaagtaca
      181 agccaaattg cgttctggtt tggccataag ctccttgggc caatgtgttg aggaacttgc
      241 cctcaacagt attgatgctg aagcaaaatg tgtggctgtc agggtgaata tggaaacctt
      301 ccaagttcaa gtgatagaca atggatttgg gatggggagt gatgatgtag agaaagtggg
      361 aaatcgttat ttcaccagta aatgccactc ggtacaggac ttggagaatc caaggtttta
      421 tggtttccga ggagaggcct tggcaaatat tgctgacatg gccagtgctg tggaaatttc
      481 gtccaagaaa aacaggacaa tgaaaacttt tgtgaaactg tttcagagtg gaaaagccct
      541 gaaagcttgt gaagctgatg tgactagagc aagcgctggg actactgtaa cagtgtataa
      601 cctattttac cagcttcctg taaggaggaa atgcatggac cctagactgg agtttgagaa
      661 ggttaggcag agaatagaag ctctctcact catgcaccct tccatttctt tctctttgag
      721 aaatgatgtt tctggttcca tggttcttca gctccctaaa accaaagacg tatgttcccg
      781 attttgtcaa atttatggat tgggaaagtc ccaaaagcta agagaaataa gttttaaata
      841 taaagagttt gagcttagtg gctatatcag ctctgaagca cattacaaca agaatatgca
      901 gtttttgttt gtgaacaaaa gactagtttt aaggacaaag ctacataaac tcattgactt
      961 tttattaagg aaagaaagta ttatatgcaa gccaaagaat ggtcccacca gtaggcaaat
     1021 gaattcaagt cttcggcacc ggtctacccc agaactctat ggcatatatg taattaatgt
     1081 gcagtgccaa ttctgtgagt atgatgtgtg catggagcca gccaaaactc tgattgaatt
     1141 tcagaactgg gacactctct tgttttgcat tcaggaagga gtgaaaatgt ttttaaagca
     1201 agaaaaatta tttgtggaat tatcaggtga ggatattaag gaatttagtg aagataatgg
     1261 ttttagttta tttgatgcta ctcttcagaa gcgtgtgact tccgatgaga ggagcaattt
     1321 ccaggaagca tgtaataata ttttagattc ctatgagatg tttaatttgc agtcaaaagc
     1381 tgtgaaaaga aaaactactg cagaaaacgt aaacacacag agttctaggg attcagaagc
     1441 taccagaaaa aatacaaatg atgcattttt gtacatttat gaatcaggtg gtccaggcca
     1501 tagcaaaatg acagagccat ctttacaaaa caaagacagc tcttgctcag aatcaaagat
     1561 gttagaacaa gagacaattg tagcatcaga agctggagaa aatgagaaac ataaaaaatc
     1621 tttcctggaa catagctctt tagaaaatcc gtgtggaacc agtttagaaa tgtttttaag
     1681 cccttttcag acaccatgtc actttgagga gagtgggcag gatctagaaa tatggaaaga
     1741 aagtactact gttaatggca tggctgccaa catcttgaaa aataatagaa ttcagaatca
     1801 accaaagaga tttaaagatg ctactgaagt gggatgccag cctctgcctt ttgcaacaac
     1861 attatgggga gtacatagtg ctcagacaga gaaagagaaa aaaaaagaat ctagcaattg
     1921 tggaagaaga aatgttttta gttatgggcg agttaaatta tgttccactg gctttataac
     1981 tcatgtagta caaaatgaaa aaactaaatc aactgaaaca gaacattcat ttaaaaatta
     2041 tgttagacct ggtcccacac gtgcccaaga aacatttgga aatagaacac gtcattcagt
     2101 tgaaactcca gacatcaaag atttagccag cactttaagt aaagaatctg gtcaattgcc
     2161 caacaaaaaa aattgcagaa cgaatataag ttatgggcta gagaatgaac ctacagcaac
     2221 ttatacaatg ttttctgctt ttcaggaagg tagcaaaaaa tcacaaacag attgcatatt
     2281 atctgataca tccccctctt tcccctggta tagacacgtt tccaatgata gtaggaaaac
     2341 agataaatta attggtttct ccaaaccaat cgtccgtaag aagctaagct tgagttcaca
     2401 gctaggatct ttagagaagt ttaagaggca atatgggaag gttgaaaatc ctctggatac
     2461 agaagtagag gaaagtaatg gagtcactac caatctcagt cttcaagttg aacctgacat
     2521 tctgctgaag gacaagaacc gcttagagaa ctctgatgtt tgtaaaatca ctactatgga
     2581 gcatagtgat tcagatagta gttgtcaacc agcaagccac atccttaact cagagaagtt
     2641 tccattctcc aaggatgaag attgtttaga acaacagatg cctagtttga gagaaagtcc
     2701 tatgaccctg aaggagttat ctctctttaa tagaaaacct ttggaccttg agaagtcatc
     2761 tgaatcacta gcctctaaat tatccagact gaagggttcc gaaagagaaa ctcaaacaat
     2821 ggggatgatg agtcgtttta atgaacttcc aaattcagat tccagtagga aagacagcaa
     2881 gttgtgcagt gtgttaacac aagatttttg tatgttattt aacaacaagc atgaaaaaac
     2941 agagaatggt gtcatcccaa catcagattc tgccacacag gataattcct ttaataaaaa
     3001 tagtaaaaca cattctaaca gcaatacaac agagaactgt gtgatatcag aaactccttt
     3061 ggtattgccc tataataatt ctaaagttac cggtaaagat tcagatgttc ttatcagagc
     3121 ctcagaacaa cagataggaa gtcttgactc tcccagtgga atgttaatga atccggtaga
     3181 agatgccaca ggtgaccaaa atggaatttg ttttcagagt gaggaatcta aagcaagagc
     3241 ttgttctgaa actgaagagt caaacacgtg ttgttcagat tggcagcggc atttcgatgt
     3301 agccctggga agaatggttt atgtcaacaa aatgactgga ctcagcacat tcattgcccc
     3361 aactgaggac attcaggctg cttgtactaa agacctgaca actgtggctg tggatgttgt
     3421 acttgagaat gggtctcagt acaggtgtca accttttaga agcgaccttg ttcttccttt
     3481 ccttccgaga gctcgagcag agaggactgt gatgagacag gataacagag atactgtgga
     3541 tgatactgtt agtagcgaat cgcttcagtc tttgttctca gaatgggaca atccagtatt
     3601 tgcccgttat ccagaggttg ctgttgatgt aagcagtggc caggctgaga gcttagcagt
     3661 taaaattcac aacatcttgt atccctatcg tttcaccaaa ggaatgattc attcaatgca
     3721 ggttctccag caagtagata acaagtttat tgcctgtttg atgagcacta agactgaaga
     3781 gaatggcgag gcaggtggga acctgctcgt gctggtggat cagcacgctg cccatgagcg
     3841 tatacgtctg gagcagctta tcattgattc ctacgagaag caacaggcac aaggctctgg
     3901 tcggaaaaaa ttactgtctt ctactctaat tcctccgcta gagataacag tgacagagga
     3961 acaaaggaga ctcttatggt gttaccacaa aaatctggaa gatctgggcc ttgaatttgt
     4021 atttccagac actagtgatt ctctggtcct tgtgggaaaa gtaccactat gttttgtgga
     4081 aagagaagcc aatgaacttc ggagaggaag atctactgtg accaagagta ttgtggagga
     4141 atttatccga gaacaactgg agctactcca gaccaccgga ggcatccaag ggacattgcc
     4201 actgactgtc cagaaggtgt tggcatccca agcctgccat ggggccatta agtttaatga
     4261 tggcctgagc ttacaggaaa gttgccgcct tattgaagct ctgtcctcat gccagctgcc
     4321 attccagtgt gctcacggga gaccttctat gctgccgtta gctgacatag accacttgga
     4381 acaggaaaaa cagattaaac ccaacctcac taaacttcgc aaaatggccc aggcctggcg
     4441 tctctttgga aaagcagagt gtgatacaag gcagagcctg cagcaatcca tgcctccctg
     4501 tgagccacca tgagaacaga atcactggtc taaaaggaac aaagggatgt tcactgtatg
     4561 cctctgagca gagagcagca gcagcaggta ccagcacggc cctgactgaa tcagcccagt
     4621 gtccctgagc agcttagaca gcagggctct ctgtatcagt ctttcttgag cagatgattc
     4681 ccctagttga gtagccagat gaaattcaag cctaaagaca attcattcat ttgcatccat
     4741 gggcacagaa ggttgctata tagtatctac cttttgctac ttatttaatg ataaaattta
     4801 atgacagttt gattggttgc ttggtttgtt atttgaaggg tgtgattttt gtttttgtac
     4861 agtttttttt caagcttcac atttgcgtgt atctaattca gctgatgctc aagtccaagg
     4921 ggtagtctgc cttcccaggc tgcccccagg gtttctgcac tggtcccctc ttttcccttc
     4981 agtcttcttc acttccctat gctgctgctt catgtgctac atctcagact taaagagttt
     5041 ctctactaca gtgaaaacat tctctagggt ctttcatcag gcctttagtt attttaggga
     5101 taaaaactat tgataaaaag gacaaggata gaacagagaa aatttaaagt cctgttccgg
     5161 gttttttgtt atgttttctt taaaaactca gagactgatg ttcaatatcc caaaccagta
     5221 aaatggtgaa aatactatga gcttgttttt taaaatatga ttttttttgg tactttataa
     5281 agtatctctt tatgtgaaag caattgtcat atcaaaacac agcatacata cgttcaacct
     5341 aaccaaatat ctttacactt tttctttcag gagacaaggg ttctttgggt ccctttcaaa
     5401 cggtatcttg gtgttattac attatgccta tctattgccc ttataatatc acttgggacc
     5461 aggactgatc gttctgcaaa tgcttgttat gccattctca atctattttt cccgcacctt
     5521 ttcacatgat ttgtggttaa taggactcaa cagactaaaa ttgcatagta gaaaaaaaat
     5581 gcaaaaagcc agctggtaat gtttattgca actggggtgc tatacaatta gtaagatgat
     5641 gcaatgagaa tttctacttt tgtatttcct gaccagcctg ctcaaagtgg cttttatatc
     5701 aattgaatga ttttcctcat tttttaatac aggaaaccaa ttcgtgctca tggaagaaaa
     5761 gttcctttgc cagcagcctt gaagtgaatc ttacaggagc aatgaaagta ttgcattcat
     5821 tagcgtctgc cccagagaag gttcagagaa aaccttcact tgttttcaag gggatccttg
     5881 tagatttacg taattggaat cctgaagaac aggccctact gtctaaaaaa tggcttttat
     5941 tcttctaaat acatataaac ggatgtttta tagatgggaa gacatgacct tagaaaggag
     6001 agagttttca gaggatttgc caggctgtca ggggctctgc ctccaggccc agtgtggcag
     6061 tgtggcctca gggcctccgc ctccctgctt gagggctgca tggaggccaa ctgtcctggg
     6121 agttgtaaaa atcttttaag gccagaccaa tttgagggat tttaaaaagt gtctcagtgc
     6181 ctcttatgat ttcagaaggt tttgctatat gtaatcccaa ctactgtttt cttgagagta
     6241 gcagaggatt agaaaaagtc ctccataaat tatgtaaccg gccttcctga ctagcctgac
     6301 tcaagcaatg taagagataa ttattctgtt ttcataattt ataagtgtgg gggcatgcct
     6361 cagcataaaa acaacctatt agggaaaaat atctaataga ttacctttat cgcctgttag
     6421 ggttttatgt tgtttttaac tcagatgcca taagaacaaa gatacatgta atttataata
     6481 gtaatcatta atacctatat tgtgctttaa ggtttacaaa ataatttttc tcatacttta
     6541 tcttagttta gtttcttgac agtccatgag gtaaggtggt agctttatca ccattttaca
     6601 aagtgggaaa cgaaggttcc tcttaggaac ctagttgtca cctttgtata ataaaacttc
     6661 gaagctcgga gctgttaact ggtttgctga aggcttagct gtaagagcca gaattcagac
     6721 ccaggtctga gtgacttcaa actgcacagt ccttcccatt attacccata tgctatccct
     6781 tatattttta atttattagg aattcattca tttataaact tggtgattca cctttattag
     6841 attctggtcg ctgaaggctt tagtaacttc agagtaaaac ttgagagatg agatgtaaaa
     6901 tgcagccatt cttgagagtt cctttttctg taacattcat caacacttca ttgagaagtg
     6961 aaggttccta tggctgtctc taccttcaag aggcttagct ttagtcactg agaaagacaa
     7021 ggaaactaat gatagaatat agtagcttct tctggcgtta ggtatcacag agtcacagct
     7081 agttacagct agccctttat tattgaaaga agaggagcta gcagtcccac tatcagaatt
     7141 aagactagag atggtaatag gagctagtat cagaaaagct taaggcaaag cataaagtgt
     7201 aggctagaat gaagctggag aatggggagg gggcttgggt aacatccaga acctggctgg
     7261 ggacctggaa ctacatgaga tgtaagaatg gagaggttct agcagtcaga ggtcaggtac
     7321 aaatgaacag ctgggatctg cgcatggcag acagtgaaaa aacccaggca agcaaaatgg
     7381 tcagagcaga aaggggccca aggccacgtt cttgagatgt ggagggggct gaggaagcca
     7441 cgccaagtaa ggacagatgc agctcagcag ttcctagcga gccctgacaa gccagctcag
     7501 ctgaagcttc gggtgggagc cagtcatggc acagtggagt gaaggaagag cagtttcagg
     7561 cacccaaaac ctgaccccca cgacctgttt tccacctgaa gagccaccca ttccatccaa
     7621 acccttggca aaagtctgct aacagagaga accggccagt atgctggcca gtcgcgatca
     7681 tgcctgtctt taccctctaa gctgaagctg ctcatcaacg gtgagatggc aaaaaggtgg
     7741 gtccagaaga ggggaaaaga agggagtctg tgaaaacaaa atgctgaaga atctgcatca
     7801 aataaaccct tccttccttc
//
