LOCUS       NM_001382226            1555 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens myeloid leukemia factor 2 (MLF2), transcript variant
            2, mRNA.
ACCESSION   NM_001382226 NR_026581 XM_005253791
VERSION     NM_001382226.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Iglesias-Martinez,L.F., Rauch,N., Wynne,K., McCann,B., Kolch,W. and
            Rauch,J.
  TITLE     Interactome dynamics of RAF1-BRAF kinase monomers and dimers
  JOURNAL   Sci Data 10 (1), 203 (2023)
   PUBMED   37045861
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1555)
  AUTHORS   Huang,D., Liu,C., Sun,X., Sun,X., Qu,Y., Tang,Y., Li,G. and Tong,T.
  TITLE     CRL4DCAF8 and USP11 oppositely regulate the stability of myeloid
            leukemia factors (MLFs)
  JOURNAL   Biochem Biophys Res Commun 529 (2), 127-132 (2020)
   PUBMED   32703400
  REMARK    GeneRIF: CRL4(DCAF8) and USP11 oppositely regulate the stability of
            myeloid leukemia factors (MLFs).
REFERENCE   4  (bases 1 to 1555)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 1555)
  AUTHORS   Rampello,A.J., Laudermilch,E., Vishnoi,N., Prophet,S.M., Shao,L.,
            Zhao,C., Lusk,C.P. and Schlieker,C.
  TITLE     Torsin ATPase deficiency leads to defects in nuclear pore
            biogenesis and sequestration of MLF2
  JOURNAL   J Cell Biol 219 (6) (2020)
   PUBMED   32342107
  REMARK    GeneRIF: Torsin ATPase deficiency leads to defects in nuclear pore
            biogenesis and sequestration of MLF2.
REFERENCE   6  (bases 1 to 1555)
  AUTHORS   Blandin,G., Marchand,S., Charton,K., Daniele,N., Gicquel,E.,
            Boucheteil,J.B., Bentaib,A., Barrault,L., Stockholm,D., Bartoli,M.
            and Richard,I.
  TITLE     A human skeletal muscle interactome centered on proteins involved
            in muscular dystrophies: LGMD interactome
  JOURNAL   Skelet Muscle 3 (1), 3 (2013)
   PUBMED   23414517
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1555)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 1555)
  AUTHORS   Walker,L.C., Waddell,N., Ten Haaf,A., Grimmond,S. and Spurdle,A.B.
  CONSRTM   kConFab Investigators
  TITLE     Use of expression data and the CGEMS genome-wide breast cancer
            association study to identify genes that may modify risk in BRCA1/2
            mutation carriers
  JOURNAL   Breast Cancer Res Treat 112 (2), 229-236 (2008)
   PUBMED   18095154
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   9  (bases 1 to 1555)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   10 (bases 1 to 1555)
  AUTHORS   Kuefer,M.U., Look,A.T., Williams,D.C., Valentine,V., Naeve,C.W.,
            Behm,F.G., Mullersman,J.E., Yoneda-Kato,N., Montgomery,K.,
            Kucherlapati,R. and Morris,S.W.
  TITLE     cDNA cloning, tissue distribution, and chromosomal localization of
            myelodysplasia/myeloid leukemia factor 2 (MLF2)
  JOURNAL   Genomics 35 (2), 392-396 (1996)
   PUBMED   8661158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125494.2 and U57342.1.
            
            On Apr 23, 2020 this sequence version replaced NR_026581.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3, all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF070539.1, BC002340.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147920, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000203630.10/ ENSP00000203630.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC125494.2         45274-45333
            61-1554             U57342.1           9-1502
            1555-1555           AC125494.2         50419-50419
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1555
                     /gene="MLF2"
                     /gene_synonym="NTN4"
                     /note="myeloid leukemia factor 2"
                     /db_xref="GeneID:8079"
                     /db_xref="HGNC:HGNC:7126"
                     /db_xref="MIM:601401"
     exon            1..203
                     /gene="MLF2"
                     /gene_synonym="NTN4"
                     /inference="alignment:Splign:2.1.0"
     exon            204..281
                     /gene="MLF2"
                     /gene_synonym="NTN4"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..978
                     /gene="MLF2"
                     /gene_synonym="NTN4"
                     /note="myelodysplasia-myeloid leukemia factor 2"
                     /codon_start=1
                     /product="myeloid leukemia factor 2"
                     /protein_id="NP_001369155.1"
                     /db_xref="CCDS:CCDS8559.1"
                     /db_xref="GeneID:8079"
                     /db_xref="HGNC:HGNC:7126"
                     /db_xref="MIM:601401"
                     /translation="MFRFMRDVEPEDPMFLMDPFAIHRQHMSRMLSGGFGYSPFLSIT
                     DGNMPGTRPASRRMQQAGAVSPFGMLGMSGGFMDMFGMMNDMIGNMEHMTAGGNCQTF
                     SSSTVISYSNTGDGAPKVYQETSEMRSAPGGIRETRRTVRDSDSGLEQMSIGHHIRDR
                     AHILQRSRNHRTGDQEERQDYINLDESEAAAFDDEWRRETSRFRQQRPLEFRRLESSG
                     AGGRRAEGPPRLAIQGPEDSPSRQSRRYDW"
     exon            282..411
                     /gene="MLF2"
                     /gene_synonym="NTN4"
                     /inference="alignment:Splign:2.1.0"
     exon            412..447
                     /gene="MLF2"
                     /gene_synonym="NTN4"
                     /inference="alignment:Splign:2.1.0"
     exon            448..501
                     /gene="MLF2"
                     /gene_synonym="NTN4"
                     /inference="alignment:Splign:2.1.0"
     exon            502..630
                     /gene="MLF2"
                     /gene_synonym="NTN4"
                     /inference="alignment:Splign:2.1.0"
     exon            631..790
                     /gene="MLF2"
                     /gene_synonym="NTN4"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1003
                     /gene="MLF2"
                     /gene_synonym="NTN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1555
                     /gene="MLF2"
                     /gene_synonym="NTN4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1533..1538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLF2"
                     /gene_synonym="NTN4"
                     /note="hexamer: AATAAA"
     polyA_site      1555
                     /gene="MLF2"
                     /gene_synonym="NTN4"
                     /note="major polyA site"
ORIGIN      
        1 acttccgccc gggcctggcc gaggttcggg ctccgttggc cgagggggcc gtacggaggt
       61 ggcagctgtg ggaggaggcg gcgtggaagg ccgaggagct caagcccgga ccaatcccca
      121 cgttccgggc cgcgaccctg accctgcagc gtaccgggaa gcgaaaccgg ccggatgggc
      181 cgctgagccc gaatcgggca ctgtgtggag ccccctggag ctgagatcag gatgttccgc
      241 ttcatgaggg acgtggagcc tgaggatccc atgttcctga tggatccctt tgctattcac
      301 cgtcagcata tgagccgtat gttgtcaggt ggctttggat atagcccctt cctcagcatc
      361 acagatggca acatgccagg gaccaggcct gccagccgcc ggatgcagca ggctggagct
      421 gtctccccct ttgggatgct gggaatgtcg ggtggtttca tggacatgtt tgggatgatg
      481 aatgacatga ttggaaacat ggaacacatg acagctggag gcaattgcca gaccttctca
      541 tcttccactg tcatctccta ctccaatacg ggtgatggtg cccccaaggt ctaccaagag
      601 acatcagaga tgcgctcggc accaggcggg atccgggaga cacggaggac tgttcgggat
      661 tcagacagtg gactggagca gatgtccatt gggcatcaca tccgggacag ggctcacatc
      721 ctccagcgct cccgaaacca tcgcacgggg gaccaggagg agcggcagga ctatatcaac
      781 ctggatgaga gtgaggccgc agcgtttgat gacgagtggc ggcgggagac ctcccgattc
      841 cggcagcagc gtcccctgga gtttcggcgg cttgagtcct caggggctgg gggacgaagg
      901 gcggaggggc ctccccgcct ggccatccag ggacctgagg actccccttc ccgacagtcc
      961 cgccgctatg actggtgagg gccccgggcc ctcagcctct cttgtacagg ctgagaggct
     1021 gagaaatcat cccctgaata actttttcct ctcgattccc atccccaatt taatattaaa
     1081 ttaacaggca agccggcccc cacctctccc tgggggtctc agggagaacc tttcacggca
     1141 ccctttccct accttttcct tctttaatct cctggtttac cattgatgac ttcgcctctg
     1201 catctactga cttgattttt cattctgcca ctccatcttc aaaccccctc acctttccca
     1261 tcctactcct gccatgcatt gaagggtcaa tgcattttgg ggtgagctct gggtttaggg
     1321 gccccctcca tccctcagct accctggatc tttgcccacc tcttcctcag agcccccact
     1381 gaggggccgt agccctatct agggctgtgg aaggagcaga ctggttccta actctctccc
     1441 tcctcctgcc cacacacatc aaaagaatct tccctacacc cttctctgcc tttatttttt
     1501 gatttgtgca acttgtaact aggtgtttat ggaataaagg agaatggaaa aaaga
//
