LOCUS       NM_001369783            2213 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens myeloid leukemia factor 1 (MLF1), transcript variant
            9, mRNA.
ACCESSION   NM_001369783 XM_005247479
VERSION     NM_001369783.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2213)
  AUTHORS   Tang,Z., Yang,Y., Chen,W. and Liang,T.
  TITLE     Epigenetic deregulation of MLF1 drives intrahepatic
            cholangiocarcinoma progression through EGFR/AKT and
            Wnt/beta-catenin signaling
  JOURNAL   Hepatol Commun 7 (8), e0204 (2023)
   PUBMED   37486965
  REMARK    GeneRIF: Epigenetic deregulation of MLF1 drives intrahepatic
            cholangiocarcinoma progression through EGFR/AKT and
            Wnt/beta-catenin signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2213)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2213)
  AUTHORS   Huang,D., Liu,C., Sun,X., Sun,X., Qu,Y., Tang,Y., Li,G. and Tong,T.
  TITLE     CRL4DCAF8 and USP11 oppositely regulate the stability of myeloid
            leukemia factors (MLFs)
  JOURNAL   Biochem Biophys Res Commun 529 (2), 127-132 (2020)
   PUBMED   32703400
  REMARK    GeneRIF: CRL4(DCAF8) and USP11 oppositely regulate the stability of
            myeloid leukemia factors (MLFs).
REFERENCE   4  (bases 1 to 2213)
  AUTHORS   Darracq,A., Pak,H., Bourgoin,V., Zmiri,F., Dellaire,G., Affar,E.B.
            and Milot,E.
  TITLE     NPM and NPM-MLF1 interact with chromatin remodeling complexes and
            influence their recruitment to specific genes
  JOURNAL   PLoS Genet 15 (11), e1008463 (2019)
   PUBMED   31675375
  REMARK    GeneRIF: the abnormal gene regulation imposed by NPM-MLF1 can be
            characterized by the enhanced recruitment of NuRD to gene
            regulatory regions. Thus, different mechanisms would orchestrate
            the dysregulation of NPM function in NPMc+- versus
            NPM1-MLF1-associated leukemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2213)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2213)
  AUTHORS   Yoneda-Kato,N., Tomoda,K., Umehara,M., Arata,Y. and Kato,J.Y.
  TITLE     Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via
            COP9 signalosome subunit 3
  JOURNAL   EMBO J 24 (9), 1739-1749 (2005)
   PUBMED   15861129
REFERENCE   7  (bases 1 to 2213)
  AUTHORS   Hanissian,S.H., Akbar,U., Teng,B., Janjetovic,Z., Hoffmann,A.,
            Hitzler,J.K., Iscove,N., Hamre,K., Du,X., Tong,Y., Mukatira,S.,
            Robertson,J.H. and Morris,S.W.
  TITLE     cDNA cloning and characterization of a novel gene encoding the
            MLF1-interacting protein MLF1IP
  JOURNAL   Oncogene 23 (20), 3700-3707 (2004)
   PUBMED   15116101
REFERENCE   8  (bases 1 to 2213)
  AUTHORS   Arber,D.A., Chang,K.L., Lyda,M.H., Bedell,V., Spielberger,R. and
            Slovak,M.L.
  TITLE     Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid
            leukemia and myelodysplasia
  JOURNAL   Hum Pathol 34 (8), 809-813 (2003)
   PUBMED   14506644
  REMARK    GeneRIF: These findings suggest that an NPM/MLF1 fusion is the
            primary molecular abnormality in t(3;5) MDS and AML with
            multilineage dysplasia, and that cases with NPM/MLF1 may be
            clinically distinct from other MDS-associated disease
REFERENCE   9  (bases 1 to 2213)
  AUTHORS   Lim,R., Winteringham,L.N., Williams,J.H., McCulloch,R.K.,
            Ingley,E., Tiao,J.Y., Lalonde,J.P., Tsai,S., Tilbrook,P.A., Sun,Y.,
            Wu,X., Morris,S.W. and Klinken,S.P.
  TITLE     MADM, a novel adaptor protein that mediates phosphorylation of the
            14-3-3 binding site of myeloid leukemia factor 1
  JOURNAL   J Biol Chem 277 (43), 40997-41008 (2002)
   PUBMED   12176995
  REMARK    GeneRIF: phosphorylation of 14-3-3 binding site by MADM
REFERENCE   10 (bases 1 to 2213)
  AUTHORS   Yoneda-Kato,N., Look,A.T., Kirstein,M.N., Valentine,M.B.,
            Raimondi,S.C., Cohen,K.J., Carroll,A.J. and Morris,S.W.
  TITLE     The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid
            leukemia produces a novel fusion gene, NPM-MLF1
  JOURNAL   Oncogene 12 (2), 265-275 (1996)
   PUBMED   8570204
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106707.9, KU178187.1 and
            AC025033.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 18, 2019 this sequence version replaced XM_005247479.5.
            
            Summary: This gene encodes an oncoprotein which is thought to play
            a role in the phenotypic determination of hemopoetic cells.
            Translocations between this gene and nucleophosmin have been
            associated with myelodysplastic syndrome and acute myeloid
            leukemia. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.181954.1,
                                           SRR5189655.221586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2149178
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000466246.7/ ENSP00000417278.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC106707.9         180940-181046
            108-956             KU178187.1         1-849
            957-2213            AC025033.20        61655-62911         c
FEATURES             Location/Qualifiers
     source          1..2213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.32"
     gene            1..2213
                     /gene="MLF1"
                     /note="myeloid leukemia factor 1"
                     /db_xref="GeneID:4291"
                     /db_xref="HGNC:HGNC:7125"
                     /db_xref="MIM:601402"
     exon            1..154
                     /gene="MLF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..959
                     /gene="MLF1"
                     /note="isoform 6 is encoded by transcript variant 9;
                     myelodysplasia-myeloid leukemia factor 1; testis tissue
                     sperm-binding protein Li 49e"
                     /codon_start=1
                     /product="myeloid leukemia factor 1 isoform 6"
                     /protein_id="NP_001356712.1"
                     /db_xref="CCDS:CCDS93414.1"
                     /db_xref="GeneID:4291"
                     /db_xref="HGNC:HGNC:7125"
                     /db_xref="MIM:601402"
                     /translation="MFRMLNSSFEDDPFFSESILAHRENMRQMIRSFSEPFGRDLLSI
                     SDGRGRAHNRRGHNDGEDSLTATSCSLVPFGDFGGMHTDVSSFQTMDQMVSNMRNYMQ
                     KLERNFGQLSVDPNGHSFCSSSVMTYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMR
                     DSDSGLEKMAIGHHIHDRAHVIKKSKNKKTGDEEVNQEFINMNESDAHAFDEEWQSEV
                     LKYKPGRHNLGNTRMRSVGHENPGSRELKRREKPQQSPAIEHGRRSNVLGDKLHIKGS
                     SVKSNKK"
     exon            155..302
                     /gene="MLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..347
                     /gene="MLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            348..431
                     /gene="MLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..560
                     /gene="MLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..720
                     /gene="MLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..853
                     /gene="MLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..2213
                     /gene="MLF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1132..1137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLF1"
                     /note="hexamer: AATAAA"
     polyA_site      1154
                     /gene="MLF1"
                     /note="major polyA site"
     regulatory      2193..2198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MLF1"
                     /note="hexamer: AATAAA"
     polyA_site      2213
                     /gene="MLF1"
ORIGIN      
        1 gagtgaggcg tcgtccgtac tggaggctag ctcttgtcgc ggccgcggcg agttaacatc
       61 gtttttccaa tctgtccgcg gctgccgcca cccaagacag agccagaatg ttcaggatgc
      121 tgaacagcag ttttgaggat gaccccttct tctctgagtc cattcttgca caccgagaaa
      181 atatgcgaca gatgataaga agtttttctg aaccctttgg aagagacttg ctcagtatct
      241 ctgatggtag agggagagct cataatcgta gaggacataa tgatggtgaa gattctttga
      301 ctgcaacgag ttgttctctt gtgccttttg gcgattttgg tggtatgcat acagatgtca
      361 gctctttcca gacaatggac caaatggtgt caaatatgag aaactatatg cagaaattag
      421 aaagaaactt cggtcaactt tcagtggatc caaatggaca ttcattttgt tcttcctcag
      481 ttatgactta ttccaaaata ggagatgaac cgccaaaggt ttttcaggcc tcaactcaaa
      541 ctcgtcgagc tccaggagga ataaaggaaa ccaggaaagc aatgagagat tctgacagtg
      601 gactagaaaa aatggctatt ggtcatcata tccatgaccg agctcatgtc attaaaaagt
      661 caaagaacaa gaagactgga gatgaagagg tcaaccagga gttcatcaat atgaatgaaa
      721 gtgatgctca tgcttttgat gaggagtggc aaagtgaggt tttgaagtac aaaccaggac
      781 gacacaatct aggaaacact agaatgagaa gtgttggcca tgagaatcct ggctcccgag
      841 aacttaaaag aagggagaaa cctcaacaaa gtccagccat tgaacatgga aggagatcaa
      901 atgttttggg ggacaaactc cacatcaaag gctcatctgt gaaaagcaac aaaaaataaa
      961 tagccatgca tttgatttgt ttagttttga ttgttttaac agttagtaat ggtgctgggt
     1021 aataagcata agaccaatct cttgctgtta aatcagttct gtccttggca actttcttct
     1081 gatatctgaa tgttcatgaa ggtcctagct ttatattgtc cctcttttag gaataaaatt
     1141 ttgattttca acaatgtgag taaattgagt ctatttaatg taaaactctt taaaacatac
     1201 taatttttta aagcttatat gcttatttcg cttccccagt tgtttttgtg ttggctaaat
     1261 attcttttat atttatcaag attgattgca gagcagttct atcacttata attagttata
     1321 agaaattata atgttaaaaa agtctcagtt tttactaaca ctgtactagg gtgatattaa
     1381 taaaggttta aataatttat ctctaatttt ataatgtgtt gtaaagccaa ctagcttaaa
     1441 actttaaaaa taataaagca aaactacact agtactcttt tatgagaaaa tagttactat
     1501 tttgataaag ggcaaggata atcaaatagt tcattttcag agaaaaatat tttaaattgc
     1561 taatgtacat gattgttttg gttataattt atttatagaa tgtatctttt ctatattaca
     1621 ttcttaatat tcaccagata ttatattgac cattctcttt aacttcttaa tgtggcatat
     1681 ttctactctc ctttcccaca aacagcttca tctgtctcca aggttaacat tctgaagctg
     1741 gagagtcctt ggagaaactc tgctcagctt ttttgtgaca tttagaaaaa tgcatttggt
     1801 attctccaaa ccagaatgat acattgtctc aaaatctgtt agacagctga tgggtgtttt
     1861 tgagcaacgt cttaataatt cagttgtttc tgttttaatt ataccattaa aaatcagctt
     1921 tagcttttta attctagaat ttaagcatca gtctgttctt ataaaagtta ggtttgaagt
     1981 ttataagaat ataaaatctt aactcacatt tgttgtttaa tatttctgtc aaggaaaaaa
     2041 gcccccaaaa attgctatca ctctataatc ctaagtattt ttcttttcaa ttttgtaagt
     2101 aaaattatat gactatgttc atacttctct aattttttat ataatatttt tgttaatttt
     2161 actagtttgt gttttatgcc tttagtcatt aaaataaaat gcaaatgtgt taa
//
