LOCUS       NM_001135553            2661 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens MAPK interacting serine/threonine kinase 1 (MKNK1),
            transcript variant 3, mRNA.
ACCESSION   NM_001135553
VERSION     NM_001135553.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2661)
  AUTHORS   Preston,S.E.J., Dahabieh,M.S., Flores Gonzalez,R.E., Goncalves,C.,
            Richard,V.R., Leibovitch,M., Dakin,E., Papadopoulos,T., Lopez
            Naranjo,C., McCallum,P.A., Huang,F., Gagnon,N., Perrino,S.,
            Zahedi,R.P., Borchers,C.H., Jones,R.G., Brodt,P., Miller,W.H. Jr.
            and Del Rincon,S.V.
  TITLE     Blocking tumor-intrinsic MNK1 kinase restricts metabolic adaptation
            and diminishes liver metastasis
  JOURNAL   Sci Adv 10 (37), eadi7673 (2024)
   PUBMED   39270021
  REMARK    GeneRIF: Blocking tumor-intrinsic MNK1 kinase restricts metabolic
            adaptation and diminishes liver metastasis.
REFERENCE   2  (bases 1 to 2661)
  AUTHORS   Shiers,S., Sahn,J.J. and Price,T.J.
  TITLE     MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal
            Ganglion
  JOURNAL   Neuroscience 515, 96-107 (2023)
   PUBMED   36764601
  REMARK    GeneRIF: MNK1 and MNK2 Expression in the Human Dorsal Root and
            Trigeminal Ganglion.
REFERENCE   3  (bases 1 to 2661)
  AUTHORS   Fu,M. and Zhang,K.
  TITLE     MAPK interacting serine/threonine kinase 1 (MKNK1), one target gene
            of miR-223-3p, correlates with neutrophils in sepsis based on
            bioinformatic analysis
  JOURNAL   Bioengineered 12 (1), 2550-2562 (2021)
   PUBMED   34115574
  REMARK    GeneRIF: MAPK interacting serine/threonine kinase 1 (MKNK1), one
            target gene of miR-223-3p, correlates with neutrophils in sepsis
            based on bioinformatic analysis.
REFERENCE   4  (bases 1 to 2661)
  AUTHORS   Zhang,P., Li,X., Zhang,S., Wu,S., Xiao,Q., Gu,Y., Guo,X., Lin,X.,
            Chen,L., Zhao,Y., Niu,L., Tang,G., Jiang,Y., Shen,L. and Zhu,L.
  TITLE     miR-370-3p Regulates Adipogenesis through Targeting Mknk1
  JOURNAL   Molecules 26 (22), 6926 (2021)
   PUBMED   34834018
  REMARK    GeneRIF: miR-370-3p Regulates Adipogenesis through Targeting Mknk1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2661)
  AUTHORS   O'Loghlen,A., Gonzalez,V.M., Jurado,T., Salinas,M. and Martin,M.E.
  TITLE     Characterization of the activity of human MAP kinase-interacting
            kinase Mnk1b
  JOURNAL   Biochim Biophys Acta 1773 (9), 1416-1427 (2007)
   PUBMED   17590453
  REMARK    GeneRIF: The activity of MKNK1 was characterized.
REFERENCE   6  (bases 1 to 2661)
  AUTHORS   O'Loghlen,A., Gonzalez,V.M., Pineiro,D., Perez-Morgado,M.I.,
            Salinas,M. and Martin,M.E.
  TITLE     Identification and molecular characterization of Mnk1b, a splice
            variant of human MAP kinase-interacting kinase Mnk1
  JOURNAL   Exp Cell Res 299 (2), 343-355 (2004)
   PUBMED   15350534
REFERENCE   7  (bases 1 to 2661)
  AUTHORS   Borsch-Haubold,A.G., Bartoli,F., Asselin,J., Dudler,T.,
            Kramer,R.M., Apitz-Castro,R., Watson,S.P. and Gelb,M.H.
  TITLE     Identification of the phosphorylation sites of cytosolic
            phospholipase A2 in agonist-stimulated human platelets and HeLa
            cells
  JOURNAL   J Biol Chem 273 (8), 4449-4458 (1998)
   PUBMED   9468497
REFERENCE   8  (bases 1 to 2661)
  AUTHORS   Fukunaga,R. and Hunter,T.
  TITLE     MNK1, a new MAP kinase-activated protein kinase, isolated by a
            novel expression screening method for identifying protein kinase
            substrates
  JOURNAL   EMBO J 16 (8), 1921-1933 (1997)
   PUBMED   9155018
REFERENCE   9  (bases 1 to 2661)
  AUTHORS   Waskiewicz,A.J., Flynn,A., Proud,C.G. and Cooper,J.A.
  TITLE     Mitogen-activated protein kinases activate the serine/threonine
            kinases Mnk1 and Mnk2
  JOURNAL   EMBO J 16 (8), 1909-1920 (1997)
   PUBMED   9155017
REFERENCE   10 (bases 1 to 2661)
  AUTHORS   de Carvalho,M.G., McCormack,A.L., Olson,E., Ghomashchi,F.,
            Gelb,M.H., Yates,J.R. 3rd and Leslie,C.C.
  TITLE     Identification of phosphorylation sites of human 85-kDa cytosolic
            phospholipase A2 expressed in insect cells and present in human
            monocytes
  JOURNAL   J Biol Chem 271 (12), 6987-6997 (1996)
   PUBMED   8636128
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG722049.1, DA502363.1,
            AB000409.1, BC002755.2 and BM665342.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001135553.3.
            
            Summary: This gene encodes a Ser/Thr protein kinase that interacts
            with, and is activated by ERK1 and p38 mitogen-activated protein
            kinases, and thus may play a role in the response to environmental
            stress and cytokines. This kinase may also regulate transcription
            by phosphorylating eIF4E via interaction with the C-terminal region
            of eIF4G. Alternatively spliced transcript variants have been noted
            for this gene. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (3) lacks an in-frame coding exon
            compared to variant 1. This results in a shorter isoform (3)
            missing an internal protein segment compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3703734.1,
                                           SRR14038193.4509604.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000371945.10/
                                                ENSP00000361013.5
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BG722049.1         32-33
            3-31                DA502363.1         1-29
            32-2199             AB000409.1         1-2168
            2200-2650           BC002755.2         2269-2719
            2651-2661           BM665342.1         18-28               c
FEATURES             Location/Qualifiers
     source          1..2661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..2661
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /note="MAPK interacting serine/threonine kinase 1"
                     /db_xref="GeneID:8569"
                     /db_xref="HGNC:HGNC:7110"
                     /db_xref="MIM:606724"
     exon            1..84
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /inference="alignment:Splign:2.1.0"
     exon            85..252
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..354
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /inference="alignment:Splign:2.1.0"
     exon            355..452
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..532
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..606
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..711
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..767
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..863
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1058
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1223
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1267
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..2661
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2633..2638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /note="hexamer: AATAAA"
     polyA_site      2661
                     /gene="MKNK1"
                     /gene_synonym="MNK1"
                     /note="major polyA site"
ORIGIN      
        1 ctagcaccgc ctcttccgcg ttctcggagg agcgatctgc aggtaggggt gcgcgcgacc
       61 gctccccggc gggagccagc gaaggtttcc atgtcagagg ccgatggaga actgaagatt
      121 gccacctacg cacaaaggcc attgagacac ttcgtgtagc tggaagacac caacttcctg
      181 acaggagctt tatttcattt gggatttcaa gtttacagat ggtatcttct caaaagttgg
      241 aaaaacctat agagatgggc agtagcgaac cccttcccat cgcagatggt gacaggagga
      301 ggaagaagaa gcggaggggc cgggccactg actccttgcc aggaaagttt gaagatatgt
      361 acaagctgac ctctgaattg cttggagagg gagcctatgc caaagttcaa ggtgccgtga
      421 gcctacagaa tggcaaagag tatgccgtca aaatcatcga gaaacaagca gggcacagtc
      481 ggagtagggt gtttcgagag gtggagacgc tgtatcagtg tcagggaaac aagaacattt
      541 tggagctgat tgagttcttt gaagatgaca caaggtttta cttggtcttt gagaaattgc
      601 aaggaggttc catcttagcc cacatccaga agcaaaagca cttcaatgag cgagaagcca
      661 gccgagtggt gcgggacgtt gctgctgccc ttgacttcct gcataccaaa ggcattgctc
      721 atcgtgatct gaaaccagaa aatatattgt gtgaatctcc agaaaaggtg tctccagtga
      781 aaatctgtga ctttgacttg ggcagtggga tgaaactgaa caactcctgt acccccataa
      841 ccacaccaga gctgaccacc ccatgtggct ctgcagaata catggcccct gaggtagtgg
      901 aggtcttcac ggaccaggcc acattctacg acaagcgctg tgacctgtgg agcctgggcg
      961 tggtcctcta catcatgctg agtggctacc cacccttcgt gggtcactgc ggggccgact
     1021 gtggctggga ccggggcgag gtctgcaggg tgtgccagaa caagctgttt gaaagcatcc
     1081 aggaaggcaa gtatgagttt cctgacaagg actgggcaca catctccagt gaagccaaag
     1141 acctcatctc caagctcctg gtgcgagatg caaagcagag acttagcgcc gcccaagttc
     1201 tgcagcaccc atgggtgcag gggcaagctc cagaaaaggg actccccacg ccgcaagtcc
     1261 tccagaggaa cagcagcaca atggacctga cgctcttcgc agctgaggcc atcgccctta
     1321 accgccagct atctcagcac gaagagaacg aactagcaga ggagccagag gcactagctg
     1381 atggcctctg ctccatgaag ctttcccctc cctgcaagtc acgcctggcc cggagacggg
     1441 ccctggccca ggcaggccgt ggtgaagaca ggagcccgcc cacagcactc tgaaatgctc
     1501 cagtcacacc ttataggccc taggcctggc caggcattgt cccctggaaa cctgtgtggc
     1561 taaagtctgc tgagcaggca gcagcctctg ctctgtggct ccattcaggc tttttcatct
     1621 acgaaggccc tgaggttccc atcaaccccc atttccctag ggtcctggag gaaaaagctt
     1681 tttccaaagg ggttgtcttt gaaaaggaaa gcaatcactt ctcactttgc ataattgcct
     1741 gcagcaggaa catctcttca ctgggctcca cctgctcacc cgcctgcaga tctgggatcc
     1801 agcctgctct caccgctgta gctgtggcgg ctggggctgc agcctgcagg gagaagcaag
     1861 aagcatcagt tgacagaggc tgccgacacg tgcctcttcc ctctcttctc tgtcaccctc
     1921 ctctggcggt ccttccacct tcctctgtcc tccggatgtc ctctttgccc gtcttctccc
     1981 ttggctgagc aaagccatcc cctcaattca gggaagggca aggagccttc ctcattcagg
     2041 aaatcaaatc agtcttccgg tctgcagcac ggaaaagcac ataatctttc tttgctgtga
     2101 ctgaaatgta tccctcgttt atcatcccct ttgtttgtga ttgctgctaa agtcagtagt
     2161 atcgtttttt taaaaaaaaa gtttggtgtt tttaaccatg ctgttccagc aaagatgata
     2221 ccttaaactc ccactgcaag cccatgaact tcccagagag tggaacggct tgctcttctt
     2281 tctagaatgt ccatgcactt gggttttaat cagcagttcc ctattattct gattttaagc
     2341 tgttcctgtg atgaacttag agacagcatc ggtgtctgct gctgtgtccc caggtcttgt
     2401 gtgggtggca cagatctggg cagttagata gtgctctgtg cctaaggtga agccacacta
     2461 gggtgaagcc tcacttccct gtttgagcaa tgcagtgcct gctgcccgtg tgcatgaagg
     2521 tacagccatt cagataagtg gaactattga gttacataaa gaaaatagat ttgcatttgt
     2581 caggcagacg tttatacaac accacggtgc ttttatacat tgtgcttatt ttaataaaac
     2641 tgaaattcta tgtgtggcct a
//
