LOCUS       NM_001414695             213 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens mitochondrial elongation factor 1 upstream open
            reading frame (MIURF), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001414695
VERSION     NM_001414695.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 213)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 213)
  AUTHORS   Dibley,M.G., Formosa,L.E., Lyu,B., Reljic,B., McGann,D.,
            Muellner-Wong,L., Kraus,F., Sharpe,A.J., Stroud,D.A. and Ryan,M.T.
  TITLE     The Mitochondrial Acyl-carrier Protein Interaction Network
            Highlights Important Roles for LYRM Family Members in Complex I and
            Mitoribosome Assembly
  JOURNAL   Mol Cell Proteomics 19 (1), 65-77 (2020)
   PUBMED   31666358
REFERENCE   3  (bases 1 to 213)
  AUTHORS   Rathore,A., Chu,Q., Tan,D., Martinez,T.F., Donaldson,C.J.,
            Diedrich,J.K., Yates,J.R. 3rd and Saghatelian,A.
  TITLE     MIEF1 Microprotein Regulates Mitochondrial Translation
  JOURNAL   Biochemistry 57 (38), 5564-5575 (2018)
   PUBMED   30215512
REFERENCE   4  (bases 1 to 213)
  AUTHORS   Samandi,S., Roy,A.V., Delcourt,V., Lucier,J.F., Gagnon,J.,
            Beaudoin,M.C., Vanderperre,B., Breton,M.A., Motard,J.,
            Jacques,J.F., Brunelle,M., Gagnon-Arsenault,I., Fournier,I.,
            Ouangraoua,A., Hunting,D.J., Cohen,A.A., Landry,C.R., Scott,M.S.
            and Roucou,X.
  TITLE     Deep transcriptome annotation enables the discovery and functional
            characterization of cryptic small proteins
  JOURNAL   Elife 6, e27860 (2017)
   PUBMED   29083303
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 213)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   6  (bases 1 to 213)
  AUTHORS   Andreev,D.E., O'Connor,P.B., Fahey,C., Kenny,E.M., Terenin,I.M.,
            Dmitriev,S.E., Cormican,P., Morris,D.W., Shatsky,I.N. and
            Baranov,P.V.
  TITLE     Translation of 5' leaders is pervasive in genes resistant to eIF2
            repression
  JOURNAL   Elife 4, e03971 (2015)
   PUBMED   25621764
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 213)
  AUTHORS   Vanderperre,B., Lucier,J.F., Bissonnette,C., Motard,J.,
            Tremblay,G., Vanderperre,S., Wisztorski,M., Salzet,M.,
            Boisvert,F.M. and Roucou,X.
  TITLE     Direct detection of alternative open reading frames translation
            products in human significantly expands the proteome
  JOURNAL   PLoS One 8 (8), e70698 (2013)
   PUBMED   23950983
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 213)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL022312.7.
            
            Summary: This gene represents an upstream open reading frame
            located in the transcripts of mitochondrial elongation factor 1
            (GeneID:) gene. The open reading frame shows a strong signature of
            protein-coding regions in PhyloCSF and translation of the 70aa
            protein is supported by peptide and ribosome profiling data.
            [provided by RefSeq, Dec 2022].
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000637854.1/
                                                  ENSP00000490747.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AL022312.7         44920-45132
FEATURES             Location/Qualifiers
     source          1..213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..213
                     /gene="MIURF"
                     /gene_synonym="AltMiD51; AltMIEF1; MIEF1; MIEF1-MP"
                     /note="mitochondrial elongation factor 1 upstream open
                     reading frame"
                     /db_xref="GeneID:127898561"
     CDS             1..213
                     /gene="MIURF"
                     /gene_synonym="AltMiD51; AltMIEF1; MIEF1; MIEF1-MP"
                     /note="MIEF1 microprotein; alternative MIEF1 protein;
                     alternative transcript upstream of MiD51"
                     /codon_start=1
                     /product="mitochondrial ribosome and complex I assembly
                     factor AltMIEF1"
                     /protein_id="NP_001401624.1"
                     /db_xref="GeneID:127898561"
                     /translation="MAPWSREAVLSLYRALLRQGRQLRYTDRDFYFASIRREFRKNQK
                     LEDAEARERQLEKGLVFLNGKLGRII"
     exon            1..213
                     /gene="MIURF"
                     /gene_synonym="AltMiD51; AltMIEF1; MIEF1; MIEF1-MP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccccgt ggagccgaga ggcggtgctg agtctctatc gggctctgtt gcgccagggc
       61 cgacagcttc gctacactga tcgagacttc tactttgcct ccatccgccg tgaattccga
      121 aaaaatcaga agctagagga cgctgaggcc cgggagaggc agctggagaa gggcctggtc
      181 tttctcaacg gcaaattggg gaggatcatt tag
//
