LOCUS       NM_138798                939 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens microtubule interacting and trafficking domain
            containing 1 (MITD1), transcript variant 1, mRNA.
ACCESSION   NM_138798
VERSION     NM_138798.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 939)
  AUTHORS   Chen,Y., Jiao,W., Wang,Y., Liang,Z., Wang,L., Li,D., Liang,Y. and
            Niu,H.
  TITLE     Microtubule interacting and trafficking domain containing 1
            deficiency leads to poor survival via tissue factor-mediated
            coagulation in bladder cancer
  JOURNAL   J Thromb Haemost 22 (7), 1956-1972 (2024)
   PUBMED   38554936
  REMARK    GeneRIF: Microtubule interacting and trafficking domain containing
            1 deficiency leads to poor survival via tissue factor-mediated
            coagulation in bladder cancer.
REFERENCE   2  (bases 1 to 939)
  AUTHORS   Dong,S., Hou,D., Peng,Y., Chen,X., Li,H. and Wang,H.
  TITLE     Pan-Cancer Analysis of the Prognostic and Immunotherapeutic Value
            of MITD1
  JOURNAL   Cells 11 (20), 3308 (2022)
   PUBMED   36291174
  REMARK    GeneRIF: Pan-Cancer Analysis of the Prognostic and
            Immunotherapeutic Value of MITD1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 939)
  AUTHORS   Zhang,Y., Li,Y., Qiu,Q., Chen,Z., Du,Y. and Liu,X.
  TITLE     MITD1 Deficiency Suppresses Clear Cell Renal Cell Carcinoma Growth
            and Migration by Inducing Ferroptosis through the TAZ/SLC7A11
            Pathway
  JOURNAL   Oxid Med Cell Longev 2022, 7560569 (2022)
   PUBMED   36046690
  REMARK    GeneRIF: MITD1 Deficiency Suppresses Clear Cell Renal Cell
            Carcinoma Growth and Migration by Inducing Ferroptosis through the
            TAZ/SLC7A11 Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 939)
  AUTHORS   Chen,C. and Sheng,Y.
  TITLE     Prognostic Impact of MITD1 and Associates With Immune Infiltration
            in Kidney Renal Clear Cell Carcinoma
  JOURNAL   Technol Cancer Res Treat 20, 15330338211036233 (2021)
   PUBMED   34346239
  REMARK    GeneRIF: Prognostic Impact of MITD1 and Associates With Immune
            Infiltration in Kidney Renal Clear Cell Carcinoma.
REFERENCE   5  (bases 1 to 939)
  AUTHORS   Chen,Y., Xu,T., Xie,F., Wang,L., Liang,Z., Li,D., Liang,Y.,
            Zhao,K., Qi,X., Yang,X. and Jiao,W.
  TITLE     Evaluating the biological functions of the prognostic genes
            identified by the Pathology Atlas in bladder cancer
  JOURNAL   Oncol Rep 45 (1), 191-201 (2021)
   PUBMED   33200223
  REMARK    GeneRIF: Evaluating the biological functions of the prognostic
            genes identified by the Pathology Atlas in bladder cancer.
REFERENCE   6  (bases 1 to 939)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 939)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 939)
  AUTHORS   Lee,S., Chang,J., Renvoise,B., Tipirneni,A., Yang,S. and
            Blackstone,C.
  TITLE     MITD1 is recruited to midbodies by ESCRT-III and participates in
            cytokinesis
  JOURNAL   Mol Biol Cell 23 (22), 4347-4361 (2012)
   PUBMED   23015756
  REMARK    GeneRIF: MITD1 participates in the abscission phase of cytokinesis
            and ESCRT-III subunits are important for the recruitment of MITD1
            to the midbody.
REFERENCE   9  (bases 1 to 939)
  AUTHORS   Hadders,M.A., Agromayor,M., Obita,T., Perisic,O., Caballe,A.,
            Kloc,M., Lamers,M.H., Williams,R.L. and Martin-Serrano,J.
  TITLE     ESCRT-III binding protein MITD1 is involved in cytokinesis and has
            an unanticipated PLD fold that binds membranes
  JOURNAL   Proc Natl Acad Sci U S A 109 (43), 17424-17429 (2012)
   PUBMED   23045692
  REMARK    GeneRIF: results suggest a model whereby MITD1 coordinates the
            activity of ESCRT-III during abscission with earlier events in the
            final stages of cell division
REFERENCE   10 (bases 1 to 939)
  AUTHORS   Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
            Sanderson,C.M.
  TITLE     A systematic analysis of human CHMP protein interactions:
            additional MIT domain-containing proteins bind to multiple
            components of the human ESCRT III complex
  JOURNAL   Genomics 88 (3), 333-346 (2006)
   PUBMED   16730941
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA109248.1 and BC018453.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138798.2.
            
            Summary: Abscission, the separation of daughter cells at the end of
            cytokinesis, is effected by endosomal sorting complexes required
            for transport III (ESCRT-III). The protein encoded by this gene
            functions as a homodimer, with the N-termini binding to a subset of
            ESCRT-III subunits and the C-termini binding to membranes. The
            encoded protein regulates ESCRT-III activity and is required for
            proper cytokinesis. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Feb
            2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.180285.1,
                                           SRR5189658.40520.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000289359.6/
                                                ENSP00000289359.2
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DA109248.1         4-32
            30-939              BC018453.1         1-910
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..939
                     /gene="MITD1"
                     /note="microtubule interacting and trafficking domain
                     containing 1"
                     /db_xref="GeneID:129531"
                     /db_xref="HGNC:HGNC:25207"
     exon            1..228
                     /gene="MITD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..827
                     /gene="MITD1"
                     /note="isoform 1 is encoded by transcript variant 1; MIT
                     domain-containing protein 1; MIT, microtubule interacting
                     and transport, domain containing 1"
                     /codon_start=1
                     /product="MIT domain-containing protein 1 isoform 1"
                     /protein_id="NP_620153.1"
                     /db_xref="CCDS:CCDS2040.1"
                     /db_xref="GeneID:129531"
                     /db_xref="HGNC:HGNC:25207"
                     /translation="MAKSGLRQDPQSTAAATVLKRAVELDSESRYPQALVCYQEGIDL
                     LLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEKEDGKYHKQIKIEENATGFS
                     YESLFREYLNETVTEVWIEDPYIRHTHQLYNFLRFCEMLIKRPCKVKTIHLLTSLDEG
                     IEQVQQSRGLQEIEESLRSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQ
                     SRFSLGYCDFDLRPCHETTVDIFHKKHTKNI"
     exon            229..330
                     /gene="MITD1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..467
                     /gene="MITD1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..554
                     /gene="MITD1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..670
                     /gene="MITD1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..731
                     /gene="MITD1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..939
                     /gene="MITD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      916..921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MITD1"
                     /note="hexamer: AATAAA"
     polyA_site      939
                     /gene="MITD1"
                     /note="major polyA site"
ORIGIN      
        1 acatgaccac ttcccggaag cgcagcagac ccgctcaact tcatcctggg ttgaggcgga
       61 ggagaacttc cagaattatg gcgaagtccg ggctgaggca ggacccgcag agcacagctg
      121 cagccactgt gctaaagcgg gcagtagaac tagattcgga gtcgcggtat ccgcaggctc
      181 tggtgtgtta ccaagagggg attgatctgc tcctgcaggt tctgaaaggt accaaagata
      241 atactaagag atgtaatctc agagaaaaaa tttccaaata catggacaga gcggaaaaca
      301 taaagaagta cttggaccaa gaaaaagaag atggaaaata tcacaagcaa attaaaatag
      361 aagagaatgc aacaggtttc agttatgagt cactttttcg cgaatacctt aatgagacag
      421 ttacagaagt ttggatagaa gatccttata ttagacatac tcatcagctg tataactttc
      481 ttcgattttg tgagatgctt attaagagac catgtaaagt aaaaactatt caccttctca
      541 cctctctgga tgaaggcatt gagcaagtgc agcaaagtag aggcctgcaa gaaatagaag
      601 agtcactcag gagtcacgga gtgctgttgg aagttcaata ctcttcttca atacatgacc
      661 gagaaattag gttcaacaat ggatggatga ttaagattgg aaggggactt gattatttta
      721 agaaaccaca gagtcgtttt tcccttggat attgtgattt tgatttaaga ccatgtcatg
      781 aaacaacagt agacattttt cataagaagc atacaaaaaa tatatgatgg gtggtagcct
      841 aatttgtatt atgtctactt taagtgaata ttggattttt tttaaaagat cacttttata
      901 atgtatgaat ttaacaataa acttttatat ttctactaa
//
