LOCUS       NM_001291291            1523 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens MISP family member 3 (MISP3), transcript variant 1,
            mRNA.
ACCESSION   NM_001291291 NR_024282 XM_001719438 XM_053966 XM_937316
VERSION     NM_001291291.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1523)
  AUTHORS   Zhu,M., Settele,F., Kotak,S., Sanchez-Pulido,L., Ehret,L.,
            Ponting,C.P., Gonczy,P. and Hoffmann,I.
  TITLE     MISP is a novel Plk1 substrate required for proper spindle
            orientation and mitotic progression
  JOURNAL   J Cell Biol 200 (6), 773-787 (2013)
   PUBMED   23509069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022098.9 and BC011002.2.
            
            On Nov 6, 2019 this sequence version replaced NM_001291291.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011002.2, DRR138523.72028.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000587086.3/ ENSP00000465157.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC022098.9         110163-110385
            224-1523            BC011002.2         1-1300
FEATURES             Location/Qualifiers
     source          1..1523
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..1523
                     /gene="MISP3"
                     /note="MISP family member 3"
                     /db_xref="GeneID:113230"
                     /db_xref="HGNC:HGNC:26963"
     exon            1..1092
                     /gene="MISP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             525..1184
                     /gene="MISP3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="uncharacterized protein MISP3 isoform 1"
                     /protein_id="NP_001278220.1"
                     /db_xref="CCDS:CCDS77246.1"
                     /db_xref="GeneID:113230"
                     /db_xref="HGNC:HGNC:26963"
                     /translation="METPIEREIRRSCEREESLRRSRGLSPGRAGRELVELRVRPVLN
                     LPGPGPALPRALERARAGAQMQRDIEREAHRQAALARPAVPEPRARSPPQPLGELKRF
                     FEAAAGSGSSAGAGDGAGPQRLPEPGGRPRSAVQGGCRVLGSAPPPFTPSLLEQEVRA
                     VREREQELQRQRRSVYGTAEFKEPTPSLTASRGDGKLVVIWPPRRKVSENGLEQEERK
                     P"
     exon            1093..1166
                     /gene="MISP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1523
                     /gene="MISP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1500..1505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MISP3"
                     /note="hexamer: AATAAA"
     polyA_site      1523
                     /gene="MISP3"
                     /note="major polyA site"
ORIGIN      
        1 ggaacccacg gccgccactg ccgccacagg tgcctcacag tgccctctgt cctcgctctg
       61 ggaatcaaaa ccccggttgg gaactgaggc ttccgaactg cttccaaccc tggacacgaa
      121 ggcccccacc ggccggagaa cgaaaccctg gggtcgtctg aagaggaggg ccaggagtcc
      181 ccagggccag acagcgaagc cccagagctg ctgcggagct gaacaccgag gtccccaagc
      241 cctccgcaaa ggacgtggag atcctggagc aagagagcga agtcctcgag ccatcagtcg
      301 agcaggacgc agagagcccc gggctgtcca cagctgcggg ctttgagagt cctgagccag
      361 gcagagacga ccctgggccg tccgaagcgc aaagggcgga ggtccagggg cagcatcccc
      421 ctccaggccc taagacctcc tcctccaggt caggctcgga agccccccac ctgcgttttc
      481 cgccgtgccc cgaggctccc cagcgtcccc cggaggagcg gttcatggag acgcccatcg
      541 agcgcgaaat ccgccgcagc tgcgaacgcg aggagagcct gcgccggagc cggggcctga
      601 gcccgggccg cgcaggccgt gaactcgtcg agctgcgcgt gcggccggtg ctcaacctgc
      661 cgggtcctgg ccccgcgctc ccgcgcgccc tggagcgggc gcgggcgggc gcgcagatgc
      721 agcgggacat cgagcgggag gcccaccggc aggcggcgct ggcgcgcccc gcggtccccg
      781 agccgcgcgc ccggtcgccg ccgcagccgc tgggcgaact caagcgcttc ttcgaggccg
      841 cggcggggag cggctcctcg gcgggggcgg gggacggcgc gggcccgcag aggctgccag
      901 agcctggggg acggccgcgc tcggccgtgc agggcgggtg ccgggtgctg ggcagcgccc
      961 cgccgccttt cactccgtca ctgctggagc aggaggtgcg cgccgtgcgc gagcgcgagc
     1021 aggaactgca gcgccagcgg cgcagcgtct atggcaccgc ggagttcaag gagcctacgc
     1081 cgagcctcac cgcgagcagg ggcgacggaa agttggtggt gatctggccc ccccgcagaa
     1141 aggtctcgga gaacggcctg gagcaggagg agcgcaaacc ttgaggtttg aaaaggctgg
     1201 gacccccggc cggaagtaac gtacgcgtca gaggaacagg gcggggggcg tctagcatta
     1261 ggcctggaga agggtcggct ctctgcattg gggaagatga aatcgacttg cctttgtgaa
     1321 attgaccagc cccctctata aaacttacag tcccccattg ggaaactgac caccacccac
     1381 aactccgcca gtgaaactgc ccagcccttc tctgcctaat tgcaaactga actaccctct
     1441 cccttgactg ttaagagggc cggagttacc gcctcgattg ccccactccc cccaccccca
     1501 ataaagcctc ttctttcagg gca
//
