LOCUS       NM_001355570             448 bp    mRNA    linear   PRI 20-MAR-2024
DEFINITION  Homo sapiens mitochondrial sheath formation associated (MISFA),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001355570
VERSION     NM_001355570.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 448)
  AUTHORS   Ramirez-Moya,J., Wert-Lamas,L., Acuna-Ruiz,A., Fletcher,A.,
            Wert-Carvajal,C., McCabe,C.J., Santisteban,P. and
            Riesco-Eizaguirre,G.
  TITLE     Identification of an interactome network between lncRNAs and miRNAs
            in thyroid cancer reveals SPTY2D1-AS1 as a new tumor suppressor
  JOURNAL   Sci Rep 12 (1), 7706 (2022)
   PUBMED   35562181
  REMARK    GeneRIF: Identification of an interactome network between lncRNAs
            and miRNAs in thyroid cancer reveals SPTY2D1-AS1 as a new tumor
            suppressor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 448)
  AUTHORS   Mise,S., Matsumoto,A., Shimada,K., Hosaka,T., Takahashi,M.,
            Ichihara,K., Shimizu,H., Shiraishi,C., Saito,D., Suyama,M.,
            Yasuda,T., Ide,T., Izumi,Y., Bamba,T., Kimura-Someya,T.,
            Shirouzu,M., Miyata,H., Ikawa,M. and Nakayama,K.I.
  TITLE     Kastor and Polluks polypeptides encoded by a single gene locus
            cooperatively regulate VDAC and spermatogenesis
  JOURNAL   Nat Commun 13 (1), 1071 (2022)
   PUBMED   35228556
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112694.12.
            
            On Apr 15, 2021 this sequence version replaced NM_001355570.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF056874.1, AA719259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000635674.2/
                                                  ENSP00000489616.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC112694.12        32411-32619
            210-298             AC112694.12        33714-33802
            299-336             AC112694.12        35780-35817
            337-448             AC112694.12        36394-36505
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..448
                     /gene="MISFA"
                     /gene_synonym="Kastor; Polluks; SPTY2D1-AS1; SPTY2D1OS"
                     /note="mitochondrial sheath formation associated"
                     /db_xref="GeneID:100506540"
                     /db_xref="HGNC:HGNC:44122"
                     /db_xref="MIM:620764"
     exon            1..209
                     /gene="MISFA"
                     /gene_synonym="Kastor; Polluks; SPTY2D1-AS1; SPTY2D1OS"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..320
                     /gene="MISFA"
                     /gene_synonym="Kastor; Polluks; SPTY2D1-AS1; SPTY2D1OS"
                     /note="SPTY2D1 antisense RNA 1 (non-protein coding);
                     putative transmembrane protein SPTY2D1OS; SPTY2D1 opposite
                     strand"
                     /codon_start=1
                     /product="mitochondrial sheath formation-associated
                     protein"
                     /protein_id="NP_001342499.1"
                     /db_xref="CCDS:CCDS86186.1"
                     /db_xref="GeneID:100506540"
                     /db_xref="HGNC:HGNC:44122"
                     /db_xref="MIM:620764"
                     /translation="MIVLGWMFFVGLVCYMGTFPELMPPTLKWQERWPVQESKTQLRR
                     RALGEDLLQNHVEGI"
     exon            210..298
                     /gene="MISFA"
                     /gene_synonym="Kastor; Polluks; SPTY2D1-AS1; SPTY2D1OS"
                     /inference="alignment:Splign:2.1.0"
     exon            299..336
                     /gene="MISFA"
                     /gene_synonym="Kastor; Polluks; SPTY2D1-AS1; SPTY2D1OS"
                     /inference="alignment:Splign:2.1.0"
     exon            337..448
                     /gene="MISFA"
                     /gene_synonym="Kastor; Polluks; SPTY2D1-AS1; SPTY2D1OS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      429..434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MISFA"
                     /gene_synonym="Kastor; Polluks; SPTY2D1-AS1; SPTY2D1OS"
                     /note="hexamer: CATAAA"
     polyA_site      448
                     /gene="MISFA"
                     /gene_synonym="Kastor; Polluks; SPTY2D1-AS1; SPTY2D1OS"
                     /note="major polyA site"
ORIGIN      
        1 atcctttgga gccaaagact cgaacagaca tgcgagacct ctaccaactg aaggtttcgt
       61 gagcgcactc ctttgccaag atcttggtga atagtctttc actgtgcaat tttatcttag
      121 aaattgtttt acgtttgatc atgattgtgc ttggctggat gttttttgtt ggacttgtgt
      181 gttacatggg cacgtttcca gagttgatgc ctccaactct gaagtggcag gagaggtggc
      241 ctgttcagga gagcaaaaca caactgagga ggcgggcttt aggtgaagat ctgctgcaga
      301 accatgtgga agggatataa atatccccca ggagggactc cagtggaagt aagcaaggat
      361 gatcctggtg aagtaatgca gctgtgaagc tcacctgacc agctgtacag ttcctgttgt
      421 tggtttcaca taaagtaatt gcacatta
//
