LOCUS       NM_018353               4577 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens MIS18 binding protein 1 (MIS18BP1), mRNA.
ACCESSION   NM_018353
VERSION     NM_018353.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4577)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4577)
  AUTHORS   Cuijpers,S.A.G., Willemstein,E. and Vertegaal,A.C.O.
  TITLE     Converging Small Ubiquitin-like Modifier (SUMO) and Ubiquitin
            Signaling: Improved Methodology Identifies Co-modified Target
            Proteins
  JOURNAL   Mol Cell Proteomics 16 (12), 2281-2295 (2017)
   PUBMED   28951443
  REMARK    GeneRIF: Results confirm the regulation of MIS18BP1 via
            SUMO-ubiquitin crosstalk during mitosis.
REFERENCE   3  (bases 1 to 4577)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 4577)
  AUTHORS   Pan,D., Klare,K., Petrovic,A., Take,A., Walstein,K., Singh,P.,
            Rondelet,A., Bird,A.W. and Musacchio,A.
  TITLE     CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is
            necessary for CENP-A loading
  JOURNAL   Elife 6, e23352 (2017)
   PUBMED   28059702
  REMARK    GeneRIF: The authors demonstrate that CDK1 controls Mis18 complex
            recruitment to centromeres by regulating oligomerization of M18BP1
            through the Mis18alpha:Mis18beta scaffold.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4577)
  AUTHORS   Dambacher,S., Deng,W., Hahn,M., Sadic,D., Frohlich,J., Nuber,A.,
            Hoischen,C., Diekmann,S., Leonhardt,H. and Schotta,G.
  TITLE     CENP-C facilitates the recruitment of M18BP1 to centromeric
            chromatin
  JOURNAL   Nucleus 3 (1), 101-110 (2012)
   PUBMED   22540025
  REMARK    GeneRIF: CENP-C works as an important factor for centromeric M18BP1
            recruitment
REFERENCE   6  (bases 1 to 4577)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 4577)
  AUTHORS   Maddox,P.S., Hyndman,F., Monen,J., Oegema,K. and Desai,A.
  TITLE     Functional genomics identifies a Myb domain-containing protein
            family required for assembly of CENP-A chromatin
  JOURNAL   J Cell Biol 176 (6), 757-763 (2007)
   PUBMED   17339379
REFERENCE   8  (bases 1 to 4577)
  AUTHORS   Fujita,Y., Hayashi,T., Kiyomitsu,T., Toyoda,Y., Kokubu,A., Obuse,C.
            and Yanagida,M.
  TITLE     Priming of centromere for CENP-A recruitment by human hMis18alpha,
            hMis18beta, and M18BP1
  JOURNAL   Dev Cell 12 (1), 17-30 (2007)
   PUBMED   17199038
  REMARK    GeneRIF: Three human proteins essential for centromere/kinetochore
            structure and function, hMis18alpha, hMis18beta, and M18BP1, the
            complex of which is accumulated specifically at the telophase-G1
            centromere, are identified.[Mis18alpha, Mis18beta, M18BP1]
REFERENCE   9  (bases 1 to 4577)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   10 (bases 1 to 4577)
  AUTHORS   Gunther,M., Laithier,M. and Brison,O.
  TITLE     A set of proteins interacting with transcription factor Sp1
            identified in a two-hybrid screening
  JOURNAL   Mol Cell Biochem 210 (1-2), 131-142 (2000)
   PUBMED   10976766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB067490.1, BC065544.1 and AW971491.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018353.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065544.1, SRR1660805.98110.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310806.9/ ENSP00000309790.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AB067490.1         201-209
            10-3975             BC065544.1         1-3966
            3976-4534           AW971491.1         37-595              c
            4535-4577           BC065544.1         4527-4569
FEATURES             Location/Qualifiers
     source          1..4577
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.2"
     gene            1..4577
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /note="MIS18 binding protein 1"
                     /db_xref="GeneID:55320"
                     /db_xref="HGNC:HGNC:20190"
                     /db_xref="MIM:618139"
     exon            1..168
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..803
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..3658
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /note="putative protein p243 which interacts with
                     transcription factor Sp1; kinetochore null 2 homolog;
                     kinetochore-associated protein KNL-2 homolog; P243;
                     hsKNL-2"
                     /codon_start=1
                     /product="mis18-binding protein 1"
                     /protein_id="NP_060823.3"
                     /db_xref="CCDS:CCDS9684.1"
                     /db_xref="GeneID:55320"
                     /db_xref="HGNC:HGNC:20190"
                     /db_xref="MIM:618139"
                     /translation="MIATPLKHSRIYLPPEASSQRRNLPMDAIFFDSIPSGTLTPVKD
                     LVKYQNSSLKLNDHKKNQFLKMTTFNNKNIFQSTMLTEATTSNSSLDISAIKPNKDGL
                     KNKANYESPGKIFLRMKEKVLRDKQEQPSRNSSLLEPQKSGNNETFTPNRVEKKKLQH
                     TYLCEEKENNKSFQSDDSSLRASVQGVPLESSNNDIFLPVKQKIQCQQEKKAPLHNLT
                     YELPTLNQEQENFLAVEARNKTLTRAQLAKQIFHSKESIVATTKSKKDTFVLESVDSA
                     DEQFQNTNAETLSTNCIPIKNGSLLMVSDSERTTEGTSQQKVKEGNGKTVPGETGLPG
                     SMKDTCKIVLATPRLHITIPRRSKRNISKLSPPRIFQTVTNGLKKNQVVQLQEWMIKS
                     INNNTAICVEGKLIDVTNIYWHSNVIIERIEHNKLRTISGNVYILKGMIDQISMKEAG
                     YPNYLIRKFMFGFPENWKEHIDNFLEQLRAGEKNREKTKQKQKTGRSVRDIRKSMKND
                     ARENQTDTAQRATTTYDFDCDNLELKSNKHSESPGATELNMCHSNCQNKPTLRFPDDQ
                     VNNTIQNGGGDDLSNQELIGKKEYKMSSKKLKIGERTNERIIKSQKQETTEELDVSID
                     ILTSREQFFSDEERKYMAINQKKAYILVTPLKSRKVIEQRCMRYNLSAGTIKAVTDFV
                     IPECQKKSPISKSMGTLENTFEGHKSKNKEDCDERDLLTVNRKIKISNLEKEQMLTSD
                     FKKNTRLLPKLKKIENQVAMSFYKHQSSPDLSSEESETEKEIKRKAEVKKTKAGNTKE
                     AVVHLRKSTRNTSNIPVILEPETEESENEFYIKQKKARPSVKETLQKSGVRKEFPITE
                     AVGSDKTNRHPLECLPGLIQDKEWNEKELQKLHCAFASLPKHKPGFWSEVAAAVGSRS
                     PEECQRKYMENPRGKGSQKHVTKKKPANSKGQNGKRGDADQKQTIKITAKVGTLKRKQ
                     QMREFLEQLPKDDHDDFFSTTPLQHQRILLPSFQDSEDDDDILPNMDKNPTTPSSVIF
                     PLVKTPQCQHVSPGMLGSINRNDCDKYVFRMQKYHKSNGGIVWGNIKKKLVETDFSTP
                     TPRRKTPFNTDLGENSGIGKLFTNAVESLDEEEKDYYFSNSDSA"
     exon            804..917
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1402
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1476
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1607
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1695
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1853
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..2005
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2099
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2928
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3101
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3262
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3411
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3499
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3554
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..4577
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4162..4167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /note="hexamer: ATTAAA"
     polyA_site      4183
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /note="major polyA site"
     regulatory      4552..4557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /note="hexamer: AATAAA"
     polyA_site      4577
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgttaga gaacgtcgcg gaggaggtaa gcgtcgcttg gcgcctggcc gccgcgggca
       61 ggatacaccg tgggcctgag gcgcgagccc ggcggcgtgc ggccctctct ccgcgcggag
      121 ccgagccgga actgcggcag tctctccctg ccaggctctt catccaaggt ttctgtggat
      181 cccttctgaa gttctatctg aaaattgcgc ttaagtgaat tttctgttag aagaacttgg
      241 ttgctacttt cttgtcaaga tgattgcaac acctttgaaa cattcaagaa tttacttacc
      301 tccagaggca tcttctcaaa ggagaaatct acccatggat gcaatctttt ttgacagcat
      361 tccttcaggc acacttactc ctgtaaaaga tttggtgaaa tatcagaact cctccttaaa
      421 attgaatgac cataaaaaga atcagttcct aaaaatgaca acttttaaca ataaaaatat
      481 atttcaatca actatgctaa cagaggctac tacctctaac agttctcttg atatcagtgc
      541 tataaagccc aacaaggatg gattaaaaaa taaagcaaac tatgaatcac caggaaaaat
      601 atttctaaga atgaaagaaa aagtactgcg tgacaagcaa gaacagccat caagaaacag
      661 tagtttgttg gaaccacaga aaagtggaaa taatgaaacc ttcactccta acagagttga
      721 aaaaaaaaaa ttgcagcata cctacctatg tgaagaaaag gaaaacaaca aatcattcca
      781 gtcagatgac agttcactaa gagcctcagt ccaaggagtt cctctagaat catcaaataa
      841 tgatattttc ctcccggtca aacaaaagat tcagtgccag caggaaaaga aagcaccact
      901 gcacaattta acttacgaac ttccaactct gaaccaagaa caggaaaatt ttttggctgt
      961 agaagcccga aacaagacat taactagagc tcagttggct aaacaaattt ttcactcaaa
     1021 ggagagtata gttgcaacca ctaaatccaa aaaggacacg tttgttttag aaagcgttga
     1081 ttctgctgat gaacaatttc aaaatactaa tgctgagact ctcagtacta attgtattcc
     1141 tattaaaaat ggcagcctgt taatggtttc tgatagtgag aggacaacag aagggacttc
     1201 gcaacagaaa gttaaggaag gaaatggaaa aacagtgcct ggagagacag gtcttccagg
     1261 ttccatgaaa gatacatgta aaattgtact tgcaacacca agacttcata taacaatacc
     1321 tcggaggtca aaaagaaata tttcaaagct ttctcctcca agaatatttc aaactgttac
     1381 aaatggactt aaaaaaaatc aggtagttca gctacaggaa tggatgatta aaagcatcaa
     1441 taataatact gctatatgtg tagaaggaaa attgatagac gtcactaaca tatattggca
     1501 cagtaatgta attatagagc ggattgagca caacaaactt aggactatat caggcaacgt
     1561 ttatatatta aaaggcatga tagaccaaat ttccatgaaa gaagcaggat atccaaatta
     1621 tctcataagg aaatttatgt ttggatttcc agaaaattgg aaagagcaca ttgataattt
     1681 tctggaacaa ttaagggctg gtgaaaagaa cagggaaaag accaaacaaa aacagaaaac
     1741 tggaagatct gtccgtgaca taaggaaatc aatgaaaaat gatgcacgag aaaaccaaac
     1801 agatactgct caaagagcca ccaccactta cgattttgat tgtgataatt tggaactgaa
     1861 gagtaataag cacagtgagt caccaggagc tacagaatta aacatgtgcc acagtaattg
     1921 ccaaaataaa ccaacattaa ggttcccaga tgaccaagta aataatacta ttcaaaatgg
     1981 aggaggagat gacttatcta atcaggaatt aattggaaaa aaagaatata aaatgtcttc
     2041 aaagaaacta aaaattggtg aaagaacaaa tgaaaggata ataaaaagtc agaagcaaga
     2101 gacaactgaa gaattggatg tatccattga tattctaacc tcaagggaac agtttttctc
     2161 agatgaagaa agaaaataca tggccatcaa tcagaagaaa gcttatattt tagtaacacc
     2221 acttaaatct agaaaagtga tagagcaaag atgcatgagg tataatctgt ccgctggcac
     2281 catcaaagca gtaacagatt ttgtaatacc agagtgtcaa aaaaaaagtc ccatcagcaa
     2341 gtccatgggg actttagaaa atacatttga aggtcataaa agtaaaaaca aggaagattg
     2401 cgatgaacgt gacttactta ctgtcaaccg gaaaataaaa atatctaacc ttgaaaagga
     2461 acaaatgctc acctctgact ttaagaaaaa taccagacta ttaccaaaat tgaagaaaat
     2521 agaaaatcag gtagctatgt cattttataa gcatcagtcc tcaccagatt tgtcaagtga
     2581 agaaagtgaa acagaaaagg aaattaaaag gaaagctgaa gttaagaaaa ccaaagcagg
     2641 aaacaccaaa gaagcagtgg ttcacctgag aaagagcaca agaaacacaa gtaatattcc
     2701 agtgattttg gaacctgaaa ctgaagaaag tgaaaatgaa ttttatatca aacaaaagaa
     2761 agctagacct tccgtcaaag aaactcttca gaagtctggt gttaggaaag agtttccaat
     2821 tactgaggca gtaggatctg ataagacaaa taggcatccc ttagaatgct tacctggttt
     2881 aattcaggat aaggaatgga atgagaagga gttacagaaa cttcattgtg cttttgcatc
     2941 tcttccaaag cacaaacctg gtttctggtc agaggtagct gcggctgtag gttctcgatc
     3001 tcctgaagaa tgccagagga aatacatgga aaatcccaga ggaaaaggat cccagaaaca
     3061 tgtcactaag aagaagccag ccaattccaa aggccaaaat ggcaagagag gtgatgctga
     3121 tcagaaacaa actattaaga taactgccaa agtgggaact cttaaaagga agcaacagat
     3181 gagggaattt ctggaacagt tgccaaaaga tgaccatgat gattttttca gtacaacacc
     3241 tttacagcat caaagaatac tgttgccaag tttccaggac agtgaagatg atgatgatat
     3301 tctgccaaat atggacaaaa atccaacaac tccatcatca gttatctttc cattggtaaa
     3361 aactcctcaa tgtcagcatg tcagtcctgg catgctaggt tctataaata ggaatgactg
     3421 tgataaatat gtttttcgta tgcaaaaata tcataaaagt aatggtggta ttgtctgggg
     3481 caacatcaag aaaaaattag ttgaaactga tttctcaact ccaacaccaa gaaggaaaac
     3541 cccatttaac acagacttag gagaaaactc tggtattgga aaacttttca ctaatgctgt
     3601 ggaatcttta gatgaagaag agaaagatta ttatttttcg aactctgatt ctgcatagta
     3661 aaatgagaaa atatgattcc tgggattttt accataaagc agacagtgtt tgtattttca
     3721 actggagtac atgtattttc tttgtaaagt agcttcctat gaaaatgtgg acttttttga
     3781 aggtttcata tgtttgtgtt caaagtaaaa tatcctcatt gctgcagctt actaaaaatg
     3841 taaagaaaat tgtttttgct cgtgtagata tctgtaaatt tgtttttgca tattaaaata
     3901 tatatagata attttttaat aagcatccaa gtctgtttac tttaagaaaa ccatttccca
     3961 aacagatttt tttttatttc aagaaaattt tgctaccatt taagtaagag aaggtgagaa
     4021 ggatgacaga ggttgtattg gtagctattg aattcatgaa aacttttaag ttagcatttg
     4081 ttagcagtta ttatccaagc cagagtagga tttgttacca gttgttatcc aaacctaatg
     4141 tttaaattac acattgttga aattaaatta cacattgttg acatgcttct ctcctgattg
     4201 tttttatttt aaacttgtga taggcatatc tatgaaacct ttgtaaattt agtttattgc
     4261 tttaccatta ttttactagg taaaattaga gaacagattt tgttctctaa tttttaagcc
     4321 ttatttacat atgcagaaac agcttaaata ttttgactag attagacaaa cagttaatag
     4381 atccaccatt aggaatcaat atattatgtc ataataaaca tcctttttct ttcactgaaa
     4441 tttcttttag aaataaactt atttttgctt gttatgtttt gaaacttgac ataggatatt
     4501 ttccctctgg ctacacattc acctaccctt gttctctatt tagattattc aaataaagtt
     4561 agtttgcttt tatagta
//
