LOCUS       NM_001388067            5983 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens mirror-image polydactyly 1 (MIPOL1), transcript
            variant 4, mRNA.
ACCESSION   NM_001388067 XM_017021004
VERSION     NM_001388067.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5983)
  AUTHORS   Leong,M.M.L., Cheung,A.K.L., Kwok,T.C.T. and Lung,M.L.
  TITLE     Functional characterization of a candidate tumor suppressor gene,
            Mirror Image Polydactyly 1, in nasopharyngeal carcinoma
  JOURNAL   Int J Cancer 146 (10), 2891-2900 (2020)
   PUBMED   31609475
  REMARK    GeneRIF: Functional characterization of a candidate tumor
            suppressor gene, Mirror Image Polydactyly 1, in nasopharyngeal
            carcinoma.
REFERENCE   2  (bases 1 to 5983)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5983)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5983)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 5983)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 5983)
  AUTHORS   Deng,H., Tan,T. and Yuan,L.
  TITLE     Advances in the molecular genetics of non-syndromic polydactyly
  JOURNAL   Expert Rev Mol Med 17, e18 (2015)
   PUBMED   26515020
  REMARK    GeneRIF: To date, at least ten loci and four non-syndromic
            polydactyly-causing genes, including the GLI3 gene, the ZNF141
            gene, the MIPOL1 gene and the PITX1 gene, have been identified.
            (Review)
            Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5983)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   8  (bases 1 to 5983)
  AUTHORS   Cheung,A.K., Lung,H.L., Ko,J.M., Cheng,Y., Stanbridge,E.J.,
            Zabarovsky,E.R., Nicholls,J.M., Chua,D., Tsao,S.W., Guan,X.Y. and
            Lung,M.L.
  TITLE     Chromosome 14 transfer and functional studies identify a candidate
            tumor suppressor gene, mirror image polydactyly 1, in
            nasopharyngeal carcinoma
  JOURNAL   Proc Natl Acad Sci U S A 106 (34), 14478-14483 (2009)
   PUBMED   19667180
  REMARK    GeneRIF: Study provides compelling evidence that chromosome 14
            harbors tumor suppressor genes associated with NPC and that a
            candidate gene, MIPOL1, is associated with tumor development.
REFERENCE   9  (bases 1 to 5983)
  AUTHORS   Kamnasaran,D., O'Brien,P.C., Zackai,E.H., Muenke,M.,
            Ferguson-Smith,M.A. and Cox,D.W.
  TITLE     Rearrangement in the PITX2 and MIPOL1 genes in a patient with a
            t(4;14) chromosome
  JOURNAL   Eur J Hum Genet 11 (4), 315-324 (2003)
   PUBMED   12700605
REFERENCE   10 (bases 1 to 5983)
  AUTHORS   Kondoh,S., Sugawara,H., Harada,N., Matsumoto,N., Ohashi,H.,
            Sato,M., Kantaputra,P.N., Ogino,T., Tomita,H., Ohta,T., Kishino,T.,
            Fukushima,Y., Niikawa,N. and Yoshiura,K.
  TITLE     A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a
            patient with mirror-image polydactyly of hands and feet
  JOURNAL   J Hum Genet 47 (3), 136-139 (2002)
   PUBMED   11954550
  REMARK    GeneRIF: candidate gene for mirror-image polydactyly of hands and
            feet anomaly.  Maps to 14q13.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL079304.3, AL121857.6,
            AL109759.4 and AL121790.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 19, 2020 this sequence version replaced XM_017021004.1.
            
            Summary: This gene encodes a coiled-coil domain-containing protein.
            The encoded protein may function as a tumor suppressor. A
            translocation that results in truncation of the protein encoded by
            this locus has been associated with mirror-image polydactyly, also
            known as Laurin-Sandrow Syndrome. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, Sep 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.700824.1,
                                           SRR18074969.1335894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684589.1/ ENSP00000506738.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AL079304.3         117553-117720
            169-306             AL121857.6         119121-119258
            307-385             AL121857.6         119847-119925
            386-617             AL121857.6         138956-139187
            618-753             AL121857.6         140676-140811
            754-859             AL121857.6         142438-142543
            860-989             AL109759.4         194507-194636       c
            990-1023            AL109759.4         171865-171898       c
            1024-1194           AL109759.4         171435-171605       c
            1195-1302           AL109759.4         110330-110437       c
            1303-1397           AL109759.4         57005-57099         c
            1398-1628           AL121790.4         28477-28707
            1629-5983           AL121790.4         75474-79828
FEATURES             Location/Qualifiers
     source          1..5983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.3-q21.1"
     gene            1..5983
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /note="mirror-image polydactyly 1"
                     /db_xref="GeneID:145282"
                     /db_xref="HGNC:HGNC:21460"
                     /db_xref="MIM:606850"
     exon            1..168
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /inference="alignment:Splign:2.1.0"
     exon            169..306
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /inference="alignment:Splign:2.1.0"
     exon            307..385
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /inference="alignment:Splign:2.1.0"
     exon            386..617
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /inference="alignment:Splign:2.1.0"
     exon            618..753
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /inference="alignment:Splign:2.1.0"
     exon            754..859
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /inference="alignment:Splign:2.1.0"
     exon            860..989
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1023
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1194
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1302
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1397
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1628
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..5983
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /note="hexamer: AATAAA"
     polyA_site      2387
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /note="major polyA site"
     regulatory      2422..2427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /note="hexamer: AATAAT"
     polyA_site      2445
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
     regulatory      5958..5963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
                     /note="hexamer: AATAAA"
     polyA_site      5983
                     /gene="MIPOL1"
                     /gene_synonym="CCDC193"
ORIGIN      
        1 aggccccacg cgccgccccg ctcctccgcc ggatcgtctg tgggtgagtc tcgagccagg
       61 aggctctgag ccagtggcga ttggctgacg cggtggctgc gcactcggcc tgagaaactc
      121 ggcaagcgcg cagtgtcgac tccccggtct atgccaggcg catctcagct aatccaaaag
      181 taaatgagaa acttagaaaa agattgccaa ttccaaatca acatatttag agaaaattgg
      241 aaaaggagaa gcttactaca gctttatttg aggacttttt aaagaacgct gggttctatc
      301 tgtgagctgc aaatcttgga gcaaaaacca gagacattgc cagagcaaac aagaacagaa
      361 atacaaatgg agaactggtc aaaagacata acccacagtt atcttgaaca agaaactacg
      421 gggataaata aaagtacgca gccagatgag caactgacta tgaattctga gaaaagtatg
      481 catcggaaat ccactgaatt agttaatgaa ataacatgtg agaacacaga atggccaggg
      541 cagagatcaa cgaattttca gatcatcagt tcttatccag atgatgagtc tgtttactgc
      601 actactgaaa aatacaacgt tatggaacat agacataatg atatgcatta tgaatgtatg
      661 actccttgtc aagttacttc agactcagat aaagagaaga caatagcatt tcttctaaaa
      721 gaattggata ttctcagaac aagcaataaa aagcttcagc agaaattggc taaagaagat
      781 aaagaacaga gaaaactaaa gtttaagctg gaactccaag agaaagaaac agaagctaaa
      841 attgctgaaa agacagcagc tctggttgaa gaagtgtatt ttgcgcagaa ggaacgtgat
      901 gaagctgtta tgtctagact gcaattagcc attgaggaga gagatgaagc aattgcacga
      961 gccaagcata tggaaatgtc tctaaaagtg ctagaaaata ttaaccctga agaaaatgac
     1021 atgacattac aggaattact gaacagaata aacaatgcag acacagggat agctattcag
     1081 aagaatggag ctataattgt ggatagaatc tacaagacca aggaatgtaa aatgagaata
     1141 actgcagaag aaatgagtgc actaatagaa gaacgggatg ctgccttgtc taagtgcaaa
     1201 cggttagagc aggagcttca tcatgtgaaa gagcagaacc agacttcagc aaacaacatg
     1261 agacatctga ctgctgaaaa caatcaagaa cgtgctctga aggcaaagtt gttatctatg
     1321 caacaagcca gagaaactgc agttcaacag tacaaaaaac tggaagagga aatccagacc
     1381 cttcgagttt actacagttt acacaaatct ttatctcaag aagaaaatct gaaggatcag
     1441 tttaactata cccttagtac atatgaagaa gctttaaaaa acagagagaa cattgtttcc
     1501 atcactcaac aacaaaatga ggaactggct actcaactgc aacaagctct gacagagcga
     1561 gcaaatatgg aattacaact tcaacatgcc agagaggcct cccaagtggc caatgaaaaa
     1621 gttcaaaagt tggaaaggct ggtggatgta ctgaggaaga aggttggaac cgggaccatg
     1681 aggacagtga tctgattgaa aaaaaacgac agtctgggga agcgatcaca tctggtgacc
     1741 aggctgcttc attcaacact gtgtaaacac caaagcctta acttagcaaa cagttgttag
     1801 aagtgggaca ctccaaccac attccaagct gagataaaat caaatcacaa atgtttaacc
     1861 actttgctgc tgacttgagt tatttatcca aatatattaa ctatagactt ttaccaatgg
     1921 gtagctataa ggttacagct tattttgtaa ctattttata tctcaatatc tttaatataa
     1981 atctttttac tgagagatca ttatagaaac atgttaaagt tggttaggat catatcttca
     2041 catatggccc tttctgaatc aaagtgcggc aaagtaaata ttgtctaagc tttaatccac
     2101 tgtgttaggt caaaacttca aatacatgca tttttcaata tagggtatat ttcttaactg
     2161 atgagagagg cttagacatg agtgtgtagt cttccttcaa tgcgtgtatg taatctttgt
     2221 tagtataaaa gatattaaat ataggtgcca agaattaaat gtataatttg tttaataaga
     2281 gatggatata ttaaaattac attcatcaag gcatgatttt tgtttcacta caaataatgc
     2341 aaactgtttt caataaaaag aggagactgt taatgtgtac ttataaattc acattgtcag
     2401 tattttttaa tattgggtct gaataattat ctgaattcta cttaagctat aagtctctgt
     2461 catttttgct tgaaaattag catgcctctg tcttaaaaga gaccatcaaa cctattaagt
     2521 attcttattg tttatctttt tttaattgcc atttgatttt tattgtggag gaggaggatc
     2581 taatatataa tattcaatac aattgtaatg tagaaatata agaatttaga aaaaagtaaa
     2641 cttgccattt ggttaaggtt acctgctttt tattttattc cagaaataag atagttacag
     2701 catagcagtc atatgaagtt atgaatagaa ctgagatttt tatgtaatta gttataggca
     2761 aaatactttc atatttttag attagacaga cgaaagacca agaggaaatg actgtgcctg
     2821 gaacaggatg aaatagacaa gtagagattt aattagcaaa aattttgtag ggaagtaaaa
     2881 ttttttctaa gtctatacgt ttttaattca tctttaagat tgagctaaat tatctaccat
     2941 tgcctattta caggataagt acattcagga caatttattg taccattctt tcatatacca
     3001 tagcagatta tccatttcaa ttttttttta ctccacagga aaatgtaagc tactttgtca
     3061 tagatcacaa aagaatcata atgctaacaa actctatttc ttccttatta aatctgtatc
     3121 cattaaagta acttttttaa ctatgagaat tagaaaataa gggacaacag gggttaaaaa
     3181 taaactgatt taatttgctc tatagtccta aagagaatta tatcctctca tagaccaatg
     3241 actctataat agagaaatat gtaatgattt ggtcatgcat ggagtcttgt ctctgggctc
     3301 tatttgaaac gtgtaacagc tccctatgtg aagaaacatt atctttaaag tcatctggga
     3361 ggtgcaggta agtaaagaga aacaattttt gtcacaaagt agtccattcc tgatctcact
     3421 taaaataaat cacaagtaaa tttgaatttt cggtttaatg ttgaaagcag atgaactttt
     3481 cttgagttat tttgtctttt agaatacaca aaatatagta taaagacatt tcacaatttc
     3541 caaacaaatc tttctacgct taaatgatca aattagaaaa accaattcct ataattaata
     3601 tgcagaactt ttatagaata tgatattata aagttaaatt tgcaaaataa ttctaacatc
     3661 cactattgtt cagtataggt aatctcccaa aaatatcaca tcctcttgaa aatgaattgt
     3721 ctacaaaatt tcaaatgcaa agtattacag ccaaatatta tcttaattaa tttcttacac
     3781 ttaaaagtgt ccatcaacag tgtgtcagat ggtctttata tattttttct gtatgaagga
     3841 atagccttgc ctactgaaga taggttctct atgtattcaa caataatgca actttagaag
     3901 tattccacac tgctgagaaa tgttgctttg agtttgcttt acacatcatc aactctaaat
     3961 cctatagtaa catgagaatt cacttcttct tgtaaaaata agtaatttac aggaaaggca
     4021 aaatgctaat actaacattt gtagcacttg atgatttaca aagtcctttt acatctgttt
     4081 tttcatttga tcctatcgac aatcataata ataataaatt atatatataa cccatataat
     4141 aacgatggtg atgataattt tagtattact gtcattataa ttattattat attcattcta
     4201 cagatgagga aacagactca gtaagccttg gaatttgcca aggactggct aggacctaga
     4261 actaagatct tataaccaca ctccatgcaa ctatgagtct ctaaatctct ctgtaagaaa
     4321 aaaatttcaa agtaaagatt ttactcttgc aatttctgtt gtgatagtac catctctttc
     4381 acatactaca tacaaattcc ctaataatca aaagattgta cacatttttt tcaatgaagt
     4441 acaataatgt gaactgcatg tgtaaacagc atcacattat taccacctct ctatggtatt
     4501 atagtggcag tatgctttgc ctcagccttc actaattagg aatattgtga caattcattg
     4561 ctaataaaac ataacatgag tctctttgta ctgtttttaa tttggcctga tgctaaaacc
     4621 tatcagctta gttttttaac atggtagtct aaacttcaag gcttgctcta tctcctagag
     4681 caatttagag ctaaaaccag taataagcaa agttattggt tataagcaag gtataagcag
     4741 ttaaagcaaa gttattaatt attaatatat gagaatttaa aattttataa ataagttaga
     4801 aattattaat gtattttaaa tatggagtaa aatattttgc taattttttt caatgataaa
     4861 gttgatcctt tgtatatttc cttattcaaa taaattcagt catcttctta tcaggttgct
     4921 tatttatata atttgtttat tttattaaaa atctagaata ttaaagattt atacttttaa
     4981 tattgaatat agtttcgtag aaaaacattt tatatgtact attcttaaag atcacaatta
     5041 tttttaaact ttctattttc aaatacttgt gattaataag gcattctatg atgaaatagc
     5101 catggcttat atatttttgt cttttcacat atgatgtgtt tggaacccaa attttttact
     5161 gattttattg tgttgttggt aactagtatt tacagctaac ctatctattc atattttaca
     5221 tatatatata tatatataca tgcacacaca ccgatacatt taccttttaa aaaaatgatt
     5281 tataagtgaa ctgttaggct ccagtgattt cagtgttttg ttcatgtttt attggaaatg
     5341 cacgtggttt cttaggcttt taaacaaata catggaatgg ttgaaagatt tattttgctc
     5401 gtgcttagct aaatatgtca tctctagaaa agatgtggtt tgttttggca ctgttttaaa
     5461 aactcaaata ttttaaacat ttgttaagtt ggagcttgca catttaaacc agcagcatac
     5521 gttccagaag agcatctcaa gttaccaaat tttttgtaat ccttttacta gaaaaatctt
     5581 ttttgaagag tttttcttgt gcttgcttcg gcagcatata tactgaaatt agaaaaagaa
     5641 aacttttctt ttttattata tattttagtg taagttaagt taaacttcta aaagttgaat
     5701 tatttaatgt aggacttcat aaatagtatt tgacaatgat aaatgtgtat ttttgagaat
     5761 cattaaaatg tatacaatga tattcctttg cagaagtctt aatatgcata atttttaatc
     5821 taattgtctt ctaaatatag ttttggtgta tgctggtatt ttagaagcca ccaatttctg
     5881 gactatctga ttattaacaa agatgtattt taatgcacaa actcaaatgt ttaaaatata
     5941 tatttacttt gtactcaaat aaaatcccct attgcaaatc cta
//
